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Clinical Trial NCT07125378 (LIFT) for Mobility Limitation, Cognitive Impairment is recruiting. See the Trial Radar Card View and AI discovery tools for all the details. Or ask anything here. | ||
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University of FloridaLiving Independence Through Functional Training (LIFT)
Clinical Trial NCT07125378 (LIFT) is designed to study Treatment for Mobility Limitation, Cognitive Impairment. It is a Phase 1 Phase 2 interventional trial that is recruiting, having started on 31 January 2026, with plans to enroll 10 participants. Led by University of Florida, it is expected to complete by 31 July 2026. The latest data from ClinicalTrials.gov was last updated on 25 November 2025.
Brief Summary
The purpose of the research is to evaluate the feasibility and benefits of a six-week hybrid task-oriented resistance exercise program for older adults who have been recently discharged from home health care.
Official Title
Living Independence Through Functional Training (LIFT): Feasibility of Hybrid Task-Oriented Resistance Exercise Following Home Health Discharge
Conditions
Mobility LimitationCognitive ImpairmentOther Study IDs
- LIFT
- IRB202500835
NCT ID Number
Start Date (Actual)
2026-01-31
Last Update Posted
2025-11-25
Completion Date (Estimated)
2026-07-31
Enrollment (Estimated)
10
Study Type
Interventional
PHASE
Phase 1
Phase 2
Phase 2
Status
Recruiting
Keywords
Home-based intervention
Exercise
Older adults
Activities of daily living
Mobility
Cognition
Exercise
Older adults
Activities of daily living
Mobility
Cognition
Primary Purpose
Treatment
Design Allocation
N/A
Interventional Model
Single Group
Masking
None (Open Label)
Arms / Interventions
| Participant Group/Arm | Intervention/Treatment |
|---|---|
ExperimentalLIFT Participants will receive a task-oriented resistance exercise program at home. | Task-oriented Resistance Exercise The intervention program includes progressive resistance exercise and daily activity exercise, delivered over a six-week period with an ideal frequency of three sessions per week. Progressive resistance exercise will be provided through a combination of in-person and online sessions, while daily activity exercise will be delivered exclusively in person. |
Primary Outcome Measures
Secondary Outcome Measures
| Outcome Measure | Measure Description | Time Frame |
|---|---|---|
Short Physical Performance Battery | The score ranges from 0 to 12, with a score of 12 indicating the best physical functioning of the lower extremity. | Baseline, 8 weeks, and 12 weeks. |
Montreal Cognitive Assessment | The score ranges from 0 to 30, with a score of 30 indicating the best global cognitive function. | Baseline, 8 weeks, and 12 weeks. |
| Outcome Measure | Measure Description | Time Frame |
|---|---|---|
Timed Up and Go Test-Single Task. | Time in seconds to complete the test, with a longer time indicating poor functional mobility. | Baseline, 8 weeks, and 12 weeks. |
Timed Up and Go-Dual Task | Time in seconds to complete the task, a longer time indicating the interference of the dual task effect on mobility. | Baseline, 8 weeks, and 12 weeks. |
List Sorting Working Memory Test | The raw score ranges from 0 to 24, with a higher score indicating better working memory. The raw score is converted to a Change Sensitive Score. | Baseline, 8 weeks, and 12 weeks. |
Dimensional Change Card Sort Test | The raw score ranges from 0 to 30, with a higher score indicating better executive function. The raw score is converted to a Change Sensitive Score. | Baseline, 8 weeks, 12 weeks. |
Flanker Inhibitory Control and Attention Test | The raw score ranges from 0 to 30, with a higher score indicating better executive function and attention. The raw score is converted to a Change Sensitive Score. | Baseline, 8 weeks, and 12 weeks |
Pattern Comparison Processing Speed Test | The raw score ranges from 0-133, with a higher score indicating better processing speed. The raw score is converted to a Change Sensitive Score. | Baseline, 8 weeks, and 12 weeks |
Speeded Matching Test | The score ranges from 0 to 130, with a higher score indicating better speed of processing. The raw score is converted to a Change Sensitive Score. | Baseline, 8 weeks, 12 weeks |
Oral Symbol Digit Test | The raw score ranges from 0 to 143, with a higher score indicating better processing speed. The raw score is converted to a Rasch score. | Baseline, 8 weeks, and 12 weeks |
Eligibility Criteria
Eligible Ages
Older Adult
Minimum Age
65 Years
Eligible Sexes
All
- between the ages of 65 and 90
- received home health rehabilitation services within the last month
- community-dwelling
- live within a 50-mile radius of the study site with wireless connectivity in the area
- mobility limitations as indicated by self-reported of using a mobility aid or having unsteady gait or walking slower than before
- cognitive decline as indicated by a score < 12 on Mini MoCA Version 2.1
- a care partner or adult family member living in the home or nearby
- willing to wear an activity tracker during the study period
- plan to receive additional skilled rehabilitation services after home health discharge
- plan to move away outside the study area in two months
- reside in an assisted living or long-term care facility or plan to relocate to such facility in the next three months
- severe vision or hearing loss that impedes activity performance or communication
- unable to stand or walk even with a mobility aid
- unable to follow a one-step command or carry on a conversation over the phone
- unable to commit to the six-week exercise program
- contradictions to resistance exercise, such as the end-stage heart failure
- a terminal disease or on hospice care
- a neurological condition affecting motor skills
- not able to provide consent.
University of Florida295 active trials to exploreStudy Central Contact
Contact: Chiung-ju Liu Associate Professor, PhD, 352-273-6496, [email protected]
2 Study Locations in 1 Countries
Florida
College of Public Health and Health Professions, University of Florida, Gainesville, Florida, 32610, United States
Chiung-ju Liu, PhD, Contact, 352-273-6495, [email protected]
Recruiting
University of Florida, Gainesville, Florida, 32610, United States
Chiung-ju Liu Associate Professor, PhD, Contact, 352-273-6496, [email protected]
Not yet recruiting