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Eli LillyA Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract (FORAGER-2)
Les détails de l'essai clinique sont principalement disponibles en anglais. Cependant, l'IA Trial Radar peut vous aider ! Cliquez simplement sur 'Expliquer l'essai' pour voir et discuter des informations sur l'essai dans la langue sélectionnée.
L'essai clinique NCT07218380 (FORAGER-2) est conçu pour étudier le treatment de Carcinome à cellules transitionnelles, Néoplasmes de la vessie, Métastase Néoplasique. Il s'agit d'un essai interventionnel en Phase III. Son statut actuel est : pas encore en recrutement. Le recrutement est prévu pour commencer le 1 novembre 2025, avec un objectif de 450 participants. Dirigé par Eli Lilly, l'essai devrait être terminé d'ici le 1 mai 2033. Les données du site ClinicalTrials.gov ont été mises à jour pour la dernière fois le 24 novembre 2025.
Résumé succinct
The purpose of this study is to test a new medicine, vepugratinib, in comparison with placebo, to see if it is safe and can help people with a bladder cancer that is advanced or has spread.
Vepugratinib or placebo will be administered in combination with enfortumab vedotin and pembrolizumab.
Study participation could last up to approximately 6 years.
Titre officiel
FORAGER-2: A Phase 3, Randomized, Double-blind, Placebo-controlled Study Evaluating the Efficacy and Safety of Vepugratinib Combined With Enfortumab Vedotin and Pembrolizumab in Adults With Untreated Locally Advanced or Metastatic Urothelial Carcinoma With an FGFR3 Genetic Alteration
Conditions
Carcinome à cellules transitionnellesNéoplasmes de la vessieMétastase NéoplasiqueAutres identifiants de l'essai
- FORAGER-2
- 27333
- J4G-MC-JZVD (Autre Identifiant) (Eli Lilly and Company)
- 2025-522855-25-00 (Numéro CTIS (UE))
Numéro NCT
Date de début (réel)
2025-11
Dernière mise à jour publiée
2025-11-24
Date de fin (estimée)
2033-05
Inscription (estimée)
450
Type d'essai
Interventionnel
PHASE
Phase III
Statut
Pas encore en recrutement
Mots clés
FGFR3
Advanced Urothelial Carcinoma
Metastatic Urothelial Carcinoma
Advanced Urothelial Carcinoma
Metastatic Urothelial Carcinoma
Objectif principal
Traitement
Plan d'attribution
Randomisé
Modèle d'intervention
Parallèle
Masquage
Double aveugle
Bras / Interventions
| Groupe de participants/Bras | Intervention/Traitement |
|---|---|
ExpérimentalVepugratinib + EV + Pembrolizumab (Safety Lead In) Vepugratinib administered orally with EV + pembrolizumab administered IV | Vepugratinib Administered orally EV Administered by IV infusion Pembrolizumab Administered by IV infusion |
ExpérimentalVepugratinib + Enfortumab Vedotin (EV) + Pembrolizumab Vepugratinib administered orally, and EV + pembrolizumab administered by intravenous (IV) infusion. | Vepugratinib Administered orally EV Administered by IV infusion Pembrolizumab Administered by IV infusion |
Comparateur placeboPlacebo + EV + Pembrolizumab Placebo administered orally, and EV + pembrolizumab administered by IV infusion. | PLACEBO Administered orally EV Administered by IV infusion Pembrolizumab Administered by IV infusion |
Critère principal d'évaluation
Critère secondaire d'évaluation
| Critères d'évaluation | Description de critères | Période |
|---|---|---|
Number of participants with treatment-related adverse events related to vepugratinib in combination with EV and pembrolizumab | From baseline up to 90 months | |
Safety Lead-in: Overall Response Rate (ORR) | ORR by Investigator Assessment. | From baseline up to 90 months |
Progression-free Survival (PFS) | PFS by blinded independent committee review (BICR). | Baseline to Study Completion (estimated as 6 years) |
| Critères d'évaluation | Description de critères | Période |
|---|---|---|
Safety Lead-in: Disease Control Rate (DCR) | DCR by investigator assessment. | From baseline up to the end of Cycle 2 (each Cycle is 21 days) |
Safety Lead-in: Time to Response (TTR) | TTR by investigator assessment. | From baseline up to 90 months |
Overall Survival (OS) | Baseline to Study Completion (estimated as 6 years) | |
Objective Response Rate (ORR) by BICR | Baseline to Study Completion (estimated as 6 years) | |
Duration of Response (DoR) | DOR by BICR. | Baseline to Study Completion (estimated as 6 years) |
Progression-free Survival (PFS) | PFS by investigator assessment. | Baseline to Study Completion (estimated as 6 years) |
Objective Response Rate (ORR) | Percentage of Participants who Achieve a Best Overall Response (BOR) of Complete Response (CR) or Partial Response (PR)ORR by investigator assessment | Baseline to Study Completion (estimated as 6 years) |
Duration of Response (DOR) | DOR by investigator assessment. | Baseline to Study Completion (estimated as 6 years) |
Progression-free Survival 2 (PFS2) | PFS2 by investigator assessment. | Baseline to Study Completion (estimated as 6 years) |
Plasma Concentrations of Vepugratinib | PK samples are to be drawn every odd cycle while participant on study. | Cycle 1 Day 1 to Study completion (estimated as 90 months) |
Change from Baseline in Global Health Status/Quality of Life (QOL) and Physical Function Measured by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30) | The EORTC QLQ-C30 is a validated self-reported general cancer questionnaire consisting of 30 items with a recall of the past 7 days. Response options range from 1) "very poor" to 7) "excellent." Higher scores represent better overall HRQoL. | Baseline to Study Completion (estimated as 6 years) |
Critères d'éligibilité
Âges éligibles
Adulte, Adulte âgé
Âge minimum
18 Years
Sexes éligibles
Tous
- Have histologically confirmed, unresectable locally advanced or metastatic urothelial cancer (mUC). Individuals with mixed histology other than small cell or neuroendocrine carcinoma are eligible if a urothelial component is present.
- Have a qualifying fibroblast growth factor receptor 3 (FGFR3) genetic alteration determined via molecular testing from a tumor or blood sample obtained at or any time after diagnosis of advanced or metastatic urothelial cancer.
- Have measurable disease by investigator assessment defined by Response Evaluation Criteria in Solid Tumors (RECIST) v1.1
- Have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2.
- Have adequate laboratory parameters
- Have received prior systemic therapy for locally advanced or metastatic urothelial cancer (mUC).
- Have any unresolved toxicities greater than Grade 1 Common Terminology Criteria for Adverse Events ([CTCAE] version 5.0) from prior neoadjuvant or adjuvant systemic therapy.
- Have ongoing sensory or motor neuropathy of Grade 2 or higher
- Have untreated or uncontrolled central nervous system (CNS) involvement or any history of leptomeningeal disease.
- Current evidence corneal keratopathy or retinal disorder confirmed by ocular examination at screening.
Contact central de l'essai
Contact: Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or, 1-317-615-4559, [email protected]
Contact: Physicians interested in becoming principal investigators please contact, [email protected]
268 Centres de l'essai dans 19 pays
Institut de Cancérologie de l'Ouest, Angers, 49055, France
Contact, 33241352700
Sophie Abadie-Lacourtoisie, Investigateur principal
CHU de Bordeaux Hop St ANDRE, Bordeaux, 33075, France
Contact, +33556794708
Marine Gross-Goupil, Investigateur principal
Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest, Bordeaux, 33076, France
Diego Teyssonneau, Investigateur principal
CHRU de Brest, Brest, 29609, France
Benjamin Auberger, Investigateur principal
Centre François Baclesse, Caen, 14076, France
Florence Joly-Lobbedez, Investigateur principal
Centre Oscar Lambret, Lille, 59020, France
Contact, 0033 (0)320009757
Yaovi AMELA, Investigateur principal
Centre Leon Berard, Lyon Cedex08, 69373, France
Contact, 33478782643
Aude Flechon, Investigateur principal
Institut Paoli-Calmettes, Marseille, 13273, France
Gwenaelle Gravis, Investigateur principal
Centre Hospitalier Universitaire de Nîmes - Institut de Cancérologie du Gard - Hôpital Universitaire Carém -T, Nîmes, 30029, France
Leticia Aptecar, Investigateur principal
Centre Hospitalier Lyon Sud, Pierre-Bénite, 69310, France
Contact, 33478864324
Denis Maillet, Investigateur principal
Oncopole Claudius Regaud, Toulouse, 31059, France
Damien POUESSEL, Investigateur principal
Gustave Roussy, Villejuif, 94800, France
Contact, 33142115276
Yohann Loriot, Investigateur principal
Hamilton Health Sciences-Juravinski Cancer Centre, Hamilton, L8V5C2, Canada
Arani Sathiyapalan, Investigateur principal
Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus, Québec, G1J 1Z4, Canada
Antoine Morin Coulombe, Investigateur principal
BC Cancer Vancouver, Vancouver, V5Z 4E6, Canada
Bernhard Eigl, Investigateur principal
Alabama
Clearview Cancer Institute, Huntsville, Alabama, 35805, United States
Contact, 256-705-4224
Marshall Schreeder, Investigateur principal
Arizona
The University of Arizona Cancer Center - North Campus, Tucson, Arizona, 85719, United States
Contact, 520-626-4703
Alejandro Recio Boiles, Investigateur principal
California
TRIO-US (Translational Research in Oncology-US), Los Angeles, California, 90024, United States
Brenda Williams, Investigateur principal
UCLA Hematology/Oncology - Santa Monica, Los Angeles, California, 90404, United States
Alexandra Drakaki, Investigateur principal
UCSF Medical Center at Mission Bay, San Francisco, California, 94158, United States
Contact, 773-837-0783
Vadim Koshkin, Investigateur principal
Hunt Cancer Institute, an Affiliate of Cedars-Sinai Cancer (TMPN), Torrance, California, 90505, United States
Contact, 310-750-3300
Hugo Hool, Investigateur principal
Colorado
AdventHealth Medical Group - Porter, Denver, Colorado, 80210, United States
Contact, 303-715-7030
Yousuf Gaffar, Investigateur principal
Colorado West Healthcare System - Grand Valley Oncology, Grand Junction, Colorado, 81505, United States
Contact, 970-644-4460
Jonathan King, Investigateur principal
Florida
AdventHealth Celebration, Celebration, Florida, 34747, United States
Contact, 407-303-2024
Guru Sonpavde, Investigateur principal
Idaho
St. Luke's Cancer Institute: Boise, Boise, Idaho, 83712, United States
Peyman Haghighat, Investigateur principal
Illinois
University of Illinois at Chicago, Chicago, Illinois, 60612, United States
Karine Tawagi, Investigateur principal
Indiana
Parkview Research Center at Parkview Regional Medical Center, Fort Wayne, Indiana, 46845, United States
Kushal Naha, Investigateur principal
Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, Indiana, 46202, United States
Tareq Salous, Investigateur principal
Franciscan Health, Indianapolis, Indiana, 46237, United States
Patrick Heckman, Investigateur principal
Kentucky
University of Kentucky Chandler Medical Center, Lexington, Kentucky, 40536, United States
Zin Myint, Investigateur principal
Louisiana
Mary Bird Perkins Cancer Center, Baton Rouge, Louisiana, 70809, United States
Contact, 225-215-1185
Victor Lin, Investigateur principal
Maryland
Johns Hopkins Hospital, Baltimore, Maryland, 21287, United States
Jean Hoffman-Censits, Investigateur principal
Massachusetts
Massachusetts General Hospital, Boston, Massachusetts, 02114, United States
Contact, 617-724-4000
Xin Gao, Investigateur principal
Michigan
Karmanos Cancer Institute, Detroit, Michigan, 48201, United States
Yusra Shao, Investigateur principal
Missouri
Washington University, St Louis, Missouri, 63108, United States
Melissa Reimers, Investigateur principal
Nevada
Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada, 89148, United States
Ammar Yousif, Investigateur principal
New York
Icahn School of Medicine at Mount Sinai, New York, New York, 10029, United States
Matthew Galsky, Investigateur principal
Columbia University Irving Medical Center, New York, New York, 10032, United States
Alexander Wei, Investigateur principal
Memorial Sloan Kettering Cancer Center, New York, New York, 10065, United States
Contact, 646-888-4737
Gopakumar Iyer, Investigateur principal
Weill Cornell Medical College, New York, New York, 10065, United States
Contact, 317-217-9178
Rohit Jain, Investigateur principal
Ohio
The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive Cancer -T, Columbus, Ohio, 43210, United States
Peng Wang, Investigateur principal
Oregon
Providence Portland Medical Center, Portland, Oregon, 97213, United States
Brendan Curti, Investigateur principal
Providence St. Vincent Medical Center, Portland, Oregon, 97225, United States
Brendan Curti, Investigateur principal
Kaiser Permanente Interstate Medical Office Central, Portland, Oregon, 97227, United States
Contact, 503-249-3315
Sandeep Mashru, Investigateur principal
Oregon Health and Science University, Portland, Oregon, 97239, United States
Ronald Ng, Investigateur principal
Pennsylvania
Lancaster General Hospital - Ann B Barshinger Cancer Institute, Lancaster, Pennsylvania, 17601, United States
Matthew Brennan, Investigateur principal
AHN Allegheny General Hospital, Pittsburgh, Pennsylvania, 15212, United States
Contact, 412-325-5700
Shifeng Mao, Investigateur principal
South Dakota
Avera Cancer Institute- Research, Sioux Falls, South Dakota, 57105, United States
Ryan Vaca, Investigateur principal
Tennessee
Tennessee Oncology Chattanooga, Chattanooga, Tennessee, 37404, United States
Kathryn Beckermann, Investigateur principal
Sarah Cannon Research Institute, Nashville, Tennessee, 37203, United States
SMO Sarah Cannon Research Inst., Investigateur principal
SCRI Oncology Partners, Nashville, Tennessee, 37203, United States
Benjamin Garmezy, Investigateur principal
Tennessee Oncology, Nashville, Tennessee, 37203, United States
Kathryn Beckermann, Investigateur principal
Vanderbilt University Medical Center, Nashville, Tennessee, 37232, United States
Alan Tan, Investigateur principal
Texas
USO-Texas Oncology-Central/South Texas, Austin, Texas, 78731, United States
Michael Lattanzi, Investigateur principal
World Research Link, Baytown, Texas, 77521, United States
Contact, 833-832-8328
Amir Rasheed, Investigateur principal
Parkland Health and Hospital System, Dallas, Texas, 75235, United States
Contact, 214-648-4180
Tian Zhang, Investigateur principal
UT Southwestern Medical Center, Dallas, Texas, 75390, United States
Contact, 214-648-4180
Tian Zhang, Investigateur principal
University of Texas MD Anderson Cancer Center, Houston, Texas, 77030-4009, United States
Arlene Siefker-Radtke, Investigateur principal
Nova Oncology, McAllen, Texas, 78504, United States
Contact, 281-944-3610
Raghad Muhsin Abdul Karim, MD, Investigateur principal
US Oncology Research Network, The Woodlands, Texas, 77380, United States
SMO Sarah Cannon Research Inst., Investigateur principal
USO - Texas Oncology - Northeast Texas, Tyler, Texas, 75702, United States
Donald Richards, Investigateur principal
Virginia
USO - Virginia Oncology Associates, Norfolk, Virginia, 23502, United States
Mark Fleming, Investigateur principal
Box Hill Hospital, Box Hill, 3128, Australia
Iris Tung, Investigateur principal
Mater Misericordiae Limited, Brisbane, 4101, Australia
Niara Oliveira, Investigateur principal
Austin Health, Heidelberg, 3084, Australia
Contact, +61420381848
Andrew Weickhardt, Investigateur principal
Macquarie University, Macquarie University, 2109, Australia
Contact, 0402856430
Alison Zhang, Investigateur principal
Sir Charles Gairdner Hospital, Perth, 6009, Australia
Rajiv Shinde, Investigateur principal
Prince of Wales Hospital, Randwick, 2031, Australia
Elizabeth Hovey, Investigateur principal
Fundação Pio XII - Hospital de Câncer de Barretos, Barretos, 14784400, Brazil
Contact, 551733216637
Hadson Araujo, Investigateur principal
CPAM - Centro de Pesquisas da Amazônia, Belém, 66063-495, Brazil
Contact, 5591999809897
Bruno Fernandes, Investigateur principal
Oncocentro de Minas Gerais, Belo Horizonte, 30180-060, Brazil
Flavio Cárcano, Investigateur principal
Hospital Mario Penna, Belo Horizonte, 30380-472, Brazil
Graziella Martins, Investigateur principal
Hospital Tacchini, Bento Gonçalves, 95700-084, Brazil
ANDRE REIRIZ, Investigateur principal
Centro Integrado de Oncologia de Curitiba, Curitiba, 80810050, Brazil
Contact, 554130242421
Karina Vianna, Investigateur principal
IOP Pesquisa, Curitiba, 82305-100, Brazil
Ronald Kool, Investigateur principal
Centro Paraibano De Oncologia - Oncoclínicas, João Pessoa, 58030-080, Brazil
Juliana Fagundes, Investigateur principal
Hospital de Cancer de Londrina, Londrina, 86015-520, Brazil
Contact, +55 43 3379-2771
Mariana Kiara, Investigateur principal
Liga Norte Riograndense Contra o Câncer, Natal, 59062-000, Brazil
Contact, +5584991425228
Andrea Gomes, Investigateur principal
Centro Gaucho Integrado De Oncologia, Hematologia, Ensino E Pesquisa, Porto Alegre, 90110-270, Brazil
Contact, 5133072943
Alan Azambuja, Investigateur principal
Hospital São Lucas da PUCRS, Porto Alegre, 90610-000, Brazil
Vinicius Goncalves, Investigateur principal
Hospital Nossa Senhora da Conceição, Porto Alegre, 91350-200, Brazil
Contact, +55 51 35160954
Gustavo Alves, Investigateur principal
Instituto Nacional de Câncer José Alencar Gomes da Silva - INCA, Rio de Janeiro, 20231-050, Brazil
pedro domingues, Investigateur principal
Instituto D'Or Pesquisa e Ensino, Rio de Janeiro, 22271-110, Brazil
Daniel Herchenhorn, Investigateur principal
Nucleo de Oncologia da Bahia, Salvador, 40170-110, Brazil
Contact, 557140097085
Andre Lima, Investigateur principal
Clinica Amo - Rio Vermelho, Salvador, 41950-640, Brazil
Contact, 557130218735
Augusto Mota, Investigateur principal
Instituto de Oncologia Saint Gallen, Santa Cruz do Sul, 96830-180, Brazil
Contact, 5551991898942
Bianca Correa Tabajara Weiss, Investigateur principal
Centro de Oncologia - CEON+ - Unidade São Caetano do Sul, São Caetano do Sul, 09541-270, Brazil
Suelen Martins, Investigateur principal
Instituto do Cancer Arnaldo Vieira de Carvalho, São Paulo, 01209-000, Brazil
Contact, +5511956598420
Patricia Marubayashi, Investigateur principal
Icesp - Instituto Do Câncer Do Estado de São Paulo, São Paulo, 01246-000, Brazil
Contact, 55 11 3893-2709
Jose Mauricio Mota, Investigateur principal
Hospital BP, São Paulo, 01321-001, Brazil
Fabio Schutz, Investigateur principal
Hospital Alemao Oswaldo Cruz, São Paulo, 01327-001, Brazil
Contact, 1135490665
Ariel Kann, Investigateur principal
Centro Paulista de Oncologia Clínica, São Paulo, 01452-000, Brazil
Contact, (17) 981090074
Denis Leonardo Fontes Jardim, Investigateur principal
IBCC - Núcleo de Pesquisa e Ensino, São Paulo, 04014-002, Brazil
Contact, 551144500360
Felipe José Cruz, Investigateur principal
Peking University First Hospital, Beijing, 100034, China
Contact, 010-64008229
Zhisong He, Investigateur principal
Peking University Third Hospital, Beijing, 100091, China
Shudong Zhang, Investigateur principal
Beijing Cancer hospital, Beijing, 100142, China
Jun Guo, Investigateur principal
Beijing GoBroad Hospital, Beijing, 102200, China
Chuanliang Cui, Investigateur principal
The First Hospital of Jilin University, Changchun, 100012, China
Ziling Liu, Investigateur principal
Xiangya Hospital Central South University, Changsha, 410008, China
Contact, 0731-84327918
minfeng chen, Investigateur principal
Hunan Cancer Hospital, Changsha, 410013, China
Shusuan JIANG, Investigateur principal
West China Hospital, Sichuan University, Chengdu, 610066, China
Peng Zhang, Investigateur principal
The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China
Contact, 023-89012012
Weiyang He, Investigateur principal
Chongqing University Cancer Hospital, Chongqing, 400030, China
Fang Yuan, Investigateur principal
The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China
Contact, 13719007083
Yongda Liu, Investigateur principal
Zhujiang Hospital, Guangzhou, 510280, China
Manming Cao, Investigateur principal
Sun Yat-Sen University Cancer Centre, Guangzhou, 511400, China
Contact, 020-87343864
Yanxia Shi, Investigateur principal
Zhejiang Provincial People's Hospital, Hangzhou, 310014, China
Contact, 15158885167
xiaolong Qi, Investigateur principal
Sir Run Run Shaw Hospital, Hangzhou, 310016, China
Da Li, Investigateur principal
Zhejiang Cancer Hospital, Hangzhou, 310022, China
Jinchao Chen, Investigateur principal
Harbin Medical University Cancer Hospital, Harbin, 150081, China
Contact, 0451-86298104
Hui Chen, Investigateur principal
Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210000, China
Hongqian Guo, Investigateur principal
Guangxi Medical University Affiliated Tumor Hospital, Nanning, 530200, China
Contact, 15877183968
Yong Tang, Investigateur principal
Ningbo First Hospital, Ningbo, 315010, China
Contact, 15958800971
Qi Ma, Investigateur principal
Renji Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, 200000, China
Contact, 862168383543
Wei Xue, Investigateur principal
Huashan Hospital, Fudan University, Shanghai, 200040, China
Haowen Jiang, Investigateur principal
Shanghai Tenth People's Hospital, Shanghai, 200072, China
Contact, 021-66301719
Xudong Yao, Investigateur principal
The Second Hospital of Tianjin Medical University, Tianjin, 300211, China
Hailong Hu, Investigateur principal
Tongji Hospital Tongji Medical,Science & Technology, Wuhan, 430030, China
Contact, 027-83363434
Shaogang Wang, Investigateur principal
Masarykuv onkologicky ustav, Brno, 656 53, Czechia
Contact, 420 543 132 216
Alexandr Poprach, Investigateur principal
Fakultni nemocnice Hradec Kralove, Hradec Králové, 500 05, Czechia
Contact, 420495832176
Jindrich Kopecky, Investigateur principal
Fakultni nemocnice Olomouc, Olomouc, 779 00, Czechia
Contact, +420 588 444 717
Hana Studentova, Investigateur principal
Fakultni nemocnice Kralovske Vinohrady, Prague, 10034, Czechia
Contact, 420267162837
Jan Dvorak, Investigateur principal
Fakultni Thomayerova nemocnice, Prague, 14059, Czechia
Contact, 420 728177828
Michaela Matouskova, Investigateur principal
Fakultni nemocnice Motol, Prague, 150 06, Czechia
Contact, 420734236410
Tomas Buchler, Investigateur principal
Aalborg Universitetshospital, Syd, Aalborg, 9000, Denmark
Contact, 004597661410
Andreas Carus, Investigateur principal
Aarhus Universitetshospital, Skejby, Aarhus, 8200, Denmark
Mads Agerbaek, Investigateur principal
Rigshospitalet, Copenhagen, 2100, Denmark
Contact, 4535458403
Helle Pappot, Investigateur principal
Herlev and Gentofte Hospital, Copenhagen, 2730, Denmark
Contact, 4538681079
Line Dohn, Investigateur principal
Næstved Sygehus, Næstved, 4700, Denmark
Dorthe Yakymenko, Investigateur principal
Helios Klinikum Bad Saarow, Bad Saarow, 15526, Germany
Contact, 0049 33631 73466
Tobias Klatte, Investigateur principal
Charité Universitaetsmedizin Berlin - Campus Mitte, Berlin, 10117, Germany
Contact, 004930450615137
Maria De Santis, Investigateur principal
Evangelisches Krankenhaus Bielefeld - Johannesstift, Bielefeld, 33611, Germany
Contact, 052177275750
Florian Weissinger, Investigateur principal
Johanniter-Krankenhaus, Bonn, 53113, Germany
Contact, 00492285432168
Carsten Ohlmann, Investigateur principal
Studienzentrum Bayenthal Urologische Partnerschaft Köln, Cologne, 50968, Germany
Contact, 0049221362025
Jorg Klier, Investigateur principal
Universitaetsklinikum Carl Gustav Carus, Technischen Universitaet Dresden, Dresden, 01307, Germany
Contact, 00493514584425
Severine Banek, Investigateur principal
Urologicum Duisburg Fachärztesozietät - Walsum, Duisburg, 47179, Germany
Contact, +49 203 5003040
Eva Hellmis, Investigateur principal
Universitaetsklinikum Duesseldorf, Düsseldorf, 40225, Germany
Contact, 492118119353
Guenter Niegisch, Investigateur principal
Universitaetsklinikum Erlangen, Erlangen, 91054, Germany
Contact, +49 (0)9131 8223122
Peter Goebell, Investigateur principal
Universitaetsklinikum Essen, Essen, 45122, Germany
Contact, +492017232637
Viktor Gruenwald, Investigateur principal
Krankenhaus Nordwest GmbH, Frankfurt, 60488, Germany
Contact, 496976013917
Inga Peters, Investigateur principal
Universitaetsklinikum Freiburg, Freiburg im Breisgau, 79106, Germany
Markus Grabbert, Investigateur principal
Universitätsmedizin Greifswald, Greifswald, 17489, Germany
Contact, 00493834865985
Cindy Roennau, Investigateur principal
Universitaetsklinikum Hamburg-Eppendorf, Hamburg, 20246, Germany
Contact, 040-7410-57673
Gunhild Von Amsberg, Investigateur principal
NCT, Heidelberg, 69120, Germany
Stefanie Zschaebitz, Investigateur principal
InVO Institut für Versorgungsforschung in der Onkologie, Koblenz, 56068, Germany
Contact, +49261921569325
Christoph Lutz, Investigateur principal
Universitätsklinikum Schleswig-Holstein, Lübeck, 23538, Germany
Contact, 045150043691
Axel Merseburger, Investigateur principal
Klinikum Rechts Der Isar Der Technischen Universität München, Munich, 81675, Germany
Contact, 498941402522
Margitta Retz, Investigateur principal
Universitätsklinikum Münster - Albert Schweitzer Campus, Münster, 48149, Germany
Martin Boegemann, Investigateur principal
Klinikum Nürnberg Nord, Nuremberg, 90419, Germany
Contact, + 49 911 398 3085
Marinela Augustin, Investigateur principal
Studienpraxis Urologie, Nürtingen, 72622, Germany
Contact, 4915201622246
Tilman Todenhöfer, Investigateur principal
Universitätsmedizin Rostock, Rostock, 18057, Germany
Contact, +49 381 494 7801
Angelika Borkowetz, Investigateur principal
Universitaetsklinikum Tuebingen, Tübingen, 72076, Germany
Eva Erne, Investigateur principal
Universitaetsklinikum Ulm, Ulm, 89081, Germany
Contact, 4973150058036
Friedemann Zengerling, Investigateur principal
Universitaetsklinikum Wuerzburg, Würzburg, 97080, Germany
Anna Seitz, Investigateur principal
Semmelweis Egyetem, Budapest, 1082, Hungary
Peter Nyirady, Investigateur principal
Országos Onkológiai Intézet, Budapest, 1122, Hungary
Contact, 3612248600
Lajos Geczi, Investigateur principal
Debreceni Egyetem Klinikai Kozpont, Debrecen, 4032, Hungary
Contact, 3652255840
Peter Arkosy, Investigateur principal
Szabolcs Szatmár Bereg Vármegyei Oktatókórház, Nyíregyháza, 4400, Hungary
Contact, 003642599700 EXT 2334
Ágnes Wéber, Investigateur principal
Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ, Szeged, 6725, Hungary
Aniko Maraz, Investigateur principal
Instituto Tumori Giovanni Paolo II, Bari, 70124, Italy
Contact, +39 0805555391
Marica Gentile, Investigateur principal
Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, 20133, Italy
Contact, 0390223903028
Giuseppe Procopio, Investigateur principal
Ospedale San Raffaele, Milan, 20132, Italy
Contact, +390226435789
Andrea Necchi, Investigateur principal
Azienda Ospedaliera Universitaria Federico II, Napoli, 80131, Italy
Contact, +393404166268
Luigi Formisano, Investigateur principal
Istituto Oncologico Veneto IRCCS, Padua, 35128, Italy
Contact, +390423732137
Marco Maruzzo, Investigateur principal
Azienda Ospedaliera Universitaria Pisana, Pisa, 56126, Italy
Luca Galli, Investigateur principal
Fondazione Policlinico Universitario Agostino Gemelli, Roma, 00168, Italy
Contact, 390630154838
Roberto Iacovelli, Investigateur principal
Istituto Nazionale Tumori Regina Elena, Rome, 00144, Italy
Fabio Calabro, Investigateur principal
National Cancer Center Hospital, Chūōku, 104-0045, Japan
Contact, 81120023812
Tatsunori Shimoi, Investigateur principal
Kyushu University Hospital, Fukuoka, 812-8582, Japan
Contact, 81120023812
Takashi Matsumoto, Investigateur principal
Hirosaki University Hospital, Hirosaki, 036-8563, Japan
Contact, 81120023812
Shingo Hatakeyama, Investigateur principal
Kanazawa University Hospital, Kanazawa, 920-8641, Japan
Contact, 81120023812
Kouji Izumi, Investigateur principal
National Cancer Center Hospital East, Kashiwa, 277-8577, Japan
Contact, 81120023812
Nobuaki Matsubara, Investigateur principal
St. Marianna University Hospital, Kawasaki, 216-8511, Japan
Contact, 81120023812
Eiji Kikuchi, Investigateur principal
Kagawa University Hospital, Kita-ku, 761-0701, Japan
Contact, 81120023812
Rikiya Taoka, Investigateur principal
Kobe City Medical Center General Hospital, Kobe, 650-0047, Japan
Contact, 81120023812
Toshinari Yamasaki, Investigateur principal
The Cancer Institute Hospital of JFCR, Kōtoku, 135-8550, Japan
Contact, 81120023812
Yuji Miura, Investigateur principal
Kyoto University Hospital, Kyoto, 606-8507, Japan
Contact, 81120023812
Akihiro Hamada, Investigateur principal
National Hospital Organization Shikoku Cancer Center, Matsuyama, 791-0280, Japan
Contact, 81120023812
Katsuyoshi Hashine, Investigateur principal
Aichi Cancer Center Hospital, Nagoya, 464-8681, Japan
Contact, 81120023812
Hiromichi Ebi, Investigateur principal
Niigata University Medical & Dental Hospital, Niigata, 951-8520, Japan
Contact, 81120023812
Tsutomu Anraku, Investigateur principal
Osaka International Cancer Institute, Osaka, 541-8567, Japan
Contact, 81120023812
Masashi Nakayama, Investigateur principal
Gunma Prefectural Cancer Center, Otashi, 373-8550, Japan
Contact, 81120023812
Masaru Hasumi, Investigateur principal
Hokkaido University Hospital, Sapporo, 060-8648, Japan
Contact, 81120023812
Haruka Miyata, Investigateur principal
Tohoku University Hospital, Sendai, 980-8574, Japan
Contact, 81120023812
Takuma Sato, Investigateur principal
Iwate Medical University Hospital, Shiwa-gun Yahaba-cho, 028-3695, Japan
Contact, 81120023812
Wataru Obara, Investigateur principal
Tokushima University Hospital, Tokushima, 770-8503, Japan
Contact, 81120023812
junya furukawa, Investigateur principal
Tsukuba University Hospital, Tsukuba, 305-8576, Japan
Contact, 81120023812
Yoshiyuki Nagumo, Investigateur principal
Amsterdam UMC, locatie VUmc, Amsterdam, 1081 HV, Netherlands
Contact, +31(0)20-4444321
Jens Voortman, Investigateur principal
Amphia Ziekenhuis, locatie Breda Molengracht, Breda, 4818 CK, Netherlands
Contact, +31 76 595 5146
Hans Westgeest, Investigateur principal
Radboudumc, Nijmegen, 6525 GA, Netherlands
Contact, +31 (0)24 3610353
Mira Franken, Investigateur principal
Erasmus Medisch Centrum, Rotterdam, 3015 GD, Netherlands
Contact, +31618842777
Debbie Robbrecht, Investigateur principal
IN VIVO, Bydgoszcz, 85-048, Poland
Contact, 48888455614
Anna Krause, Investigateur principal
Szpital Wojewódzki im. Mikoaja Kopernika w Koszalinie, Koszalin, 75-581, Poland
Contact, 48502204953
Mariusz Kwiatkowski, Investigateur principal
Pratia MCM Krakow, Krakow, 30-727, Poland
Contact, 48 505 169 040
Anna Drosik Kwasniewska, Investigateur principal
AIDPORT Sp. z o.o., Skórzewo, 60-185, Poland
Piotr Tomczak, Investigateur principal
GYNCENTRUM Szpital, Sosnowiec, 41-208, Poland
Sylwia Szablowska-Siwik, Investigateur principal
Luxmed Onkologia sp. z o. o., Warsaw, 01-748, Poland
Pawel Morawski, Investigateur principal
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie, Warsaw, 02-781, Poland
Contact, 48225462433
Pawel Wiechno, Investigateur principal
WSD MEDI, Warsaw, 02-786, Poland
Anna Wasko Grabowska, Investigateur principal
Medical Concierge Centrum Medyczne, Warsaw, 02-798, Poland
Contact, 602300992
Piotr Radziszewski, Investigateur principal
Szpital Grochowski im. dr med. Rafała Masztaka SPZOZ, Warsaw, 04-073, Poland
Contact, 48 22 5152 591
Iwona Skoneczna, Investigateur principal
Wojskowy Instytut Medyczny Państwowy Instytut Badawczy, Warsaw, 04-141, Poland
Szymon Borowiec, Investigateur principal
Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wrocławiu, Wrocaw, 50-556, Poland
Anna Kolodziej, Investigateur principal
National Cancer Center, Goyang-si, 10408, South Korea
Ho Kyung Seo, Investigateur principal
Chungnam national university hospital, Junggu, 35015, South Korea
Hyo Jin Lee, Investigateur principal
Gachon University Gil Medical Center, Namdong-gu, 21565, South Korea
Joo-Hwan Park, Investigateur principal
Seoul National University Bundang Hospital, Seongnam, 13620, South Korea
Contact, 820317877842
Eun Hee Jung, Investigateur principal
Seoul National University Hospital, Seoul, 03080, South Korea
Jeonghwan Youk, Investigateur principal
Severance Hospital, Yonsei University Health System, Seoul, 03722, South Korea
Contact, 82222288138
Sang Joon Shin, Investigateur principal
Asan Medical Center, Seoul, 05505, South Korea
Contact, 82-2-3010-3266
Inkeun Park, Investigateur principal
Samsung Medical Center, Seoul, 06351, South Korea
Contact, 82-2-3410-3459
Se Hoon Park, Investigateur principal
The Catholic Univ. of Korea Seoul St. Mary's Hospital, Seoul, 06591, South Korea
Contact, 82-10-9056-6116
In-Ho Kim, Investigateur principal
Ewha Womans University Mokdong Hospital, Seoul, 07985, South Korea
Jungmin Jo, Investigateur principal
Hospital Infanta Cristina, Badajoz, 06006, Spain
Contact, 924218040
Marta Gonzalez Cordero, Investigateur principal
Institut Català d'Oncologia (ICO) - Badalona, Badalona, 08916, Spain
Contact, 34 934978925
Albert Font Pous, Investigateur principal
OSI Ezkerraldea-Enkarterri-Cruces - Hospital Universitario Cruces, Barakaldo, 48903, Spain
Ricardo Fernández Rodríguez, Investigateur principal
Hospital Universitari Vall d'Hebron, Barcelona, 08035, Spain
Contact, 932746000 x 4350
Rafael Morales Barrera, Investigateur principal
Hospital Clínic de Barcelona, Barcelona, 08036, Spain
Contact, 34 932275402
Oscar Reig Torras, Investigateur principal
Hospital de la Santa Creu i Sant Pau, Barcelona, 08041, Spain
Contact, 34935565638
Jose Pablo Maroto Rey, Investigateur principal
Hospital Universitario Reina Sofia, Córdoba, 14004, Spain
MARIA JOSE MENDEZ VIDAL, Investigateur principal
Hospital General Universitario de Elche, Elche, 03202, Spain
Federico Jose Vazquez Mazon, Investigateur principal
Institut Català d'Oncologia (ICO) - Girona, Girona, 17007, Spain
Contact, 34972225834
Nuria Sala Gonzalez, Investigateur principal
Instituto Catalan de Oncologia - Hospital Duran i Reynals, Hospitalet, 08907, Spain
Contact, +34 932603261
Irene Ortiz Rubio, Investigateur principal
Hospital Insular de Gran Canaria, Las Palmas de Gran Canaria, 35016, Spain
Alfonso Gómez de Liaño Lista, Investigateur principal
Hospital La Princesa, Madrid, 28006, Spain
Contact, +34915202200
Patricia Toquero Diez, Investigateur principal
Hospital General Universitario Gregorio Marañon, Madrid, 28009, Spain
Contact, 34914265238
Jose Arranz Arija, Investigateur principal
MD Anderson Cancer Center, Madrid, 28033, Spain
Lucrecia Ruiz, Investigateur principal
Hospital Universitario Ramón y Cajal, Madrid, 28034, Spain
Contact, (+34) 913368263
Pablo Gajate Borau, Investigateur principal
Hospital Clinico San Carlos, Madrid, 28040, Spain
Contact, 913307545
Javier Puente Vazquez, Investigateur principal
Hospital Universitario 12 de Octubre, Madrid, 28041, Spain
Contact, 0034 91 390 83 39
Daniel Castellano Gauna, Investigateur principal
Hospital Universitario La Paz, Madrid, 28046, Spain
Contact, 917277516
Alvaro Pinto Marin, Investigateur principal
H.R.U Málaga - Hospital General, Málaga, 29011, Spain
Contact, 951308130
Alvaro Montesa Pino, Investigateur principal
Complejo Hospitalario de Navarra, Pamplona, 31009, Spain
Contact, 8.00 - 15.00
Nuria Lainez Milagro, Investigateur principal
Hospital Universitario Quironsalud Madrid, Pozuelo de Alarcón, 28223, Spain
Contact, +34914521987
ELENA ALMAGRO CASADO, Investigateur principal
Hospital Universitari Sant Joan de Reus, Reus, 43204, Spain
Marc Grifoll Escoda, Investigateur principal
Hospital Universitario Marqués de Valdecilla, Santander, 39008, Spain
Contact, 607552230
Ignacio Duran Martinez, Investigateur principal
CHUS - Hospital Clinico Universitario, Santiago de Compostela, 15706, Spain
Contact, 34981950512
Urbano Anido Herranz, Investigateur principal
Hospital Universitario Virgen Del Rocio, Seville, 41013, Spain
Contact, 34955013068
Begona Perez Valderrama, Investigateur principal
Hospital Arnau de Vilanova, Valencia, 46015, Spain
Contact, 679370073
Jose Garcia Sanchez, Investigateur principal
Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City, 807, Taiwan
Wen-Jeng Wu, Investigateur principal
Chang Gung Memorial Hospital at Kaohsiung, Kaohsiung Niao Sung Dist, 83301, Taiwan
Contact, 886-972919696
Yu-Li Su, Investigateur principal
China Medical University Hospital, Taichung, 404332, Taiwan
Contact, +886422052121
Chao-Hsiang Chang, Investigateur principal
Taichung Veterans General Hospital, Taichung, 407, Taiwan
Jian-Ri Li, Investigateur principal
National Cheng Kung University Hospital, Tainan, 704, Taiwan
Contact, 0980971870
Wen-Pin Su, Investigateur principal
Chi Mei Medical Center, Tainan, 71004, Taiwan
Nai-Wen Kang, Investigateur principal
Chi Mei Hospital - Liouying Branch, Tainan, 73657, Taiwan
Yen-Hsun Chen, Investigateur principal
National Taiwan University Hospital, Taipei, 10002, Taiwan
Yu-Chieh Tsai, Investigateur principal
National Taiwan University Cancer Center (NTUCC), Taipei, 106, Taiwan
Ying-Chun Shen, Investigateur principal
Taipei Veterans General Hospital, Taipei, 11217, Taiwan
Contact, 886228757519-323
Yi-Hsiu Huang, Investigateur principal
Chang Gung Medical Foundation-Linkou Branch, Taoyuan District, 333, Taiwan
Contact, 886-3-3281200
See-Tong Pang, Investigateur principal
Adana Medical Park Seyhan Hastanesi, Adana, 01140, Turkey (Türkiye)
Contact, 905325005269
Ali Besen, Investigateur principal
Sakarya University School of Medicine, Adapazarı, 54100, Turkey (Türkiye)
Contact, +90 5054785576
Ilhan Hacibekiroglu, Investigateur principal
Ankara University Health Practice and Research Hospitals, Ankara, 06100, Turkey (Türkiye)
Contact, 00903125957321
Yuksel Urun, Investigateur principal
Ankara Bilkent Şehir Hastanesi, Ankara, 06800, Turkey (Türkiye)
Contact, 905555306271
Mehmet Ali Nahit Sendur, Investigateur principal
Antalya Egitim ve Arastırma Hastanesi, Antalya, 07100, Turkey (Türkiye)
Contact, 905336488217
Derya KIVRAK SALIM, Investigateur principal
Memorial Diyarbakır Hastanesi, Diyarbakır, 21070, Turkey (Türkiye)
Contact, 90 5337677131
Muhammet kaplan, Investigateur principal
Trakya University, Edirne, 22030, Turkey (Türkiye)
Contact, 90 5334364678
Muhammet Hacioglu, Investigateur principal
Gaziantep Universitesi Sahinbey Arastirma ve Uygulama Hastanesi, Gaziantep, 27310, Turkey (Türkiye)
Contact, 05065118207
tulay kus, Investigateur principal
Dr. Lutfi Kirdar Kartal Training and Research Hospital, Istanbul, 34890, Turkey (Türkiye)
Mahmut Gumus, Investigateur principal
Marmara Universitesi Pendik Egitim Arastirma Hastanesi, Istanbul, 34899, Turkey (Türkiye)
Contact, 905433389339
Murat Sari, Investigateur principal
zmir Katip Çelebi Üniversitesi Atatürk Eitim Ve Aratrma Hastanesi, Izmir, 35360, Turkey (Türkiye)
Contact, 905324078648
Ahmet Alacacioglu, Investigateur principal
Huddersfield Royal Infirmary, Huddersfield, HD3 3EA, United Kingdom
Ursula Hofmann, Investigateur principal
St Bartholomew's Hospital, London, EC1A 7BE, United Kingdom
Contact, 02078828494
Thomas Powles, Investigateur principal
University College London Hospital, London, NW1 2PG, United Kingdom
Ursula McGovern, Investigateur principal
Royal Marsden Hospital (Sutton), London, SM2 5PT, United Kingdom
Contact, +44 (0) 2086613529
Robert Huddart, Investigateur principal
Royal Marsden Hospital (Chelsea), London, SW3 6JJ, United Kingdom
Contact, +44 (0) 2086613529
Robert Huddart, Investigateur principal
The Christie NHS Foundation Trust, Manchester, M20 4BX, United Kingdom
Contact, 01614468409
Yee Pei Song, Investigateur principal
Weston Park Hospital, Sheffield, S10 2SJ, United Kingdom
Syed Hussain, Investigateur principal