bêta
IA Trial Radar
L'essai clinique NCT07207811 (CLEOPATTRA) pour Cardiomyopathie Amyloïde à Transthyrétine (ATTR CM) est en recrutement. Consultez la vue en carte du Radar des Essais Cliniques et les outils de découverte par IA pour tous les détails, ou posez vos questions ici.
Un essai clinique correspond aux filtres sélectionnés
Vue en carte
Retour à la recherche

CLEOPATTRA: A Research Study to Look at the Effects of Treatment With a Medicine Called Coramitug (NNC6019-0001) in People With Heart Failure Due to Transthyretin Amyloid (ATTR) Amyloidosis

En recrutement
Les détails de l'essai clinique sont principalement disponibles en anglais. Cependant, l'IA Trial Radar peut vous aider ! Cliquez simplement sur 'Expliquer l'essai' pour voir et discuter des informations sur l'essai dans la langue sélectionnée.
L'essai clinique NCT07207811 (CLEOPATTRA) est conçu pour étudier le treatment de Cardiomyopathie Amyloïde à Transthyrétine (ATTR CM). Il s'agit d'un essai interventionnel en Phase III. Son statut actuel est : en recrutement. L'essai a débuté le 2 octobre 2025 et vise à recruter 1 280 participants. Dirigé par Novo Nordisk, l'essai devrait être terminé d'ici le 29 juin 2029. Les données du site ClinicalTrials.gov ont été mises à jour pour la dernière fois le 16 octobre 2025.
Résumé succinct
This study will find out if a new medicine called NNC6019-0001 can help reduce the risk of heart-related death and illness in participants with a condition called transthyretin amyloid cardiomyopathy (ATTR-CM), which affects the heart. Participants will either receive NNC6019-0001 or a placebo (a treatment with no active medicine), and which one they get is decided by chance. Everyone in the study will continue receiving their usual heart treatments as recommended by their doctor.
Titre officiel

CLEOPATTRA: Effects of NNC6019-0001 Versus Placebo on Cardiovascular Outcomes in Participants With Transthyretin Amyloid Cardiomyopathy (ATTR-CM)

Conditions
Cardiomyopathie Amyloïde à Transthyrétine (ATTR CM)
Autres identifiants de l'essai
  • CLEOPATTRA
  • NN6019-4958
  • U1111-1315-5366 (Autre Identifiant) (World Health Organization (WHO))
  • 2024-518899-31 (Autre Identifiant) (European Medical Agency (EMA))
Numéro NCT
NCT07207811
Date de début (réel)
2025-10-02
Dernière mise à jour publiée
2025-10-16
Date de fin (estimée)
2029-06-29
Inscription (estimée)
1 280
Type d'essai
Interventionnel
PHASE
Phase III
Statut
En recrutement
Objectif principal
Traitement
Plan d'attribution
Randomisé
Modèle d'intervention
Parallèle
Masquage
Quadruple aveugle
Bras / Interventions
Groupe de participants/BrasIntervention/Traitement
ExpérimentalNNC6019-0001
Participants will receive NNC6019-0001 intravenously (IV). Participants will also have the option to continue any Standard of care (SoC) treatments as recommended by their medical health professional.
NNC6019-0001
NNC6019-0001 will be administered IV.
Comparateur placeboPlacebo
Participants will receive placebo matched to NNC6019-0001 IV. Participants will also have the option to continue any SoC treatments as recommended by their medical health professional.
Placebo (NNC6019-0001)
Placebo matched to NNC6019-0001 will be administered IV.
Critère principal d'évaluation
Critères d'évaluationDescription de critèresPériode
Number of occurrences of composite endpoint of cardiovascular (CV) deaths and recurrent CV events (CV hospitalisations and urgent heart failure [HF] visits)
Measured as count of events.
From baseline (week 0) to end of study (EOS) (up to approximately 4 years)
Critère secondaire d'évaluation
Critères d'évaluationDescription de critèresPériode
Change in Kansas city cardiomyopathy questionnaire- clinical summary score (KCCQ-CSS)
Measured as score on a scale. KCCQ-CSS is a score derived from a 23-item patient-reported outcome (PRO) measure assessing health status in individuals with HF. The score ranges from 0 to 100, with higher scores indicating better health status.
From baseline (week 0) to approximately 2 years
Change in Kansas city cardiomyopathy questionnaire- overall summary score (KCCQ-OSS)
Measured as score on a scale. KCCQ-OSS is a score derived from a 23-item PRO measure assessing health status in individuals with HF. The score ranges from 0 to 100, with higher scores indicating better health status.
From baseline (week 0) to approximately 2 years
Change in 6-minute walk distance (6MWD)
Measured in meters.
From baseline (week 0) to approximately 2 years
Number of occurrences of CV events (CV hospitalisation and urgent HF visits)
Measured as count of events.
From baseline (week 0) to EOS (up to approximately 4 years)
Time to occurrence of CV death
Measured in months.
From baseline (week 0) to EOS (up to approximately 4 years)
Time to occurrence of all-cause death
Measured in months.
From baseline (week 0) to EOS (up to approximately 4 years)
Time to first occurrence of composite CKD endpoint: CV death, onset of a persistent decline in eGFR of ≥30% from baseline, onset of a persistent eGFR <15 mL/min/1.73 m^2, or initiation of chronic KRT, including dialysis or kidney transplantation
Measured in months. Composite chronic kidney disease (CKD) endpoint comprised of (1) CV death, (2) onset of a persistent decline in estimated glomerular filtration rate (eGFR) of greater than or equal to 30 percent (%) from baseline, (3) onset of a persistent eGFR less than or equal to 15 milliliters per minute per 1.73 square meters (mL/min/1.73 m\^2), or (4) initiation of chronic kidney replacement therapy (KRT), including dialysis or kidney transplantation.
From baseline (week 0) to EOS (up to approximately 4 years)
Time to hospitalisation due to HF or urgent HF visit
Measured in months.
From baseline (week 0) to EOS (up to approximately 4 years)
Time to CV events (CV hospitalisation and urgent HF visit)
Measured in months.
From baseline (week 0) to EOS (up to approximately 4 years)
Number of occurrences of composite endpoint of CV deaths and recurrent CV events (CV hospitalisation, urgent HF visits, and outpatient HF visits)
Measured as count of events.
From baseline (week 0) to EOS (up to approximately 4 years)
Participant achieving threshold for clinically meaningful within-patient change from the participant's perspective in KCCQ-CSS
Measured as count of participants.
From baseline (week 0) to approximately 2 years
Participant achieving threshold for clinically meaningful within-patient change from the participant's perspective in KCCQ-OSS
Measured as count of participants.
From baseline (week 0) to approximately 2 years
Participant achieving threshold for clinically meaningful within-patient change from the participant's perspective in 6-minute walk test (6MWT)
Measured as count of participants.
From baseline (week 0) to approximately 2 years
Change in stroke volume (SV)
Measured in milliliter (mL).
From baseline (week 0) to week 52
Change in N-terminal pro B-type natriuretic peptide (NT-proBNP)
Measured as ratio to baseline.
From baseline (week 0) to week 52
Change in high-sensitivity (hs) troponin I
Measured in nanograms per milliliter (ng/mL).
From baseline (week 0) to week 52
Change in troponin T
Measured in ng/mL.
From baseline (week 0) to week 52
Hierarchical composite of time to all-cause death as assessed by the win ratio
Measured as total wins for each treatment group.
From baseline (week 0) up to approximately 2 years
Hierarchical composite of number of CV events (CV hospitalisations or urgent HF visits) as assessed by the win ratio
Measured as total wins for each treatment group.
From baseline (week 0) up to approximately 2 years
Hierarchical composite of difference > 15, > 10 and > 5 points in KCCQ-OSS as assessed by the win ratio
Measured as total wins for each treatment group.
From baseline (Week 0) to approximately 2 years
Hierarchical composite of difference > 70 and > 30 meters in 6-minute walk test (6MWT) as assessed by the win ratio
Measured as total wins for each treatment group.
From baseline (Week 0) to approximately 2 years
Critères d'éligibilité

Âges éligibles
Adulte, Adulte âgé
Âge minimum
18 Years
Sexes éligibles
Tous
  • Male or female.
  • Age 18 years or above at the time of signing the informed consent.
  • Have an established diagnosis of ATTR-CM (wild-type ATTR [ATTRwt] or variant ATTR [ATTRv]), with cardiac amyloid infiltration, increased left ventricular (LV) wall thickness, and HF.

Note: Target ATTRv recruitment is approximately 15 percent of the study population.

  1. Cardiac amyloid infiltration demonstrated by:

    • Cardiac biopsy positive for TTR amyloid, OR
    • Grade 2 or 3 cardiac uptake at pyrophosphate (PYP)/diphosphono-1,2-propanodicarboxylic acid (DPD)/ hydroxymethylene diphosphonate (HMDP) scintigraphy with single-photon emission computed tomography (SPECT/CT) combined with an extracardiac biopsy positive for TTR amyloid, OR
    • Grade 2 or 3 cardiac uptake at PYP/DPD/HMDP scintigraphy with SPECT/CT combined with normal serum free light chain ratio, and negative serum and urine protein electrophoresis with immunofixation (SPIE & UPIE).

    Notes:

    • Non-invasive diagnostic pathway will be confirmed by a centralised expert review.
    • Bone tracer scintigraphy will be conducted using 99m-technetium (Tc)-labelled pyrophosphate (99mTc-PYP), 99mTc-labelled 3,3-diphosphono-1,2-propanodicarboxylic acid (99mTc-DPD), or 99mTc-labeled hydroxymethylene diphosphonate (99mTc-HMDP).

  2. Increased LV wall thickness, as assessed by centralised review of echocardiography, showing interventricular septal wall thickness greater than or equal to 12 millimeter (mm).

  3. Chronic HF (New York Heart Association [NYHA] Class I-IV) requiring ongoing treatment with a loop diuretic with:

    • At least 1 documented hospitalisation for HF, OR
    • History of HF manifested by signs or symptoms of volume overload or elevated intracardiac pressures (e.g., elevated jugular venous pressure, shortness of breath, signs of pulmonary congestion on x-ray or auscultation, or peripheral oedema).
    • Expected to be on stable cardiovascular medical therapy (defined as no greater than 50 percent dose adjustment and no categorical changes of medications), with the exception of diuretics, 4 weeks prior to the randomisation visit.
    • Completed more than 50 meters on the 6MWT at screening.

  • Known or suspected hypersensitivity to study intervention(s) or related products.
  • Current or previous participation (dosing with active treatment) in a study for an investigational ATTR depleting drug or ATTR gene editing therapy.
  • Total bilirubin greater than 3 times the upper limit of normal (ULN) at screening.
  • Current diagnosis or history of amyloid light chain, other non-ATTR amyloidosis, known leptomeningeal amyloidosis, or multiple myeloma.
  • HF not primarily caused by ATTR-CM (e.g., due to hypertension, valvular heart disease, or ischemic heart disease in the opinion of the investigator).
  • Currently hospitalised or hospitalised within 14 days prior to screening.
  • Currently treated with positive inotropic medication.
  • Uncorrected, severe, haemodynamically significant, left-sided heart valve disease.

Note: Pre-existing echocardiogram up to 2 years old may be used.

  • Acute coronary syndrome, unstable angina, stroke, transient ischemic attack, coronary revascularisation, cardiac device implantation, cardiac valve repair, or major surgery within 60 days of screening.
  • Prior solid organ transplant or planned solid organ transplant during the study.
  • Left ventricular ejection fraction (LVEF) less than 30 percent as assessed by centralised review of echocardiography.
  • Presence or history of malignant neoplasm (other than basal or squamous cell skin cancer, in situ carcinomas of the cervix, carcinoma in situ/high-grade prostatic intraepithelial neoplasia [PIN], low-risk prostate cancer, or on stable therapy for prostate cancer) within 3 years before screening.
  • End-stage renal disease (estimated glomerular filtration rate [eGFR] less than 15 mL/min/1.73 m^2 at screening, or chronic/intermittent haemodialysis or peritoneal dialysis).
Novo Nordisk A/S logoNovo Nordisk134 essais cliniques actifs à explorer
Contact central de l'essai
Contact: Novo Nordisk, (+1) 866-867-7178, [email protected]
271 Centres de l'essai dans 16 pays
Centre Hospitalier Universitaire d'Amiens-Picardie - Site Sud, Amiens, 80054, France
Pas encore en recrutement
Centre Hospital Regional Et Universitaire De Tours (Chru Tours) - Houpital Trousseau, Chambray-lès-Tours, 37170, France
Pas encore en recrutement
Hospital Henri Mondor, Créteil, 94000, France
Pas encore en recrutement
CHU De Dijon Hopital Du Bocage, Dijon, 21079, France
Pas encore en recrutement
Centre Hospitalier Departemental Vendee (CHD) - L'Hopital de la Roche-sur-Yon (CHD Les Oudairies), La Roche-sur-Yon, 85925, France
Pas encore en recrutement
Centre Hospitalier Universitaire de Grenoble (CHUG) Hopital Nord, La Tronche, 38043, France
Pas encore en recrutement
Assistance Publique Hopitaux de Marseille (AP-HM) - Hopital de La Timone, Marseille, 13385, France
Pas encore en recrutement
Hospital Center Annecy Genevois-Centre Hospitalier de la Region d'Annecy CHRA, Metz-Tessy, 74370, France
Pas encore en recrutement
Centre Hospitalier Regional Universitaire (CHRU) Montpellier Arnaud de Villeneuve, Montpellier, 34295, France
Pas encore en recrutement
CHU De Nantes - Hopital Laennec, Nantes, 44093, France
Pas encore en recrutement
Centre Hospitalier Universitaire de Nice - Hopital Pasteur, Nice, 06001, France
Pas encore en recrutement
Groupement Hospitalier Universitaire Ouest - Hopital Europeen Georges-Pompidou (HEGP), Paris, 75015, France
Pas encore en recrutement
Hopital Bichat - Claude-Bernard, Paris, 75018, France
Pas encore en recrutement
Centre Hospitalier Universitaire de Bordeaux - Hopital Haut-Leveque, Pessac, 33604, France
Pas encore en recrutement
Centre Hospitalier Universitaire de Poitiers la Miletrie, Poitiers, 86021, France
Pas encore en recrutement
Centre Hospitalier Universitaire (CHU) de Rennes, Rennes, 35000, France
Pas encore en recrutement
Centre Hospitalier de Toulon - Hopital Sainte-Musse, Toulon, 83100, France
Pas encore en recrutement
Centre Hospitalier Universitaire (CHU) de Toulouse - Hopital Rangueil, Toulouse, 31059, France
Pas encore en recrutement
Private Hospital Medipole, Villeurbanne, 69100, France
Pas encore en recrutement

Anderlecht

Hopital Universitaire de Bruxelles/ Academisch Ziekenhuis Brussel, Brussels, Anderlecht, 1070, Belgium
Pas encore en recrutement

Brussels Capital

Universite Catholique de Louvain (UCL) - Cliniques Universitaires Saint-Luc, Woluwe-Saint-Lambert, Brussels Capital, 1200, Belgium
Pas encore en recrutement

Brusselss

Universitair Ziekenhuis Brussel, Jette, Brusselss, 1090, Belgium
Pas encore en recrutement

Limburg

ZOL Genk, Campus Sint-Jan, Waterschei-Zwartberg, Limburg, 3600, Belgium
Pas encore en recrutement

Oost-Vlaanderen

AZORG Ziekenhuis, Aalst, Oost-Vlaanderen, 9300, Belgium
Pas encore en recrutement
Algemeen Ziekenhuis Sint-Blasius (AZSB), Sint-Gillis-Dendermonde, Oost-Vlaanderen, 9200, Belgium
Pas encore en recrutement
Az Middelheim, Antwerp, 2020, Belgium
Pas encore en recrutement
Algemeen Ziekenhuis Sint-Jan, Bruges, 8000, Belgium
Pas encore en recrutement
Universitair Ziekenhuis Leuven, Leuven, 3000, Belgium
Pas encore en recrutement
Centre Hospitalier Regional CHR de la Citadelle, Liège, 4000, Belgium
Pas encore en recrutement
Clinique Universitaire de Mont Godinne, Yvoir, 5530, Belgium
Pas encore en recrutement

Alberta

University of Calgary, Calgary, Alberta, T2N 1N4, Canada
Pas encore en recrutement

British Columbia

Vancouver General Hospital, Vancouver, British Columbia, V5Z 1M9, Canada
Pas encore en recrutement

Chicoutimi

CIUSSS du Saguenay Lac-Saint-Jean, Québec, Chicoutimi, G7H 7M4, Canada
Pas encore en recrutement

Nova Scotia

Nova Scotia Health Authority, Halifax, Nova Scotia, B3S 0H6, Canada
Pas encore en recrutement

Ontario

Health Sciences North Research Institute-Advanced Medical Research Institute of Canada, Greater Sudbury, Ontario, P3E 5J1, Canada
Pas encore en recrutement
Cardio Health Clinical Trials, Hamilton, Ontario, L8W 3K5, Canada
Pas encore en recrutement
London Health Sciences Centre - University Hospital, London, Ontario, N6A 5A5, Canada
Pas encore en recrutement
Cardio Health Clinical Trials, Mississauga, Ontario, L5M 2S6, Canada
Pas encore en recrutement
Cardiohealth Medical Clinic, Scarborough Village, Ontario, M1B 0A7, Canada
Pas encore en recrutement
Riverside Cardiology and Diagnostic Imaging, Toronto, Ontario, M6N 1B5, Canada
Pas encore en recrutement
Hotel Dieu de Quebec, Québec, G1R 2J6, Canada
Pas encore en recrutement

Arizona

Mayo Clinic Hospital, Phoenix, Arizona, 85054, United States
Pas encore en recrutement

California

University of California San Diego (UCSD) - Sulpizio Cardiovascular Center (SCVC), La Jolla, California, 92037, United States
Pas encore en recrutement
Keck School of Medicine USC - Healthcare Consultation Center 2 (HCCII), Los Angeles, California, 90033, United States
Pas encore en recrutement
UCI Medical Center, Orange, California, 92868, United States
Pas encore en recrutement
Profound Research LLC at Southern California Heart Specialists, Pasadena, California, 91105, United States
Pas encore en recrutement
University of California, San Francisco Medical Center, San Francisco, California, 94143, United States
Pas encore en recrutement
Northbay Cardiology Inc., Santa Rosa, California, 95405, United States
En recrutement
Lucile Packard Children's Hospital, Stanford, California, 94305, United States
Pas encore en recrutement

Connecticut

Yale University School of Medicine, New Haven, Connecticut, 06510, United States
Pas encore en recrutement

District of Columbia

MedStar Heart & Vascular Institute (MHVI) - MedStar Washington Hospital Center, Washington D.C., District of Columbia, 20010-3017, United States
Pas encore en recrutement

Florida

UF Health Heart and Vascular Hospital, Gainesville, Florida, 32608, United States
Pas encore en recrutement

Georgia

Northeast Georgia Heart Center, Pc (Nghc), Gainesville, Georgia, 30501-3466, United States
Pas encore en recrutement

Illinois

Northwestern University Clinical and Translational Sciences Institute, Chicago, Illinois, 60611, United States
Pas encore en recrutement
The University of Chicago Medicine, Chicago, Illinois, 60637, United States
Pas encore en recrutement
Endeavor Health - Glenbrook Hospital, Glenview, Illinois, 60026, United States
Pas encore en recrutement

Indiana

Indiana University (IU) Health - Methodist Professional Center II, Indianapolis, Indiana, 46202, United States
Pas encore en recrutement

Louisiana

LCMC - LSU University Medical Center New Orleans LCMC Center, New Orleans, Louisiana, 70112, United States
Pas encore en recrutement

Maryland

University of Maryland Medical Center (UMMC) - R Adams Cowley Shock Trauma Center, Baltimore, Maryland, 21201, United States
Pas encore en recrutement
University of Maryland Medical Center (UMMC), Baltimore, Maryland, 21201, United States
Pas encore en recrutement
John Hopkins Medicine, Baltimore, Maryland, 21287, United States
Pas encore en recrutement

Massachusetts

Tufts Medical Center (TMC) - Cancer Center, Boston, Massachusetts, 02111, United States
Pas encore en recrutement
Massachusetts General Hospital, Boston, Massachusetts, 02114, United States
Pas encore en recrutement

Michigan

University of Michigan Health System, Ann Arbor, Michigan, 48109, United States
Pas encore en recrutement
Henry Ford Health, Detroit, Michigan, 48202, United States
Pas encore en recrutement
Profound Research, Farmington Hills, Michigan, 48334, United States
Pas encore en recrutement

Minnesota

Mayo Clinic, Rochester, Minnesota, 55905, United States
Pas encore en recrutement

Mississippi

Cardiology Associates Research, LLc, Tupelo, Mississippi, 38801, United States
Pas encore en recrutement

Missouri

Saint Luke's Hospital of Kansas City, Kansas City, Missouri, 64111, United States
Pas encore en recrutement
Saint Louis University, St Louis, Missouri, 63110, United States
Pas encore en recrutement
Washington University School of Medicine, St Louis, Missouri, 63110, United States
Pas encore en recrutement

Nebraska

University of Nebraska Medical Center, Omaha, Nebraska, 68198, United States
Pas encore en recrutement

New York

North Shore University Hospital, Northwell Health, Manhasset, New York, 11030, United States
Pas encore en recrutement
New York University Medical Centre, New York, New York, 10016, United States
Pas encore en recrutement
Weill Cornell Medical Center, New York, New York, 10021, United States
Pas encore en recrutement
Mount Sinai Medical Center, New York, New York, 10029, United States
Pas encore en recrutement
Columbia University Medical Center, New York, New York, 10032, United States
Pas encore en recrutement
Laurelton Heart Specialist, PC, Rosedale, New York, 11422, United States
Pas encore en recrutement

North Carolina

Duke University Health System, Durham, North Carolina, 27750, United States
Pas encore en recrutement

Ohio

The Carl and Edyth Lindner-Center for Research and Education at The Christ Hospital, Cincinnati, Ohio, 45219-2906, United States
Pas encore en recrutement

Oregon

Oregon Health and Science University, Portland, Oregon, 97239, United States
Pas encore en recrutement

Pennsylvania

Abington Hospital - Jefferson Health, Abington, Pennsylvania, 19001, United States
Pas encore en recrutement
Penn State Milton S.Hershey Medical Center - Penn State Hershey Cancer Institute, Hershey, Pennsylvania, 17033, United States
Pas encore en recrutement
Penn Medicine: University of Pennsylvania Health System, Philadelphia, Pennsylvania, 19104, United States
Pas encore en recrutement
University of Pittsburgh Medical Center (UPMC) - Center for Image-Guided Neurosurgery, Pittsburgh, Pennsylvania, 15213-2536, United States
Pas encore en recrutement

South Carolina

Prisma Health, Greenville, South Carolina, 29607, United States
Pas encore en recrutement

Tennessee

Saint Thomas Health, Nashville, Tennessee, 37205, United States
Pas encore en recrutement

Texas

Ascension Seton Heart Institute - Medical Park Tower Location, Austin, Texas, 78705, United States
Pas encore en recrutement
St. Davids Heart and Vascular, Austin, Texas, 78751, United States
Pas encore en recrutement
Baylor Scott & White Research Institute - Annette C. and Harold C. Simmons Transplant Institute, Dallas, Texas, 75246, United States
Pas encore en recrutement
University of Texas Southwestern Medical Center, Dallas, Texas, 75390-9045, United States
Pas encore en recrutement
Baylor St. Luke Medical Center, Houston, Texas, 77030, United States
Pas encore en recrutement
Houston Methodist Hospital, Houston, Texas, 77030, United States
Pas encore en recrutement
Baylor Scott & White The Heart Hospital, Plano, Texas, 75093, United States
Pas encore en recrutement

Virginia

Inova Fairfax Hospital - Inova Heart and Vascular Institute, Falls Church, Virginia, 22042, United States
Pas encore en recrutement
Sentara Cardiovascular Research Institute, Norfolk, Virginia, 23507, United States
Pas encore en recrutement
Virginia Commonwealth University Medical Center, Richmond, Virginia, 23219, United States
Pas encore en recrutement

Washington

University of Washington Medical Center - Montlake, Seattle, Washington, 98195, United States
Pas encore en recrutement
Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington, 99201, United States
Pas encore en recrutement

New South Wales

ST Vincent's Hospital Sydney, Darlinghurst, New South Wales, 2010, Australia
Pas encore en recrutement
Liverpool Renal Clinical Research Centre, Liverpool, New South Wales, 2170, Australia
Pas encore en recrutement
Westmead Hospital, Westmead, New South Wales, 2145, Australia
Pas encore en recrutement

Queensland

Advara HeartCare - Milton, Milton, Queensland, 4064, Australia
Pas encore en recrutement
Metro South Health - Princess Alexandra Hospital (PAH), Woolloongabba, Queensland, 4102, Australia
Pas encore en recrutement

South Australia

Central Adelaide Local Health Network - Royal Adelaide Hospital, Adelaide, South Australia, 5000, Australia
Pas encore en recrutement
Flinders Private Hospital, Adelaide, South Australia, 5042, Australia
Pas encore en recrutement
Advara HeartCare - Leabrook, Leabrook, South Australia, 5068, Australia
Pas encore en recrutement

Tasmania

Hobart Hospital-Royal Hobart Hospital, Hobart, Tasmania, 7000, Australia
Pas encore en recrutement

Victoria

Victorian Heart Hospital, Clayton, Victoria, 03168, Australia
Pas encore en recrutement
The Alfred Hospital, Melbourne, Victoria, 3004, Australia
Pas encore en recrutement

Western Australia

Joondalup Cardiovascular Trials Foundation Inc., Joondalup, Western Australia, 6027, Australia
Pas encore en recrutement
Fiona Stanley Hospital, Murdoch, Western Australia, 6150, Australia
Pas encore en recrutement

Estado de Bahia

Instituto D'Or de Pesquisa e Ensino - Hospital Cardio Pulmonar (HCP), Salvador, Estado de Bahia, 40170-130, Brazil
Pas encore en recrutement

Federal District

L2 IP - Instituto de Pesquisas Clinicas LTDA, Brasília, Federal District, 70200-730, Brazil
Pas encore en recrutement

Minas Gerais

Cardresearch Cardiologia Assistencial e de Pesquisa Ltda, Belo Horizonte, Minas Gerais, 30150-274, Brazil
Pas encore en recrutement
NUPEC Cardio, Belo Horizonte, Minas Gerais, 30220, Brazil
Pas encore en recrutement
Eurolatino Pesquisas Medicas Ltda - (Eurolatino Medical Research - EMR), Uberlândia, Minas Gerais, 38400-500, Brazil
Pas encore en recrutement

Paraná

Pontificia Universidade Catolica do Parana (PUCPR) - Centro de Ciencias Biologicas e da Saude (CCBS), Curitiba, Paraná, 80215-901, Brazil
Pas encore en recrutement

Recife - PE

Instituto D'Or de Pesquisa e Ensino - Recife, Recife - PE, Recife - PE, 50070-490, Brazil
Pas encore en recrutement

Rio Grande do Sul

Universidade de Caxias do sul, Caxias do Sul, Rio Grande do Sul, 95070560, Brazil
Pas encore en recrutement
Hospital Moinhos de Vento, Porto Alegre, Rio Grande do Sul, 90035-001, Brazil
Pas encore en recrutement

São Paulo

Universidade Estadual de Campinas - UNICAMP, Campinas, São Paulo, 13083-887, Brazil
Pas encore en recrutement
Synvia Laboratórios e Toxicologia Ltda - Synvia Clinical, Campinas, São Paulo, 13087-567, Brazil
Pas encore en recrutement
Centro Avancado de Pesquisa-Estudo para-Diagnostico-CAPED, Ribeirão Preto, São Paulo, 14026-020, Brazil
Pas encore en recrutement
Instituto de Cardiologia Dante Pazzanese, São Paulo, 04012-180, Brazil
Pas encore en recrutement
Pseg Centro De Pesquisa Clinica S.A, São Paulo, 04038-002, Brazil
Pas encore en recrutement
Universidade de Sao Paulo (USP) Hospital das Clinicas da Faculdade de Medicina (HCFMUSP), São Paulo, 05403-900, Brazil
Pas encore en recrutement

Anhui

Anhui Provincial Hospital, Hefei, Anhui, 230001, China
Pas encore en recrutement

Beijing Municipality

Peking University First Hospital, Beijing, Beijing Municipality, 100034, China
Pas encore en recrutement
FuWai Hospital, CAMS & PUMC, Beijing, Beijing Municipality, 100037, China
Pas encore en recrutement
Beijing University Third Hospital, Beijing, Beijing Municipality, 100191, China
Pas encore en recrutement
Beijing Hospital, Beijing, Beijing Municipality, 100730, China
Pas encore en recrutement
Peking Union Medical College Hospital, Beijing, Beijing Municipality, 100730, China
Pas encore en recrutement

Changchun

China-Japan Union Hospital, Changchun, Changchun, 130033, China
Pas encore en recrutement

Fujian

The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, 350005, China
Pas encore en recrutement

Guangdong

Southern Medical University, Guangzhou, Guangdong, 510000, China
Pas encore en recrutement
Guangdong Academy of Medical Science (GAMS) - Guangdong General Hospital (GGH) - Guangdong Neuroscience Institute, Guangzhou, Guangdong, 510080, China
Pas encore en recrutement

Guizhou

Affiliated Hospital of Guiyang Medical College, Guiyang, Guizhou, 550004, China
Pas encore en recrutement

Hebei

The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, China
Pas encore en recrutement

Heilongjiang

The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150001, China
Pas encore en recrutement

Henan

The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China
Pas encore en recrutement

Hubei

Huazhong University of Science and Technology - Tongji Medical College - Tongji Hospital, Wuhan, Hubei, 430030, China
Pas encore en recrutement
Wuhan University - Renmin Hospital (Hubei General Hospital), Wuhan, Hubei, 430060, China
Pas encore en recrutement

Hunan

Xiangya Hospital, Changsha, Hunan, 410008, China
Pas encore en recrutement
The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China
Pas encore en recrutement
The Third Xiangya Hospital of Central South University, Changsha, Hunan, 410013, China
Pas encore en recrutement

Jiangsu

Nanjing Medical University (NMU) - Jiangsu Province Hospital (First Affiliated Hospital), Nanjing, Jiangsu, 210029, China
Pas encore en recrutement

Liaoning

Shengjing University Of China Medical University, Liaoning, Liaoning, 110004, China
Pas encore en recrutement

Shandong

Qi-Lu Hospital of Shandong University School of Medicine, Jinan, Shandong, 250012, China
Pas encore en recrutement
Shandong University School of Medicine - Shandong Provincial Hospital (SPH), Jinan, Shandong, 250021, China
Pas encore en recrutement

Shanghai Municipality

Renji Hospital, Shanghai, Shanghai Municipality, 200127, China
Pas encore en recrutement
Shanghai Jiao Tong University (SJTU) - Shanghai Chest Hospital (SCH), Shanghaishi, Shanghai Municipality, 200025, China
Pas encore en recrutement

Shanxi

Shanxi Medical University - First Hospital, Taiyuan, Shanxi, 30001, China
Pas encore en recrutement

Tianjin Municipality

Tianjin Medical University General Hospital, Tianjin, Tianjin Municipality, 300052, China
Pas encore en recrutement
TEDA Hospital, Tianjin, Tianjin Municipality, 300457, China
Pas encore en recrutement

Zhejiang

The First Affiliated Hospital, School of Medicine, ZheJiang University, Hangzhou, Zhejiang, 310003, China
Pas encore en recrutement
The First Affiliated Hospital Of Chongqing Medical University, Chongqing, 400000, China
Pas encore en recrutement
The Second Affiliated Hospital Of Nanchang University, Nanchang, 330000, China
Pas encore en recrutement

Královéhradecký kraj

Edumed s.r.o., Broumov, Královéhradecký kraj, 55001, Czechia
Pas encore en recrutement
St. Anne''s University Hospital / International Clinical research Centre, Brno, 65691, Czechia
Pas encore en recrutement
Fakultni nemocnice Olomouc, Olomouc, 779 00, Czechia
Pas encore en recrutement
Fakultni Nemocnice Ostrava, Ostrava-Poruba, 708 52, Czechia
Pas encore en recrutement
Interni klinika kardiologie a angiologie 1. Lekarske fakulty a Vseobecne fakultni nemocnice v Praze, Prague, 12808, Czechia
Pas encore en recrutement
IKEM, Kardiologicka klinika, Prague, 140 21, Czechia
Pas encore en recrutement
Kardiologie-MUDr. Antonin Dufka, Uherské Hradiště, 686 01, Czechia
Pas encore en recrutement

Capital Region

Hjertecentret (The Heart Center)-Copenhagen University Hospital/Rigshosptalet, Copenhagen, Capital Region, 2100, Denmark
Pas encore en recrutement

Central Jutland

Aarhus Universitetshospital Skejby, Aarhus, Central Jutland, 8200, Denmark
Pas encore en recrutement
Odense Universitetshospital, Odense C, 5000, Denmark
Pas encore en recrutement
Universitätsklinik Der Ruhr-Universität Bochum, Bad Oeynhausen, 32545, Germany
Pas encore en recrutement
Charite - Universitaetsmedizin Berlin, Berlin, 10117, Germany
Pas encore en recrutement
Klinikum Bielefeld Mitte, Bielefeld, 33604, Germany
Pas encore en recrutement
Universitaetsklinikum Koeln, Cologne, 50937, Germany
Pas encore en recrutement
Universitatsklinikum Carl Gustav Carus, Dresden, 01307, Germany
Pas encore en recrutement
University Heart Center Freiburg, Freiburg im Breisgau, 79106, Germany
Pas encore en recrutement
Universitatsklinikum Heidelberg, Heidelberg, 69120, Germany
Pas encore en recrutement
Universitaetsklinikum Jena, Jena, 07747, Germany
Pas encore en recrutement
Universitaetsklinikum Schleswig-Holstein, Kiel, 24105, Germany
Pas encore en recrutement
University of Munich (LMU)-Grosshadern Hospital, Munich, 81377, Germany
Pas encore en recrutement
Deutsches Herzzentrum Muenchen, München, 80636, Germany
Pas encore en recrutement
Universitaetsklinikum Muenster, Münster, 48149, Germany
Pas encore en recrutement
University of Wurzburg, Comprehensive Heart Failure Center (CHFC), Würzburg, 97078, Germany
Pas encore en recrutement
Policlinico S.Orsola Malpighi, Universita di Bologna, Bologna, 40138, Italy
Pas encore en recrutement
Azienda Sanitaria del Sudtirol-Ospedale di Bolzano, Bolzano, 39100, Italy
Pas encore en recrutement
Azienda Ospedaliera Spedali Civili di Brescia-Universita degli Studi Di Brescia, Brescia, 25123, Italy
Pas encore en recrutement
Azienda Ospedaliero Universitaria Policlinico Gaspare Rodolico - San Marco, Catania, 95123, Italy
Pas encore en recrutement
Azienda Ospedaliera Universitaria Di Ferrara, Cona, 44124, Italy
Pas encore en recrutement
Universita Degli Studi Di Firenze - Azienda Ospedaliero-Universitaria Careggi (AOUC), Florence, 50134, Italy
Pas encore en recrutement
Ospedale di Ivrea, Ivrea, 10015, Italy
Pas encore en recrutement
Azienda Ospedaliera Universitaria Gaetano Martino Messina, Messina, 98125, Italy
Pas encore en recrutement
Fondazione Irccs Ca' Granda Ospedale Maggioe Policlinico Di Milano, Milan, 20122, Italy
Pas encore en recrutement
Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Ospedale San Raffaele (HSR) (Istituto Scientifico Universitario San Raffaele), Milan, 20132, Italy
Pas encore en recrutement
Centro Cardiologico Monzino IRCCS, Milan, 20138, Italy
Pas encore en recrutement
Azienda Ospedaliera San Paolo - Universita Degli Studi Di Milano, Milan, 20142, Italy
Pas encore en recrutement
Istituto Auxologico Italiano, IRCCS, Milan, 20145, Italy
Pas encore en recrutement
Instituto Pio Albergo Trivulzio, Milan, 20146, Italy
Pas encore en recrutement
ASST Grande Ospedale Metropolitano Niguarda, Milan, 20162, Italy
Pas encore en recrutement
Azienda Ospedaliera dei Colli - Ospedale Monaldi, Napoli, 80131, Italy
Pas encore en recrutement
Divisione di Cardiologia con Utic ed Emodinamica, Napoli, 80131, Italy
Pas encore en recrutement
Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone, Palermo, 90127, Italy
Pas encore en recrutement
Amyloidosis Research & Treatment Center, Fondazione Irccs Policlinico San Matteo, Pavia, 27100, Italy
Pas encore en recrutement
Universita degli Studi di Perugia, Perugia, 06121, Italy
Pas encore en recrutement
Fondazione Toscana Gabriele Monasterio Per La Ricerca Medica E Di Sanita Pubblica (Ftgm), Pisa, 56126, Italy
Pas encore en recrutement
Istituto Patologia Speciale Medica Universita Cattolica del Sacro Cuore - Policlinico Universitario Agostino Gemelli, Rome, 00168, Italy
Pas encore en recrutement
Ospedale Sant'Andrea Hospital, Rome, 00189, Italy
Pas encore en recrutement
Polo Cardiologico - Ospedale Cattinara (ASUGI), Trieste, 34149, Italy
Pas encore en recrutement

Aichi-ken

Nagoya University Hospital, Nagoya, Aichi-ken, 466-8560, Japan
Pas encore en recrutement

Ehime

Uwajima City Hospital, Uwajima-shi, Ehime, 798-8510, Japan
Pas encore en recrutement

Fukuoka

Saiseikai Fukuoka General Hospital, Fukuoka, Fukuoka, 810-0001, Japan
Pas encore en recrutement
Hospital of University of Occupational and Environmental Health, Kitakyushu, Fukuoka, 807-8555, Japan
Pas encore en recrutement
Kurume University - Research Center for Innovative Cancer Therapy, Kurume-shi, Fukuoka, 830-0011, Japan
Pas encore en recrutement

Hokkaid

Sapporo Medical University Hospital, Sapporo, Hokkaid, 060-8543, Japan
Pas encore en recrutement

Hyōgo

Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Hyōgo, 660-8550, Japan
Pas encore en recrutement
Hyogo Prefectural Harima-Himeji General Medical Center, Himeji, Hyōgo, 670-0836, Japan
Pas encore en recrutement
Kobe University Hospital, Kobe, Hyōgo, 6500017, Japan
Pas encore en recrutement

Kanagawa

Showa University Fujigaoka Hospital, Yokohama, Kanagawa, 227-8501, Japan
Pas encore en recrutement

Kochi

Kochi Medical School Hospital, Nankoku-shi, Kochi, 783-8505, Japan
Pas encore en recrutement

Kumamoto

Kumamoto University Hospital, Kumamoto, Kumamoto, 860-8556, Japan
Pas encore en recrutement

Mie-ken

Mie University Hospital, Tsu, Mie-ken, 514-8507, Japan
Pas encore en recrutement

Nagano

Shinshu University Hospital, Shinshu University Graduate School Of Medicine, Matsumoto, Nagano, 390-8621, Japan
Pas encore en recrutement

Nagasaki

Nagasaki University Hospital, Nagasaki, Nagasaki, 852-8501, Japan
Pas encore en recrutement

Nara

Nara Medical University Hospital, Kashihara, Nara, 634-8522, Japan
Pas encore en recrutement

Osaka

Osaka Metropolitan University Hospital, Osaka, Osaka, 545-8586, Japan
Pas encore en recrutement
National Cerebral and Cardiovascular Center, Suita, Osaka, 564-8565, Japan
Pas encore en recrutement

Tokyo

Nippon Medical School Hospital, Bunkyo-ku, Tokyo, 113-8603, Japan
Pas encore en recrutement

Yamaguchi

Yamaguchi University Hospital, Yamaguchi Prefecture, Yamaguchi, 755-8505, Japan
Pas encore en recrutement
Kitasato University - Kitasato University Hospital (KUH), Kanagawa, 2520375, Japan
Pas encore en recrutement
Social Welfare Organization Imperial Gift Foundation, Inc. Saiseikai Kumamoto Hospital, Kumamoto, 861-4193, Japan
Pas encore en recrutement
University Hospital Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan
Pas encore en recrutement
Keio University Hospital, Tokyo, 160-8582, Japan
Pas encore en recrutement
Toyama Prefectural Central Hospital, Toyama, 930-0975, Japan
Pas encore en recrutement

South Holland

Erasmus Medisch Centrum 1, Rotterdam, South Holland, 3015 GD, Netherlands
Pas encore en recrutement
University Medical Center Groningen, Groningen, 9713 GZ, Netherlands
Pas encore en recrutement
Maastricht University Medical Center (MUMC), Maastricht, 6229 HX, Netherlands
Pas encore en recrutement
Universitair Medisch Centrum Utrecht (UMC Utrecht), Utrecht, 3584 CX, Netherlands
Pas encore en recrutement

Gyeonggi-do

Seoul National University Bundang Hospital (SNUBH), Seongnam-si, Gyeonggi-do, 13620, South Korea
Pas encore en recrutement
Inje University Haeundae Paik Hospital, Busan, 48108, South Korea
Pas encore en recrutement
Inha University Hospital, Incheon, 22332, South Korea
Pas encore en recrutement
Seoul National University Hospital, Seoul, 03080, South Korea
Pas encore en recrutement
Severance Hospital, Yonsei University Health System, Seoul, 03722, South Korea
Pas encore en recrutement
Samsung Medical Center, Seoul, 06351, South Korea
Pas encore en recrutement
The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, 06591, South Korea
Pas encore en recrutement
Complejo Hospitalario Universitario A Coruna, A Coruña, 15006, Spain
Pas encore en recrutement
Hospital Universitari Germans Trias i Pujol (HUGTP), Badalona, 08916, Spain
Pas encore en recrutement
Hospital de la Santa Creu i Sant Pau, Barcelona, 08025, Spain
Pas encore en recrutement
Hospital Universitario Vall d'Hebron, Barcelona, 08035, Spain
Pas encore en recrutement
Hospital Clinic de Barcelona (Hospital Clinic i Provincial), Barcelona, 08036, Spain
Pas encore en recrutement
Hospital Universitario de Basurto, Bilbao, 48013, Spain
Pas encore en recrutement
Hospital Universitario Reina Sofia, Córdoba, 14004, Spain
Pas encore en recrutement
Hospital Universitario de Bellvitge, L'Hospitalet de Llobregat, 08907, Spain
Pas encore en recrutement
Hospital Universitario Doctor Negrin, Las Palmas de Gran Canaria, 35010, Spain
Pas encore en recrutement
Hospital Universitario Ramon y Cajal, Madrid, 28034, Spain
Pas encore en recrutement
Hospital Universitario La Paz, Madrid, 28046, Spain
Pas encore en recrutement
Hospital Universitario Puerta de Hierro de Majadahonda, Majadahonda, 28222, Spain
Pas encore en recrutement
Hospital Universitario Virgen de la Victoria, Málaga, 29010, Spain
Pas encore en recrutement
Hospital Son Llatzer (HSLL), Palma de Mallorca, 07198, Spain
Pas encore en recrutement
Hospital Clinico Universitario De Santiago De Compostela, Santiago de Compostela, 15706, Spain
Pas encore en recrutement
Universidad de Sevilla - Hospital Universitario Virgen Macarena, Seville, 41009, Spain
Pas encore en recrutement
Hospital Universitario Virgen del Rocio, Seville, 41013, Spain
Pas encore en recrutement
Servicio Andaluz de Salud (SAS) - Hospital San Juan de la Cruz, Úbeda, 23400, Spain
Pas encore en recrutement
Fundacion Investigacion Clinico de Valencia (FIHCUV) - Instituto de Investigacion Sanitaria (INCLIVA), Valencia, 46010, Spain
Pas encore en recrutement
Universitat de Valencia - Hospital Universitari i Politecnic La Fe de Valencia (Hospital La Fe Bulevar Sur), Valencia, 46026, Spain
Pas encore en recrutement
Hospital Clinico Universitario Lozano Blesa de Zaragoza, Zaragoza, 50009, Spain
Pas encore en recrutement

Greater London

The Royal Free Hospital - Royal Free London NHS Foundation Trust, London, Greater London, NW3 2QG, United Kingdom
Pas encore en recrutement

Greater Manchester

Synexus Manchester Clinical Research Centre, Manchester, Greater Manchester, M15 6SE, United Kingdom
Pas encore en recrutement

Lanarkshire

Synexus Scotland Clinical Research Centre, Bellshill, Lanarkshire, ML4 3NJ, United Kingdom
Pas encore en recrutement

Northumberland

Synexus North East Clinical Research Centre, Hexham, Northumberland, NE46 1QJ, United Kingdom
Pas encore en recrutement

West Midlands

Synexus Midlands Clinical Research Centre, Birmingham, West Midlands, B15 2SQ, United Kingdom
Pas encore en recrutement
Velocity Clinical Research, Bristol, Bristol, BS8 2RA, United Kingdom
Pas encore en recrutement
Synexus Wales Clinical Research Centre, Cardiff, CF15 9SS, United Kingdom
Pas encore en recrutement
Synexus Merseyside Clinical Research Centre, Liverpool, L22 0LG, United Kingdom
Pas encore en recrutement
Richmond Pharmacology - MHRA Phase 1 Unit, London, SE1 1YR, United Kingdom
Pas encore en recrutement