Klinische Studien Radar

Precisely define the variability in changes in physical function

Measured by the Short Physical Performance Battery (SPPB), a 0-12 categorical scale of walking speed, standing balance, and repeated sit-to-stand time, with higher scores reflecting better physical function.

baseline, 6 months

Precisely define the variability in changes in blood glucose concentrations in response to a meal tolerance test

Blood glucose concentrations (millimoles/liter) will be measured in response to a physiologically relevant meal challenge. Lower values are indicative of better metabolic health.

baseline, 6 months

Precisely define the variability in changes in skeletal muscle size.

Measured by computed tomography scans of the mid-thigh. Larger muscle cross-sectional area (cm\^2) reflects a greater quantity of skeletal muscle.

baseline, 6 months

Precisely define the variability in changes in skeletal muscle strength.

Measured by the one-repetition maximum, in newtons, on a leg press device, with higher scores reflecting greater skeletal muscle strength.

baseline, 6 months

Precisely define the variability in changes in six-minute walk distance.

Measured by the distance (meters) walked in six minutes, with longer distances reflecting better physical function.

baseline, 6 months

Precisely define the variability in insulin secretion in response to a mixed meal tolerance test.

Blood insulin concentrations (pmol/L) will be measured in response to a physiologically relevant meal challenge. Insulin concentrations in a physiological range reflect better metabolic health, while low insulin concentrations can reflect an impaired insulin response and high insulin concentrations can reflect peripheral insulin resistance.

baseline, 6 months

Precisely define the variability in changes in the percentage of glycated hemoglobin in the blood.

Measured by the percentage of glycated hemoglobin in the blood (often referred to as HbA1c). A lower percentage of HbAlc reflects lower blood glucose concentrations over the past two to three months.

baseline, 6 months

Precisely define the variability in changes in blood lipids.

Blood lipids, including total cholesterol, low density lipoproteins (LDLs), high density lipoproteins (HDLs), and triglycerides will be measured. Lower levels of total cholesterol (mg/dL), LDLs (mg/dL), and triglycerides (mg/dL), and higher levels of HDLs (mg/dL), are reflective of better metabolic health.

baseline, 6 months

Precisely define the variability in changes in waist-to-hip ratio.

The circumference (cm) of the waist and hips will be measured and a ratio will be calculated. A lower waist-to-hip ratio is reflective of a better body composition (less central obesity or visceral fat).

baseline, 6 months