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Effect of Physical Activity Pattern on Cardiometabolic Health (PACE)

Offene Rekrutierung
Die Details der klinischen Studie sind hauptsächlich auf Englisch verfügbar. Trial Radar KI kann jedoch helfen! Klicken Sie einfach auf 'Studie erklären', um die Informationen zur Studie in der ausgewählten Sprache anzuzeigen und zu besprechen.
Die klinische Studie NCT05838508 (PACE) ist eine interventionsstudie zur Untersuchung von Lebensstil und hat den Status offene rekrutierung. Die Studie startete am 11. Oktober 2024 und soll 26 Teilnehmer aufnehmen. Durchgeführt von Brigham and Women's Krankenhaus ist der Abschluss für 30. August 2026 geplant. Die Daten von ClinicalTrials.gov wurden zuletzt am 13. Juni 2025 aktualisiert.
Kurzbeschreibung

The goal of this study is to understand the interaction between the circadian system and physical activity.

Participants will:

  • complete 2 inpatient stays
  • perform moderate exercise
  • be provided with identical meals
  • have frequent blood draws
  • provide urine and saliva samples
Ausführliche Beschreibung
The endogenous circadian system (i.e., an internal biological rhythm) plays an important role in regulating blood glucose, blood pressure, and energy expenditure. Physical activity improves health and reduces the risk for cardiovascular diseases and type 2 diabetes. The goal of this study is to understand the interaction between the circadian system and physical activity. We aim to test whether such relationship between the circadian system and physical activity can be used to enhance the health benefits of physical activity.
Offizieller Titel

Effect of Physical Activity Pattern on Cardiometabolic Health

Erkrankungen
Lebensstil
Weitere Studien-IDs
NCT-Nummer
NCT05838508
Studienbeginn (tatsächlich)
2024-10-11
Zuletzt aktualisiert
2025-06-13
Studienende (vorauss.)
2026-08-30
Geplante Rekrutierung
26
Studientyp
Interventionsstudie
PHASE
Nicht zutreffend
Status
Offene Rekrutierung
Stichwörter
exercise
circadian system
physical activity
glucose tolerance
blood pressure
Primäres Ziel
Grundlagenforschung
Zuteilungsmethode
Randomisiert
Interventionsmodell
Cross-over
Verblindung
Einfach verblindet
Studienarme/Interventionen
Teilnehmergruppe/StudienarmIntervention/Behandlung
ExperimentellExercise A-B Intervention
The Exercise A first, then the Exercise B intervention.
Bewegungsintervention
Research participants will be assigned to two exercise conditions.
ExperimentellExercise B-A Intervention
The Exercise B first, then the Exercise A intervention.
Bewegungsintervention
Research participants will be assigned to two exercise conditions.
Hauptergebnismessungen
ErgebnismessungBeschreibung der MessungZeitrahmen
glucose level
mean glucose level after exercise session
24-hour test period after exercise
mean arterial pressure
mean arterial pressure after exercise session
24-hour test period after exercise
Nebenergebnismessungen
ErgebnismessungBeschreibung der MessungZeitrahmen
insulin sensitivity index
Oral Minimal Model method estimates mean insulin sensitivity based on blood glucose and insulin levels from two mixed meal tests after exercise session
about 12 and 24 hours after exercise
beta-cell function index
Oral Minimal Model method estimates mean beta-cell function based on blood glucose, insulin and c-peptide levels from two mixed meal tests after exercise session
about 12 and 24 hours after exercise
total peripheral resistance
total peripheral resistance derived from BP waveform measured by finger plethysmography
24-hour test period after exercise
autonomic nervous system activity
derived by time-domain heart rate variability analysis
24-hour test period after exercise
Eignungskriterien

Zugelassene Altersgruppen
Erwachsene
Mindestalter
18 Years
Zugelassene Geschlechter
Alle
Akzeptiert gesunde Freiwillige
Ja
  • 18-45 yr old
  • Body mass index (BMI) 18.5 - 34.9 kg/m2
  • No acute, chronic or debilitating medical conditions (e.g. metabolic, cardiovascular, respiratory, neurological, cancers, etc.)
  • Willing to adhere to the protocol requirements for the duration of the study

  • Currently smoking/vaping or 5 or more years of smoking/vaping
  • Currently pregnant or breastfeeding
  • History of drug or alcohol dependency
  • History of psychiatric illness or disorder
  • Any hospitalization due to COVID-19
  • Inability to exercise for any reason
  • Any known contraindication to exercise testing based on current ACSM guidelines
Brigham and Women's Hospital logoBrigham and Women's Krankenhaus392 aktive klinische Studien zum Erkunden
National Heart, Lung, and Blood Institute (NHLBI) logoNationales Herz-, Lungen- und Blutinstitut, USA758 aktive klinische Studien zum Erkunden
Verantwortliche Partei
Jingyi Qian, Hauptprüfer, Investigator, Brigham and Women's Hospital
Zentrale Studienkontakte
Kontakt: Jingyi Qian, PhD, 6175257423, [email protected]
Kontakt: Vy Nguyen, B.S., 617-525-0662, [email protected]
1 Studienstandorte in 1 Ländern

Massachusetts

Brigham and Women's Hospital, Boston, Massachusetts, 02115, United States
Jingyi Qian, PhD, Kontakt, 6175257423, [email protected]
Vy Nguyen, B.S., Kontakt, 617-525-0662, [email protected]
Frank Scheer, PhD, Prüfarzt
Jingyi Qian, PhD, Hauptprüfer
Offene Rekrutierung