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Clinical Trial NCT03621813 for Cancer is active, not recruiting. See the Trial Radar Card View and AI discovery tools for all the details. Or ask anything here.
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Exercise Rehabilitation in Veteran Cancer Survivors 9 Veterans Exercise-Based

Active, not recruiting
Clinical Trial NCT03621813 is an interventional study for Cancer that is active, not recruiting. It started on 19 August 2019 with plans to enroll 9 participants. Led by VA Office of Research and Development, it is expected to complete by 30 December 2026. The latest data from ClinicalTrials.gov was last updated on 18 February 2026.
Brief Summary
Exercise rehabilitation has the potential as a non-pharmacological approach to reduce persistent neuropathic pain in Veterans with lung cancer. By examining the effects of exercise training in Veteran cancer survivors with NSCLC, there is the potential to revolutionize care for a: common, debilitating, and inadequately treated symptom in a growing population. This could lead to a larger investigation to fill critical...Show More
Detailed Description
Persistent or chronic neuropathic pain, either post-thoracotomy persistent pain (PTPP) or chemotherapy-induced peripheral neuropathy (CIPN) occurs in a majority of lung cancer patients. Thus, not only is this neuropathic pain widespread; there is no way to prevent its development, and long-term use of opioids for control of symptoms could result in addiction. Ultimately, PTPP and CIPN can lead to long-term suffering ...Show More
Official Title

Progressive Activity-Based Rehabilitation in Veteran Cancer Survivors With Chronic Pain

Conditions
Cancer
Other Study IDs
  • E2870-P
  • HP-00081388 (Other Identifier) (Baltimore VAMC)
NCT ID Number
NCT03621813
Start Date (Actual)
2019-08-19
Last Update Posted
2026-02-18
Completion Date (Estimated)
2026-12-30
Enrollment (Estimated)
9
Study Type
Interventional
PHASE
N/A
Status
Active, not recruiting
Keywords
Neuropathic Pain
Exercise
Lung Cancer
Primary Purpose
Treatment
Design Allocation
Non-Randomized
Interventional Model
Sequential
Masking
Single
Arms / Interventions
Participant Group/ArmIntervention/Treatment
OtherControl
Participants maintain their current activity level.
Control
Participants are instructed to maintain current activity level and are monitored for changes.
Active ComparatorExercise Rehabilitation
Participants will exercise 2x/week at training facilities and at home one day a week.
Exercise Rehabilitation
This training is designed to improve fitness, target the major muscle groups for strength, and to improve balance. Aerobic exercise of walking on a treadmill will be performed. Thera-Bands will be used for resistance exercise for the lower and upper body. Balance program includes core exercises (stepping, weight shifts, etc.) and other progressive exercises.
Primary Outcome Measures
Outcome MeasureMeasure DescriptionTime Frame
Pain Visual Analog Scale Change
Scale of 0 (no pain) to 100 (worst imaginable pain)
Measured at baseline, after 6 weeks control, and after 6 week intervention
Secondary Outcome Measures
Outcome MeasureMeasure DescriptionTime Frame
Patient-Reported Outcomes Measurement System Neuropathic Pain Quality (PROMIS-PQ Neuro) Change
0-10 numeric rating
Measured at baseline, after 6 weeks control, and after 6 week intervention
Fitness Change
VO2peak
Measured at baseline, after 6 weeks control, and after 6 week intervention
Strength Change
knee extensor strength
Measured at baseline, after 6 weeks control, and after 6 week intervention
Participation Assistant
Eligibility Criteria

Eligible Ages
Adult, Older Adult
Minimum Age
60 Years
Eligible Sexes
All
  1. Age 60-80 years
  2. Diagnosis with lung cancer
  3. History of treatment with either thoracotomy procedure or neurotoxic chemotherapy or both
  4. Completion of thoracotomy or chemotherapy > or = 6 months
  5. Ability to walk on a treadmill
  6. Karnofsky performance status > 70
  7. Score > 1 Neuropathic Pain Scale

  1. Presence of metastatic (stage IV)
  2. Life expectancy < 6 months
  3. Musculoskeletal or medical conditions which preclude participation in an exercise program
VA Office of Research and Development logoVA Office of Research and Development
Baltimore VA Medical Center logoBaltimore VA Medical Center
No contact data.
1 Study Locations in 1 Countries

Maryland

Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD, Baltimore, Maryland, 21201, United States