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Clinical Trial NCT06421740 (REACH-AD) for Atopic Dermatitis is recruiting. See the Trial Radar Card View and AI discovery tools for all the details. Or ask anything here.
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An Observational Study to Assess Real-World Use of Upadacitinib Tablets in Adolescent and Adult Participants With Moderate to Severe Atopic Dermatitis in China (REACH-AD) 1,000 Real-World Evidence Adolescent Observational

Recruiting
Clinical Trial NCT06421740 (REACH-AD) is an observational study for Atopic Dermatitis that is recruiting. It started on 7 June 2024 with plans to enroll 1,000 participants. Led by AbbVie, it is expected to complete by 1 June 2026. The latest data from ClinicalTrials.gov was last updated on 12 March 2026.
Brief Summary
Atopic dermatitis (AD) is a skin condition that may cause a rash and itching due to inflammation of the skin.

Upadacitinib is an approved drug for treating AD. Approximately 1000 adolescents and adult participants who are prescribed upadacitinib by their physician in accordance with local label will be enrolled in up to 40 sites in China.

Participants will receive oral upadacitinib tablets as prescribed by their ph...

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Official Title

REal-world Utilization and Treatment Target ACHievement With Upadacitinib in Adolescents and Adults With Moderate to Severe Atopic Dermatitis in China

Conditions
Atopic Dermatitis
Other Study IDs
  • REACH-AD
  • P24-965
NCT ID Number
NCT06421740
Start Date (Actual)
2024-06-07
Last Update Posted
2026-03-12
Completion Date (Estimated)
2026-06
Enrollment (Estimated)
1,000
Study Type
Observational
Status
Recruiting
Keywords
Upadacitinib
Rinvoq
Arms / Interventions
Participant Group/ArmIntervention/Treatment
Upadacitinib
Participants will receive upadacitinib as prescribed by their physician according to local label.
N/A
Primary Outcome Measures
Outcome MeasureMeasure DescriptionTime Frame
Number of participants with a dose change
Dose change includes: Changed dose, dose escalation or dose tapering.
12 Months
Number of participants with Upadacitinib drug compliance
The participants missed medication, regardless of reason, or incompliance with the prescription as per medical advice are to be recorded in the eDiary, choosing the reason: "Forgot, Self-reduction of medication, interruption because of AE, interruption not due to safety/tolerability, for other reasons". If no eDiary entries are found within 30 days before the visit, the participant will need to complete the following question in ePRO: timely Upadacitinib intake per medical advice in past 30 days (yes/no); if "no", days-off-drug, intentionally or accidentally, and if "intentionally", reason for incompliance with medical prescription.
12 Months
Number of participants with interruption or permanent discontinuation
Interruption: Upadacitinib is temporarily interrupted due to atopic dermatitis disease condition, economic, tolerance, AE, or personal reasons, and the investigator considers there is still possibility of Upadacitinib re-initiating within the patient's study follow-up period. Discontinuation: Upadacitinib is permanently discontinued for safety or any other reasons, and the investigator considers Upadacitinib will not be used again, at least within the participant's study follow-up period.
12 Months
Participation Assistant
Eligibility Criteria

Eligible Ages
Child, Adult, Older Adult
Minimum Age
12 Years
Eligible Sexes
All
  • Adolescents (body weight >= 40 kg at the Baseline Visit for patients between >= 12 and < 18 years of age) and adults at the time of enrollment.
  • Clinical diagnosis of moderate to severe atopic dermatitis at the time of enrollment.
  • UPA treatment is indicated for AD and prescribed as per Chinese label / SmPC.
  • The decision to prescribe UPA is made prior to and independent of study participation.
  • The participant should not be treated with UPA prior to this study.
  • Participants who are willing and able to participate in the collection of patient-reported data, including ePROs and eDiary via apps.
  • The participant (legal representative for adolescents) voluntarily signed an informed consent before any study-related activities are conducted.

  • The participant is currently participating in interventional research (not including noninterventional study, observational study, or registry participation).
  • Any circumstances that the investigator believes may limit the patient's participation and compliance with study procedures.
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Study Central Contact
Contact: Judy Yu, [email protected]
38 Study Locations in 1 Countries

Beijing Municipality

Beijing Anzhen Hospital /ID# 273443, Beijing, Beijing Municipality, 100029, China
Active, not recruiting
China-Japan Friendship Hospital /ID# 274778, Beijing, Beijing Municipality, 100029, China
Active, not recruiting
Peking University First Hospital /ID# 274865, Beijing, Beijing Municipality, 100034, China
Active, not recruiting
Peking Unversity Third hospital /ID# 274864, Beijing, Beijing Municipality, 100191, China
Active, not recruiting
Peking Union Medical College Hospital (East) - Dongdan Campus /ID# 264193, Beijing, Beijing Municipality, 100730, China
Active, not recruiting

Fujian

The First Affiliated Hospital Of Fujian Medical University /ID# 268210, Fuzhou, Fujian, 350005, China
Active, not recruiting
Changgeng Hospital /ID# 268209, Xiamen, Fujian, 361022, China
Recruiting

Guangdong

Guangzhou Dermatology Hospital /ID# 271684, Guangzhou, Guangdong, 510095, China
Active, not recruiting
The Fifth Affiliated Hospital Of Sun Yat-Sen University /ID# 268618, Zhuhai, Guangdong, 519000, China
Recruiting

Hainan

Hainan Fifth People's Hospital /ID# 269747, Hainan, Hainan, 200000, China
Recruiting

Hebei

Hebei Engineering University Affiliated Hospital /ID# 268660, Handan, Hebei, 200000, China
Recruiting

Heilongjiang

The Second Affiliated Hospital Of Harbin Medical University /ID# 270872, Harbin, Heilongjiang, 150001, China
Recruiting

Henan

People's Hospital of Henan Province /ID# 269744, Zhengzhou, Henan, 450003, China
Recruiting

Hubei

Wuhan Integrated TCM & Western Medicine Hospital（Wuhan No.1 Hospital) /ID# 272374, Wuhan, Hubei, 430022, China
Recruiting
Tongji Hospital /ID# 269745, Wuhan, Hubei, 430030, China
Recruiting

Hunan

Xiangya Hospital Central South University /ID# 272373, Changsha, Hunan, 410008, China
Active, not recruiting

Jiangsu

Nanjing Drum Tower Hospital /ID# 268616, Nanjing, Jiangsu, 210008, China
Recruiting
Affiliated Hospital Of Nantong University /ID# 269743, Nantong, Jiangsu, 226001, China
Recruiting
The First Affiliated Hospital of Soochow University /ID# 269742, Suzhou, Jiangsu, 215006, China
Recruiting
The Affiliated Hospital of Xuzhou Medical College /ID# 268208, Xuzhou, Jiangsu, 221006, China
Recruiting

Liaoning

Dalian Dermatosis Hospital /ID# 272495, Dalian, Liaoning, 116041, China
Active, not recruiting
The People's Hospital of Liaoning Province /ID# 268206, Shenyang, Liaoning, 110016, China
Completed

Shandong

Shandong Provincial Hospital /ID# 268661, Jinan, Shandong, 250001, China
Recruiting
Jining Medical University - Affiliated Hospital /ID# 270873, Jining, Shandong, 272029, China
Recruiting
Weifang People'S Hospital /ID# 268659, Weifang, Shandong, 261041, China
Recruiting

Shanghai Municipality

Ruijin Hospital /ID# 268658, Shanghai, Shanghai Municipality, 200025, China
Active, not recruiting
Huashan Hospital Of Fudan University /ID# 270277, Shanghai, Shanghai Municipality, 200040, China
Recruiting
Shanghai Sixth People'S Hospital /ID# 268617, Shanghai, Shanghai Municipality, 200233, China
Recruiting
Shanghai Skin Disease Hospital /ID# 268657, Shanghai, Shanghai Municipality, 200443, China
Recruiting

Sichuan

West China Hospital of Sichuan University /ID# 268313, Chengdu, Sichuan, 610041, China
Active, not recruiting
Sichuan Provincial People's Hospital /ID# 268314, Chengdu, Sichuan, 610072, China
Recruiting
The Affiliated Hospital Of Southwest Medical University /ID# 268207, Luzhou, Sichuan, 646600, China
Recruiting

Xinjiang

People's Hospital of Xinjiang Uygur Autonomous Region /ID# 269746, Ürümqi, Xinjiang, 830001, China
Recruiting

Yunnan

The First Affiliated Hospital of Kunming Medical College /ID# 273451, Kunming, Yunnan, 650032, China
Recruiting

Zhejiang

Zhejiang Provincial Hospital of Chinese Medicine /ID# 268613, Hangzhou, Zhejiang, 310006, China
Recruiting
Ningbo No.6 hospital /ID# 268315, Ningbo, Zhejiang, 315040, China
Recruiting
Taizhou Central Hospital /ID# 268211, Taizhou, Zhejiang, 318000, China
Recruiting
Zhuji People'S Hospital /ID# 268614, Zhuji, Zhejiang, 315000, China
Recruiting