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O estudo clínico NCT04759586 para Linfoma primário de grandes células B do mediastino está ativo, não recrutando. Consulte a visualização em cartões do Radar de Estudos Clínicos e as ferramentas de descoberta de IA para ver todos os detalhes. Ou pergunte qualquer coisa aqui. | ||
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Instituto Nacional do Câncer, EUANivolumab in Combination With Chemo-Immunotherapy for the Treatment of Newly Diagnosed Primary Mediastinal B-Cell Lymphoma Fase III 244 Imunoterapia Anticorpo monoclonal
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O estudo clínico NCT04759586 procura avaliar tratamento para Linfoma primário de grandes células B do mediastino. Este é um estudo intervencionista de Fase III. Seu status atual é: ativo, não recrutando. O estudo começou em 5 de outubro de 2021 e pretende incluir 244 participantes. Coordenado por o Instituto Nacional do Câncer, EUA e deve ser concluído em 31 de dezembro de 2026. Essas informações foram atualizadas no ClinicalTrials.gov em 30 de março de 2026.
Resumo
This phase III trial compares the effects of nivolumab with chemo-immunotherapy versus chemo-immunotherapy alone in treating patients with newly diagnosed primary mediastinal B-cell lymphoma (PMBCL). Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of cancer cells to grow and spread. Treatment for PMBCL involves chemot...Mostrar mais
Descrição detalhada
PRIMARY OBJECTIVE:
I. To determine if nivolumab + chemo-immunotherapy results in a superior long term progression-free survival (PFS) (events defined as disease progression confirmed by central review or death) when compared with chemo-immunotherapy alone in patients with newly diagnosed primary mediastinal B-cell lymphoma.
SECONDARY OBJECTIVES:
I. To compare the rates of "efficacy-related event-free survival (EFS...
Mostrar maisTítulo oficial
A Randomized Phase 3 Trial of Nivolumab (NSC# 748726) in Combination With Chemo-Immunotherapy for the Treatment of Newly Diagnosed Primary Mediastinal B-Cell Lymphoma
Condições médicas
Linfoma primário de grandes células B do mediastinoOutros IDs do estudo
- NCI-2021-01071
- NCI-2021-01071 (Identificador de registro) (CTRP (Clinical Trial Reporting Program))
- ANHL1931 (Outro identificador) (Children's Oncology Group)
- ANHL1931 (Outro identificador) (CTEP)
- U10CA180886 (Subvenção/Contrato NIH (EUA))
Número NCT
Data de início (real)
2021-10-05
Última atualização postada
2026-03-30
Data de conclusão (estimada)
2026-12-31
Inscrição (estimada)
244
Tipo de estudo
Intervencionista
FASE
Fase III
Status
Ativo, não recrutando
Propósito principal
Tratamento
Alocação do design
Randomizado
Modelo de intervenção
Paralelo
Cegamento (Mascaramento)
Nenhum (Aberto)
Braços / Intervenções
| Grupo de participantes/Braço | Intervenção/Tratamento |
|---|---|
Comparador ativoArm A (DA-EPOCH-R) See Detailed Description | Coleta de biospecimen Undergo blood and CSF sample collection Aspiração de medula óssea Undergo bone marrow biopsy and aspiration Biópsia da medula óssea Undergo bone marrow biopsy and aspiration Tomografia computadorizada Undergo CT or PET/CT Cyclophosphamide Given IV Doxorubicin Hydrochloride Given IV Echocardiography Test Undergo ECHO Etoposide Phosphate Given IV Filgrastim Given SC Punção lombar Undergo LP Pegfilgrastim Given SC Tomografia por emissão de pósitrons Undergo PET/CT Prednisolona Given PO Prednisone Given PO Rituximabe Given IV Rituximab and Hyaluronidase Human Given SC Vincristine Sulfate Given IV |
ExperimentalArm B (DA-EPOCH-R, nivolumab) Patients receive treatment as in Arm A. Patients also receive nivolumab IV over 30 minutes on day 1. Treatment repeats every 21 days for up to 6 cycles (5 if the patient had 1 prior cycle of treatment) in the absence of disease progression or unacceptable toxicity. Patients undergo ECHO and LP for CSF collection during screening. Patients undergo ECHO during screening and as clinically indicated and LP for CSF collec...Mostrar mais | Coleta de biospecimen Undergo blood and CSF sample collection Aspiração de medula óssea Undergo bone marrow biopsy and aspiration Biópsia da medula óssea Undergo bone marrow biopsy and aspiration Tomografia computadorizada Undergo CT or PET/CT Cyclophosphamide Given IV Doxorubicin Hydrochloride Given IV Echocardiography Test Undergo ECHO Etoposide Phosphate Given IV Filgrastim Given SC Punção lombar Undergo LP Nivolumab Given IV Pegfilgrastim Given SC Tomografia por emissão de pósitrons Undergo PET/CT Prednisolona Given PO Prednisone Given PO Rituximabe Given IV Rituximab and Hyaluronidase Human Given SC Vincristine Sulfate Given IV |
Comparador ativoArm C (R-CHOP) Patients receive prednisone or prednisolone PO QD on days 1-5 and rituximab IV or rituximab and hyaluronidase human SC over 5 minutes on day 1 or 5. Patients also receive cyclophosphamide IV over 30-60 minutes, doxorubicin hydrochloride IV over 1-15 minutes or up to 60 minutes, and vincristine sulfate IV over 1 or up to 60 minutes on day 1. Treatment repeats every 21 days for up to 6 cycles (5 if the patient had 1 pr...Mostrar mais | Coleta de biospecimen Undergo blood and CSF sample collection Aspiração de medula óssea Undergo bone marrow biopsy and aspiration Biópsia da medula óssea Undergo bone marrow biopsy and aspiration Tomografia computadorizada Undergo CT or PET/CT Cyclophosphamide Given IV Doxorubicin Hydrochloride Given IV Echocardiography Test Undergo ECHO Punção lombar Undergo LP Tomografia por emissão de pósitrons Undergo PET/CT Prednisolona Given PO Prednisone Given PO Rituximabe Given IV Rituximab and Hyaluronidase Human Given SC Vincristine Sulfate Given IV |
ExperimentalArm D (R-CHOP, nivolumab) Patients receive treatment as in Arm C. Patients also receive nivolumab IV over 30 minutes on day 1. Treatment repeats every 21 days for up to 6 cycles (5 if the patient had 1 prior cycle of treatment) in the absence of disease progression or unacceptable toxicity. Patients undergo ECHO during screening and as clinically indicated and LP for CSF collection optionally during screening. Patients also undergo CT or PET/...Mostrar mais | Coleta de biospecimen Undergo blood and CSF sample collection Aspiração de medula óssea Undergo bone marrow biopsy and aspiration Biópsia da medula óssea Undergo bone marrow biopsy and aspiration Tomografia computadorizada Undergo CT or PET/CT Cyclophosphamide Given IV Doxorubicin Hydrochloride Given IV Echocardiography Test Undergo ECHO Punção lombar Undergo LP Nivolumab Given IV Tomografia por emissão de pósitrons Undergo PET/CT Prednisolona Given PO Prednisone Given PO Rituximabe Given IV Rituximab and Hyaluronidase Human Given SC Vincristine Sulfate Given IV |
Comparador ativoArm E (R-CHOP, radiation therapy) Patients receive treatment as in Arm C. Within 6-8 weeks after completion of chemotherapy, patients undergo radiation therapy over 25 fractions. Patients undergo ECHO during screening and as clinically indicated and LP for CSF collection optionally during screening. Patients also undergo CT or PET/CT throughout the trial. Additionally, patients undergo bone marrow biopsy and aspiration optionally during screening and...Mostrar mais | Coleta de biospecimen Undergo blood and CSF sample collection Aspiração de medula óssea Undergo bone marrow biopsy and aspiration Biópsia da medula óssea Undergo bone marrow biopsy and aspiration Tomografia computadorizada Undergo CT or PET/CT Cyclophosphamide Given IV Doxorubicin Hydrochloride Given IV Echocardiography Test Undergo ECHO Punção lombar Undergo LP Tomografia por emissão de pósitrons Undergo PET/CT Prednisolona Given PO Prednisone Given PO Terapia de radiação Undergo radiation therapy Rituximabe Given IV Rituximab and Hyaluronidase Human Given SC Vincristine Sulfate Given IV |
ExperimentalArm F (R-CHOP, nivolumab, radiation therapy) Patients receive treatment as in Arm D. Within 6-8 weeks after completion of chemotherapy, patients undergo radiation therapy over 25 fractions. Patients undergo ECHO during screening and as clinically indicated and LP for CSF collection optionally during screening. Patients also undergo CT or PET/CT throughout the trial. Additionally, patients undergo bone marrow biopsy and aspiration optionally during screening and...Mostrar mais | Coleta de biospecimen Undergo blood and CSF sample collection Aspiração de medula óssea Undergo bone marrow biopsy and aspiration Biópsia da medula óssea Undergo bone marrow biopsy and aspiration Tomografia computadorizada Undergo CT or PET/CT Cyclophosphamide Given IV Doxorubicin Hydrochloride Given IV Echocardiography Test Undergo ECHO Punção lombar Undergo LP Nivolumab Given IV Tomografia por emissão de pósitrons Undergo PET/CT Prednisolona Given PO Prednisone Given PO Terapia de radiação Undergo radiation therapy Rituximabe Given IV Rituximab and Hyaluronidase Human Given SC |
Desfecho primário
Desfecho secundário
| Medida de desfecho | Descrição da medida | Prazo |
|---|---|---|
Progression-free survival (PFS) | The primary analysis will be a one-sided Log-rank test stratified by choice of backbone and radiation therapy and whether the patient had a cycle of therapy prior to enrolling. | From enrollment on the study to first occurrence of relapse/progression or death, assessed up to 7 years |
| Medida de desfecho | Descrição da medida | Prazo |
|---|---|---|
Efficacy-related event-free survival | Will be analyzed using a one-sided stratified Log-rank test at alpha = 0.05 or 0.025, as appropriate, with events defined as progression, change in therapy due to a finding that led to concern about efficacy, biopsy + disease after 6 cycles of therapy, and death. | Up to 7 years |
Therapy-related event-free survival | Will be analyzed using a one-sided stratified Log-rank test at alpha = 0.05 or 0.025, as appropriate, with events defined as progression, change in therapy due to a finding that led to concern about efficacy, biopsy + disease after 6 cycles of therapy, and death. | Up to 7 years |
Overall survival | Will be analyzed using a one-sided stratified Log-rank test at alpha = 0.05 or 0.025, as appropriate, with events defined as only death. | Up to 7 years |
Proportion of positive positron emission tomography (PET) scans | Will be analyzed descriptively with a point estimate and Clopper-Pearson 95% confidence interval in the trial overall and in each treatment arm separately. The prognostic significance of positive PET after 6 cycles of therapy will be evaluated using a Cox proportional hazards regression on PFS with PET result (positive versus \[vs.\] negative), choice of backbone (rituximab \[R\]-cyclophosphamide, doxorubicin, vincristine, and prednisone \[CHOP\] + radiation therapy \[RT\] regardless of end-of-therapy imaging vs. R-CHOP without RT unless biopsy positive at end-of-therapy vs. dose-adjusted \[DA\]-etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin \[EPOCH\]-R without RT unless biopsy positive at end of therapy), and assignment to nivolumab (yes vs. no) as covariates. | Up to 6 cycle (1 cycle = 21 days) |
Assistente de participação
Critérios de elegibilidade
Idades elegíveis
Criança, Adulto, Idoso
Idade mínima
2 Years
Sexos elegíveis
Todos
Age >= 2 years
Patient must have histologically confirmed primary mediastinal B-cell lymphoma (PMBCL) as defined by World Health Organization (WHO) criteria
Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1, or 2 or ECOG performance status of 3 if poor performance is related to lymphoma
- Children's Oncology Group (COG) Institutions: Use Karnofsky for patients >= 17 and < 18 years of age and Lansky for patients < 17 years of age
Adults (age 18 or older): Creatinine clearance >= 30 mL/min, as estimated by the Cockcroft and Gault formula. The creatinine value used in the calculation must have been obtained within 28 days prior to registration. Estimated creatinine clearance is based on actual body weight
Pediatric Patients (age < 18 years): The following must have been obtained within 14 days prior to registration:
Measured or calculated (based on institutional standard) creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2, or
Serum creatinine =< 1.5 x institutional upper limit of normal (IULN), or a serum creatinine based on age/sex as follows:
- Age : 2 to < 6 year; Maximum serum creatinine (mg/dL): 0.8 (male; 0.8 (female)
- Age : 6 to < 10 years; Maximum serum creatinine (mg/dL): 1 (male); 1 (female)
- Age : 10 to < 13 years; Maximum serum creatinine (mg/dL): 1.2 (male); 1.2 (female)
- Age : 13 to < 16 years; Maximum serum creatinine (mg/dL): 1.5 (male); 1.4 (female)
- Age : >= 16 years to < 18 years; Maximum serum creatinine (mg/dL): 1.7 (male); 1.4 (female)
Patients with abnormal liver function will be eligible to enroll if the lab abnormality is thought to be due to the lymphoma or Gilbert's syndrome
Age >= 18 years: Ejection fraction of >= 50% by echocardiogram
Age < 18 years: Shortening fraction of >= 27% by echocardiogram, or ejection fraction of >= 50% by radionuclide angiogram
Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial
For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated
Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load
All patients and/or their parents or legal guardians must sign a written informed consent
All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met
Administration of prior anti-cancer therapy except as outlined below:
- A short course (=< 2 weeks) of corticosteroids for the relief of lymphoma-related symptoms
- A single course of COP (cyclophosphamide, vincristine, and prednisone)
- One cycle of chemo-immunotherapy including R-CHOP, DA-EPOCH-R, a pediatric mature B-cell non-Hodgkin lymphoma (B-NHL) induction therapy (such as ANHL1131), or intrathecal chemotherapy that has not started more than 21 days prior to enrollment
Active ischemic heart disease or heart failure
Active uncontrolled infection
Central nervous system (CNS) involvement of lymphoma
Patients with a prior or concurrent malignancy whose natural history or treatment has the potential to interfere with safety or efficacy assessment of this trial
Active autoimmune disease that has required systemic treatment (such as disease modifying agents, corticosteroids, or immunosuppressive agents) in the past 2 years. Replacement therapy such as thyroxine, insulin or physiologic corticosteroid for adrenal or pituitary insufficiency is not considered a form of systemic treatment
In patients < 18 years of age hepatitis B serologies consistent with past or current infections
Patients with severe hepatic impairment (Child-Pugh class C or serum total bilirubin > 5.0 mg/dL) unless thought to be due to lymphoma or Gilbert's syndrome
Female patients who are pregnant since fetal toxicities and teratogenic effects have been noted for several of the study drugs. A pregnancy test is required for female patients of childbearing potential
Sexually active patients of reproductive potential who have not agreed to use a highly effective contraceptive method (failure rate of < 1% per year when used consistently and correctly) for the duration of their study participation
Lactating females are not eligible unless they have agreed not to breastfeed their infants starting with the first dose of study therapy and for at least 6 months after the last dose of rituximab
Instituto Nacional do Câncer, EUA3019 estudos clínicos ativos para explorarSem dados de contato.
233 Locais do estudo em 4 países
Alabama
Children's Hospital of Alabama, Birmingham, Alabama, 35233, United States
USA Health Strada Patient Care Center, Mobile, Alabama, 36604, United States
Alaska
Providence Alaska Medical Center, Anchorage, Alaska, 99508, United States
Arizona
Banner Children's at Desert, Mesa, Arizona, 85202, United States
Banner University Medical Center - Tucson, Tucson, Arizona, 85719, United States
Arkansas
Arkansas Children's Hospital, Little Rock, Arkansas, 72202-3591, United States
California
UC Irvine Health Cancer Center-Newport, Costa Mesa, California, 92627, United States
Kaiser Permanente Downey Medical Center, Downey, California, 90242, United States
City of Hope Comprehensive Cancer Center, Duarte, California, 91010, United States
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine, California, 92612, United States
City of Hope at Irvine Lennar, Irvine, California, 92618, United States
Loma Linda University Medical Center, Loma Linda, California, 92354, United States
Miller Children's and Women's Hospital Long Beach, Long Beach, California, 90806, United States
Children's Hospital Los Angeles, Los Angeles, California, 90027, United States
Cedars Sinai Medical Center, Los Angeles, California, 90048, United States
Mattel Children's Hospital UCLA, Los Angeles, California, 90095, United States
Valley Children's Hospital, Madera, California, 93636, United States
Kaiser Permanente-Oakland, Oakland, California, 94611, United States
Children's Hospital of Orange County, Orange, California, 92868, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange, California, 92868, United States
Lucile Packard Children's Hospital Stanford University, Palo Alto, California, 94304, United States
University of California Davis Comprehensive Cancer Center, Sacramento, California, 95817, United States
Rady Children's Hospital - San Diego, San Diego, California, 92123, United States
Colorado
Children's Hospital Colorado, Aurora, Colorado, 80045, United States
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center, Denver, Colorado, 80218, United States
Connecticut
Connecticut Children's Medical Center, Hartford, Connecticut, 06106, United States
Delaware
Alfred I duPont Hospital for Children, Wilmington, Delaware, 19803, United States
District of Columbia
MedStar Georgetown University Hospital, Washington D.C., District of Columbia, 20007, United States
Children's National Medical Center, Washington D.C., District of Columbia, 20010, United States
Florida
Broward Health Medical Center, Fort Lauderdale, Florida, 33316, United States
Golisano Children's Hospital of Southwest Florida, Fort Myers, Florida, 33908, United States
UF Health Cancer Institute - Gainesville, Gainesville, Florida, 32610, United States
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood, Florida, 33021, United States
Nemours Children's Clinic-Jacksonville, Jacksonville, Florida, 32207, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida, 33136, United States
Arnold Palmer Hospital for Children, Orlando, Florida, 32806, United States
Nemours Children's Hospital, Orlando, Florida, 32827, United States
Johns Hopkins All Children's Hospital, St. Petersburg, Florida, 33701, United States
Tampa General Hospital, Tampa, Florida, 33606, United States
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa, Florida, 33607, United States
Georgia
Emory Proton Therapy Center, Atlanta, Georgia, 30308, United States
Emory University Hospital Midtown, Atlanta, Georgia, 30308, United States
Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia, 30322, United States
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia, 30329, United States
Emory Saint Joseph's Hospital, Atlanta, Georgia, 30342, United States
Memorial Health University Medical Center, Savannah, Georgia, 31404, United States
Hawaii
Kapiolani Medical Center for Women and Children, Honolulu, Hawaii, 96826, United States
Idaho
Saint Luke's Cancer Institute - Boise, Boise, Idaho, 83712, United States
Illinois
Rush-Copley Medical Center, Aurora, Illinois, 60504, United States
Lurie Children's Hospital-Chicago, Chicago, Illinois, 60611, United States
Northwestern University, Chicago, Illinois, 60611, United States
University of Illinois, Chicago, Illinois, 60612, United States
University of Chicago Comprehensive Cancer Center, Chicago, Illinois, 60637, United States
Carle at The Riverfront, Danville, Illinois, 61832, United States
Decatur Memorial Hospital, Decatur, Illinois, 62526, United States
Northwestern Medicine Cancer Center Kishwaukee, DeKalb, Illinois, 60115, United States
Carle Physician Group-Effingham, Effingham, Illinois, 62401, United States
Northwestern Medicine Cancer Center Delnor, Geneva, Illinois, 60134, United States
Northwestern Medicine Lake Forest Hospital, Lake Forest, Illinois, 60045, United States
Carle Physician Group-Mattoon/Charleston, Mattoon, Illinois, 61938, United States
Loyola University Medical Center, Maywood, Illinois, 60153, United States
HSHS Saint Elizabeth's Hospital, O'Fallon, Illinois, 62269, United States
Advocate Children's Hospital-Oak Lawn, Oak Lawn, Illinois, 60453, United States
Advocate Children's Hospital-Park Ridge, Park Ridge, Illinois, 60068, United States
Saint Jude Midwest Affiliate, Peoria, Illinois, 61637, United States
Southern Illinois University School of Medicine, Springfield, Illinois, 62702, United States
Springfield Clinic, Springfield, Illinois, 62702, United States
Springfield Memorial Hospital, Springfield, Illinois, 62781, United States
Carle Cancer Center, Urbana, Illinois, 61801, United States
Northwestern Medicine Cancer Center Warrenville, Warrenville, Illinois, 60555, United States
Indiana
Riley Hospital for Children, Indianapolis, Indiana, 46202, United States
Reid Health, Richmond, Indiana, 47374, United States
Iowa
UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny, Iowa, 50023, United States
UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive, Iowa, 50325, United States
Blank Children's Hospital, Des Moines, Iowa, 50309, United States
Mercy Medical Center - Des Moines, Des Moines, Iowa, 50314, United States
UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines, Iowa, 50314, United States
University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa, 52242, United States
Siouxland Regional Cancer Center, Sioux City, Iowa, 51101, United States
UI Health Care Mission Cancer and Blood - Waukee Clinic, Waukee, Iowa, 50263, United States
Kansas
Wesley Medical Center, Wichita, Kansas, 67214, United States
Kentucky
University of Kentucky/Markey Cancer Center, Lexington, Kentucky, 40536, United States
Norton Children's Hospital, Louisville, Kentucky, 40202, United States
Louisiana
Children's Hospital New Orleans, New Orleans, Louisiana, 70118, United States
Ochsner Medical Center Jefferson, New Orleans, Louisiana, 70121, United States
Maine
Eastern Maine Medical Center, Bangor, Maine, 04401, United States
Maine Children's Cancer Program, Scarborough, Maine, 04074, United States
Maryland
University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland, 21201, United States
Greater Baltimore Medical Center, Baltimore, Maryland, 21204, United States
Sinai Hospital of Baltimore, Baltimore, Maryland, 21215, United States
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland, 21287, United States
Walter Reed National Military Medical Center, Bethesda, Maryland, 20889-5600, United States
Massachusetts
Tufts Medical Center, Boston, Massachusetts, 02111, United States
Dana-Farber Cancer Institute, Boston, Massachusetts, 02215, United States
Michigan
C S Mott Children's Hospital, Ann Arbor, Michigan, 48109, United States
Children's Hospital of Michigan, Detroit, Michigan, 48201, United States
Henry Ford Hospital, Detroit, Michigan, 48202, United States
Michigan State University, East Lansing, Michigan, 48823, United States
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids, Michigan, 49503, United States
Bronson Methodist Hospital, Kalamazoo, Michigan, 49007, United States
Corewell Health Lakeland Hospitals - Niles Hospital, Niles, Michigan, 49120, United States
Corewell Health Children's, Royal Oak, Michigan, 48073, United States
Minnesota
Minnesota Oncology - Burnsville, Burnsville, Minnesota, 55337, United States
Mercy Hospital, Coon Rapids, Minnesota, 55433, United States
Fairview Southdale Hospital, Edina, Minnesota, 55435, United States
Unity Hospital, Fridley, Minnesota, 55432, United States
Minnesota Oncology Hematology PA-Maplewood, Maplewood, Minnesota, 55109, United States
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis, Minnesota, 55404, United States
Abbott-Northwestern Hospital, Minneapolis, Minnesota, 55407, United States
Park Nicollet Clinic - Saint Louis Park, Saint Louis Park, Minnesota, 55416, United States
United Hospital, Saint Paul, Minnesota, 55102, United States
Mississippi
University of Mississippi Medical Center, Jackson, Mississippi, 39216, United States
Missouri
Saint Luke's Hospital, Chesterfield, Missouri, 63017, United States
Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters, Missouri, 63376, United States
Siteman Cancer Center at West County Hospital, Creve Coeur, Missouri, 63141, United States
Children's Mercy Hospitals and Clinics, Kansas City, Missouri, 64108, United States
Washington University School of Medicine, St Louis, Missouri, 63110, United States
Siteman Cancer Center-South County, St Louis, Missouri, 63129, United States
Siteman Cancer Center at Christian Hospital, St Louis, Missouri, 63136, United States
Mercy Hospital Saint Louis, St Louis, Missouri, 63141, United States
Nebraska
Children's Hospital and Medical Center of Omaha, Omaha, Nebraska, 68114, United States
University of Nebraska Medical Center, Omaha, Nebraska, 68198, United States
Nevada
Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas, Nevada, 89135, United States
Renown Regional Medical Center, Reno, Nevada, 89502, United States
New Hampshire
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire, 03756, United States
New Jersey
Memorial Sloan Kettering Basking Ridge, Basking Ridge, New Jersey, 07920, United States
Hackensack University Medical Center, Hackensack, New Jersey, 07601, United States
Memorial Sloan Kettering Monmouth, Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Bergen, Montvale, New Jersey, 07645, United States
Morristown Medical Center, Morristown, New Jersey, 07960, United States
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick, New Jersey, 08903, United States
Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, 08903, United States
Saint Joseph's Regional Medical Center, Paterson, New Jersey, 07503, United States
New Mexico
Presbyterian Hospital, Albuquerque, New Mexico, 87106, United States
New York
Albany Medical Center, Albany, New York, 12208, United States
Roswell Park Cancer Institute, Buffalo, New York, 14263, United States
Memorial Sloan Kettering Commack, Commack, New York, 11725, United States
Memorial Sloan Kettering Westchester, Harrison, New York, 10604, United States
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, New York, 11040, United States
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York, 10032, United States
Memorial Sloan Kettering Cancer Center, New York, New York, 10065, United States
NYP/Weill Cornell Medical Center, New York, New York, 10065, United States
University of Rochester, Rochester, New York, 14642, United States
Stony Brook University Medical Center, Stony Brook, New York, 11794, United States
State University of New York Upstate Medical University, Syracuse, New York, 13210, United States
Montefiore Medical Center - Moses Campus, The Bronx, New York, 10467, United States
Memorial Sloan Kettering Nassau, Uniondale, New York, 11553, United States
New York Medical College, Valhalla, New York, 10595, United States
Wilmot Cancer Institute at Webster, Webster, New York, 14580, United States
North Carolina
Mission Hospital, Asheville, North Carolina, 28801, United States
AdventHealth Infusion Center Asheville, Asheville, North Carolina, 28803, United States
Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina, 28203, United States
Novant Health Presbyterian Medical Center, Charlotte, North Carolina, 28204, United States
East Carolina University, Greenville, North Carolina, 27834, United States
AdventHealth Hendersonville, Hendersonville, North Carolina, 28792, United States
Wake Forest University Health Sciences, Winston-Salem, North Carolina, 27157, United States
North Dakota
Sanford Broadway Medical Center, Fargo, North Dakota, 58122, United States
Ohio
Children's Hospital Medical Center of Akron, Akron, Ohio, 44308, United States
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 45229, United States
Rainbow Babies and Childrens Hospital, Cleveland, Ohio, 44106, United States
Cleveland Clinic Foundation, Cleveland, Ohio, 44195, United States
Nationwide Children's Hospital, Columbus, Ohio, 43205, United States
Dayton Children's Hospital, Dayton, Ohio, 45404, United States
Dayton Physician LLC - Englewood, Dayton, Ohio, 45415, United States
Greater Dayton Cancer Center, Kettering, Ohio, 45409, United States
Kettering Medical Center, Kettering, Ohio, 45429, United States
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo, Ohio, 43606, United States
Oklahoma
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, United States
Oregon
Legacy Emanuel Children's Hospital, Portland, Oregon, 97227, United States
Oregon Health and Science University, Portland, Oregon, 97239, United States
Pennsylvania
Lehigh Valley Hospital-Cedar Crest, Allentown, Pennsylvania, 18103, United States
Geisinger Medical Center, Danville, Pennsylvania, 17822, United States
Penn State Children's Hospital, Hershey, Pennsylvania, 17033, United States
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, 19104, United States
Saint Christopher's Hospital for Children, Philadelphia, Pennsylvania, 19134, United States
Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania, 15224, United States
Rhode Island
Rhode Island Hospital, Providence, Rhode Island, 02903, United States
South Carolina
Prisma Health Richland Hospital, Columbia, South Carolina, 29203, United States
Saint Francis Hospital, Greenville, South Carolina, 29601, United States
BI-LO Charities Children's Cancer Center, Greenville, South Carolina, 29605, United States
Saint Francis Cancer Center, Greenville, South Carolina, 29607, United States
Prisma Health Cancer Institute - Eastside, Greenville, South Carolina, 29615, United States
South Dakota
Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota, 57117-5134, United States
Tennessee
East Tennessee Childrens Hospital, Knoxville, Tennessee, 37916, United States
Saint Jude Children's Research Hospital, Memphis, Tennessee, 38105, United States
The Children's Hospital at TriStar Centennial, Nashville, Tennessee, 37203, United States
Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee, 37232, United States
Texas
Texas Tech University Health Sciences Center-Amarillo, Amarillo, Texas, 79106, United States
Dell Children's Medical Center of Central Texas, Austin, Texas, 78723, United States
Driscoll Children's Hospital, Corpus Christi, Texas, 78411, United States
Medical City Dallas Hospital, Dallas, Texas, 75230, United States
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas, 75390, United States
El Paso Children's Hospital, El Paso, Texas, 79905, United States
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas, 77030, United States
Houston Methodist Hospital, Houston, Texas, 77030, United States
M D Anderson Cancer Center, Houston, Texas, 77030, United States
Covenant Children's Hospital, Lubbock, Texas, 79410, United States
UMC Cancer Center / UMC Health System, Lubbock, Texas, 79415, United States
Children's Hospital of San Antonio, San Antonio, Texas, 78207, United States
Methodist Children's Hospital of South Texas, San Antonio, Texas, 78229, United States
University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229, United States
Utah
Primary Children's Hospital, Salt Lake City, Utah, 84113, United States
Virginia
University of Virginia Cancer Center, Charlottesville, Virginia, 22908, United States
Inova Fairfax Hospital, Falls Church, Virginia, 22042, United States
Children's Hospital of The King's Daughters, Norfolk, Virginia, 23507, United States
VCU Massey Comprehensive Cancer Center, Richmond, Virginia, 23298, United States
Carilion Children's, Roanoke, Virginia, 24014, United States
Washington
Valley Medical Center, Renton, Washington, 98055, United States
Seattle Children's Hospital, Seattle, Washington, 98105, United States
Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington, 99204, United States
Mary Bridge Children's Hospital and Health Center, Tacoma, Washington, 98405, United States
Madigan Army Medical Center, Tacoma, Washington, 98431, United States
West Virginia
West Virginia University Charleston Division, Charleston, West Virginia, 25304, United States
Wisconsin
University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin, 53792, United States
Marshfield Medical Center-Marshfield, Marshfield, Wisconsin, 54449, United States
New South Wales
John Hunter Children's Hospital, Hunter Regional Mail Centre, New South Wales, 2310, Australia
The Children's Hospital at Westmead, Westmead, New South Wales, 2145, Australia
Queensland
Queensland Children's Hospital, South Brisbane, Queensland, 4101, Australia
Victoria
Royal Children's Hospital, Parkville, Victoria, 3052, Australia
Western Australia
Perth Children's Hospital, Perth, Western Australia, 6009, Australia
Alberta
University of Alberta Hospital, Edmonton, Alberta, T6G 2B7, Canada
Manitoba
CancerCare Manitoba, Winnipeg, Manitoba, R3E 0V9, Canada
Newfoundland and Labrador
Janeway Child Health Centre, St. John's, Newfoundland and Labrador, A1B 3V6, Canada
Nova Scotia
IWK Health Centre, Halifax, Nova Scotia, B3K 6R8, Canada
Ontario
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton, Ontario, L8N 3Z5, Canada
Children's Hospital, London, Ontario, N6A 5W9, Canada
Children's Hospital of Eastern Ontario, Ottawa, Ontario, K1H 8L1, Canada
Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada
Quebec
The Montreal Children's Hospital of the MUHC, Montreal, Quebec, H3H 1P3, Canada
Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec, H3T 1C5, Canada
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke, Quebec, J1H 5N4, Canada
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Québec, G1V 4G2, Canada
HIMA San Pablo Oncologic Hospital, Caguas, 00726, Puerto Rico