베타
임상 레이더 AI
임상시험 NCT07498686은(는) RT-QuIC에 대해 모집중 상태입니다. 모든 세부 정보를 보려면 임상시험 레이더 카드 뷰와 AI 발견 도구를 확인하거나 여기에서 무엇이든 물어보세요.
하나의 임상시험이 필터 기준과 일치합니다.
카드 뷰

Plasma a-Synuclein Aggregation Seeding Activity as a Novel Biomarker for Neurodegeneration Disease 458 바이오마커 기반 신규 요법

모집중
임상시험 세부 정보는 주로 영어로 제공됩니다. 하지만 임상 레이더 AI가 도와드릴 수 있습니다! '임상시험 설명'를 클릭하여 선택한 언어로 임상시험 정보를 확인하고, 이에 대해 AI와 논의해 보세요.
임상시험 NCT07498686은(는) RT-QuIC에 대해 알아보는 관찰연구입니다. 현재 상태는 모집중이며, 연구는 2023년 5월 1일에 시작되어 458명의 참여자를 모집하고 있습니다. Xuanwu Hospital, Beijing이(가) 진행하며, 2026년 12월 23일까지 완료될 예정입니다. ClinicalTrials.gov의 가장 최근 정보는 2026년 3월 27일에 갱신되었습니다.
간단한 개요
Synuclein disease, also known as Synucleinopathies, is a general term for a class of degenerative diseases. It mainly includes Parkinson's disease (PD), Dementia with lewy bodies (DLB), Multiple system atrophy (MSA) and so on. The disease is characterized by the abnormal folding of alpha-synuclein (α-syn) in the peripheral and central nervous system, resulting in the production of lewy bodies, lewy neurites, neurons,...더 보기
공식 제목

Plasma a-Synuclein Aggregation Seeding Activity as a Novel Biomarker for Neurodegeneration Disease

질환명
RT-QuIC
기타 연구 식별자
  • 115
NCT 번호
실제 연구 시작일
2023-05-01
최신 업데이트 게시
2026-03-27
예상 연구 완료일
2026-12-23
계획된 등록 인원
458
연구종류
관찰연구
상태
모집중
키워드
PD, MSA, PSP, Neurodegeneration disease, alpha-synuclein
시험군 / 개입
참가자 그룹/시험군개입/치료
Control
Control: healthy subjects,
해당 없음
PD
parkinson's disease patients
해당 없음
MSA
MSA: multiple system atrophy
해당 없음
PSP
progressive supranuclear palsy
해당 없음
주요결과변수
결과변수측정값 설명시간 범위
slope
slope of all Fluorescence value
From enrollment to the end of treatment at 21 weeks
MAX
Maximum fluorescence value
From enrollment to the end of treatment at 21 weeks
참여 도우미
적격성 기준

연령대
성인, 노인
최소 연령
18 Years
참여 가능한 성별
전체
건강한 참가자 허용

- Grouping criteria for PD patients: All PD patients who join the group need to meet the following conditions at the same time: The diagnosis of primary PD patients is based on the 2015 International Association for Movement Disorders (MDS) Parkinson's disease diagnosis standard, and all patients need to meet the clinical diagnosis or likely Parkinson's disease diagnosis criteria. Quasi; All patients come from the outpatient clinic of Xuanwu Hospital Affiliated to Capital Medical University, and the clinical evaluation and disease diagnosis are completed by a movement disorder specialist. This project is approved by the Ethics Committee of Xuanwu Hospital Affiliated to Capital Medical University. The subjects who participated in the study signed the informed consent form. Fully improve the information of PD patients and form an NSFC 2024 clinical information database. Establish an evaluation scale based on various indicators such as basic demographic data, general disease status and past history and exercise symptom evaluation, including Hoehn & Yahr staging, unified Parkinson's disease assessment scale (MDS- UPDRS), concise mental state examination (MMSE) examination, Monte Lear scale (MOCA), rapid eye movement sleep behavior disorder Hong Kong questionnaire (RBDQ-HK), Hamilton depression scale (HAMD) and anxiety scale (HAMA), integrating a number of sports and non-sports indicators, comprehensively considering and evaluating the patient's condition, for the follow-up relevant Sexual analysis provides accurate and complete clinical information.MSA patients need to meet the MSA clinical diagnosis criteria updated in 2008 by the Europe Multiple System Atrophy Study Group (EMSA-SG). For DLB patients, use the 2017 standard for diagnosis and grouping.

  • Patients with Parkinson's syndrome but not primary PD, patients with brain surgery/deep brain electrode stimulation, or patients diagnosed with dementia according to the Diagnostic and Statistical Manual of Mental Illness formulated by the American Association of Mental Illness. PD patients with mild cognitive dysfunction are not excluded.
Xuanwu Hospital, Beijing logoXuanwu Hospital, Beijing
연구 대표 연락처
연락처: Weiwei YANG, Ph.D., +86 010-83198271, [email protected]
2 1개국에 임상시험 장소

Beijing Municipality

Xuanwu Hospital, Beijing, Beijing Municipality, 100053, China
완료
Xuanwu Hospital, Beijing, Beijing Municipality, 100053, China
Weiwei YANG, 연락처, +86 010-83198271, [email protected]
모집중