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Clinical Trial NCT07319546 for Knee Osteoarthristis, Arthroplasties, Knee Replacement is recruiting. See the Trial Radar Card View and AI discovery tools for all the details. Or ask anything here.
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Accelerated Rehabilitation in Individuals After Total Knee Arthroplasty 32 Randomized Double-Blind

Recruiting
Clinical Trial NCT07319546 is an interventional study for Knee Osteoarthristis, Arthroplasties, Knee Replacement that is recruiting. It started on 1 December 2025 with plans to enroll 32 participants. Led by Mahidol University, it is expected to complete by 30 June 2027. The latest data from ClinicalTrials.gov was last updated on 6 January 2026.
Brief Summary
The primary aim of this double-blind randomized controlled trial is to evaluate the effectiveness of an accelerated rehabilitation protocol on knee joint function and quality of life in individuals undergoing TKA compared to conventional rehabilitation in Dali, Yunan, China. The study will include patients aged 50-80 years who are scheduled for primary unilateral TKA. Participants will be randomly assigned to either ...Show More
Official Title

Effectiveness of Accelerated Rehabilitation on Knee Joint Function and Quality of Life in Individuals With Total Knee Arthroplasty: A Double Blind Randomized Controlled Trial

Conditions
Knee OsteoarthristisArthroplasties, Knee Replacement
Other Study IDs
  • MU-CIRB 2025/443.2908
NCT ID Number
NCT07319546
Start Date (Actual)
2025-12-01
Last Update Posted
2026-01-06
Completion Date (Estimated)
2027-06-30
Enrollment (Estimated)
32
Study Type
Interventional
PHASE
N/A
Status
Recruiting
Primary Purpose
Treatment
Design Allocation
Randomized
Interventional Model
Parallel
Masking
Double
Arms / Interventions
Participant Group/ArmIntervention/Treatment
ExperimentalAccelerated rehabilitation
Rehabilitaion after TKR with the accelerated and optimal loading concepts
Accelerated exercise
Based on optimal and accelerated concepts
Active ComparatorConventional rehabilitation
Routine exercise
Conventional program
Primary Outcome Measures
Outcome MeasureMeasure DescriptionTime Frame
Knee injury and Osteoarthritis Outcome Score (KOOS)
From enrollment to the end of 6-month follow-up
Participation Assistant
Eligibility Criteria

Eligible Ages
Adult, Older Adult
Minimum Age
50 Years
Eligible Sexes
All
  • Patients diagnosed with end-stage knee OA necessitating primary unilateral TKA.

  • History of joint infections, cancer, or inflammatory arthritis.
  • End-stage OA from rheumatoid or septic arthritis.
  • Individuals with neurological disorders such as Alzheimer's disease, - Parkinson's disease, stroke.
  • Individuals who are unable to follow a structured rehabilitation protocol.
  • Previous history of knee surgeries (other than arthroscopy).
  • Severe comorbidities that would hinder participation (e.g., advanced cardiovascular diseases).
  • Individuals who have severe osteoporosis.
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Study Central Contact
Contact: Liying Yang, PT, M.Sc., +86 18787638700, [email protected]
1 Study Locations in 1 Countries

Yunnan

Hospital, Dali, Yunnan, China
Liying Yang, PT, M.Sc., Contact, +86 18787638700, [email protected]
Recruiting