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Clinical Trial NCT07476989 for Carbohydrate Metabolism, Hepatic Glycogen Storage, Healthy Adult Male is not yet recruiting. See the Trial Radar Card View and AI discovery tools for all the details. Or ask anything here. | ||
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Effects of Dual-Source Carbohydrate Intake and Liver Glycogen Repletion After Overnight Fasting. 12 Crossover Design Exercise-Based
Clinical Trial NCT07476989 is an interventional study for Carbohydrate Metabolism, Hepatic Glycogen Storage, Healthy Adult Male and is currently not yet recruiting. Enrollment is planned to begin on 1 March 2026 and continue until the study accrues 12 participants. Led by Manchester Metropolitan University, this study is expected to complete by 1 December 2026. The latest data from ClinicalTrials.gov was last updated on 17 March 2026.
Brief Summary
This study is looking at whether eating a breakfast which has two different sources of carbohydrates, glucose and fructose (found in foods like honey and fruits), can increase how much glycogen can be stored in the liver. Glucose is a type of sugar that the body uses to provide energy during exercise. When it is not circulating in the blood, it is stored in the muscles and liver. The stored version of glucose is ofte...Show More
Detailed Description
Glycogen stores in the muscle and liver play a crucial role in providing fuel during prolonged exercise and strenuous activities, which can rapidly deplete these stores, leading to increased fatigue and reduced performance. During prolonged exercise, liver glycogen is broken down to maintain blood glucose (sugar) levels and provide an important fuel source for the exercising muscles. Accordingly, liver glycogen is im...Show More
Official Title
The Effects of a Dual-Source High-Carbohydrate Breakfast on Hepatic Glycogen Storage Following an Overnight Fast.
Conditions
Carbohydrate MetabolismHepatic Glycogen StorageHealthy Adult MaleOther Study IDs
- 84304
NCT ID Number
Start Date (Actual)
2026-03
Last Update Posted
2026-03-17
Completion Date (Estimated)
2026-12
Enrollment (Estimated)
12
Study Type
Interventional
PHASE
N/A
Status
Not yet recruiting
Keywords
Glucose
Fructose
Liver glycogen storage
Magnetic resonance spectroscopy
Fructose
Liver glycogen storage
Magnetic resonance spectroscopy
Primary Purpose
Basic Science
Design Allocation
Randomized
Interventional Model
Crossover Assignment
Masking
None (Open Label)
Arms / Interventions
| Participant Group/Arm | Intervention/Treatment |
|---|---|
ExperimentalControl No breakfast | No breakfast Participants will come in and receive no breakfast, which will act as a control group. |
Experimental0% fructose Breakfast containing 0% fructose | Breakfast (0% Fructose) Participants will receive a breakfast of 3g/kg of body mass of carbohydrate with 0% fructose content. |
Experimental50% fructose Breakfast containing 50% fructose | Breakfast (50% fructose) Participants will receive a breakfast of 3g/kg of body mass of carbohydrate with 50% fructose content. |
Primary Outcome Measures
Secondary Outcome Measures
| Outcome Measure | Measure Description | Time Frame |
|---|---|---|
Change in liver glycogen content | The change in liver glycogen content will be determined using 13C magnetic resonance spectroscopy | 3 hours |
| Outcome Measure | Measure Description | Time Frame |
|---|---|---|
Total carbohydrate oxidation | Total carbohydrate oxidation will be measured using indirect calorimetry | 3 hours |
Total fat oxidation | Total fat oxidation will be measured using indirect calorimetry | 3 hours |
Stomach volume | Stomach volume will be measured using MRI | 3 hours |
Plasma glucose | Measured via blood collection | 3 hours |
Plasma lactate | Measured via blood collection | 3 hours |
Plasma insulin | Measured via blood collection | 3 hours |
Plasma glucagon | Measured via blood collection | 3 hours |
Gastrointestinal symptoms | Participants will be asked to rate how they are feeling on a scale of 0-10 (0 = no discomfort and 10 = very severe discomfort) on whether they feel nauseous, having any regurgitation, stomach fullness, experiencing any cramps and if they have an urge to defecate. | 3 hours |
Appetite | To measure appetite (which will include being asked on hunger, fullness, satisfaction and prospective food consumption), participants will be shown a 100mm visual analog scale, which will have descriptors on both ends (e.g., I am not hungry at all, and I have never been hungrier in my life), and they will rate their appetite by drawing an intersecting vertical line along the horizontal line. The previous rating will be hidden to prevent the influence of a prior rating on the subsequent reporting. | 3 hours |
Participation Assistant
Eligibility Criteria
Eligible Ages
Adult
Minimum Age
18 Years
Eligible Sexes
Male
Accepts Healthy Volunteers
Yes
- A male (at birth) aged between 18 and 45.
- Regularly training for a specific sport (must include cycling) at least 3 times per week (with the purpose of competing).
- VO2 peak >50 (ml.kg.min)
- A current non-smoker/vaper (must not have smoked or vaped within the last 6 months)
- Do not have any medical conditions or are taking any medications or supplements which can affect the study's outcome measures.
- Free from any metallic implants, including permanent jewellery (that can't be removed)
- No known intolerances or allergies to any component of the nutritional supplement
- Are not a male (at birth) aged between 18 and 45.
- Do not regularly train for a specific sport (must include cycling) at least 3 times per week (with the purpose of competing).
- Does not have a VO2 max/peak >50 (ml.kg.min)
- A current smoker/vaper (must not have smoked or vaped within the last 6 months)
- Have any medical conditions or are taking any medications or supplements which can affect the study's outcome measures
- Have any metallic implants, including permanent jewellery (that can't be removed)
- Known intolerances or allergies to any component of the nutritional supplement.
Manchester Metropolitan University- Cargill
- The University of Bath
No contact data.