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Randomized Study in Children and Adolescents With Migraine: Acute Treatment Phase III 2 100 Randomisé Adolescent

En recrutement
Les détails de l'essai clinique sont principalement disponibles en anglais. Cependant, l'IA Trial Radar peut vous aider ! Cliquez simplement sur 'Expliquer l'étude' pour voir et discuter des informations sur l'étude dans la langue sélectionnée.
L'essai clinique NCT04649242 est conçu pour étudier le traitement de Pediatric Migraine. Il s'agit d'une étude interventionnel en Phase III. Son statut actuel est : en recrutement. L'étude a débuté le 15 janvier 2021 et vise à recruter 2 100 participants. Dirigée par Pfizer, l'étude devrait être terminée d'ici le 9 janvier 2029. Les données du site ClinicalTrials.gov ont été mises à jour pour la dernière fois le 20 mars 2026.
Résumé succinct
The purpose of this study is to test the safety and efficacy of BHV-3000 versus placebo in the acute treatment of moderate or severe migraine in children and adolescents.
Titre officiel

Phase 3, Multicenter, Randomized, Double-blind, Group Sequential, Placebo-controlled Study to Assess Efficacy and Safety of Rimegepant for the Treatment of Migraine (With or Without Aura) in Children and Adolescents ≥ 6 to < 18 Years of Age

Pathologies
Pediatric Migraine
Autres identifiants de l'étude
  • BHV3000-311
  • C4951002 (Autre Identifiant) (Alias Study Number)
  • 2020-003517-35 (Identifiant de registre) (CTIS (EU))
  • 2024-512743-23-00 (Identifiant de registre) (CTIS (EU))
Numéro NCT
NCT04649242
Date de début (réel)
2021-01-15
Dernière mise à jour publiée
2026-03-20
Date de fin (estimée)
2029-01-09
Inscription (estimée)
2 100
Type d'étude
Interventionnel
PHASE
Phase III
Statut
En recrutement
Mots clés
Migraine
Acute treatment
Phonophobia
Photophobia
Nausea
Pediatric
Children
Adolescent
Pediatric Migraine
Objectif principal
Traitement
Méthode d'allocation
Randomisé
Modèle d'intervention
Séquentiel
Masquage
Triple aveugle
Bras / Interventions
Groupe de participants/BrasIntervention/Traitement
Comparateur actifBHV3000 (active drug)
BHV3000 (rimegepant) 75 mg or 50 mg ODT
Rimegepant/BHV3000
BHV3000 (rimegepant) 75 mg or 50 mg ODT
Comparateur placeboPlacebo
Matching 75 mg or 50 mg ODT placebo
Placebo apparié
Matching 75 mg or 50 mg ODT placebo
Critère principal d'évaluation
Critères d'évaluationDescription de la mesurePériode
To evaluate the efficacy of rimegepant compared with placebo in the acute treatment of migraine in adolescent population (≥ 12 to <18 years of age) as measured by pain freedom using the number of patients reporting no pain.
Pain freedom will be assessed in adolescent population (≥ 12 to \< 18 years of age) on a 4-point numeric rating scale (0=none, 1=mild, 2=moderate, 3=severe).
2 hours post-dose
Critère secondaire d'évaluation
Critères d'évaluationDescription de la mesurePériode
To compare rimegepant with placebo for pain freedom in children and adolescents combined.
Pain freedom will be assessed in children and adolescents (≥ 6 to \< 18 years of age) using a 4-point numeric rating scale (0=none, 1=mild, 2=moderate, 3=severe). Pain freedom will be assessed in children (\> 6 to \< 12 years of age) using the 5-Face VAS (Face 5 = 'severe pain', Faces 4 and 3 = 'moderate pain', Face 2 = 'mild pain', Face 1 = 'no pain').
2 hours post-dose
To compare rimegepant with placebo on freedom from the most bothersome symptom (MBS) associated with migraine in adolescents.
Freedom from MBS (nausea, phonophobia or photophobia) will be measured using a binary scale (0=absent, 1=present).
2 hours post-dose
To compare rimegepant with placebo on the probabilities of requiring rescue medication within in adolescents.
Use of rescue medication will be assessed using the numbers of participants that take rescue medication.
Within 24 hours and 48 hours of initial treatment
To compare rimegepant with placebo on sustained pain freedom in adolescents.
Sustained pain freedom will be assessed using the number of participants that do not use any rescue medications and do not experience any headache pain post dose.
2 to 24 hours post-dose
To compare rimegepant with placebo on sustained pain freedom in adolescents.
Sustained pain freedom will be assessed using the number of participants that do not use any rescue medications and do not experience any headache pain post dose.
2 to 48 hours post-dose
To compare rimegepant with placebo on the ability to function normally as reported on the Functional Disability scale in adolescents.
The proportion of participants able to function normally will be assessed using the number that self-report as "normal" on the Functional Disability scale.
2 hours post-dose
To compare rimegepant with placebo for pain freedom in children.
Pain freedom will be assessed using the number of children (≥ 6 to \< 12 years of age) that report no pain measured by a 5-Face VAS (Face 5 = 'severe pain', Faces 4 and 3 = 'moderate pain', Face 2 = 'mild pain', Face 1 = 'no pain').
2 hours post-dose
To compare rimegepant with placebo on freedom from the most bothersome symptom (MBS) associated with migraine in children and combined children and adolescents.
Freedom from the most bothersome symptom (nausea, phonophobia or photophobia) will be assessed using the number of participants that report the absence of MBS measured using a binary scale (0=absent, 1=present).
2 hours post-dose
To compare rimegepant with placebo on the probabilities of requiring rescue medication in children and combined children and adolescents.
The probabilities of requiring rescue medication will be assessed using the numbers of participants that take rescue medication within initial treatment.
Within 24 hours and 48 hours of initial treatment.
To compare rimegepant with placebo on sustained pain freedom in children and combined children and adolescents.
Sustained pain freedom will be assessed using the number of participants that do not use any rescue medications and do not experience any headache pain post dose.
2 to 24 hours post-dose
To compare rimegepant with placebo on sustained pain freedom in children and combined children and adolescents.
Sustained pain freedom will be assessed using the number of participants that do not use any rescue medications and do not experience any headache pain post dose.
2 to 48 hours post-dose
To compare rimegepant with placebo on freedom from photophobia in adolescents, children and combined children and adolescents.
Freedom from photophobia will be assessed by the number of participants that report the absence of photophobia post dose that reported the presence of photophobia at baseline.
2 hours post-dose
To compare rimegepant with placebo on freedom from phonophobia in adolescents, children and combined children and adolescents.
Freedom from phonophobia will be assessed by the number of participants that report the absence of phonophobia post dose that reported the presence of phonophobia at baseline.
2 hours post-dose
To compare rimegepant with placebo on freedom from nausea in adolescents, children and combined children and adolescents.
Freedom from nausea will be assessed by the number of participants that report the absence of nausea post dose that reported the presence of nausea at baseline.
2 hours post-dose
To compare rimegepant with placebo on pain relief in adolescents, children and combined children and adolescents.
Pain relief will be assessed using the number of participants that report a pain level of moderate or severe at baseline and then report a pain level of none or mild post dose.
2 hours post-dose
To compare rimegepant with placebo in adolescents, children and combined children and adolescents on pain relief.
Time to first report of pain relief will be based on the first time point a participant reports a pain level of none or mild.
Time to patients first report of pain relief of none or mild post dose up to 48 hours.
Assistant à la participation
Critères d'éligibilité

Âges éligibles
Enfant
Âge minimum
6 Years
Sexes éligibles
Tous

  1. History of migraine (with or without aura) for > 6 months before Screening according to the IHS Classification ICHD-319 specifications for pediatric migraine. History may be verified using both medical records and recall by the participant and/or participant's parent(s)/legal representative(s).

  2. History of 1 to 8 moderate or severe attacks per month during the 2 months prior to enrollment, with attacks lasting > 3 hours without treatment, and attacks occurring at intervals > 24 hours.

  3. Prophylactic migraine medication are permitted if the dose has been stable for at least 12 weeks prior to the Baseline Visit, and the dose is not expected to change during the course of the study.

    1. Participants may remain on one (1) medication with possible migraine prophylactic effects, excluding CGRP antagonists \[biologic or small molecule\], during the treatment phases.
    2. Concomitant use of a CGRP antagonist, such as erenumab or fremanezumab, is prohibited.
    3. Previously discontinued prophylactic migraine medication must have done so at least 90 days prior to the Screening Visit.

  4. Verbally distinguish between migraine and other types of headaches.

  5. Participants must have a weight > 40 kg at the Screening Visit.

  6. Adequate venous access for blood sampling.

  7. Male and female participants ≥ 6 to < 18 years of age (participants must not reach their 18th birthday during the study).

  1. History of cluster headache or hemiplegic migraine headache.
  2. Confounding and clinically significant pain syndrome that may interfere with the participant's ability to participate in this study.
  3. Current psychiatric condition that is uncontrolled and/or untreated for a minimum of 6 months prior to the Screening Visit. Participants with a lifetime history of psychosis and/or mania.
  4. History of suicidal behavior or major psychiatric disorder.
  5. Current diagnosis or history of substance abuse; positive drug test at Screening.
  6. History of moderate or severe head trauma or other neurological disorder (including seizure disorder) or systemic medical disease that is likely to affect central nervous system functioning.
  7. Recent or planned surgery, requiring general anesthesia, <8 weeks prior to the Screening Visit.
  8. Participant has had gastrointestinal surgery that interferes with physiological absorption and motility (i.e., gastric bypass, duodenectomy, or gastric banding).
  9. Current diagnosis of viral hepatitis or a history of liver disease.
  10. Conditions considered clinically relevant in the context of the study such as uncontrolled hypertension (high blood pressure), diabetes, a life-threatening allergy
Pfizer logoPfizer457 essais cliniques actifs à explorer
Contact central de l'étude
Contact: Pfizer Pfizer CT.gov Call Center, 1-800-718-1021, [email protected]
245 Centres de l'étude dans 9 pays

British Columbia

OCT Research ULC, Kelowna, British Columbia, V1Y 1Z9, Canada
En recrutement

Quebec

Diex Recherche Sherbrooke Inc, Sherbrooke, Quebec, J1L 0H8, Canada
Actif, ne recrute pas

Alabama

Achieve Clinical Research, LLC d/b/a Accel Research Sites-Neurology and Neurodiagnostic of Alabama, Birmingham, Alabama, 35244, United States
Actif, ne recrute pas

Arizona

Perseverance Research Center, LLC, Scottsdale, Arizona, 85253, United States
En recrutement
Physicians Research Group, Tempe, Arizona, 85284, United States
Actif, ne recrute pas

California

Advanced Research Center, Inc., Anaheim, California, 92805, United States
En recrutement
Adult & Child Neurology Medical Associates, Costa Mesa, California, 92627, United States
En recrutement
ProScience Research Group, Culver City, California, 90230, United States
En recrutement
Memorial Health Services, Fountain Valley, California, 92708, United States
En recrutement
Neuro-Pain Medical Center, Fresno, California, 93710, United States
En recrutement
Regents of the University of California (UC San Diego), La Jolla, California, 92093, United States
En recrutement
Adult & Child Neurology Medical Associates, Long Beach, California, 90806, United States
En recrutement
Miller Children's & Women's Hospital Long Beach, Long Beach, California, 90806, United States
En recrutement
National Research Institute, Los Angeles, California, 90057, United States
Actif, ne recrute pas
Velocity Clinical Research - North Hollywood, North Hollywood, California, 91606, United States
Actif, ne recrute pas
Children's Hospital of Orange County - Inpatient Pharmacy, Orange, California, 92868, United States
Pas encore en recrutement
Children's Hospital of Orange County - Neuroscience Center, Orange, California, 92868, United States
Pas encore en recrutement
Children's Hospital of Orange County, Orange, California, 92868, United States
Pas encore en recrutement
The Neurology Group, Pomona, California, 91767, United States
En recrutement
University of California, Davis Midtown Clinic, Sacramento, California, 95816, United States
Actif, ne recrute pas
UC Davis Medical Center, Investigational Drug Service (IDS) Pharmacy, Sacramento, California, 95817, United States
Actif, ne recrute pas
University of California, Davis Clinical and Translational Science Center Clinical Research (CCRC), Sacramento, California, 95817, United States
Actif, ne recrute pas
Velocity Clinical Research, San Bernardino (IP Delivery and Administering Location), San Bernardino, California, 92408, United States
En recrutement
Pacific Clinical Research Management Group LLC, Upland, California, 91786, United States
Actif, ne recrute pas
Sunwise Clinical Research, Walnut Creek, California, 94596, United States
En recrutement

Colorado

Children's Hospital Colorado- lnvestigational Drug Services, Aurora, Colorado, 80045, United States
En recrutement
Children's Hospital Colorado, Aurora, Colorado, 80045, United States
En recrutement
Colorado Springs Neurological Associates, PC, Colorado Springs, Colorado, 80907, United States
En recrutement
Colorado Springs Neurological Associates, PC, Colorado Springs, Colorado, 80919, United States
En recrutement

Connecticut

CT Clinical Research, Cromwell, Connecticut, 06416, United States
En recrutement
Connecticut Children's Medical Center, Hartford, Connecticut, 06106, United States
Actif, ne recrute pas
Ki Health Partners, LLc, dba New England Institute for Clinical Research, Stamford, Connecticut, 06905, United States
En recrutement

Delaware

Nemours Children's Hospital, Delaware, Wilmington, Delaware, 19803, United States
Actif, ne recrute pas

District of Columbia

Children's National Medical Center, Washington D.C., District of Columbia, 20010, United States
En recrutement

Florida

Topaz Clinical Research, Inc., Apopka, Florida, 32703, United States
Actif, ne recrute pas
Beautiful Minds Clinical Research Center, Cutler Bay, Florida, 33157, United States
Interrompu
DeLand Clinical Research Unit, DeLand, Florida, 32720, United States
Interrompu
Sarkis Clinical Trials, Gainesville, Florida, 32607, United States
Actif, ne recrute pas
Multi-Specialty Research Associates, Inc., Lake City, Florida, 32055, United States
Actif, ne recrute pas
Watson Clinic Center for Research, Inc., Lakeland, Florida, 33805, United States
Interrompu
Watson Clinic LLP, Lakeland, Florida, 33805, United States
Interrompu
AppleMed Research Group, LLC, Miami, Florida, 33126, United States
En recrutement
Medical Research Center of Miami II, Inc, Miami, Florida, 33134, United States
Actif, ne recrute pas
Nicklaus Children's Hospital, Research Institute, Miami, Florida, 33155, United States
Pas encore en recrutement
South Florida Research Phase I-IV, Inc, Miami, Florida, 33166, United States
En recrutement
Brainstorm Research, Miami, Florida, 33176, United States
Actif, ne recrute pas
Advanced Research for Health Improvement, LLC/ Dr. Cordero's Pediatric Office, Naples, Florida, 34102, United States
Actif, ne recrute pas
Aqualane Clinical Research, Naples, Florida, 34105, United States
En recrutement
Coastal Clinical Research Specialists, Orange Park, Florida, 32073, United States
Actif, ne recrute pas
Clinical Associates of Orlando, LLC, Orlando, Florida, 32819, United States
En recrutement
Bioresearch Institute, Pembroke Pines, Florida, 33026, United States
Interrompu
Forcare Clinical Research, Tampa, Florida, 33613, United States
En recrutement
Premiere Research Institute at Palm Beach Neurology, West Palm Beach, Florida, 33407, United States
Actif, ne recrute pas

Georgia

Children's Healthcare of Atlanta, Inc., Atlanta, Georgia, 30329, United States
En recrutement
Childrens Healthcare of Atlanta, Atlanta, Georgia, 30329, United States
En recrutement
Rare Disease Research, LLC, Atlanta, Georgia, 30329, United States
Actif, ne recrute pas
Pivotal Clinical Research & Associates, LLC, Brunswick, Georgia, 31520, United States
En recrutement
CenExel iResearch, LLC, Decatur, Georgia, 30030, United States
En recrutement

Illinois

Chicago Headache Center & Research Institute, Chicago, Illinois, 60657, United States
En recrutement
AMR-Baber Research Inc, Naperville, Illinois, 60563, United States
En recrutement

Indiana

Options Research Group, LLC, Westfield, Indiana, 46074, United States
En recrutement

Iowa

Velocity Clinical Research, Sioux City, Sioux City, Iowa, 51106, United States
En recrutement
Integrated Clinical Trial Services, West Des Moines, Iowa, 50265, United States
En recrutement

Kansas

Clinical Associates Midwest, LLC, Kansas City, Kansas, 66214, United States
En recrutement
College Park Family Care Center Physicians Group- Neurology Research Dept., Overland Park, Kansas, 66212, United States
Actif, ne recrute pas

Kentucky

Kentucky Neuroscience Institute Child Neurology-- "Patients Seen", Lexington, Kentucky, 40504, United States
Actif, ne recrute pas
UK Center for Clinical and Translational Science (CCTS) -- "Patients Seen", Lexington, Kentucky, 40536, United States
Actif, ne recrute pas
University of Kentucky Hospital, Lexington, Kentucky, 40536, United States
Actif, ne recrute pas

Louisiana

Ochsner Clinic Foundation, New Orleans, Louisiana, 70121, United States
Actif, ne recrute pas
Neurology and Headache Center, Inc., Shreveport, Louisiana, 71105, United States
Actif, ne recrute pas

Massachusetts

Boston Clinical Trials, Boston, Massachusetts, 02131, United States
Actif, ne recrute pas
MedVadis Research Corporation, Waltham, Massachusetts, 02451, United States
Actif, ne recrute pas

Michigan

Michigan Head Pain & Neurological Institute, Ann Arbor, Michigan, 48104, United States
En recrutement
Corewell Health, for and on behalf of Spectrum Health Hospital and Corewell Health Medical Group, Grand Rapids, Michigan, 49503, United States
En recrutement
Corewell Health, Helen DeVos Children's Hospital, Grand Rapids, Michigan, 49503, United States
En recrutement
Wellnow Urgent Care and Research, Kalamazoo, Michigan, 49048, United States
Actif, ne recrute pas
Beaumont Hospital Royal Oak Campus, Royal Oak, Michigan, 48073, United States
En recrutement

Minnesota

Brackenridge Outpatient Research Pharmacy, Rochester, Minnesota, 55905, United States
En recrutement
Clinical Research Trials Unit, Rochester, Minnesota, 55905, United States
En recrutement
Mayo Clinic, Rochester, Minnesota, 55905, United States
En recrutement

Mississippi

Precise Research Centers, Flowood, Mississippi, 39232, United States
En recrutement

Missouri

Sharlin Health Neuroscience Research Center, Ozark, Missouri, 65721, United States
En recrutement
Clinvest Research, LLC, Springfield, Missouri, 65810, United States
Actif, ne recrute pas

Montana

Boeson Research, Great Falls, Montana, 59405, United States
En recrutement
Boeson Research, Kalispell, Montana, 59901, United States
Actif, ne recrute pas
Heart & Hands Midwifery, Kalispell, Montana, 59901, United States
Actif, ne recrute pas
Blue Moose Pediatrics, Missoula, Montana, 59804, United States
En recrutement
Boeson Research Laboratory, Missoula, Montana, 59804, United States
En recrutement
Boeson Research, Missoula, Montana, 59804, United States
En recrutement

Nebraska

Alivation Research, LLC., Lincoln, Nebraska, 68526, United States
Interrompu
Children's Hospital & Medical Center, Omaha, Nebraska, 68114, United States
En recrutement

New Jersey

HMH Jersey Shore University Medical Center, Neptune City, New Jersey, 07753, United States
En recrutement

New York

Dent Neurosciences Research Center, Amherst, New York, 14226, United States
En recrutement
True North Neurology, Commack, New York, 11725, United States
En recrutement
Northwell Health/ Division of Pediatric Neurology, Lake Success, New York, 11042, United States
En recrutement
NYU Langone Hospital-Long Island, Clinical Research Center, Mineola, New York, 11501, United States
Actif, ne recrute pas
NYU Langone Hospital-Long Island, Pediatric Neurology, Mineola, New York, 11501, United States
Actif, ne recrute pas
New York Neurology Associates, New York, New York, 10003, United States
En recrutement
Weill Cornell Medicine, New York, New York, 10021, United States
En recrutement
Mount Sinai Hospital - Pharmacy Department, New York, New York, 10029, United States
Actif, ne recrute pas
Columbia University Medical Center Research Pharmacy, New York, New York, 10032, United States
Actif, ne recrute pas
Columbia University Pediatric Neuromuscular Center, New York, New York, 10032, United States
Actif, ne recrute pas
Irving Center for Clinical and Translational Research, Outpatient Clinical Research Unit, New York, New York, 10032, United States
Actif, ne recrute pas
The Neurological Institute of New York, New York, New York, 10032, United States
Actif, ne recrute pas
The Trustees of Columbia University and The New York and Presbyterian Hospital, New York, New York, 10032, United States
Actif, ne recrute pas
North Suffolk Neurology P.C, Port Jefferson Station, New York, 11776, United States
Actif, ne recrute pas
Finger Lakes Clinical Research, Rochester, New York, 14618, United States
Interrompu
Prime Global Research, LLC, The Bronx, New York, 10456, United States
Interrompu

North Carolina

New Hope Clinical Research, Charlotte, North Carolina, 28211, United States
Actif, ne recrute pas
OnSite Clinical Solutions, LLC, Charlotte, North Carolina, 28277, United States
En recrutement
Velocity Clinical Research, Inc., Durham, North Carolina, 27701, United States
En recrutement
Headache Wellness Center, PC, Greensboro, North Carolina, 27405, United States
En recrutement

Ohio

Akron Children's Hospital, Akron, Ohio, 44308, United States
En recrutement
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 45229, United States
En recrutement
Velocity Clinical Research, Cincinnati, Ohio, 45242, United States
En recrutement
University Hospitals Cleveland Medical Center, Cleveland, Ohio, 44106, United States
En recrutement
Nationwide Children's Hospital, Columbus, Ohio, 43205, United States
Actif, ne recrute pas
Wellnow Urgent Care and Research, Columbus, Ohio, 43228, United States
Actif, ne recrute pas
Neuro-Behavioral Clinical Research, Inc., North Canton, Ohio, 44720, United States
Actif, ne recrute pas

Oklahoma

IPS Research Company, Oklahoma City, Oklahoma, 73106, United States
Actif, ne recrute pas
Lynn Institute of Tulsa, Tulsa, Oklahoma, 74135, United States
Actif, ne recrute pas

Oregon

Velocity Clinical Research, Grants Pass, Grants Pass, Oregon, 97527, United States
Actif, ne recrute pas
Providence Health & Services Investigational Drug Services Westside, Portland, Oregon, 97225, United States
En recrutement
Providence Neuroscience Institute - Research Coordinator's Office, Portland, Oregon, 97225, United States
En recrutement
Providence Pediatric Neurology, Portland, Oregon, 97225, United States
En recrutement
Providence St. Vincent Medical Center, Portland, Oregon, 97225, United States
En recrutement

Pennsylvania

Clario, Philadelphia, Pennsylvania, 19103, United States
En recrutement
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, 19104, United States
Actif, ne recrute pas

Rhode Island

Velocity Clinical Research-Providence, East Greenwich, Rhode Island, 02818, United States
En recrutement

South Carolina

Premier Neurology, PC, Greenville, South Carolina, 29605, United States
Actif, ne recrute pas
Tribe Clinical Research, LLC, Greenville, South Carolina, 29607, United States
Actif, ne recrute pas
Velocity Clinical Research - Greenville, Greenville, South Carolina, 29615, United States
Actif, ne recrute pas

Tennessee

Holston Medical Group., Kingsport, Tennessee, 37660, United States
Actif, ne recrute pas
Holston Medical Group, Kingsport, Tennessee, 37660, United States
Actif, ne recrute pas
Le Bonheur Children's Hospital - Outpatient Building, Memphis, Tennessee, 38103, United States
En recrutement
Le Bonheur Children's Hospital, Memphis, Tennessee, 38103, United States
En recrutement
Le Bonheur Childrens Hospital - Childrens Foundation Research Institute, Memphis, Tennessee, 38103, United States
En recrutement
Access Clinical Trials, Inc., Nashville, Tennessee, 37203, United States
Actif, ne recrute pas

Texas

Dell Children's Medical Center, Austin, Texas, 78723, United States
En recrutement
Child Neurology Consultants of Austin - South Austin, Austin, Texas, 78749, United States
En recrutement
Child Neurology Consultants of Austin - Central Austin, Austin, Texas, 78757, United States
En recrutement
BioBehavioral Research of Austin, Austin, Texas, 78759, United States
Actif, ne recrute pas
Houston Clinical Trials, LLC, Bellaire, Texas, 77401, United States
En recrutement
Infinite Research Group, LLC, Dallas, Texas, 75201, United States
En recrutement
Children's Medical Center, Dallas, Dallas, Texas, 75235, United States
En recrutement
Children's Medical Center, Pediatric Anesthesiology Research (Study supplies only), Dallas, Texas, 75235, United States
En recrutement
Cedar Health Research, Dallas, Texas, 75251, United States
En recrutement
FutureSearch Trials of Dallas, LLC, Dallas, Texas, 75251, United States
En recrutement
The University of Texas Southwestern Medical Center, Dallas, Texas, 75390, United States
En recrutement
ANESC Research, El Paso, Texas, 79912, United States
En recrutement
North Texas Institute of Neurology and Headache, Frisco, Texas, 75034, United States
Actif, ne recrute pas
UTHealth Houston, Houston, Texas, 77030, United States
En recrutement
Pain and Headache Centers of Texas, Houston, Texas, 77054, United States
En recrutement
SCLA Management, Houston, Texas, 77077, United States
En recrutement
Houston Clinical Research,LLC., Houston, Texas, 77081, United States
Actif, ne recrute pas
NeuroCare Plus, Houston, Texas, 77094, United States
En recrutement
AIM Trials, LLC, Plano, Texas, 75093, United States
En recrutement

Utah

JBR Clinical Research, Salt Lake City, Utah, 84107, United States
En recrutement
Wasatch Clinical Research , LLC(Administrative Location), Salt Lake City, Utah, 84107, United States
En recrutement

Vermont

The University of Vermont Medical Center, Burlington, Vermont, 05401, United States
Actif, ne recrute pas

Virginia

Pediatric Research of Charlottesville, LLC (Regulatory Only), Charlottesville, Virginia, 22902, United States
En recrutement
Pediatric Research of Charlottesville, LLC, Charlottesville, Virginia, 22902, United States
En recrutement
Children's Hospital of the King's Daughters, Norfolk, Virginia, 23507, United States
En recrutement
Children's Specialty Group, PLLC, Norfolk, Virginia, 23507, United States
En recrutement
Children's Specialty Group, PLLC, Division of Childhood & Adolescent Neurology, Norfolk, Virginia, 23510, United States
En recrutement
National Clinical Research, Inc., Richmond, Virginia, 23294, United States
Actif, ne recrute pas

Washington

Northwest Clinical Research Center, Bellevue, Washington, 98007, United States
En recrutement
Eastside Therapeutic Resource, Inc. dba Core Clinical Research, Everett, Washington, 98201, United States
Actif, ne recrute pas
Seattle Children's Hospital Investigational Drug Services, Seattle, Washington, 98105, United States
En recrutement
Seattle Children's Hospital, Seattle, Washington, 98105, United States
En recrutement

Wisconsin

Clinical Investigation Specialists, Inc, Kenosha, Wisconsin, 53144, United States
En recrutement
University Hospital, Madison, Wisconsin, 53792, United States
En recrutement

Anhui

First Affiliated Hospital of Bengbu Medical College Neurology, Bengbu, Anhui, 233000, China
En recrutement
Anhui Provincial Hospital, Hefei, Anhui, 230000, China
En recrutement

Beijing Municipality

Chinese PLA General Hospital, Beijing, Beijing Municipality, 100089, China
En recrutement

Chongqing Municipality

" The First Affiliated Hospital of Chongqing Medical University", Chongqing, Chongqing Municipality, 400042, China
En recrutement

Gansu

Lanzhou university second hospital, Lanzhou, Gansu, 730030, China
En recrutement

Guangdong

Shenzhen Children's Hospital, Shenzhen, Guangdong, 518034, China
En recrutement

Hainan

Hainan General Hospital, Haikou, Hainan, 571140, China
En recrutement

Hebei

The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, China
En recrutement
The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050004, China
En recrutement

Henan

People's Hospital of Zhengzhou, Zhengzhou, Henan, 450000, China
En recrutement

Hubei

Jingzhou First People's Hospital, Jingzhou, Hubei, 434000, China
En recrutement
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, China
En recrutement
Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, China
En recrutement

Hunan

The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410000, China
En recrutement
Hunan Children's Hospital, Changsha, Hunan, 410007, China
En recrutement
The Third Xiangya Hospital of Central South University, Changsha, Hunan, 410013, China
En recrutement

Jiangsu

The Second People's Hospital of Lianyungang, Lianyungang, Jiangsu, 222002, China
En recrutement
The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215006, China
En recrutement
Wuxi Children's Hospital, Wuxi, Jiangsu, 214023, China
En recrutement
Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, 214115, China
En recrutement
Xuzhou Children's Hospital, Xuzhou, Jiangsu, 221002, China
En recrutement
Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, 212001, China
En recrutement

Jilin

The First Hospital of Jilin University, Pediatric Neurology, Changchun, Jilin, 130021, China
En recrutement

Ningxia

General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 756000, China
En recrutement

Shaanxi

Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, 710068, China
En recrutement
Xi'an Gaoxin Hospital Neurology Department, Xi'an, Shaanxi, 710075, China
En recrutement
Yan 'an University Xianyang Hospital, Xianyang, Shaanxi, 716000, China
En recrutement

Shandong

Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, 250013, China
En recrutement
Liaocheng People's Hospital, Liaocheng, Shandong, 252000, China
En recrutement

Sichuan

West China Hospital of Sichuan University, Chengdu, Sichuan, 610041, China
En recrutement

Zhejiang

Children's Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310052, China
En recrutement
Ningbo Women and Children's Hospital, Ningbo, Zhejiang, 315012, China
En recrutement
The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China
En recrutement
Lu 'an People's Hospital, Lu'an, China
En recrutement
Children's Hospital of Shanghai, Shanghai, China
En recrutement
Shengjing Hospital of China Medical University, Shenyang, China
En recrutement
The First Affiliated Hospital of Shihezi University School of Medicine, Shihezi, China
Actif, ne recrute pas
Wuhan Children's Hospital, Wuhan, China
En recrutement

Fukuoka

Jinnouchi Neurosurgical Clinic, Kasuga-shi, Fukuoka, 816-0802, Japan
En recrutement
Ikeda Neurosurgical Clinic, Kasuga-shi, Fukuoka, 816-0824, Japan
En recrutement

Gunma

Hikita Pediatric Clinic, Kiryu-shi, Gunma, 3760035, Japan
En recrutement

Hyōgo

Konan Medical Center, Higashinada-ku Kobe-shi, Hyōgo, 658-0064, Japan
En recrutement
Yamaguchi Clinic, Nishinomiya-shi, Hyōgo, 663-8204, Japan
En recrutement

Ibaraki

Mito Kyodo General Hospital, Mito, Ibaraki, 310-0015, Japan
En recrutement

Kagoshima-ken

Tanaka Neurosurgery & Headache Clinic, Kagoshima, Kagoshima-ken, 890-0052, Japan
En recrutement

Miyagi

Sendai Headache and Neurology Clinic, Taihaku-ku Sendai-shi, Miyagi, 982-0014, Japan
En recrutement

Osaka

Tennoji Dai Brain Clinic, Abeno-ku Osaka-shi, Osaka, 545-0053, Japan
En recrutement
Tominaga Clinic, Naniwa-ku, Osaka, 556-0015, Japan
En recrutement

Tokyo

Tokyo Headache Clinic, Shibuya-ku, Tokyo, 151-0051, Japan
En recrutement
Tokyo Medical University Hospital, Shinjuku-ku, Tokyo, 160-0023, Japan
Pas encore en recrutement
Local lndependent Administrative Corporation Hiroshima City Hospital Organization Hiroshima City, Hiroshima, 730-8518, Japan
En recrutement

Mexico City

Clinstile S.A. de C.V., Col. Roma Norte, Mexico City, C.P. 06700., Mexico
En recrutement

Sinaloa

Neurociencias Estudios Clinicos S.C., Culiacán, Sinaloa, 800200, Mexico
En recrutement

State of Mexico

Clinical Reseach Institute, S.C., Tlalnepantla, State of Mexico, C.P. 54055, Mexico
En recrutement
Unidad de Investigacion en Salud de Chihuahua S.C., Chihuahua City, 31203, Mexico
En recrutement

Lower Silesian Voivodeship

MIGRE Polskie Centrum Leczenia Migreny Anna Gryglas-Dworak, Wroclaw, Lower Silesian Voivodeship, 52-210, Poland
En recrutement
NZOZ Wielospecjalistyczna Poradnia Lekarska SYNAPSIS, Lech Szczechowski, Katowice, 40-123, Poland
Actif, ne recrute pas
Centrum Medyczne Plejady, Krakow, 30-363, Poland
En recrutement
Wojewódzki Specjalistyczny Szpital Dzieciecy im. Sw. Ludwika w Krakowie, Apteka Szpitalna, Krakow, 31-503, Poland
En recrutement
Clinical Research Center Sp. z.o.o. Medic-R Spolka komandytowa, Poznan, 61-731, Poland
En recrutement
Euromedis Sp. z o. o., Szczecin, 70-111, Poland
Actif, ne recrute pas

Cantabria

Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, 39008, Spain
Actif, ne recrute pas
Hospital Universitario Vall d'Hebron, Barcelona, 08035, Spain
En recrutement
Centre d'Atencio Primaria Balenya, Barcelona, 08550, Spain
Actif, ne recrute pas
Instituto de Investigaciones del Sueno, Madrid, 28036, Spain
Actif, ne recrute pas
Hospital Universitario Virgen del Rocío, Seville, 41013, Spain
En recrutement
Hospital Clinico Universitario de Valladolid, Valladolid, 47005, Spain
En recrutement

Skåne LÄN [se-12]

ProbarE i Lund AB, Lund, Skåne LÄN [se-12], 22222, Sweden
En recrutement
Avdelningen för kliniska Prövningar, Universitetssjukhuset Örebro, Örebro, 703 62, Sweden
Actif, ne recrute pas
ProbarE i Stockholm AB, Stockholm, 113 29, Sweden
En recrutement
Leicester Royal Infirmary, Leicester, LE1 5WW, United Kingdom
Actif, ne recrute pas
Re:Cognition Health Limited, London, W1G 9JF, United Kingdom
En recrutement
Great Ormond Street Hospital for Children NHS Foundation Trust, London, WC1N 3JH, United Kingdom
En recrutement