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Clinical Trial NCT05405322 (TRANSITIONS) for HIV Infections, Adolescent Behavior, Transition is active, not recruiting. See the Trial Radar Card View and AI discovery tools for all the details. Or ask anything here.
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Improving Care and Community Representation for Adolescents and Young Adults Living With HIV in West Africa (TRANSITIONS)

Active, not recruiting
Clinical Trial NCT05405322 (TRANSITIONS) is an observational study for HIV Infections, Adolescent Behavior, Transition that is active, not recruiting. It started on 7 April 2021 with plans to enroll 267 participants. Led by Institut de Recherche pour le Developpement, it is expected to complete by 31 December 2024. The latest data from ClinicalTrials.gov was last updated on 28 June 2024.
Brief Summary
Context: HIV-positive young people aged 15 to 24 are a heterogeneous population in terms of gender, age, mode of transmission, sexual orientation and risk-taking. This most vulnerable age group is at greater risk of disruption of medical care and poor compliance, and has greater needs for psychosocial support and differentiated health services. It remains highly invisible in West African countries, both in the definition of care policies and in the allocation of resources and community representation.

Objectives: The overall objective of the project is to contribute to the improvement of retention in care, health and well-being of adolescents and young adults living with HIV (AYAHIV) and to support their integration into the community space.

SO1: Support the operationalisation of the transition of HIV-infected adolescents from paediatrics to adult medical services in a stakeholder inclusive, participatory and responsive approach SO2: Contribute to the empowerment and autonomy of adolescents and young adults living with HIV in the project environment SO3: Contribute to the generation and dissemination of evidence-based information and recommendations on the situation and needs of adolescents and young adults, including key populations, living with HIV

Target: Approximately 67 caregivers∙e∙s ≥ 25 years old, of which 64%F, 30 peer-referent associations of 20-24 years old (ratio F/H= 1:1), 700 AYAHIV ≥ 15 years old, of which 47%F, in paediatrics and 500-600 AYAHIV aged 15-24 years old in adult medicine, of which 41%F, and including AYAHIV associations Summary of activities: Based on the capitalisation and pooling of experiences of partner teams, the project proposes to support the implementation of transition in a pragmatic approach, adapted to the needs of adolescents and inclusive of carers, adolescents and community peers. More globally, it contributes to improving the health, empowerment and autonomy of HIV-positive youth, including key populations, in particular through support to training, structuring and community representation of youth associations, documentation of the conditions of entry into care and their specific needs, including digital health, production and availability of evidence and recommendations in this West African context and advocacy building.

A multidisciplinary and participatory research-action project, carried out by the IRD in Senegal and financed by Sidaction, accompanies the three specific objectives of the project.

Detailed Description

Context: HIV-positive young people aged 15 to 24 are a heterogeneous population in terms of gender, age, mode of transmission, sexual orientation and risk-taking. This most vulnerable age group is at greater risk of disruption of medical care and poor compliance, and has greater needs for psychosocial support and differentiated health services. It remains highly invisible in West African countries, both in the definition of care policies and in the allocation of resources and community representation.

Objectives: The overall objective of the project is to contribute to the improvement of retention in care, health and well-being of adolescents and young adults living with HIV (AYAHIV) and to support their integration into the community space.

SO1: Support the operationalisation of the transition of HIV-infected adolescents from paediatrics to adult medical services in a stakeholder inclusive, participatory and responsive approach SO2: Contribute to the empowerment and autonomy of adolescents and young adults living with HIV in the project environment SO3: Contribute to the generation and dissemination of evidence-based information and recommendations on the situation and needs of adolescents and young adults, including key populations, living with HIV

Target: Approximately 67 caregivers∙e∙s ≥ 25 years old, of which 64%F, 30 peer-referent associations of 20-24 years old (ratio F/H= 1:1), 700 AYAHIV ≥ 15 years old, of which 47%F, in paediatrics and 500-600 AYAHIV aged 15-24 years old in adult medicine, of which 41%F, and including AYAHIV associations Summary of activities: Based on the capitalisation and pooling of experiences of partner teams, the project proposes to support the implementation of transition in a pragmatic approach, adapted to the needs of adolescents and inclusive of carers, adolescents and community peers. More globally, it contributes to improving the health, empowerment and autonomy of HIV-positive youth, including key populations, in particular through support to training, structuring and community representation of youth associations, documentation of the conditions of entry into care and their specific needs, including digital health, production and availability of evidence and recommendations in this West African context and advocacy building.

A multidisciplinary and participatory research-action project, carried out by the IRD in Senegal and financed by Sidaction, accompanies the three specific objectives of the project.

Expected impact :

  • Seamless operationalisation of the supported and coordinated transition in care process and scaling up to the level of the 12 countries of the EVA network.
  • Young associative actors are able to advocate to guide decision-makers, based on the evidence they have helped to produce (participatory approach)
  • The ultimate change, expected at the end of the project, is that institutional stakeholders will integrate these recommendations into the national programme for the care of PLHIV, both operationally and financially.
Official Title

Inclusive Programme for the Optimisation of Health and Well-being of HIV-positive Young People (15-24 Years) and for the Promotion of Their Community Representation in Senegal and Burkina Faso (2021 => 36 Months) (TRANSITIONS)

Conditions
HIV InfectionsAdolescent BehaviorTransition
Other Study IDs
  • TRANSITIONS
  • 999999
NCT ID Number
Start Date (Actual)
2021-04-07
Last Update Posted
2024-06-28
Completion Date (Estimated)
2024-12-31
Enrollment (Estimated)
267
Study Type
Observational
Status
Active, not recruiting
Keywords
adolescent
HIV infection
transition
west africa
community
peer
Primary Outcome Measures
Outcome MeasureMeasure DescriptionTime Frame
retention in care
percent of adolescents who remain in care
Month 12
retention in care
percent of adolescents who remain in care
Month 21
Secondary Outcome Measures
Outcome MeasureMeasure DescriptionTime Frame
virologic suppression
percent of adolescents who maintain or reach undetectable viral load
Month 12
virologic suppression
percent of adolescents who maintain or reach undetectable viral load
Month 21
quality of life in relation to health
percent of adolescents who improve their score of quality of life in relation to health
Month 12
quality of life in relation to health
percent of adolescents who improve their score of quality of life in relation to health
Month 21
level of preparedness to adult care
percent of adolescents who improve their score of preparedness to adult care
Month 12
Eligibility Criteria

Eligible Ages
Child, Adult
Minimum Age
15 Years
Eligible Sexes
All
  • being HIV-infected
  • aged 15 to 24 years
  • on antiretroviral treatment
  • HIV status disclosed
  • caretaker's written consent (if < 18 years)
  • adolescent's written consent

  • mental illness
Institut de Recherche pour le Developpement logoInstitut de Recherche pour le Developpement
  • 🏛️Sidaction
  • 🏛️EXPERTISE FRANCE, Paris France
  • 🏛️Children and HIV Network in AFRICA (EVA), Dakar Senegal
  • 🎓Cheikh Anta Diop University, Senegal
Study Responsible Party
Cecile Cames, Principal Investigator, Dr, Institut de Recherche pour le Developpement
No contact data.
4 Study Locations in 2 Countries
CHU CDG, Ouagadougou, Burkina Faso
CHU YO, Ouagadougou, Burkina Faso
Chnear Albert Royer, Dakar, 00000, Senegal
Centre hospitalier Roi Baudouin, Guédiawaye, Senegal