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De klinische studie NCT04649242 voor Pediatric Migraine is rekruterend. Bekijk de kaartweergave van de Klinische Studies Radar en de AI-ontdekkingstools voor alle details. Of stel hier een vraag.
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Randomized Study in Children and Adolescents With Migraine: Acute Treatment Fase 3 2.100 Gerandomiseerd Adolescenten

Rekruterend
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De klinische studie NCT04649242 onderzoekt behandeling bij Pediatric Migraine. Deze Fase 3 interventioneel-studie heeft de status rekruterend. Het doel is om 2.100 deelnemers te includeren vanaf 15 januari 2021. De studie wordt geleid door Pfizer en de voltooiing is gepland op 9 januari 2029. Laatste update op ClinicalTrials.gov: 20 maart 2026.
Beknopte samenvatting
The purpose of this study is to test the safety and efficacy of BHV-3000 versus placebo in the acute treatment of moderate or severe migraine in children and adolescents.
Officiële titel

Phase 3, Multicenter, Randomized, Double-blind, Group Sequential, Placebo-controlled Study to Assess Efficacy and Safety of Rimegepant for the Treatment of Migraine (With or Without Aura) in Children and Adolescents ≥ 6 to < 18 Years of Age

Aandoeningen
Pediatric Migraine
Andere studie-ID's
  • BHV3000-311
  • C4951002 (Overige identificatiecode) (Alias Study Number)
  • 2020-003517-35 (Register-ID) (CTIS (EU))
  • 2024-512743-23-00 (Register-ID) (CTIS (EU))
NCT-ID
NCT04649242
Startdatum (Werkelijk)
2021-01-15
Laatste update geplaatst
2026-03-20
Verwachte einddatum
2029-01-09
Inschrijving (Geschat)
2.100
Studietype
Interventioneel
FASE
Fase 3
Status
Rekruterend
Trefwoorden
Migraine
Acute treatment
Phonophobia
Photophobia
Nausea
Pediatric
Children
Adolescent
Pediatric Migraine
Primaire doel
Behandeling
Toewijzing
Gerandomiseerd
Interventiemodel
Sequentieel
Blindering
Drievoudig blind
Armen / Interventies
Deelnemersgroep/StudiearmInterventie/Behandeling
Actieve comparatorBHV3000 (active drug)
BHV3000 (rimegepant) 75 mg or 50 mg ODT
Rimegepant/BHV3000
BHV3000 (rimegepant) 75 mg or 50 mg ODT
Placebo-comparatorPlacebo
Matching 75 mg or 50 mg ODT placebo
Overeenkomend placebo
Matching 75 mg or 50 mg ODT placebo
Primaire uitkomst
UitkomstmaatBeschrijving van de uitkomstmaatTijdsbestek
To evaluate the efficacy of rimegepant compared with placebo in the acute treatment of migraine in adolescent population (≥ 12 to <18 years of age) as measured by pain freedom using the number of patients reporting no pain.
Pain freedom will be assessed in adolescent population (≥ 12 to \< 18 years of age) on a 4-point numeric rating scale (0=none, 1=mild, 2=moderate, 3=severe).
2 hours post-dose
Secundaire uitkomst
UitkomstmaatBeschrijving van de uitkomstmaatTijdsbestek
To compare rimegepant with placebo for pain freedom in children and adolescents combined.
Pain freedom will be assessed in children and adolescents (≥ 6 to \< 18 years of age) using a 4-point numeric rating scale (0=none, 1=mild, 2=moderate, 3=severe). Pain freedom will be assessed in children (\> 6 to \< 12 years of age) using the 5-Face VAS (Face 5 = 'severe pain', Faces 4 and 3 = 'moderate pain', Face 2 = 'mild pain', Face 1 = 'no pain').
2 hours post-dose
To compare rimegepant with placebo on freedom from the most bothersome symptom (MBS) associated with migraine in adolescents.
Freedom from MBS (nausea, phonophobia or photophobia) will be measured using a binary scale (0=absent, 1=present).
2 hours post-dose
To compare rimegepant with placebo on the probabilities of requiring rescue medication within in adolescents.
Use of rescue medication will be assessed using the numbers of participants that take rescue medication.
Within 24 hours and 48 hours of initial treatment
To compare rimegepant with placebo on sustained pain freedom in adolescents.
Sustained pain freedom will be assessed using the number of participants that do not use any rescue medications and do not experience any headache pain post dose.
2 to 24 hours post-dose
To compare rimegepant with placebo on sustained pain freedom in adolescents.
Sustained pain freedom will be assessed using the number of participants that do not use any rescue medications and do not experience any headache pain post dose.
2 to 48 hours post-dose
To compare rimegepant with placebo on the ability to function normally as reported on the Functional Disability scale in adolescents.
The proportion of participants able to function normally will be assessed using the number that self-report as "normal" on the Functional Disability scale.
2 hours post-dose
To compare rimegepant with placebo for pain freedom in children.
Pain freedom will be assessed using the number of children (≥ 6 to \< 12 years of age) that report no pain measured by a 5-Face VAS (Face 5 = 'severe pain', Faces 4 and 3 = 'moderate pain', Face 2 = 'mild pain', Face 1 = 'no pain').
2 hours post-dose
To compare rimegepant with placebo on freedom from the most bothersome symptom (MBS) associated with migraine in children and combined children and adolescents.
Freedom from the most bothersome symptom (nausea, phonophobia or photophobia) will be assessed using the number of participants that report the absence of MBS measured using a binary scale (0=absent, 1=present).
2 hours post-dose
To compare rimegepant with placebo on the probabilities of requiring rescue medication in children and combined children and adolescents.
The probabilities of requiring rescue medication will be assessed using the numbers of participants that take rescue medication within initial treatment.
Within 24 hours and 48 hours of initial treatment.
To compare rimegepant with placebo on sustained pain freedom in children and combined children and adolescents.
Sustained pain freedom will be assessed using the number of participants that do not use any rescue medications and do not experience any headache pain post dose.
2 to 24 hours post-dose
To compare rimegepant with placebo on sustained pain freedom in children and combined children and adolescents.
Sustained pain freedom will be assessed using the number of participants that do not use any rescue medications and do not experience any headache pain post dose.
2 to 48 hours post-dose
To compare rimegepant with placebo on freedom from photophobia in adolescents, children and combined children and adolescents.
Freedom from photophobia will be assessed by the number of participants that report the absence of photophobia post dose that reported the presence of photophobia at baseline.
2 hours post-dose
To compare rimegepant with placebo on freedom from phonophobia in adolescents, children and combined children and adolescents.
Freedom from phonophobia will be assessed by the number of participants that report the absence of phonophobia post dose that reported the presence of phonophobia at baseline.
2 hours post-dose
To compare rimegepant with placebo on freedom from nausea in adolescents, children and combined children and adolescents.
Freedom from nausea will be assessed by the number of participants that report the absence of nausea post dose that reported the presence of nausea at baseline.
2 hours post-dose
To compare rimegepant with placebo on pain relief in adolescents, children and combined children and adolescents.
Pain relief will be assessed using the number of participants that report a pain level of moderate or severe at baseline and then report a pain level of none or mild post dose.
2 hours post-dose
To compare rimegepant with placebo in adolescents, children and combined children and adolescents on pain relief.
Time to first report of pain relief will be based on the first time point a participant reports a pain level of none or mild.
Time to patients first report of pain relief of none or mild post dose up to 48 hours.
Deelname-assistent
Geschiktheidscriteria

Leeftijd van deelnemers
Kind
Minimumleeftijd
6 Years
Geslachten die in aanmerking komen voor de studie
Allen

  1. History of migraine (with or without aura) for > 6 months before Screening according to the IHS Classification ICHD-319 specifications for pediatric migraine. History may be verified using both medical records and recall by the participant and/or participant's parent(s)/legal representative(s).

  2. History of 1 to 8 moderate or severe attacks per month during the 2 months prior to enrollment, with attacks lasting > 3 hours without treatment, and attacks occurring at intervals > 24 hours.

  3. Prophylactic migraine medication are permitted if the dose has been stable for at least 12 weeks prior to the Baseline Visit, and the dose is not expected to change during the course of the study.

    1. Participants may remain on one (1) medication with possible migraine prophylactic effects, excluding CGRP antagonists \[biologic or small molecule\], during the treatment phases.
    2. Concomitant use of a CGRP antagonist, such as erenumab or fremanezumab, is prohibited.
    3. Previously discontinued prophylactic migraine medication must have done so at least 90 days prior to the Screening Visit.

  4. Verbally distinguish between migraine and other types of headaches.

  5. Participants must have a weight > 40 kg at the Screening Visit.

  6. Adequate venous access for blood sampling.

  7. Male and female participants ≥ 6 to < 18 years of age (participants must not reach their 18th birthday during the study).

  1. History of cluster headache or hemiplegic migraine headache.
  2. Confounding and clinically significant pain syndrome that may interfere with the participant's ability to participate in this study.
  3. Current psychiatric condition that is uncontrolled and/or untreated for a minimum of 6 months prior to the Screening Visit. Participants with a lifetime history of psychosis and/or mania.
  4. History of suicidal behavior or major psychiatric disorder.
  5. Current diagnosis or history of substance abuse; positive drug test at Screening.
  6. History of moderate or severe head trauma or other neurological disorder (including seizure disorder) or systemic medical disease that is likely to affect central nervous system functioning.
  7. Recent or planned surgery, requiring general anesthesia, <8 weeks prior to the Screening Visit.
  8. Participant has had gastrointestinal surgery that interferes with physiological absorption and motility (i.e., gastric bypass, duodenectomy, or gastric banding).
  9. Current diagnosis of viral hepatitis or a history of liver disease.
  10. Conditions considered clinically relevant in the context of the study such as uncontrolled hypertension (high blood pressure), diabetes, a life-threatening allergy
Pfizer logoPfizer457 actieve klinische studies om te verkennen
Centraal Contactpersoon
Contact: Pfizer Pfizer CT.gov Call Center, 1-800-718-1021, [email protected]
245 Studielocaties in 9 landen

Alabama

Achieve Clinical Research, LLC d/b/a Accel Research Sites-Neurology and Neurodiagnostic of Alabama, Birmingham, Alabama, 35244, United States
Actief, niet rekruterend

Arizona

Perseverance Research Center, LLC, Scottsdale, Arizona, 85253, United States
Rekruterend
Physicians Research Group, Tempe, Arizona, 85284, United States
Actief, niet rekruterend

California

Advanced Research Center, Inc., Anaheim, California, 92805, United States
Rekruterend
Adult & Child Neurology Medical Associates, Costa Mesa, California, 92627, United States
Rekruterend
ProScience Research Group, Culver City, California, 90230, United States
Rekruterend
Memorial Health Services, Fountain Valley, California, 92708, United States
Rekruterend
Neuro-Pain Medical Center, Fresno, California, 93710, United States
Rekruterend
Regents of the University of California (UC San Diego), La Jolla, California, 92093, United States
Rekruterend
Adult & Child Neurology Medical Associates, Long Beach, California, 90806, United States
Rekruterend
Miller Children's & Women's Hospital Long Beach, Long Beach, California, 90806, United States
Rekruterend
National Research Institute, Los Angeles, California, 90057, United States
Actief, niet rekruterend
Velocity Clinical Research - North Hollywood, North Hollywood, California, 91606, United States
Actief, niet rekruterend
Children's Hospital of Orange County - Inpatient Pharmacy, Orange, California, 92868, United States
Nog niet rekruterend
Children's Hospital of Orange County - Neuroscience Center, Orange, California, 92868, United States
Nog niet rekruterend
Children's Hospital of Orange County, Orange, California, 92868, United States
Nog niet rekruterend
The Neurology Group, Pomona, California, 91767, United States
Rekruterend
University of California, Davis Midtown Clinic, Sacramento, California, 95816, United States
Actief, niet rekruterend
UC Davis Medical Center, Investigational Drug Service (IDS) Pharmacy, Sacramento, California, 95817, United States
Actief, niet rekruterend
University of California, Davis Clinical and Translational Science Center Clinical Research (CCRC), Sacramento, California, 95817, United States
Actief, niet rekruterend
Velocity Clinical Research, San Bernardino (IP Delivery and Administering Location), San Bernardino, California, 92408, United States
Rekruterend
Pacific Clinical Research Management Group LLC, Upland, California, 91786, United States
Actief, niet rekruterend
Sunwise Clinical Research, Walnut Creek, California, 94596, United States
Rekruterend

Colorado

Children's Hospital Colorado- lnvestigational Drug Services, Aurora, Colorado, 80045, United States
Rekruterend
Children's Hospital Colorado, Aurora, Colorado, 80045, United States
Rekruterend
Colorado Springs Neurological Associates, PC, Colorado Springs, Colorado, 80907, United States
Rekruterend
Colorado Springs Neurological Associates, PC, Colorado Springs, Colorado, 80919, United States
Rekruterend

Connecticut

CT Clinical Research, Cromwell, Connecticut, 06416, United States
Rekruterend
Connecticut Children's Medical Center, Hartford, Connecticut, 06106, United States
Actief, niet rekruterend
Ki Health Partners, LLc, dba New England Institute for Clinical Research, Stamford, Connecticut, 06905, United States
Rekruterend

Delaware

Nemours Children's Hospital, Delaware, Wilmington, Delaware, 19803, United States
Actief, niet rekruterend

District of Columbia

Children's National Medical Center, Washington D.C., District of Columbia, 20010, United States
Rekruterend

Florida

Topaz Clinical Research, Inc., Apopka, Florida, 32703, United States
Actief, niet rekruterend
Beautiful Minds Clinical Research Center, Cutler Bay, Florida, 33157, United States
Beëindigd
DeLand Clinical Research Unit, DeLand, Florida, 32720, United States
Beëindigd
Sarkis Clinical Trials, Gainesville, Florida, 32607, United States
Actief, niet rekruterend
Multi-Specialty Research Associates, Inc., Lake City, Florida, 32055, United States
Actief, niet rekruterend
Watson Clinic Center for Research, Inc., Lakeland, Florida, 33805, United States
Beëindigd
Watson Clinic LLP, Lakeland, Florida, 33805, United States
Beëindigd
AppleMed Research Group, LLC, Miami, Florida, 33126, United States
Rekruterend
Medical Research Center of Miami II, Inc, Miami, Florida, 33134, United States
Actief, niet rekruterend
Nicklaus Children's Hospital, Research Institute, Miami, Florida, 33155, United States
Nog niet rekruterend
South Florida Research Phase I-IV, Inc, Miami, Florida, 33166, United States
Rekruterend
Brainstorm Research, Miami, Florida, 33176, United States
Actief, niet rekruterend
Advanced Research for Health Improvement, LLC/ Dr. Cordero's Pediatric Office, Naples, Florida, 34102, United States
Actief, niet rekruterend
Aqualane Clinical Research, Naples, Florida, 34105, United States
Rekruterend
Coastal Clinical Research Specialists, Orange Park, Florida, 32073, United States
Actief, niet rekruterend
Clinical Associates of Orlando, LLC, Orlando, Florida, 32819, United States
Rekruterend
Bioresearch Institute, Pembroke Pines, Florida, 33026, United States
Beëindigd
Forcare Clinical Research, Tampa, Florida, 33613, United States
Rekruterend
Premiere Research Institute at Palm Beach Neurology, West Palm Beach, Florida, 33407, United States
Actief, niet rekruterend

Georgia

Children's Healthcare of Atlanta, Inc., Atlanta, Georgia, 30329, United States
Rekruterend
Childrens Healthcare of Atlanta, Atlanta, Georgia, 30329, United States
Rekruterend
Rare Disease Research, LLC, Atlanta, Georgia, 30329, United States
Actief, niet rekruterend
Pivotal Clinical Research & Associates, LLC, Brunswick, Georgia, 31520, United States
Rekruterend
CenExel iResearch, LLC, Decatur, Georgia, 30030, United States
Rekruterend

Illinois

Chicago Headache Center & Research Institute, Chicago, Illinois, 60657, United States
Rekruterend
AMR-Baber Research Inc, Naperville, Illinois, 60563, United States
Rekruterend

Indiana

Options Research Group, LLC, Westfield, Indiana, 46074, United States
Rekruterend

Iowa

Velocity Clinical Research, Sioux City, Sioux City, Iowa, 51106, United States
Rekruterend
Integrated Clinical Trial Services, West Des Moines, Iowa, 50265, United States
Rekruterend

Kansas

Clinical Associates Midwest, LLC, Kansas City, Kansas, 66214, United States
Rekruterend
College Park Family Care Center Physicians Group- Neurology Research Dept., Overland Park, Kansas, 66212, United States
Actief, niet rekruterend

Kentucky

Kentucky Neuroscience Institute Child Neurology-- "Patients Seen", Lexington, Kentucky, 40504, United States
Actief, niet rekruterend
UK Center for Clinical and Translational Science (CCTS) -- "Patients Seen", Lexington, Kentucky, 40536, United States
Actief, niet rekruterend
University of Kentucky Hospital, Lexington, Kentucky, 40536, United States
Actief, niet rekruterend

Louisiana

Ochsner Clinic Foundation, New Orleans, Louisiana, 70121, United States
Actief, niet rekruterend
Neurology and Headache Center, Inc., Shreveport, Louisiana, 71105, United States
Actief, niet rekruterend

Massachusetts

Boston Clinical Trials, Boston, Massachusetts, 02131, United States
Actief, niet rekruterend
MedVadis Research Corporation, Waltham, Massachusetts, 02451, United States
Actief, niet rekruterend

Michigan

Michigan Head Pain & Neurological Institute, Ann Arbor, Michigan, 48104, United States
Rekruterend
Corewell Health, for and on behalf of Spectrum Health Hospital and Corewell Health Medical Group, Grand Rapids, Michigan, 49503, United States
Rekruterend
Corewell Health, Helen DeVos Children's Hospital, Grand Rapids, Michigan, 49503, United States
Rekruterend
Wellnow Urgent Care and Research, Kalamazoo, Michigan, 49048, United States
Actief, niet rekruterend
Beaumont Hospital Royal Oak Campus, Royal Oak, Michigan, 48073, United States
Rekruterend

Minnesota

Brackenridge Outpatient Research Pharmacy, Rochester, Minnesota, 55905, United States
Rekruterend
Clinical Research Trials Unit, Rochester, Minnesota, 55905, United States
Rekruterend
Mayo Clinic, Rochester, Minnesota, 55905, United States
Rekruterend

Mississippi

Precise Research Centers, Flowood, Mississippi, 39232, United States
Rekruterend

Missouri

Sharlin Health Neuroscience Research Center, Ozark, Missouri, 65721, United States
Rekruterend
Clinvest Research, LLC, Springfield, Missouri, 65810, United States
Actief, niet rekruterend

Montana

Boeson Research, Great Falls, Montana, 59405, United States
Rekruterend
Boeson Research, Kalispell, Montana, 59901, United States
Actief, niet rekruterend
Heart & Hands Midwifery, Kalispell, Montana, 59901, United States
Actief, niet rekruterend
Blue Moose Pediatrics, Missoula, Montana, 59804, United States
Rekruterend
Boeson Research Laboratory, Missoula, Montana, 59804, United States
Rekruterend
Boeson Research, Missoula, Montana, 59804, United States
Rekruterend

Nebraska

Alivation Research, LLC., Lincoln, Nebraska, 68526, United States
Beëindigd
Children's Hospital & Medical Center, Omaha, Nebraska, 68114, United States
Rekruterend

New Jersey

HMH Jersey Shore University Medical Center, Neptune City, New Jersey, 07753, United States
Rekruterend

New York

Dent Neurosciences Research Center, Amherst, New York, 14226, United States
Rekruterend
True North Neurology, Commack, New York, 11725, United States
Rekruterend
Northwell Health/ Division of Pediatric Neurology, Lake Success, New York, 11042, United States
Rekruterend
NYU Langone Hospital-Long Island, Clinical Research Center, Mineola, New York, 11501, United States
Actief, niet rekruterend
NYU Langone Hospital-Long Island, Pediatric Neurology, Mineola, New York, 11501, United States
Actief, niet rekruterend
New York Neurology Associates, New York, New York, 10003, United States
Rekruterend
Weill Cornell Medicine, New York, New York, 10021, United States
Rekruterend
Mount Sinai Hospital - Pharmacy Department, New York, New York, 10029, United States
Actief, niet rekruterend
Columbia University Medical Center Research Pharmacy, New York, New York, 10032, United States
Actief, niet rekruterend
Columbia University Pediatric Neuromuscular Center, New York, New York, 10032, United States
Actief, niet rekruterend
Irving Center for Clinical and Translational Research, Outpatient Clinical Research Unit, New York, New York, 10032, United States
Actief, niet rekruterend
The Neurological Institute of New York, New York, New York, 10032, United States
Actief, niet rekruterend
The Trustees of Columbia University and The New York and Presbyterian Hospital, New York, New York, 10032, United States
Actief, niet rekruterend
North Suffolk Neurology P.C, Port Jefferson Station, New York, 11776, United States
Actief, niet rekruterend
Finger Lakes Clinical Research, Rochester, New York, 14618, United States
Beëindigd
Prime Global Research, LLC, The Bronx, New York, 10456, United States
Beëindigd

North Carolina

New Hope Clinical Research, Charlotte, North Carolina, 28211, United States
Actief, niet rekruterend
OnSite Clinical Solutions, LLC, Charlotte, North Carolina, 28277, United States
Rekruterend
Velocity Clinical Research, Inc., Durham, North Carolina, 27701, United States
Rekruterend
Headache Wellness Center, PC, Greensboro, North Carolina, 27405, United States
Rekruterend

Ohio

Akron Children's Hospital, Akron, Ohio, 44308, United States
Rekruterend
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 45229, United States
Rekruterend
Velocity Clinical Research, Cincinnati, Ohio, 45242, United States
Rekruterend
University Hospitals Cleveland Medical Center, Cleveland, Ohio, 44106, United States
Rekruterend
Nationwide Children's Hospital, Columbus, Ohio, 43205, United States
Actief, niet rekruterend
Wellnow Urgent Care and Research, Columbus, Ohio, 43228, United States
Actief, niet rekruterend
Neuro-Behavioral Clinical Research, Inc., North Canton, Ohio, 44720, United States
Actief, niet rekruterend

Oklahoma

IPS Research Company, Oklahoma City, Oklahoma, 73106, United States
Actief, niet rekruterend
Lynn Institute of Tulsa, Tulsa, Oklahoma, 74135, United States
Actief, niet rekruterend

Oregon

Velocity Clinical Research, Grants Pass, Grants Pass, Oregon, 97527, United States
Actief, niet rekruterend
Providence Health & Services Investigational Drug Services Westside, Portland, Oregon, 97225, United States
Rekruterend
Providence Neuroscience Institute - Research Coordinator's Office, Portland, Oregon, 97225, United States
Rekruterend
Providence Pediatric Neurology, Portland, Oregon, 97225, United States
Rekruterend
Providence St. Vincent Medical Center, Portland, Oregon, 97225, United States
Rekruterend

Pennsylvania

Clario, Philadelphia, Pennsylvania, 19103, United States
Rekruterend
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, 19104, United States
Actief, niet rekruterend

Rhode Island

Velocity Clinical Research-Providence, East Greenwich, Rhode Island, 02818, United States
Rekruterend

South Carolina

Premier Neurology, PC, Greenville, South Carolina, 29605, United States
Actief, niet rekruterend
Tribe Clinical Research, LLC, Greenville, South Carolina, 29607, United States
Actief, niet rekruterend
Velocity Clinical Research - Greenville, Greenville, South Carolina, 29615, United States
Actief, niet rekruterend

Tennessee

Holston Medical Group., Kingsport, Tennessee, 37660, United States
Actief, niet rekruterend
Holston Medical Group, Kingsport, Tennessee, 37660, United States
Actief, niet rekruterend
Le Bonheur Children's Hospital - Outpatient Building, Memphis, Tennessee, 38103, United States
Rekruterend
Le Bonheur Children's Hospital, Memphis, Tennessee, 38103, United States
Rekruterend
Le Bonheur Childrens Hospital - Childrens Foundation Research Institute, Memphis, Tennessee, 38103, United States
Rekruterend
Access Clinical Trials, Inc., Nashville, Tennessee, 37203, United States
Actief, niet rekruterend

Texas

Dell Children's Medical Center, Austin, Texas, 78723, United States
Rekruterend
Child Neurology Consultants of Austin - South Austin, Austin, Texas, 78749, United States
Rekruterend
Child Neurology Consultants of Austin - Central Austin, Austin, Texas, 78757, United States
Rekruterend
BioBehavioral Research of Austin, Austin, Texas, 78759, United States
Actief, niet rekruterend
Houston Clinical Trials, LLC, Bellaire, Texas, 77401, United States
Rekruterend
Infinite Research Group, LLC, Dallas, Texas, 75201, United States
Rekruterend
Children's Medical Center, Dallas, Dallas, Texas, 75235, United States
Rekruterend
Children's Medical Center, Pediatric Anesthesiology Research (Study supplies only), Dallas, Texas, 75235, United States
Rekruterend
Cedar Health Research, Dallas, Texas, 75251, United States
Rekruterend
FutureSearch Trials of Dallas, LLC, Dallas, Texas, 75251, United States
Rekruterend
The University of Texas Southwestern Medical Center, Dallas, Texas, 75390, United States
Rekruterend
ANESC Research, El Paso, Texas, 79912, United States
Rekruterend
North Texas Institute of Neurology and Headache, Frisco, Texas, 75034, United States
Actief, niet rekruterend
UTHealth Houston, Houston, Texas, 77030, United States
Rekruterend
Pain and Headache Centers of Texas, Houston, Texas, 77054, United States
Rekruterend
SCLA Management, Houston, Texas, 77077, United States
Rekruterend
Houston Clinical Research,LLC., Houston, Texas, 77081, United States
Actief, niet rekruterend
NeuroCare Plus, Houston, Texas, 77094, United States
Rekruterend
AIM Trials, LLC, Plano, Texas, 75093, United States
Rekruterend

Utah

JBR Clinical Research, Salt Lake City, Utah, 84107, United States
Rekruterend
Wasatch Clinical Research , LLC(Administrative Location), Salt Lake City, Utah, 84107, United States
Rekruterend

Vermont

The University of Vermont Medical Center, Burlington, Vermont, 05401, United States
Actief, niet rekruterend

Virginia

Pediatric Research of Charlottesville, LLC (Regulatory Only), Charlottesville, Virginia, 22902, United States
Rekruterend
Pediatric Research of Charlottesville, LLC, Charlottesville, Virginia, 22902, United States
Rekruterend
Children's Hospital of the King's Daughters, Norfolk, Virginia, 23507, United States
Rekruterend
Children's Specialty Group, PLLC, Norfolk, Virginia, 23507, United States
Rekruterend
Children's Specialty Group, PLLC, Division of Childhood & Adolescent Neurology, Norfolk, Virginia, 23510, United States
Rekruterend
National Clinical Research, Inc., Richmond, Virginia, 23294, United States
Actief, niet rekruterend

Washington

Northwest Clinical Research Center, Bellevue, Washington, 98007, United States
Rekruterend
Eastside Therapeutic Resource, Inc. dba Core Clinical Research, Everett, Washington, 98201, United States
Actief, niet rekruterend
Seattle Children's Hospital Investigational Drug Services, Seattle, Washington, 98105, United States
Rekruterend
Seattle Children's Hospital, Seattle, Washington, 98105, United States
Rekruterend

Wisconsin

Clinical Investigation Specialists, Inc, Kenosha, Wisconsin, 53144, United States
Rekruterend
University Hospital, Madison, Wisconsin, 53792, United States
Rekruterend

British Columbia

OCT Research ULC, Kelowna, British Columbia, V1Y 1Z9, Canada
Rekruterend

Quebec

Diex Recherche Sherbrooke Inc, Sherbrooke, Quebec, J1L 0H8, Canada
Actief, niet rekruterend

Anhui

First Affiliated Hospital of Bengbu Medical College Neurology, Bengbu, Anhui, 233000, China
Rekruterend
Anhui Provincial Hospital, Hefei, Anhui, 230000, China
Rekruterend

Beijing Municipality

Chinese PLA General Hospital, Beijing, Beijing Municipality, 100089, China
Rekruterend

Chongqing Municipality

" The First Affiliated Hospital of Chongqing Medical University", Chongqing, Chongqing Municipality, 400042, China
Rekruterend

Gansu

Lanzhou university second hospital, Lanzhou, Gansu, 730030, China
Rekruterend

Guangdong

Shenzhen Children's Hospital, Shenzhen, Guangdong, 518034, China
Rekruterend

Hainan

Hainan General Hospital, Haikou, Hainan, 571140, China
Rekruterend

Hebei

The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, China
Rekruterend
The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050004, China
Rekruterend

Henan

People's Hospital of Zhengzhou, Zhengzhou, Henan, 450000, China
Rekruterend

Hubei

Jingzhou First People's Hospital, Jingzhou, Hubei, 434000, China
Rekruterend
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, China
Rekruterend
Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, China
Rekruterend

Hunan

The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410000, China
Rekruterend
Hunan Children's Hospital, Changsha, Hunan, 410007, China
Rekruterend
The Third Xiangya Hospital of Central South University, Changsha, Hunan, 410013, China
Rekruterend

Jiangsu

The Second People's Hospital of Lianyungang, Lianyungang, Jiangsu, 222002, China
Rekruterend
The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215006, China
Rekruterend
Wuxi Children's Hospital, Wuxi, Jiangsu, 214023, China
Rekruterend
Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, 214115, China
Rekruterend
Xuzhou Children's Hospital, Xuzhou, Jiangsu, 221002, China
Rekruterend
Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, 212001, China
Rekruterend

Jilin

The First Hospital of Jilin University, Pediatric Neurology, Changchun, Jilin, 130021, China
Rekruterend

Ningxia

General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 756000, China
Rekruterend

Shaanxi

Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, 710068, China
Rekruterend
Xi'an Gaoxin Hospital Neurology Department, Xi'an, Shaanxi, 710075, China
Rekruterend
Yan 'an University Xianyang Hospital, Xianyang, Shaanxi, 716000, China
Rekruterend

Shandong

Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, 250013, China
Rekruterend
Liaocheng People's Hospital, Liaocheng, Shandong, 252000, China
Rekruterend

Sichuan

West China Hospital of Sichuan University, Chengdu, Sichuan, 610041, China
Rekruterend

Zhejiang

Children's Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310052, China
Rekruterend
Ningbo Women and Children's Hospital, Ningbo, Zhejiang, 315012, China
Rekruterend
The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China
Rekruterend
Lu 'an People's Hospital, Lu'an, China
Rekruterend
Children's Hospital of Shanghai, Shanghai, China
Rekruterend
Shengjing Hospital of China Medical University, Shenyang, China
Rekruterend
The First Affiliated Hospital of Shihezi University School of Medicine, Shihezi, China
Actief, niet rekruterend
Wuhan Children's Hospital, Wuhan, China
Rekruterend

Fukuoka

Jinnouchi Neurosurgical Clinic, Kasuga-shi, Fukuoka, 816-0802, Japan
Rekruterend
Ikeda Neurosurgical Clinic, Kasuga-shi, Fukuoka, 816-0824, Japan
Rekruterend

Gunma

Hikita Pediatric Clinic, Kiryu-shi, Gunma, 3760035, Japan
Rekruterend

Hyōgo

Konan Medical Center, Higashinada-ku Kobe-shi, Hyōgo, 658-0064, Japan
Rekruterend
Yamaguchi Clinic, Nishinomiya-shi, Hyōgo, 663-8204, Japan
Rekruterend

Ibaraki

Mito Kyodo General Hospital, Mito, Ibaraki, 310-0015, Japan
Rekruterend

Kagoshima-ken

Tanaka Neurosurgery & Headache Clinic, Kagoshima, Kagoshima-ken, 890-0052, Japan
Rekruterend

Miyagi

Sendai Headache and Neurology Clinic, Taihaku-ku Sendai-shi, Miyagi, 982-0014, Japan
Rekruterend

Osaka

Tennoji Dai Brain Clinic, Abeno-ku Osaka-shi, Osaka, 545-0053, Japan
Rekruterend
Tominaga Clinic, Naniwa-ku, Osaka, 556-0015, Japan
Rekruterend

Tokyo

Tokyo Headache Clinic, Shibuya-ku, Tokyo, 151-0051, Japan
Rekruterend
Tokyo Medical University Hospital, Shinjuku-ku, Tokyo, 160-0023, Japan
Nog niet rekruterend
Local lndependent Administrative Corporation Hiroshima City Hospital Organization Hiroshima City, Hiroshima, 730-8518, Japan
Rekruterend

Mexico City

Clinstile S.A. de C.V., Col. Roma Norte, Mexico City, C.P. 06700., Mexico
Rekruterend

Sinaloa

Neurociencias Estudios Clinicos S.C., Culiacán, Sinaloa, 800200, Mexico
Rekruterend

State of Mexico

Clinical Reseach Institute, S.C., Tlalnepantla, State of Mexico, C.P. 54055, Mexico
Rekruterend
Unidad de Investigacion en Salud de Chihuahua S.C., Chihuahua City, 31203, Mexico
Rekruterend

Lower Silesian Voivodeship

MIGRE Polskie Centrum Leczenia Migreny Anna Gryglas-Dworak, Wroclaw, Lower Silesian Voivodeship, 52-210, Poland
Rekruterend
NZOZ Wielospecjalistyczna Poradnia Lekarska SYNAPSIS, Lech Szczechowski, Katowice, 40-123, Poland
Actief, niet rekruterend
Centrum Medyczne Plejady, Krakow, 30-363, Poland
Rekruterend
Wojewódzki Specjalistyczny Szpital Dzieciecy im. Sw. Ludwika w Krakowie, Apteka Szpitalna, Krakow, 31-503, Poland
Rekruterend
Clinical Research Center Sp. z.o.o. Medic-R Spolka komandytowa, Poznan, 61-731, Poland
Rekruterend
Euromedis Sp. z o. o., Szczecin, 70-111, Poland
Actief, niet rekruterend

Cantabria

Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, 39008, Spain
Actief, niet rekruterend
Hospital Universitario Vall d'Hebron, Barcelona, 08035, Spain
Rekruterend
Centre d'Atencio Primaria Balenya, Barcelona, 08550, Spain
Actief, niet rekruterend
Instituto de Investigaciones del Sueno, Madrid, 28036, Spain
Actief, niet rekruterend
Hospital Universitario Virgen del Rocío, Seville, 41013, Spain
Rekruterend
Hospital Clinico Universitario de Valladolid, Valladolid, 47005, Spain
Rekruterend

Skåne LÄN [se-12]

ProbarE i Lund AB, Lund, Skåne LÄN [se-12], 22222, Sweden
Rekruterend
Avdelningen för kliniska Prövningar, Universitetssjukhuset Örebro, Örebro, 703 62, Sweden
Actief, niet rekruterend
ProbarE i Stockholm AB, Stockholm, 113 29, Sweden
Rekruterend
Leicester Royal Infirmary, Leicester, LE1 5WW, United Kingdom
Actief, niet rekruterend
Re:Cognition Health Limited, London, W1G 9JF, United Kingdom
Rekruterend
Great Ormond Street Hospital for Children NHS Foundation Trust, London, WC1N 3JH, United Kingdom
Rekruterend