Radar des Essais Cliniques

Life expectancy of <3 months in the opinion of the investigator.

Any medical or psychiatric condition including recent (within the past year) or active suicidal ideation/behavior or laboratory abnormality that may increase the risk of study participation or make the participant inappropriate for the study.

Participants with any history of another malignancy within 3 years before the first dose of study intervention, or any evidence of residual disease from a previously diagnosed malignancy.

Known or suspected hypersensitivity, intolerance, or contraindication to any excipient contained in the drug formulation of sigvotatug vedotin or pembrolizumab.

Participants with any of the following respiratory conditions:

1. Evidence of noninfectious or drug-induced ILD or pneumonitis
2. Known DLCO (adjusted for hemoglobin) <50% predicted.
3. Grade ≥3 pulmonary disease unrelated to underlying malignancy

Known active CNS lesions are excluded. Participants with definitively treated brain metastases (surgery and/or radiotherapy) may be eligible. Clinically inactive brain metastases of longest diameter <0.5 cm are permitted.

Major surgery (defined as a surgery requiring inpatient hospitalization of at least 48 hours) within 21 days or minor surgery within 7 days prior to first dose of study intervention.

Receipt of a live vaccine within 30 days prior to first dose of study intervention.

Pre-existing peripheral neuropathy Grade ≥2 per NCI CTCAE v5.0.

Uncontrolled diabetes mellitus, defined as HbA1c ≥8.0% or HbA1c between 7.0% and 8.0% with associated diabetes symptoms (polyuria or polydipsia) that are not otherwise explained.

Prior immune-related AE that led to anti-PD-(L)1 treatment discontinuation, required a high-dose steroid taper (≥0.5 mg/kg prednisone or equivalent per day) for >2 weeks, or required treatment with systemic immunosuppressive therapy.

History of autoimmune disease that has required systemic treatment in the past 2 years

Participants with prior solid organ or bone marrow transplantation.

Currently receiving a high-dose steroid (>10 mg prednisone or equivalent per day) or other immune suppressant or has a condition requiring a chronic high-dose steroid or immune suppressant.

Prior and concomitant therapy:

1. Any prior treatment with MMAE-derived drugs or IB6 targeting agents.

2. Prior systemic therapy, including anti-PD-(L)1 therapy, for locally advanced, unresectable, or metastatic NSCLC.

   • (Neo)adjuvant anti-PD-(L)1 is allowed if recurrence or progression occurred ≥9 months after the last dose.
   • Other (neo)adjuvant or definitive therapy is allowed if recurrence or progression occurred ≥6 months after the last dose.

3. Prior radiotherapy to the lung within 6 months of first dose of study intervention, referencing the last date radiotherapy was received.

4. Chemotherapy, biologics, and/or other antitumor treatment with immunotherapy not specifically prohibited that is completed less than 4 weeks prior to first dose of study intervention, or 2 weeks for palliative radiotherapy.

5. Any prior therapy with an immune-oncology agent directed to a stimulatory or co-inhibitory T-cell receptor

History of or current ongoing infection, including participants positive for active HIV, HBV, or HCV.

Severe uncontrolled cardiac or cerebrovascular condition within the previous 6 months