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Clinical Trial NCT05986461 for Complex Regional Pain Syndromes is recruiting. See the Trial Radar Card View and AI discovery tools for all the details. Or ask anything here. | ||
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Seoul National UniversitySpatially Transcriptomics Reveals Molecular Signatures in CRPS 10 Observational
Clinical Trial NCT05986461 is an observational study for Complex Regional Pain Syndromes that is recruiting. It started on 18 July 2023 with plans to enroll 10 participants. Led by Seoul National University, it is expected to complete by 31 December 2024. The latest data from ClinicalTrials.gov was last updated on 29 May 2024.
Brief Summary
This observational study aims to understand phenotype-specific molecular signatures in patients with complex regional pain syndrome (CRPS).
Detailed Description
Participants who meet the diagnostic criteria for CRPS, aged 19~80 years, and agree to participate in this study will undergo a 4mm-sized skin punch biopsy in the involved limb, as well as the contralateral side (internal control).
Spatial transcriptomics will be used to identify immune cell signatures and differentially regulated genes (DEGs) in the epidermis, vasculature, sweat gland, and nerve plexus of the invo...
Show MoreOfficial Title
Spatially Resolved Transcriptomics Reveals Phenotype-specific Molecular Signatures in Complex Regional Pain Syndrome
Conditions
Complex Regional Pain SyndromesPublications
Scientific articles and research papers published about this clinical trial:Other Study IDs
- 2304-052-1421
NCT ID Number
Start Date (Actual)
2023-07-18
Last Update Posted
2024-05-29
Completion Date (Estimated)
2024-12-31
Enrollment (Estimated)
10
Study Type
Observational
Status
Recruiting
Primary Outcome Measures
| Outcome Measure | Measure Description | Time Frame |
|---|---|---|
Numerical Rating Scale (NRS) | Intensity of pain (now, weekly avarege, weekly maximum) | At the time of biopsy |
Thermography | Thermography of the involved limb | At the time of diagnosis |
Quantitative Sensory Testing (QST) | Vibration Detection Threshold (VDT), Cold Detection Threshold (CDT) | At the time of diagnosis |
Participation Assistant
Eligibility Criteria
Eligible Ages
Adult, Older Adult
Minimum Age
19 Years
Eligible Sexes
All
- Meets the Budapest diagnostic criteria
- Consents to participation in this study
- Aged between 19 and 80 years old
- Symptoms and/or signs of sensory, vasomotor, and sudomotor changes
- Who do not agree to participate in this study
- Who has contraindications for skin punch biopsy (e.g. thrombocytopenia, taking anticoagulant drugs)
Seoul National University377 active studies to exploreHanyang UniversityStudy Responsible Party
Jeeyoun Moon, Principal Investigator, Professor, Seoul National University
Study Central Contact
Contact: Jee Youn Moon, MD, PhD, 82-10-5299-2036, [email protected]
Contact: Jeongsoo Kim, MD, 82-10-4734-6422, [email protected]
1 Study Locations in 1 Countries
Seoul National University Hospital, Seoul, South Korea
Jee Youn Moon, M.D., Contact, 82-10-5299-2036, [email protected]
Jee Youn Moon, M.D., Principal Investigator
Recruiting