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Clinical Trial NCT07081711 for Cardiovascular Diseases, Heart Failure, Ischemic Heart Disease, Non-ischemic Cardiomyopathy, Valvular Heart Disease, Metabolic Cardiomyopathy, Congenital Heart Disease, Aortic Diseases, Atrial Fibrillation, Ventricular Fibrillation is not yet recruiting. See the Trial Radar Card View and AI discovery tools for all the details. Or ask anything here. | ||
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Longitudinal Validation of CIRC Technologies 1,000 Biomarker-Driven Novel Treatment
Clinical Trial NCT07081711 is an observational study for Cardiovascular Diseases, Heart Failure, Ischemic Heart Disease, Non-ischemic Cardiomyopathy, Valvular Heart Disease, Metabolic Cardiomyopathy, Congenital Heart Disease, Aortic Diseases, Atrial Fibrillation, Ventricular Fibrillation and is currently not yet recruiting. Enrollment is planned to begin on 1 April 2026 and continue until the study accrues 1,000 participants. Led by The Cleveland Clinic, this study is expected to complete by 1 August 2037. The latest data from ClinicalTrials.gov was last updated on 23 March 2026.
Brief Summary
Cardiovascular disease is the leading cause of death worldwide. Advanced cardiovascular imaging using Magnetic Resonance Imaging (MRI) has proven to be effective in providing gold standard myocardial tissue characterization. Moreover, the intrinsic advantage of MRI's lack of exposure to ionizing radiation is particularly beneficial. At the same time, blood work can be very useful in early detection of certain cardiom...Show More
Detailed Description
The primary clinical objective of the clinical study is to determine and compare cardiac microstructural phenotypes by cardiac MRI in patients and healthy controls and their relationship to cardiac structure/function with these MRI technologies.
Aim 1: What are the myocardial microstructure phenotypes in both patients with cardiovascular disease and healthy cohorts? Are they linked to other prevalent macro structure...
Show MoreOfficial Title
Longitudinal Validation of CIRC Technologies
Conditions
Cardiovascular DiseasesHeart FailureIschemic Heart DiseaseNon-ischemic CardiomyopathyValvular Heart DiseaseMetabolic CardiomyopathyCongenital Heart DiseaseAortic DiseasesAtrial FibrillationVentricular FibrillationOther Study IDs
NCT ID Number
Start Date (Actual)
2026-04
Last Update Posted
2026-03-23
Completion Date (Estimated)
2037-08
Enrollment (Estimated)
1,000
Study Type
Observational
Status
Not yet recruiting
Keywords
MRI
Arms / Interventions
| Participant Group/Arm | Intervention/Treatment |
|---|---|
Healthy Volunteer Subjects without cardiovascular disease | N/A |
Cardiovascular Disease Patients Patients with known or suspected cardiovascular disease | N/A |
Primary Outcome Measures
| Outcome Measure | Measure Description | Time Frame |
|---|---|---|
Myocardial Microstructure (Helix Angle) via Next Generation Cardiac MRI | The primary clinical objective of the clinical study is the qualitative comparison of cardiac microstructural phenotypes by cardiac MRI in patients and healthy controls | Collected at each Research MRI timepoint |
Participation Assistant
Eligibility Criteria
Eligible Ages
Adult, Older Adult
Minimum Age
18 Years
Eligible Sexes
All
Accepts Healthy Volunteers
Yes
- Age ≥ 18 years of age
- Provision of written informed consent
- Vulnerable populations will be excluded from this study including Prisoners
- Other contraindications to CMR imaging to be determined by standard MRI protocols
- Decisionally impaired (e.g., dementia or cognitive disability)
The Cleveland Clinic- National Institutes of Health (NIH)
- National Heart, Lung, and Blood Institute (NHLBI)747 active studies to explore
Study Responsible Party
Christopher Nguyen, Principal Investigator, Director of Cardiovascular Innovation Research Center, The Cleveland Clinic
No contact data.