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Lo studio clinico NCT06020482 (MMF) per Molecular Markers of Fibrosis of Single Types of Endometriosis and Their Use in Predicting Disease Severity è in arruolamento. Consulti la vista a schede del Radar degli Studi Clinici e gli strumenti di scoperta IA per tutti i dettagli. Oppure, ponga pure una domanda qui. | ||
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Molecular Markes of Fibrosis of Endometriosis and Their Use in Predicting Disease Severity (MMF) 120
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La sperimentazione clinica NCT06020482 (MMF) è uno studio osservazionale per Molecular Markers of Fibrosis of Single Types of Endometriosis and Their Use in Predicting Disease Severity, attualmente in arruolamento. Avviato il 1 aprile 2023, prevede di arruolare 120 partecipanti. Sotto la guida di General University Hospital, Prague, dovrebbe concludersi entro il 31 dicembre 2026. I dati più recenti da ClinicalTrials.gov sono stati aggiornati l'ultima volta il 31 agosto 2023.
Sommario breve
The primary aim of the project is to analyse gene expression in individual types of ectopic endometrium (ovarian endometriosis, peritoneal endometriosis, deep infiltrating endometriosis) and compare it with gene expression in eutopic endometrium. The analysis focuses on the identification of genes with significantly increased expression in each type of ectopic endometrium and comparison of their expression with the d...Mostra di più
Descrizione dettagliata
Endometriosis is defined as the presence of endometrial-like tissue outside the uterine cavity. It is a chronic benign estrogen-dependent disease affecting approximately 10% of women of reproductive age. It significantly affects the quality of life of affected women despite available treatment. The disease is most manifested by symptoms of pain (chronic pelvic pain, dysmenorrhea, dyspareunia, dyschesia) and sterility...Mostra di più
Titolo ufficiale
Molecular Markes of Fibrosis of Single Types of Endometriosis and Their Use in Predicting Disease Severity
Patologie
Molecular Markers of Fibrosis of Single Types of Endometriosis and Their Use in Predicting Disease SeverityAltri ID dello studio
- MMF
- GIP-23-L-03-223
Numero NCT
Data di inizio (effettiva)
2023-04-01
Ultimo aggiornamento pubblicato
2023-08-31
Data di completamento (stimata)
2026-12-31
Arruolamento (previsto)
120
Tipo di studio
Osservazionale
Stato
In arruolamento
Parole chiave
endometriosis, moleculars markers of fibrosis, deep infiltrating endometriosis
Bracci / Interventi
| Gruppo/Braccio di partecipanti | Intervento/Trattamento |
|---|---|
A-OE women with ovarian endometriosis (study group) | Molecular markes of fibrosis of single types of endometriosis and their use in predicting disease severity The aim of the study is to analyze molecular markers of fibrosis in female patients with endometriosis vs. without endometriosis. These features will be compared for their clinical status and progression of the disease before and after treatment. Identification and validation of these features appears to be a crucial step in predicting progression of the disease. Moreover, we would be able to modify follow-up and tre...Mostra di più |
A-PE women with peitoneal endometriosis (study group) | Molecular markes of fibrosis of single types of endometriosis and their use in predicting disease severity The aim of the study is to analyze molecular markers of fibrosis in female patients with endometriosis vs. without endometriosis. These features will be compared for their clinical status and progression of the disease before and after treatment. Identification and validation of these features appears to be a crucial step in predicting progression of the disease. Moreover, we would be able to modify follow-up and tre...Mostra di più |
A-DE women with deep infiltrating endometriosis (study group) | Molecular markes of fibrosis of single types of endometriosis and their use in predicting disease severity The aim of the study is to analyze molecular markers of fibrosis in female patients with endometriosis vs. without endometriosis. These features will be compared for their clinical status and progression of the disease before and after treatment. Identification and validation of these features appears to be a crucial step in predicting progression of the disease. Moreover, we would be able to modify follow-up and tre...Mostra di più |
B women without endometriosis | N.D. |
Esito primario
| Misure di esito | Descrizione della misura | Arco temporale |
|---|---|---|
Molecular markers of fibrosis of single types of endometriosis and their use in predicting disease severity | The aim of our study is to analyze molecular markers of fibrosis in eutopic and ectopic endometrium in women with endometriosis and compare them with endometrium of women without endometriosis. These markers will be correlated with the clinical state and course of disease before and after treatment. By this analysis we would like to find parameters that may correlate with the severity of the disease, risk of recurrence or postoperative complications. | The project is supposed to be lasting 3 years. |
Assistente alla partecipazione
Criteri di eleggibilità
Età idonea
Adulto
Età minima
18 Years
Sessi idonei
Femmina
- women (18-45 years)
- signed informed consent with the study
- absence of hormonal treatment 3 months before the planned procedure
Inclusion criteria for group A:
- laparoscopically and histologically confirmed endometriosis dg.
Inclusion criteria for group B:
- patients without endometriosis
- patients who are undergoing an elective laparoscopic or hysteroscopic procedure in our department for another benign indication
- patients with excluded malignant disease
- absence of informed consent
- patients who do not meet the inclusion criteria during surgery
- patient younger than 18 years of age or older than 45 years of age
General University Hospital, PragueParte responsabile dello studio
Zdenka Lisa, Investigatore principale, M.D., General University Hospital, Prague
Nessun dato di contatto
1 Centri dello studio in 1 paesi
General University Hospital in Prague, Prague, 12808, Czechia
Zdenka Lisa, M.D., Contatto, +420224967003, [email protected]
Michael Fanta, M.D., Contatto, 0042224967004, [email protected]
In arruolamento