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Randomized Study in Children and Adolescents With Migraine: Acute Treatment Phase 3 2,100 Randomized Adolescent

Recruiting
Clinical Trial NCT04649242 is designed to study Treatment for Pediatric Migraine. It is a Phase 3 interventional study that is recruiting, having started on 15 January 2021, with plans to enroll 2,100 participants. Led by Pfizer, it is expected to complete by 9 January 2029. The latest data from ClinicalTrials.gov was last updated on 20 March 2026.
Brief Summary
The purpose of this study is to test the safety and efficacy of BHV-3000 versus placebo in the acute treatment of moderate or severe migraine in children and adolescents.
Official Title

Phase 3, Multicenter, Randomized, Double-blind, Group Sequential, Placebo-controlled Study to Assess Efficacy and Safety of Rimegepant for the Treatment of Migraine (With or Without Aura) in Children and Adolescents ≥ 6 to < 18 Years of Age

Conditions
Pediatric Migraine
Other Study IDs
  • BHV3000-311
  • C4951002 (Other Identifier) (Alias Study Number)
  • 2020-003517-35 (Registry Identifier) (CTIS (EU))
  • 2024-512743-23-00 (Registry Identifier) (CTIS (EU))
NCT ID Number
NCT04649242
Start Date (Actual)
2021-01-15
Last Update Posted
2026-03-20
Completion Date (Estimated)
2029-01-09
Enrollment (Estimated)
2,100
Study Type
Interventional
PHASE
Phase 3
Status
Recruiting
Keywords
Migraine
Acute treatment
Phonophobia
Photophobia
Nausea
Pediatric
Children
Adolescent
Pediatric Migraine
Primary Purpose
Treatment
Design Allocation
Randomized
Interventional Model
Sequential
Masking
Triple
Arms / Interventions
Participant Group/ArmIntervention/Treatment
Active ComparatorBHV3000 (active drug)
BHV3000 (rimegepant) 75 mg or 50 mg ODT
Rimegepant/BHV3000
BHV3000 (rimegepant) 75 mg or 50 mg ODT
Placebo ComparatorPlacebo
Matching 75 mg or 50 mg ODT placebo
Matching placebo
Matching 75 mg or 50 mg ODT placebo
Primary Outcome Measures
Outcome MeasureMeasure DescriptionTime Frame
To evaluate the efficacy of rimegepant compared with placebo in the acute treatment of migraine in adolescent population (≥ 12 to <18 years of age) as measured by pain freedom using the number of patients reporting no pain.
Pain freedom will be assessed in adolescent population (≥ 12 to \< 18 years of age) on a 4-point numeric rating scale (0=none, 1=mild, 2=moderate, 3=severe).
2 hours post-dose
Secondary Outcome Measures
Outcome MeasureMeasure DescriptionTime Frame
To compare rimegepant with placebo for pain freedom in children and adolescents combined.
Pain freedom will be assessed in children and adolescents (≥ 6 to \< 18 years of age) using a 4-point numeric rating scale (0=none, 1=mild, 2=moderate, 3=severe). Pain freedom will be assessed in children (\> 6 to \< 12 years of age) using the 5-Face VAS (Face 5 = 'severe pain', Faces 4 and 3 = 'moderate pain', Face 2 = 'mild pain', Face 1 = 'no pain').
2 hours post-dose
To compare rimegepant with placebo on freedom from the most bothersome symptom (MBS) associated with migraine in adolescents.
Freedom from MBS (nausea, phonophobia or photophobia) will be measured using a binary scale (0=absent, 1=present).
2 hours post-dose
To compare rimegepant with placebo on the probabilities of requiring rescue medication within in adolescents.
Use of rescue medication will be assessed using the numbers of participants that take rescue medication.
Within 24 hours and 48 hours of initial treatment
To compare rimegepant with placebo on sustained pain freedom in adolescents.
Sustained pain freedom will be assessed using the number of participants that do not use any rescue medications and do not experience any headache pain post dose.
2 to 24 hours post-dose
To compare rimegepant with placebo on sustained pain freedom in adolescents.
Sustained pain freedom will be assessed using the number of participants that do not use any rescue medications and do not experience any headache pain post dose.
2 to 48 hours post-dose
To compare rimegepant with placebo on the ability to function normally as reported on the Functional Disability scale in adolescents.
The proportion of participants able to function normally will be assessed using the number that self-report as "normal" on the Functional Disability scale.
2 hours post-dose
To compare rimegepant with placebo for pain freedom in children.
Pain freedom will be assessed using the number of children (≥ 6 to \< 12 years of age) that report no pain measured by a 5-Face VAS (Face 5 = 'severe pain', Faces 4 and 3 = 'moderate pain', Face 2 = 'mild pain', Face 1 = 'no pain').
2 hours post-dose
To compare rimegepant with placebo on freedom from the most bothersome symptom (MBS) associated with migraine in children and combined children and adolescents.
Freedom from the most bothersome symptom (nausea, phonophobia or photophobia) will be assessed using the number of participants that report the absence of MBS measured using a binary scale (0=absent, 1=present).
2 hours post-dose
To compare rimegepant with placebo on the probabilities of requiring rescue medication in children and combined children and adolescents.
The probabilities of requiring rescue medication will be assessed using the numbers of participants that take rescue medication within initial treatment.
Within 24 hours and 48 hours of initial treatment.
To compare rimegepant with placebo on sustained pain freedom in children and combined children and adolescents.
Sustained pain freedom will be assessed using the number of participants that do not use any rescue medications and do not experience any headache pain post dose.
2 to 24 hours post-dose
To compare rimegepant with placebo on sustained pain freedom in children and combined children and adolescents.
Sustained pain freedom will be assessed using the number of participants that do not use any rescue medications and do not experience any headache pain post dose.
2 to 48 hours post-dose
To compare rimegepant with placebo on freedom from photophobia in adolescents, children and combined children and adolescents.
Freedom from photophobia will be assessed by the number of participants that report the absence of photophobia post dose that reported the presence of photophobia at baseline.
2 hours post-dose
To compare rimegepant with placebo on freedom from phonophobia in adolescents, children and combined children and adolescents.
Freedom from phonophobia will be assessed by the number of participants that report the absence of phonophobia post dose that reported the presence of phonophobia at baseline.
2 hours post-dose
To compare rimegepant with placebo on freedom from nausea in adolescents, children and combined children and adolescents.
Freedom from nausea will be assessed by the number of participants that report the absence of nausea post dose that reported the presence of nausea at baseline.
2 hours post-dose
To compare rimegepant with placebo on pain relief in adolescents, children and combined children and adolescents.
Pain relief will be assessed using the number of participants that report a pain level of moderate or severe at baseline and then report a pain level of none or mild post dose.
2 hours post-dose
To compare rimegepant with placebo in adolescents, children and combined children and adolescents on pain relief.
Time to first report of pain relief will be based on the first time point a participant reports a pain level of none or mild.
Time to patients first report of pain relief of none or mild post dose up to 48 hours.
Participation Assistant
Eligibility Criteria

Eligible Ages
Child
Minimum Age
6 Years
Eligible Sexes
All

  1. History of migraine (with or without aura) for > 6 months before Screening according to the IHS Classification ICHD-319 specifications for pediatric migraine. History may be verified using both medical records and recall by the participant and/or participant's parent(s)/legal representative(s).

  2. History of 1 to 8 moderate or severe attacks per month during the 2 months prior to enrollment, with attacks lasting > 3 hours without treatment, and attacks occurring at intervals > 24 hours.

  3. Prophylactic migraine medication are permitted if the dose has been stable for at least 12 weeks prior to the Baseline Visit, and the dose is not expected to change during the course of the study.

    1. Participants may remain on one (1) medication with possible migraine prophylactic effects, excluding CGRP antagonists \[biologic or small molecule\], during the treatment phases.
    2. Concomitant use of a CGRP antagonist, such as erenumab or fremanezumab, is prohibited.
    3. Previously discontinued prophylactic migraine medication must have done so at least 90 days prior to the Screening Visit.

  4. Verbally distinguish between migraine and other types of headaches.

  5. Participants must have a weight > 40 kg at the Screening Visit.

  6. Adequate venous access for blood sampling.

  7. Male and female participants ≥ 6 to < 18 years of age (participants must not reach their 18th birthday during the study).

  1. History of cluster headache or hemiplegic migraine headache.
  2. Confounding and clinically significant pain syndrome that may interfere with the participant's ability to participate in this study.
  3. Current psychiatric condition that is uncontrolled and/or untreated for a minimum of 6 months prior to the Screening Visit. Participants with a lifetime history of psychosis and/or mania.
  4. History of suicidal behavior or major psychiatric disorder.
  5. Current diagnosis or history of substance abuse; positive drug test at Screening.
  6. History of moderate or severe head trauma or other neurological disorder (including seizure disorder) or systemic medical disease that is likely to affect central nervous system functioning.
  7. Recent or planned surgery, requiring general anesthesia, <8 weeks prior to the Screening Visit.
  8. Participant has had gastrointestinal surgery that interferes with physiological absorption and motility (i.e., gastric bypass, duodenectomy, or gastric banding).
  9. Current diagnosis of viral hepatitis or a history of liver disease.
  10. Conditions considered clinically relevant in the context of the study such as uncontrolled hypertension (high blood pressure), diabetes, a life-threatening allergy
Pfizer logoPfizer457 active studies to explore
Study Central Contact
Contact: Pfizer Pfizer CT.gov Call Center, 1-800-718-1021, [email protected]
245 Study Locations in 9 Countries

Alabama

Achieve Clinical Research, LLC d/b/a Accel Research Sites-Neurology and Neurodiagnostic of Alabama, Birmingham, Alabama, 35244, United States
Active, not recruiting

Arizona

Perseverance Research Center, LLC, Scottsdale, Arizona, 85253, United States
Recruiting
Physicians Research Group, Tempe, Arizona, 85284, United States
Active, not recruiting

California

Advanced Research Center, Inc., Anaheim, California, 92805, United States
Recruiting
Adult & Child Neurology Medical Associates, Costa Mesa, California, 92627, United States
Recruiting
ProScience Research Group, Culver City, California, 90230, United States
Recruiting
Memorial Health Services, Fountain Valley, California, 92708, United States
Recruiting
Neuro-Pain Medical Center, Fresno, California, 93710, United States
Recruiting
Regents of the University of California (UC San Diego), La Jolla, California, 92093, United States
Recruiting
Adult & Child Neurology Medical Associates, Long Beach, California, 90806, United States
Recruiting
Miller Children's & Women's Hospital Long Beach, Long Beach, California, 90806, United States
Recruiting
National Research Institute, Los Angeles, California, 90057, United States
Active, not recruiting
Velocity Clinical Research - North Hollywood, North Hollywood, California, 91606, United States
Active, not recruiting
Children's Hospital of Orange County - Inpatient Pharmacy, Orange, California, 92868, United States
Not yet recruiting
Children's Hospital of Orange County - Neuroscience Center, Orange, California, 92868, United States
Not yet recruiting
Children's Hospital of Orange County, Orange, California, 92868, United States
Not yet recruiting
The Neurology Group, Pomona, California, 91767, United States
Recruiting
University of California, Davis Midtown Clinic, Sacramento, California, 95816, United States
Active, not recruiting
UC Davis Medical Center, Investigational Drug Service (IDS) Pharmacy, Sacramento, California, 95817, United States
Active, not recruiting
University of California, Davis Clinical and Translational Science Center Clinical Research (CCRC), Sacramento, California, 95817, United States
Active, not recruiting
Velocity Clinical Research, San Bernardino (IP Delivery and Administering Location), San Bernardino, California, 92408, United States
Recruiting
Pacific Clinical Research Management Group LLC, Upland, California, 91786, United States
Active, not recruiting
Sunwise Clinical Research, Walnut Creek, California, 94596, United States
Recruiting

Colorado

Children's Hospital Colorado- lnvestigational Drug Services, Aurora, Colorado, 80045, United States
Recruiting
Children's Hospital Colorado, Aurora, Colorado, 80045, United States
Recruiting
Colorado Springs Neurological Associates, PC, Colorado Springs, Colorado, 80907, United States
Recruiting
Colorado Springs Neurological Associates, PC, Colorado Springs, Colorado, 80919, United States
Recruiting

Connecticut

CT Clinical Research, Cromwell, Connecticut, 06416, United States
Recruiting
Connecticut Children's Medical Center, Hartford, Connecticut, 06106, United States
Active, not recruiting
Ki Health Partners, LLc, dba New England Institute for Clinical Research, Stamford, Connecticut, 06905, United States
Recruiting

Delaware

Nemours Children's Hospital, Delaware, Wilmington, Delaware, 19803, United States
Active, not recruiting

District of Columbia

Children's National Medical Center, Washington D.C., District of Columbia, 20010, United States
Recruiting

Florida

Topaz Clinical Research, Inc., Apopka, Florida, 32703, United States
Active, not recruiting
Beautiful Minds Clinical Research Center, Cutler Bay, Florida, 33157, United States
Terminated
DeLand Clinical Research Unit, DeLand, Florida, 32720, United States
Terminated
Sarkis Clinical Trials, Gainesville, Florida, 32607, United States
Active, not recruiting
Multi-Specialty Research Associates, Inc., Lake City, Florida, 32055, United States
Active, not recruiting
Watson Clinic Center for Research, Inc., Lakeland, Florida, 33805, United States
Terminated
Watson Clinic LLP, Lakeland, Florida, 33805, United States
Terminated
AppleMed Research Group, LLC, Miami, Florida, 33126, United States
Recruiting
Medical Research Center of Miami II, Inc, Miami, Florida, 33134, United States
Active, not recruiting
Nicklaus Children's Hospital, Research Institute, Miami, Florida, 33155, United States
Not yet recruiting
South Florida Research Phase I-IV, Inc, Miami, Florida, 33166, United States
Recruiting
Brainstorm Research, Miami, Florida, 33176, United States
Active, not recruiting
Advanced Research for Health Improvement, LLC/ Dr. Cordero's Pediatric Office, Naples, Florida, 34102, United States
Active, not recruiting
Aqualane Clinical Research, Naples, Florida, 34105, United States
Recruiting
Coastal Clinical Research Specialists, Orange Park, Florida, 32073, United States
Active, not recruiting
Clinical Associates of Orlando, LLC, Orlando, Florida, 32819, United States
Recruiting
Bioresearch Institute, Pembroke Pines, Florida, 33026, United States
Terminated
Forcare Clinical Research, Tampa, Florida, 33613, United States
Recruiting
Premiere Research Institute at Palm Beach Neurology, West Palm Beach, Florida, 33407, United States
Active, not recruiting

Georgia

Children's Healthcare of Atlanta, Inc., Atlanta, Georgia, 30329, United States
Recruiting
Childrens Healthcare of Atlanta, Atlanta, Georgia, 30329, United States
Recruiting
Rare Disease Research, LLC, Atlanta, Georgia, 30329, United States
Active, not recruiting
Pivotal Clinical Research & Associates, LLC, Brunswick, Georgia, 31520, United States
Recruiting
CenExel iResearch, LLC, Decatur, Georgia, 30030, United States
Recruiting

Illinois

Chicago Headache Center & Research Institute, Chicago, Illinois, 60657, United States
Recruiting
AMR-Baber Research Inc, Naperville, Illinois, 60563, United States
Recruiting

Indiana

Options Research Group, LLC, Westfield, Indiana, 46074, United States
Recruiting

Iowa

Velocity Clinical Research, Sioux City, Sioux City, Iowa, 51106, United States
Recruiting
Integrated Clinical Trial Services, West Des Moines, Iowa, 50265, United States
Recruiting

Kansas

Clinical Associates Midwest, LLC, Kansas City, Kansas, 66214, United States
Recruiting
College Park Family Care Center Physicians Group- Neurology Research Dept., Overland Park, Kansas, 66212, United States
Active, not recruiting

Kentucky

Kentucky Neuroscience Institute Child Neurology-- "Patients Seen", Lexington, Kentucky, 40504, United States
Active, not recruiting
UK Center for Clinical and Translational Science (CCTS) -- "Patients Seen", Lexington, Kentucky, 40536, United States
Active, not recruiting
University of Kentucky Hospital, Lexington, Kentucky, 40536, United States
Active, not recruiting

Louisiana

Ochsner Clinic Foundation, New Orleans, Louisiana, 70121, United States
Active, not recruiting
Neurology and Headache Center, Inc., Shreveport, Louisiana, 71105, United States
Active, not recruiting

Massachusetts

Boston Clinical Trials, Boston, Massachusetts, 02131, United States
Active, not recruiting
MedVadis Research Corporation, Waltham, Massachusetts, 02451, United States
Active, not recruiting

Michigan

Michigan Head Pain & Neurological Institute, Ann Arbor, Michigan, 48104, United States
Recruiting
Corewell Health, for and on behalf of Spectrum Health Hospital and Corewell Health Medical Group, Grand Rapids, Michigan, 49503, United States
Recruiting
Corewell Health, Helen DeVos Children's Hospital, Grand Rapids, Michigan, 49503, United States
Recruiting
Wellnow Urgent Care and Research, Kalamazoo, Michigan, 49048, United States
Active, not recruiting
Beaumont Hospital Royal Oak Campus, Royal Oak, Michigan, 48073, United States
Recruiting

Minnesota

Brackenridge Outpatient Research Pharmacy, Rochester, Minnesota, 55905, United States
Recruiting
Clinical Research Trials Unit, Rochester, Minnesota, 55905, United States
Recruiting
Mayo Clinic, Rochester, Minnesota, 55905, United States
Recruiting

Mississippi

Precise Research Centers, Flowood, Mississippi, 39232, United States
Recruiting

Missouri

Sharlin Health Neuroscience Research Center, Ozark, Missouri, 65721, United States
Recruiting
Clinvest Research, LLC, Springfield, Missouri, 65810, United States
Active, not recruiting

Montana

Boeson Research, Great Falls, Montana, 59405, United States
Recruiting
Boeson Research, Kalispell, Montana, 59901, United States
Active, not recruiting
Heart & Hands Midwifery, Kalispell, Montana, 59901, United States
Active, not recruiting
Blue Moose Pediatrics, Missoula, Montana, 59804, United States
Recruiting
Boeson Research Laboratory, Missoula, Montana, 59804, United States
Recruiting
Boeson Research, Missoula, Montana, 59804, United States
Recruiting

Nebraska

Alivation Research, LLC., Lincoln, Nebraska, 68526, United States
Terminated
Children's Hospital & Medical Center, Omaha, Nebraska, 68114, United States
Recruiting

New Jersey

HMH Jersey Shore University Medical Center, Neptune City, New Jersey, 07753, United States
Recruiting

New York

Dent Neurosciences Research Center, Amherst, New York, 14226, United States
Recruiting
True North Neurology, Commack, New York, 11725, United States
Recruiting
Northwell Health/ Division of Pediatric Neurology, Lake Success, New York, 11042, United States
Recruiting
NYU Langone Hospital-Long Island, Clinical Research Center, Mineola, New York, 11501, United States
Active, not recruiting
NYU Langone Hospital-Long Island, Pediatric Neurology, Mineola, New York, 11501, United States
Active, not recruiting
New York Neurology Associates, New York, New York, 10003, United States
Recruiting
Weill Cornell Medicine, New York, New York, 10021, United States
Recruiting
Mount Sinai Hospital - Pharmacy Department, New York, New York, 10029, United States
Active, not recruiting
Columbia University Medical Center Research Pharmacy, New York, New York, 10032, United States
Active, not recruiting
Columbia University Pediatric Neuromuscular Center, New York, New York, 10032, United States
Active, not recruiting
Irving Center for Clinical and Translational Research, Outpatient Clinical Research Unit, New York, New York, 10032, United States
Active, not recruiting
The Neurological Institute of New York, New York, New York, 10032, United States
Active, not recruiting
The Trustees of Columbia University and The New York and Presbyterian Hospital, New York, New York, 10032, United States
Active, not recruiting
North Suffolk Neurology P.C, Port Jefferson Station, New York, 11776, United States
Active, not recruiting
Finger Lakes Clinical Research, Rochester, New York, 14618, United States
Terminated
Prime Global Research, LLC, The Bronx, New York, 10456, United States
Terminated

North Carolina

New Hope Clinical Research, Charlotte, North Carolina, 28211, United States
Active, not recruiting
OnSite Clinical Solutions, LLC, Charlotte, North Carolina, 28277, United States
Recruiting
Velocity Clinical Research, Inc., Durham, North Carolina, 27701, United States
Recruiting
Headache Wellness Center, PC, Greensboro, North Carolina, 27405, United States
Recruiting

Ohio

Akron Children's Hospital, Akron, Ohio, 44308, United States
Recruiting
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 45229, United States
Recruiting
Velocity Clinical Research, Cincinnati, Ohio, 45242, United States
Recruiting
University Hospitals Cleveland Medical Center, Cleveland, Ohio, 44106, United States
Recruiting
Nationwide Children's Hospital, Columbus, Ohio, 43205, United States
Active, not recruiting
Wellnow Urgent Care and Research, Columbus, Ohio, 43228, United States
Active, not recruiting
Neuro-Behavioral Clinical Research, Inc., North Canton, Ohio, 44720, United States
Active, not recruiting

Oklahoma

IPS Research Company, Oklahoma City, Oklahoma, 73106, United States
Active, not recruiting
Lynn Institute of Tulsa, Tulsa, Oklahoma, 74135, United States
Active, not recruiting

Oregon

Velocity Clinical Research, Grants Pass, Grants Pass, Oregon, 97527, United States
Active, not recruiting
Providence Health & Services Investigational Drug Services Westside, Portland, Oregon, 97225, United States
Recruiting
Providence Neuroscience Institute - Research Coordinator's Office, Portland, Oregon, 97225, United States
Recruiting
Providence Pediatric Neurology, Portland, Oregon, 97225, United States
Recruiting
Providence St. Vincent Medical Center, Portland, Oregon, 97225, United States
Recruiting

Pennsylvania

Clario, Philadelphia, Pennsylvania, 19103, United States
Recruiting
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, 19104, United States
Active, not recruiting

Rhode Island

Velocity Clinical Research-Providence, East Greenwich, Rhode Island, 02818, United States
Recruiting

South Carolina

Premier Neurology, PC, Greenville, South Carolina, 29605, United States
Active, not recruiting
Tribe Clinical Research, LLC, Greenville, South Carolina, 29607, United States
Active, not recruiting
Velocity Clinical Research - Greenville, Greenville, South Carolina, 29615, United States
Active, not recruiting

Tennessee

Holston Medical Group., Kingsport, Tennessee, 37660, United States
Active, not recruiting
Holston Medical Group, Kingsport, Tennessee, 37660, United States
Active, not recruiting
Le Bonheur Children's Hospital - Outpatient Building, Memphis, Tennessee, 38103, United States
Recruiting
Le Bonheur Children's Hospital, Memphis, Tennessee, 38103, United States
Recruiting
Le Bonheur Childrens Hospital - Childrens Foundation Research Institute, Memphis, Tennessee, 38103, United States
Recruiting
Access Clinical Trials, Inc., Nashville, Tennessee, 37203, United States
Active, not recruiting

Texas

Dell Children's Medical Center, Austin, Texas, 78723, United States
Recruiting
Child Neurology Consultants of Austin - South Austin, Austin, Texas, 78749, United States
Recruiting
Child Neurology Consultants of Austin - Central Austin, Austin, Texas, 78757, United States
Recruiting
BioBehavioral Research of Austin, Austin, Texas, 78759, United States
Active, not recruiting
Houston Clinical Trials, LLC, Bellaire, Texas, 77401, United States
Recruiting
Infinite Research Group, LLC, Dallas, Texas, 75201, United States
Recruiting
Children's Medical Center, Dallas, Dallas, Texas, 75235, United States
Recruiting
Children's Medical Center, Pediatric Anesthesiology Research (Study supplies only), Dallas, Texas, 75235, United States
Recruiting
Cedar Health Research, Dallas, Texas, 75251, United States
Recruiting
FutureSearch Trials of Dallas, LLC, Dallas, Texas, 75251, United States
Recruiting
The University of Texas Southwestern Medical Center, Dallas, Texas, 75390, United States
Recruiting
ANESC Research, El Paso, Texas, 79912, United States
Recruiting
North Texas Institute of Neurology and Headache, Frisco, Texas, 75034, United States
Active, not recruiting
UTHealth Houston, Houston, Texas, 77030, United States
Recruiting
Pain and Headache Centers of Texas, Houston, Texas, 77054, United States
Recruiting
SCLA Management, Houston, Texas, 77077, United States
Recruiting
Houston Clinical Research,LLC., Houston, Texas, 77081, United States
Active, not recruiting
NeuroCare Plus, Houston, Texas, 77094, United States
Recruiting
AIM Trials, LLC, Plano, Texas, 75093, United States
Recruiting

Utah

JBR Clinical Research, Salt Lake City, Utah, 84107, United States
Recruiting
Wasatch Clinical Research , LLC(Administrative Location), Salt Lake City, Utah, 84107, United States
Recruiting

Vermont

The University of Vermont Medical Center, Burlington, Vermont, 05401, United States
Active, not recruiting

Virginia

Pediatric Research of Charlottesville, LLC (Regulatory Only), Charlottesville, Virginia, 22902, United States
Recruiting
Pediatric Research of Charlottesville, LLC, Charlottesville, Virginia, 22902, United States
Recruiting
Children's Hospital of the King's Daughters, Norfolk, Virginia, 23507, United States
Recruiting
Children's Specialty Group, PLLC, Norfolk, Virginia, 23507, United States
Recruiting
Children's Specialty Group, PLLC, Division of Childhood & Adolescent Neurology, Norfolk, Virginia, 23510, United States
Recruiting
National Clinical Research, Inc., Richmond, Virginia, 23294, United States
Active, not recruiting

Washington

Northwest Clinical Research Center, Bellevue, Washington, 98007, United States
Recruiting
Eastside Therapeutic Resource, Inc. dba Core Clinical Research, Everett, Washington, 98201, United States
Active, not recruiting
Seattle Children's Hospital Investigational Drug Services, Seattle, Washington, 98105, United States
Recruiting
Seattle Children's Hospital, Seattle, Washington, 98105, United States
Recruiting

Wisconsin

Clinical Investigation Specialists, Inc, Kenosha, Wisconsin, 53144, United States
Recruiting
University Hospital, Madison, Wisconsin, 53792, United States
Recruiting

British Columbia

OCT Research ULC, Kelowna, British Columbia, V1Y 1Z9, Canada
Recruiting

Quebec

Diex Recherche Sherbrooke Inc, Sherbrooke, Quebec, J1L 0H8, Canada
Active, not recruiting

Anhui

First Affiliated Hospital of Bengbu Medical College Neurology, Bengbu, Anhui, 233000, China
Recruiting
Anhui Provincial Hospital, Hefei, Anhui, 230000, China
Recruiting

Beijing Municipality

Chinese PLA General Hospital, Beijing, Beijing Municipality, 100089, China
Recruiting

Chongqing Municipality

" The First Affiliated Hospital of Chongqing Medical University", Chongqing, Chongqing Municipality, 400042, China
Recruiting

Gansu

Lanzhou university second hospital, Lanzhou, Gansu, 730030, China
Recruiting

Guangdong

Shenzhen Children's Hospital, Shenzhen, Guangdong, 518034, China
Recruiting

Hainan

Hainan General Hospital, Haikou, Hainan, 571140, China
Recruiting

Hebei

The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, China
Recruiting
The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050004, China
Recruiting

Henan

People's Hospital of Zhengzhou, Zhengzhou, Henan, 450000, China
Recruiting

Hubei

Jingzhou First People's Hospital, Jingzhou, Hubei, 434000, China
Recruiting
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, China
Recruiting
Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, China
Recruiting

Hunan

The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410000, China
Recruiting
Hunan Children's Hospital, Changsha, Hunan, 410007, China
Recruiting
The Third Xiangya Hospital of Central South University, Changsha, Hunan, 410013, China
Recruiting

Jiangsu

The Second People's Hospital of Lianyungang, Lianyungang, Jiangsu, 222002, China
Recruiting
The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215006, China
Recruiting
Wuxi Children's Hospital, Wuxi, Jiangsu, 214023, China
Recruiting
Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, 214115, China
Recruiting
Xuzhou Children's Hospital, Xuzhou, Jiangsu, 221002, China
Recruiting
Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, 212001, China
Recruiting

Jilin

The First Hospital of Jilin University, Pediatric Neurology, Changchun, Jilin, 130021, China
Recruiting

Ningxia

General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 756000, China
Recruiting

Shaanxi

Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, 710068, China
Recruiting
Xi'an Gaoxin Hospital Neurology Department, Xi'an, Shaanxi, 710075, China
Recruiting
Yan 'an University Xianyang Hospital, Xianyang, Shaanxi, 716000, China
Recruiting

Shandong

Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, 250013, China
Recruiting
Liaocheng People's Hospital, Liaocheng, Shandong, 252000, China
Recruiting

Sichuan

West China Hospital of Sichuan University, Chengdu, Sichuan, 610041, China
Recruiting

Zhejiang

Children's Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310052, China
Recruiting
Ningbo Women and Children's Hospital, Ningbo, Zhejiang, 315012, China
Recruiting
The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China
Recruiting
Lu 'an People's Hospital, Lu'an, China
Recruiting
Children's Hospital of Shanghai, Shanghai, China
Recruiting
Shengjing Hospital of China Medical University, Shenyang, China
Recruiting
The First Affiliated Hospital of Shihezi University School of Medicine, Shihezi, China
Active, not recruiting
Wuhan Children's Hospital, Wuhan, China
Recruiting

Fukuoka

Jinnouchi Neurosurgical Clinic, Kasuga-shi, Fukuoka, 816-0802, Japan
Recruiting
Ikeda Neurosurgical Clinic, Kasuga-shi, Fukuoka, 816-0824, Japan
Recruiting

Gunma

Hikita Pediatric Clinic, Kiryu-shi, Gunma, 3760035, Japan
Recruiting

Hyōgo

Konan Medical Center, Higashinada-ku Kobe-shi, Hyōgo, 658-0064, Japan
Recruiting
Yamaguchi Clinic, Nishinomiya-shi, Hyōgo, 663-8204, Japan
Recruiting

Ibaraki

Mito Kyodo General Hospital, Mito, Ibaraki, 310-0015, Japan
Recruiting

Kagoshima-ken

Tanaka Neurosurgery & Headache Clinic, Kagoshima, Kagoshima-ken, 890-0052, Japan
Recruiting

Miyagi

Sendai Headache and Neurology Clinic, Taihaku-ku Sendai-shi, Miyagi, 982-0014, Japan
Recruiting

Osaka

Tennoji Dai Brain Clinic, Abeno-ku Osaka-shi, Osaka, 545-0053, Japan
Recruiting
Tominaga Clinic, Naniwa-ku, Osaka, 556-0015, Japan
Recruiting

Tokyo

Tokyo Headache Clinic, Shibuya-ku, Tokyo, 151-0051, Japan
Recruiting
Tokyo Medical University Hospital, Shinjuku-ku, Tokyo, 160-0023, Japan
Not yet recruiting
Local lndependent Administrative Corporation Hiroshima City Hospital Organization Hiroshima City, Hiroshima, 730-8518, Japan
Recruiting

Mexico City

Clinstile S.A. de C.V., Col. Roma Norte, Mexico City, C.P. 06700., Mexico
Recruiting

Sinaloa

Neurociencias Estudios Clinicos S.C., Culiacán, Sinaloa, 800200, Mexico
Recruiting

State of Mexico

Clinical Reseach Institute, S.C., Tlalnepantla, State of Mexico, C.P. 54055, Mexico
Recruiting
Unidad de Investigacion en Salud de Chihuahua S.C., Chihuahua City, 31203, Mexico
Recruiting

Lower Silesian Voivodeship

MIGRE Polskie Centrum Leczenia Migreny Anna Gryglas-Dworak, Wroclaw, Lower Silesian Voivodeship, 52-210, Poland
Recruiting
NZOZ Wielospecjalistyczna Poradnia Lekarska SYNAPSIS, Lech Szczechowski, Katowice, 40-123, Poland
Active, not recruiting
Centrum Medyczne Plejady, Krakow, 30-363, Poland
Recruiting
Wojewódzki Specjalistyczny Szpital Dzieciecy im. Sw. Ludwika w Krakowie, Apteka Szpitalna, Krakow, 31-503, Poland
Recruiting
Clinical Research Center Sp. z.o.o. Medic-R Spolka komandytowa, Poznan, 61-731, Poland
Recruiting
Euromedis Sp. z o. o., Szczecin, 70-111, Poland
Active, not recruiting

Cantabria

Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, 39008, Spain
Active, not recruiting
Hospital Universitario Vall d'Hebron, Barcelona, 08035, Spain
Recruiting
Centre d'Atencio Primaria Balenya, Barcelona, 08550, Spain
Active, not recruiting
Instituto de Investigaciones del Sueno, Madrid, 28036, Spain
Active, not recruiting
Hospital Universitario Virgen del Rocío, Seville, 41013, Spain
Recruiting
Hospital Clinico Universitario de Valladolid, Valladolid, 47005, Spain
Recruiting

Skåne LÄN [se-12]

ProbarE i Lund AB, Lund, Skåne LÄN [se-12], 22222, Sweden
Recruiting
Avdelningen för kliniska Prövningar, Universitetssjukhuset Örebro, Örebro, 703 62, Sweden
Active, not recruiting
ProbarE i Stockholm AB, Stockholm, 113 29, Sweden
Recruiting
Leicester Royal Infirmary, Leicester, LE1 5WW, United Kingdom
Active, not recruiting
Re:Cognition Health Limited, London, W1G 9JF, United Kingdom
Recruiting
Great Ormond Street Hospital for Children NHS Foundation Trust, London, WC1N 3JH, United Kingdom
Recruiting