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A Study to See if an Energy Drink With Caffeine and Green Tea Increases Fat Burning When Exercising Phase 4 40 Exercise-Based

Not yet recruiting
Clinical Trial NCT07434752 is designed to study Treatment for Exercise. This Phase 4 interventional study is not yet recruiting. Enrollment is planned to begin on 1 February 2026 until the study accrues 40 participants. Led by RDC Clinical Pty Ltd, this study is expected to complete by 1 December 2026. The latest data from ClinicalTrials.gov was last updated on 27 February 2026.
Brief Summary
The goal of this study is to evaluate the influence of consuming a drink containing a combination of caffeine and green tea extracts on fat oxidation responses at rest, during and after a period of endurance type exercise.
Detailed Description
This study investigates whether consuming an energy drink containing caffeine and green tea extract before exercise increases fat burning (oxidation) compared with a placebo drink. Healthy, moderately active adults will attend three visits at clinic over 3-5 weeks. The first visit determines each participant's individual exercise intensity that maximises fat use during cycling. At two subsequent visits, participants ...Show More
Official Title

Influence of Caffeine and Green Tea Extracts Consumption on Basal, Peri- and Post-exercise Fat Oxidation

Conditions
Exercise
Other Study IDs
  • GRIFEX
NCT ID Number
NCT07434752
Start Date (Actual)
2026-02
Last Update Posted
2026-02-27
Completion Date (Estimated)
2026-12
Enrollment (Estimated)
40
Study Type
Interventional
PHASE
Phase 4
Status
Not yet recruiting
Keywords
metabolism
Primary Purpose
Treatment
Design Allocation
Randomized
Interventional Model
Crossover Assignment
Masking
Quadruple
Arms / Interventions
Participant Group/ArmIntervention/Treatment
ExperimentalActive
Two 355 mL cans of "XS Energy + BURN" drink containing caffeine and green tea extract.
Active (Green tea and caffeine)
Two 355 mL cans of "XS Energy + BURN" drink containing caffeine and green tea extract.
OtherPlacebo
Two 355 mL cans of placebo drink but without the active ingredients (caffeine and green tea extract).
Placebo
Two 355 mL cans of placebo drink but without the active ingredients (caffeine and green tea extract).
Primary Outcome Measures
Outcome MeasureMeasure DescriptionTime Frame
Fat oxidation as measured by indirect calorimetry
Change from baseline to the end of the study period in Fat oxidation as measured by indirect calorimetry (metabolic cart); baseline (pre-drink), post-drink (pre-exercise), time sequence e.g., every 5-min during exercise, 10, 20 and 30-min post-exercise. Change from baseline \& total. Fat oxidation will be measured continuously throughout the exercise and the 30-min post-exercise window, to facilitate total, and any other temporal fat oxidation timepoints.
Baseline to 30 mins post exercise
Secondary Outcome Measures
Outcome MeasureMeasure DescriptionTime Frame
Carbohydrate oxidation; indirect calorimetry
Change from baseline to the end of the study period in Carbohydrate oxidation; indirect calorimetry; same timing as fat oxidation (baseline (pre-drink), post-drink (pre-exercise), time sequence e.g., every 5-min during exercise, 10, 20 and 30-min post-exercise.). Change from baseline \& total.
Baseline to 30 mins post exercise
Respiratory exchange ratio; indirect calorimetry
Change from baseline to the end of the study period in Respiratory exchange ratio; indirect calorimetry; same timing as fat oxidation (baseline (pre-drink), post-drink (pre-exercise), time sequence e.g., every 5-min during exercise, 10, 20 and 30-min post-exercise). Change from baseline \& total
Baseline to 30 mins post exercise
Exercise efficiency; indirect calorimetry
Change from baseline to the end of the study period in Exercise efficiency; indirect calorimetry; time sequence during exercise e.g., every 5-min. Change from the beginning of exercise \& average
Baseline to 30 mins post exercise
Participation Assistant
Eligibility Criteria

Eligible Ages
Adult
Minimum Age
18 Years
Eligible Sexes
All
Accepts Healthy Volunteers
Yes
  • Passing the Exercise and Sport Science Australia adult pre-exercise screening system (APSS) stage 1 & 2 (see appendix 4).
  • Between the ages of 18 and 45,
  • Not sedentary, and not completing more than 150 minutes of low and/or moderate and/or or vigorous intensity endurance exercise a week,
  • Ability to commit to in principle fulfilment of all 3 trial visits,
  • No history of coagulopathy e.g., DVT, stroke,
  • No known heart disease,
  • No known pancreatic insufficiency,
  • No known inflammatory bowel disease, or prior bowel resection or bypass surgery (excluding gastric banding and sleeve),
  • BMI of 22.0 to 34.9 kg/m2,
  • No known allergies to caffeine or green tea extract,
  • No known type I or II diabetes,
  • No uncontrolled concurrent illness,
  • No known current pregnancy or breastfeeding women
  • No current regular consumption of supplements (>2 times a week) or foods and drinks containing caffeine and/or green tea extracts (>2 times per day, weekly).
  • Agree not to consume caffeine for 12-hours prior to the clinic visit.

  • Triggering any of the exclusion screening criteria as outlined below, and in compliment with the Exercise and Sport Science Australia adult pre-exercise screening system (APSS).
  • Under the age of 18 or over the age of 45,
  • Sedentary, or completing over 150 minutes of low and/or moderate and/or or vigorous intensity endurance exercise a week,
  • Inability to commit to in principle fulfilment of all 3 trial visits,
  • History of coagulopathy e.g., DVT, stroke,
  • Known heart disease,
  • Known pancreatic insufficiency,
  • Known inflammatory bowel disease, or prior bowel resection or bypass surgery (excluding gastric banding and sleeve),
  • BMI < 22.0 or > 34.9 kg/m2,
  • Known allergies to caffeine or green tea extract,
  • Known type I or II diabetes,
  • Uncontrolled concurrent illness,
  • Taking GLP-1 agonists, caffeine, or any other medication known to affect metabolism.
  • Known current pregnancy or breastfeeding women.
  • Currently regularly consuming supplements, foods or drinks containing a caffeine and green tea extract blend, or not willing to abstain for the study
RDC Clinical Pty Ltd logoRDC Clinical Pty Ltd
Amway Corp logoAmway Corp
Study Central Contact
Contact: Llion Roberts, PhD, +61755528451, [email protected]
1 Study Locations in 1 Countries

Queensland

Griffith University, Gold Coast Campus, Southport, Queensland, 4222, Australia