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治験 NCT05926219（対象：老化、筋萎縮または筋力低下、Sarcopenia in Elderly、サルコペニア）は募集中です。詳細は治験レーダーのタイル表示と AI 発見ツールで確認するか、ここで質問してください。
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C-Protein in Fatigue and Aging

募集中
治験(臨床試験)の詳細は主に英語で提供されています。しかし、治験レーダーAIが支援できます！「治験を説明」をクリックして、選択した言語で試験情報を表示し、議論してください。
治験番号 NCT05926219 は 介入研究 臨床試験 で、老化、筋萎縮または筋力低下、Sarcopenia in Elderly、サルコペニア に関するものです。現在は 募集中 で、2017年11月6日 から開始しています。24 名の参加者 の募集が計画されています。この治験は オレゴン大学 によって主催され、2027年1月1日 に完了予定です。ClinicalTrials.gov からの最新更新日は 2025年5月7日 です。
概要
This study is investigating changes to the proteins in skeletal muscle that contribute to reduced muscle size and muscle function that occurs with aging.
詳細説明
Age-related muscle atrophy and contractile dysfunction have been well described at the cellular level, but the molecular mechanisms that contribute to this dysfunction are poorly understood. Improved understanding of these mechanisms is critically important for the improvement of physical rehabilitation in older adults at risk for mobility impairment and physical disability. Our studies will pursue pre-clinical evidence that post translational modification of specific proteins in skeletal muscle lead to an "aging phenotype" in skeletal muscle that may unlock new strategies for improving physical function in older adults with physical frailty.
公式タイトル

Skeletal Muscle Myosin Binding Protein C in Fatigue and Aging

疾患／病気
老化筋萎縮または筋力低下Sarcopenia in Elderlyサルコペニア
その他の研究識別子
NCT番号
NCT05926219
開始日
2017-11-06
最終更新日
2025-05-07
終了予定日
2027-01
目標参加者数
24
試験の種類
介入研究
治験の相・段階
該当なし
状況
募集中
キーワード
muscle
aging
elderly
myosin
protein
sarcomere
exercise
function
atrophy
contractile
strength
balance
mobility
MyBP-C
fiber
biopsy
skeletal muscle
fatigue
主目的
基礎研究
割付方法
該当なし
介入モデル
単一群割当
盲検化
なし（非盲検）
群（アーム）／介入
参加グループ/群介入/治療法
実験的Fatigue
Volunteers will perform one-legged knee extension exercise until fatigue while seated on an ergometer. Volunteers will then undergo bilateral skeletal muscle biopsies of the vastus lateralis muscle in their thigh.
Fatiguing Exercise
Volunteers will perform knee extension exercise of the dominant limb while seated in a chair designed for exercise of the knee extensor muscle group. The chair will be equipped with a lever arm, aligned with the axis of rotation of the knee and fixed to the distal shank, 2 centimeters proximal to the ankle joint. The lever arm will be instrumented to provide resistance and measure velocity. The volunteers will perform 3-5 maximum voluntary contractions (MVC) to determine peak torque. Once established, volunteers will rest for 5 minutes before initiating the fatigue protocol, whereby they will perform repeated MVC of the dominant limb against resistance equal to or less than 50% of MVC until range of motion cannot be maintained. Because the goal of this exercise is to uniformly fatigue the quadriceps muscle group, this exercise will be performed continuously. It is expected to take between 1 and 3 minutes to achieve the desired level of fatigue.
主要評価項目
評価指標指標の説明時間枠
Phosphorylation of myosin binding protein c (MyBP-C)
Muscle tissue is immediately frozen after biopsy. Liquid chromatography and high resolution mass spectrometry will be used to do a full analysis of the phosphorylation sites on MyBP-C isolated from the biopsied muscle tissue.
One week after the participant undergoes the biopsies.
副次評価項目
評価指標指標の説明時間枠
Muscle fiber Force
Ex vivo assessment of Force (mN) will be performed on muscle fibers and bundles isolated from fatigued and non-fatigued muscle biopsies.
Within three weeks of the intervention and biopsies.
Muscle fiber Tension
Ex vivo assessment of Tension (kPa) will be performed on muscle fibers and bundles isolated from fatigued and non-fatigued muscle biopsies.
Within three weeks of the intervention and biopsies.
Muscle fiber Velocity
Ex vivo assessment of Velocity (Lo/s) will be performed on muscle fibers and bundles isolated from fatigued and non-fatigued muscle biopsies.
Within three weeks of the intervention and biopsies.
Muscle fiber Power
Ex vivo assessment of Power (w/L) will be performed on muscle fibers and bundles isolated from fatigued and non-fatigued muscle biopsies.
Within three weeks of the intervention and biopsies.
適格基準

対象年齢
成人, 高齢者
試験の最低年齢
18 Years
対象性別
全て
健康なボランティアを受け入れる
はい
  • Adults between the ages 18-35 or 65-80 years
  • Healthy by self-report
  • Willing to participate in all aspects of the study design including muscle biopsy, unilateral exercise, and physical activity monitoring
  • Fluent in English (due to lack of translation services, it is not practical to conduct the study using a language other than English).

  • Orthopaedic limitation (severe knee osteoarthritis, prior joint replacement, etc.).
  • Volunteer has dementia or related mental issues that potentially put the subject at risk as determined by prior diagnosis.
  • Volunteer has known untreated endocrine disease (hypo/hyper thyroidism, Addison's Disease or Cushing's syndrome, etc.)
  • Volunteer has untreated/poorly-controlled hypertension (stage 2, per American College of Cardiology [>140/90 mmHg]).
  • Volunteer has significant heart, liver, kidney or respiratory disease.
  • Volunteer has diabetes (insulin dependent or non-insulin dependent).
  • Volunteer has known coagulopathies.
  • Volunteer has taken anabolic steroids in the prior six months.
  • Volunteer has received treatment for cancer (other than effective Mohs Surgery for successful removal of basal cell or squamous cell carcinomas)
  • Unexpected weight loss >5kg is last 12 months
  • Volunteer is an active smoker or quit within the last year.
  • Volunteer has known current alcohol or drug use disorder (AUD; defined as binge drinking of >4 days in the last month. Binge drinking is >5 drinks for men and >4 drinks for women, per occasion). Or, if a volunteer reports drinking in excess of "low risk" per NIAAA (>7 drinks/week for men and >3 drinks/day for women and >14 drinks/week and >4 drinks/day).
  • Volunteer has a diagnosed neuromuscular disorder.
  • Volunteer has allergy to lidocaine.
University of Oregon logoオレゴン大学111 件のアクティブな治験を探索
試験中央連絡先
連絡先: Damien M Callahan, Ph.D., 541-346-5040, [email protected]
連絡先: Karen Wiedenfeld Needham, BS, 541-346-7610, [email protected]
1 1カ国の場所

Oregon

University of Oregon, Eugene, Oregon, 97403, United States
Damien M Callahan, Ph.D., 連絡先, 458-205-5343, [email protected]
Damien M Callahan, Ph.D., 研究責任者
募集中