בטא
רדאר קליני AI
הניסוי הקליני NCT06901869 (ActivPARK) עבור מחלת פרקינסון, חוסר פעילות גופנית הוא מגייס. לכל הפרטים, עיינו בתצוגת הכרטיסים של רדאר ניסויים קליניים ובכלי הגילוי של AI. אפשר גם לשאול כל דבר כאן.
ניסוי אחד תואם לקריטריוני המסנן
תצוגת כרטיסים

Physical Activity in Persons With Parkinson's Disease (ActivPARK)

מגייס
פרטי הניסויים הקליניים זמינים בעיקר באנגלית. רדאר קליני AI יכול לעזור! לחץ על 'קבל הסבר' כדי לצפות ולשוחח על מידע מהניסוי בשפה המועדפת עליך.
הניסוי הקליני NCT06901869 (ActivPARK) הוא מחקר מסוג תצפיתי עבור מחלת פרקינסון, חוסר פעילות גופנית, שנמצא כעת במצב מגייס. המחקר התחיל ב-25 במרץ 2025 ומתוכנן לכלול 50 משתתפים. המחקר מנוהל על ידי מכון קרולינסקה וצפוי להסתיים ב-1 בדצמבר 2026. מידע זה עודכן לאחרונה באתר ClinicalTrials.gov ב-4 באפריל 2025.
סיכום קצר
Parkinson's disease (PD) is a leading neurodegenerative health condition in Sweden and a public health concern. Although no cure exists, functional independence and participation in society remain top priorities, and can be achieved through targeted physical activity (PA) interventions. To date, few longitudinal cohort studies have been conducted, using PA as main outcome in therapy research, partly due to the complex nature of predicting and controlling this phenomenon. To help address this knowledge gap, the overall purpose of the future long-term (ActivPARK) study is to enhance knowledge of the evolution of PA behavior, and how it is influenced beyond the disease characteristics using a broad explanatory model, in persons with PD from a diversity of settings in Sweden with the aim of prescribing tailored and personalized interventions to enhance functioning, health, and wellbeing throughout the disease progression and recommend potential health care pathway modifications.

The investigators have just established an expert group, comprising researchers, healthcare professionals, and PD organisations (including persons with PD) and reached consensus on essential priority clinical therapy research questions on PA and methodological considerations. The next phase entails performing a multicentre feasibility/pilot study, further developing and refining the assessment battery and research questions linked to the improved explanatory model for PA and methodology, to inform the definite larger clinical cohort study.

כותרת רשמית

ActivPARK - Physical Activity in Persons With Parkinson's Disease- Pilot Study

מצבים רפואיים
מחלת פרקינסוןחוסר פעילות גופנית
מזהי מחקר נוספים
  • ActivPARK
  • 2024-07526-01
  • 2024-06332 (מספר מענק/מימון אחר) (Swedish Research Council)
מספר NCT
תחילת המחקר (בפועל)
2025-03-25
עדכון אחרון שפורסם
2025-04-04
סיום המחקר (מוערך)
2026-12
השתתפות (מוערכת)
50
סוג המחקר
תצפיתי
סטטוס
מגייס
זרועות / התערבויות
קבוצת משתתפים/זרועהתערבות/טיפול
People with Parkinson's disease
No intervention
לא זמין
תוצאה ראשית
מדד תוצאהתיאור המדידהטווח זמן
Feasibility of the assessment battery - length of the clinical examination and questionnaires
The pilot/feasibility study aims to evaluate feasibility of the assessment battery measured the time it takes to complete the examination and questionnaires.
Baseline
Feasibility of the assessment battery - perception of the clinical examination
Feasibility of the assessment battery will also be evaluated through semi-structured questions regarding fatique, concentration, pain/discomfort to the participants after the clinical examination.
Baseline
Feasibility of the assessment battery -Compliance to questionnaires sent via REDCap
Compliance will be measured with percentages of completed questionnaires in REDCap.
Baselline
Feasibility of the assessment battery - Suitability of the primary outcome
Suitability of the accelerometers in the home environment as the primary outcome for the targeted patient group will be assessed by the percentage of participants that are able to wear the accelerometer for at least 4 days days and render valid data.
Baseline
Physical activity levels
The ActiGraph accelerometer (GT3X+, ActiGraph, Pensacola, FL, US) will be used to measure absolute and relative time spent in sedentary behavior, low intensity physical activity (LIPA) and moderate to vigorous intensity physical activity (MVPA), by total time in bouts.
Baseline
תוצאה משנית
מדד תוצאהתיאור המדידהטווח זמן
Physical activity - self rated
Frändin Grimby scale, ranging from 1 to 6, higher score=better.
Baseline
Disease severity, Parkinson symptoms
Movement Disorders Society- Unified Parkinson's Disease Rating Scale (MDS- UPDRS) parts 1 to 4. Higher scores = worse/more symptoms
Baseline
Gait
Gait speed in m/s measured with the 10 meter walking test or through gait analysis.
Baseline
Balance performance
Assessed with the Mini-BESTest. Mini-Balance Evaluation Systems Test a rating scale for dynamic balance incorporating 14 different balance and gait items that were assessed by a physical therapist on a scale from 0-2. Maximum points 28. 0-28 points with higher scores indicating better balance control
Baseline
Anxiety and depression
Assessed with Hospital Anxiety and Depression Scale (HADS), 0-24 on the depression and anxiety part respectively. Lower score=better
Baseline
Cognitive performance
Assessed with the Montreal Cognitive Assessment (MoCA), 0-25, higher score = better
Baseline and 3 year follow-up
Self assessed cognitive function
Assessed with Executive function questionnaire (DEX), 20 items scored 1 to 4, max 80, more scores= worse.
Baseline
Non-Motor Symptoms
Non-Motor Symptoms Questionnaire (NMSQ), 30 questions with yes/no answer. More yes answers = more non-motor symptoms
Baseline
Walking ability- self assessed
WALK-12G questionnaire, 0 and 42 points, with higher scores reflecting greater perceived walking difficulties (higher=worse)
Baseline
Freezing of gait - self-assessed
Freezing of gait questionnaire (FOGQsa), 6 questions/items, scored 1 to 5 (higher=worse)
Baseline
Balance confidence
Activities specific balance confidence (ABC scale), 16 items which is scored 1 to 10 and then divided by 16. 0-100%, higher % = better
Baseline
Motivation
Behavioural Regulation in Exercise Questionnaire (BREQ 4), 28 items score 1 to 7 and divided into subcomponents: Amotivation, External regulation, Introjected avoidance, Introjected approach, Identified regulation, Integrated regulation, Intrinsic regulation
Baseline
Fatigue
Parkinson's Fatigue Scale (PFS-16), 16 items scored 1 to 5 from strongly disagree to strongly agree . more points/score= worse.
Baseline
Disability
World health organization (WHO) disability assessment schedule (Whodas 2.0), 12 self-assessed questions (12 to 60) more points=worse
Baseline
Self-efficacy
Self-efficacy of exercise/PA (ESES), 10 questions, scored 1-4. higher=better
Baseline
Sleep
Scales for Outcomes in Parkinson's disease - Sleep (SCOPA-SLEEP), 4 parts, A-2 questions, B-5 questions , C-1 question and D- 6 questions. Higher= worse
Baseline
Self rated pain
Assessed with visual analog scale, VAS from 0 to 100
Baseline
Health related quality of life
Parkinson's Disease Questionnaire (PDQ39). The Parkinson's Disease Questionnaire (PDQ-39) assesses how often people with Parkinson's experience difficulties across 8 dimensions of daily living (mobility, activities of daily living, emotional well-being, stigma, social support, cognitions, communications and bodily discomfort). The sum score is as a percentage score ranging between 0 and 100. Higher is better
Baseline
Wellbeing
The WHO- Five Well-Being Index (WHO-5), 5 questions ranging from 0 to 5, 0-25, higher=better
Baseline
Nutrition
Mini Nutritional Assessment, max 14. higher = better
Baseline
קריטריוני זכאות

גילאים מוערכים למחקר
ילד, מבוגר, מבוגר יותר
מגדרים מוערכים למחקר
הכל
  • Diagnosed with Parkinson's disease
  • Mild to severe disease severity ( Hoehn & Yahr 1-4).

  • None
המשתתף האחראי למחקר
Erika Franzén, חוקר ראשי, Professor, Karolinska Institutet
איש קשר מרכזי למחקר
צור קשר: Compliance Office Karolinska Insitutet, +46852480000, [email protected]
צור קשר: Erika Franzén, +46852488878, [email protected]
1 מיקומי המחקר ב-1 מדינות

Solna

Karolinska institutet, Stockholm, Solna, 17177, Sweden
Erika Franzén, PhD, צור קשר, +46852488878, [email protected]
Erika Franzén, PhD, חוקר ראשי
מגייס