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临床试验 NCT04649242 针对Pediatric Migraine目前招募中。请查看临床试验雷达卡片视图和 AI 发现工具了解所有详情，或在此提出任何问题。
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Randomized Study in Children and Adolescents With Migraine: Acute Treatment III期 2,100 随机化 青少年

招募中
临床试验详情主要以英语提供。然而，试验雷达 AI可以提供帮助！只需点击“试验详解”即可查看和讨论您选择的语言的试验信息。
临床试验NCT04649242旨在研究治疗，主要针对Pediatric Migraine。这是一项III期 干预性研究试验，目前试验状态为招募中。试验始于2021年1月15日，计划招募2,100名患者。该研究由辉瑞主导，预计于2029年1月9日完成。试验数据来源于ClinicalTrials.gov，最后更新时间为2026年3月20日。
简要概括
The purpose of this study is to test the safety and efficacy of BHV-3000 versus placebo in the acute treatment of moderate or severe migraine in children and adolescents.
官方标题

Phase 3, Multicenter, Randomized, Double-blind, Group Sequential, Placebo-controlled Study to Assess Efficacy and Safety of Rimegepant for the Treatment of Migraine (With or Without Aura) in Children and Adolescents ≥ 6 to < 18 Years of Age

疾病
Pediatric Migraine
其他研究标识符
  • BHV3000-311
  • C4951002 (其他标识符) (Alias Study Number)
  • 2020-003517-35 (注册标识符) (CTIS (EU))
  • 2024-512743-23-00 (注册标识符) (CTIS (EU))
NCT编号
NCT04649242
实际开始日期
2021-01-15
最近更新发布
2026-03-20
预计完成日期
2029-01-09
计划入组人数
2,100
研究类型
干预性研究
试验分期 (阶段)
III期
试验状态
招募中
关键词
Migraine
Acute treatment
Phonophobia
Photophobia
Nausea
Pediatric
Children
Adolescent
Pediatric Migraine
主要目的
治疗方法
分配方式
随机
干预模型
序贯设计
盲法
三盲
试验组/干预措施
参与者组/试验组干预措施/治疗方法
阳性对照BHV3000 (active drug)
BHV3000 (rimegepant) 75 mg or 50 mg ODT
Rimegepant/BHV3000
BHV3000 (rimegepant) 75 mg or 50 mg ODT
安慰剂对照Placebo
Matching 75 mg or 50 mg ODT placebo
匹配安慰剂
Matching 75 mg or 50 mg ODT placebo
主要终点
结果指标度量标准描述时间框架
To evaluate the efficacy of rimegepant compared with placebo in the acute treatment of migraine in adolescent population (≥ 12 to <18 years of age) as measured by pain freedom using the number of patients reporting no pain.
Pain freedom will be assessed in adolescent population (≥ 12 to \< 18 years of age) on a 4-point numeric rating scale (0=none, 1=mild, 2=moderate, 3=severe).
2 hours post-dose
次要终点
结果指标度量标准描述时间框架
To compare rimegepant with placebo for pain freedom in children and adolescents combined.
Pain freedom will be assessed in children and adolescents (≥ 6 to \< 18 years of age) using a 4-point numeric rating scale (0=none, 1=mild, 2=moderate, 3=severe). Pain freedom will be assessed in children (\> 6 to \< 12 years of age) using the 5-Face VAS (Face 5 = 'severe pain', Faces 4 and 3 = 'moderate pain', Face 2 = 'mild pain', Face 1 = 'no pain').
2 hours post-dose
To compare rimegepant with placebo on freedom from the most bothersome symptom (MBS) associated with migraine in adolescents.
Freedom from MBS (nausea, phonophobia or photophobia) will be measured using a binary scale (0=absent, 1=present).
2 hours post-dose
To compare rimegepant with placebo on the probabilities of requiring rescue medication within in adolescents.
Use of rescue medication will be assessed using the numbers of participants that take rescue medication.
Within 24 hours and 48 hours of initial treatment
To compare rimegepant with placebo on sustained pain freedom in adolescents.
Sustained pain freedom will be assessed using the number of participants that do not use any rescue medications and do not experience any headache pain post dose.
2 to 24 hours post-dose
To compare rimegepant with placebo on sustained pain freedom in adolescents.
Sustained pain freedom will be assessed using the number of participants that do not use any rescue medications and do not experience any headache pain post dose.
2 to 48 hours post-dose
To compare rimegepant with placebo on the ability to function normally as reported on the Functional Disability scale in adolescents.
The proportion of participants able to function normally will be assessed using the number that self-report as "normal" on the Functional Disability scale.
2 hours post-dose
To compare rimegepant with placebo for pain freedom in children.
Pain freedom will be assessed using the number of children (≥ 6 to \< 12 years of age) that report no pain measured by a 5-Face VAS (Face 5 = 'severe pain', Faces 4 and 3 = 'moderate pain', Face 2 = 'mild pain', Face 1 = 'no pain').
2 hours post-dose
To compare rimegepant with placebo on freedom from the most bothersome symptom (MBS) associated with migraine in children and combined children and adolescents.
Freedom from the most bothersome symptom (nausea, phonophobia or photophobia) will be assessed using the number of participants that report the absence of MBS measured using a binary scale (0=absent, 1=present).
2 hours post-dose
To compare rimegepant with placebo on the probabilities of requiring rescue medication in children and combined children and adolescents.
The probabilities of requiring rescue medication will be assessed using the numbers of participants that take rescue medication within initial treatment.
Within 24 hours and 48 hours of initial treatment.
To compare rimegepant with placebo on sustained pain freedom in children and combined children and adolescents.
Sustained pain freedom will be assessed using the number of participants that do not use any rescue medications and do not experience any headache pain post dose.
2 to 24 hours post-dose
To compare rimegepant with placebo on sustained pain freedom in children and combined children and adolescents.
Sustained pain freedom will be assessed using the number of participants that do not use any rescue medications and do not experience any headache pain post dose.
2 to 48 hours post-dose
To compare rimegepant with placebo on freedom from photophobia in adolescents, children and combined children and adolescents.
Freedom from photophobia will be assessed by the number of participants that report the absence of photophobia post dose that reported the presence of photophobia at baseline.
2 hours post-dose
To compare rimegepant with placebo on freedom from phonophobia in adolescents, children and combined children and adolescents.
Freedom from phonophobia will be assessed by the number of participants that report the absence of phonophobia post dose that reported the presence of phonophobia at baseline.
2 hours post-dose
To compare rimegepant with placebo on freedom from nausea in adolescents, children and combined children and adolescents.
Freedom from nausea will be assessed by the number of participants that report the absence of nausea post dose that reported the presence of nausea at baseline.
2 hours post-dose
To compare rimegepant with placebo on pain relief in adolescents, children and combined children and adolescents.
Pain relief will be assessed using the number of participants that report a pain level of moderate or severe at baseline and then report a pain level of none or mild post dose.
2 hours post-dose
To compare rimegepant with placebo in adolescents, children and combined children and adolescents on pain relief.
Time to first report of pain relief will be based on the first time point a participant reports a pain level of none or mild.
Time to patients first report of pain relief of none or mild post dose up to 48 hours.
参与助手
资格标准

适龄参与研究
儿童
最低年龄要求
6 Years
适龄性别
全部

  1. History of migraine (with or without aura) for > 6 months before Screening according to the IHS Classification ICHD-319 specifications for pediatric migraine. History may be verified using both medical records and recall by the participant and/or participant's parent(s)/legal representative(s).

  2. History of 1 to 8 moderate or severe attacks per month during the 2 months prior to enrollment, with attacks lasting > 3 hours without treatment, and attacks occurring at intervals > 24 hours.

  3. Prophylactic migraine medication are permitted if the dose has been stable for at least 12 weeks prior to the Baseline Visit, and the dose is not expected to change during the course of the study.

    1. Participants may remain on one (1) medication with possible migraine prophylactic effects, excluding CGRP antagonists \[biologic or small molecule\], during the treatment phases.
    2. Concomitant use of a CGRP antagonist, such as erenumab or fremanezumab, is prohibited.
    3. Previously discontinued prophylactic migraine medication must have done so at least 90 days prior to the Screening Visit.

  4. Verbally distinguish between migraine and other types of headaches.

  5. Participants must have a weight > 40 kg at the Screening Visit.

  6. Adequate venous access for blood sampling.

  7. Male and female participants ≥ 6 to < 18 years of age (participants must not reach their 18th birthday during the study).

  1. History of cluster headache or hemiplegic migraine headache.
  2. Confounding and clinically significant pain syndrome that may interfere with the participant's ability to participate in this study.
  3. Current psychiatric condition that is uncontrolled and/or untreated for a minimum of 6 months prior to the Screening Visit. Participants with a lifetime history of psychosis and/or mania.
  4. History of suicidal behavior or major psychiatric disorder.
  5. Current diagnosis or history of substance abuse; positive drug test at Screening.
  6. History of moderate or severe head trauma or other neurological disorder (including seizure disorder) or systemic medical disease that is likely to affect central nervous system functioning.
  7. Recent or planned surgery, requiring general anesthesia, <8 weeks prior to the Screening Visit.
  8. Participant has had gastrointestinal surgery that interferes with physiological absorption and motility (i.e., gastric bypass, duodenectomy, or gastric banding).
  9. Current diagnosis of viral hepatitis or a history of liver disease.
  10. Conditions considered clinically relevant in the context of the study such as uncontrolled hypertension (high blood pressure), diabetes, a life-threatening allergy
Pfizer logo辉瑞457 个活跃的临床试验可供探索
研究中心联系人
联系人: Pfizer Pfizer CT.gov Call Center, 1-800-718-1021, [email protected]
245 位于 9 个国家/地区的研究中心

Anhui

First Affiliated Hospital of Bengbu Medical College Neurology, Bengbu, Anhui, 233000, China
招募中
Anhui Provincial Hospital, Hefei, Anhui, 230000, China
招募中

Beijing Municipality

Chinese PLA General Hospital, Beijing, Beijing Municipality, 100089, China
招募中

Chongqing Municipality

" The First Affiliated Hospital of Chongqing Medical University", Chongqing, Chongqing Municipality, 400042, China
招募中

Gansu

Lanzhou university second hospital, Lanzhou, Gansu, 730030, China
招募中

Guangdong

Shenzhen Children's Hospital, Shenzhen, Guangdong, 518034, China
招募中

Hainan

Hainan General Hospital, Haikou, Hainan, 571140, China
招募中

Hebei

The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, China
招募中
The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050004, China
招募中

Henan

People's Hospital of Zhengzhou, Zhengzhou, Henan, 450000, China
招募中

Hubei

Jingzhou First People's Hospital, Jingzhou, Hubei, 434000, China
招募中
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, China
招募中
Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, China
招募中

Hunan

The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410000, China
招募中
Hunan Children's Hospital, Changsha, Hunan, 410007, China
招募中
The Third Xiangya Hospital of Central South University, Changsha, Hunan, 410013, China
招募中

Jiangsu

The Second People's Hospital of Lianyungang, Lianyungang, Jiangsu, 222002, China
招募中
The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215006, China
招募中
Wuxi Children's Hospital, Wuxi, Jiangsu, 214023, China
招募中
Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, 214115, China
招募中
Xuzhou Children's Hospital, Xuzhou, Jiangsu, 221002, China
招募中
Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, 212001, China
招募中

Jilin

The First Hospital of Jilin University, Pediatric Neurology, Changchun, Jilin, 130021, China
招募中

Ningxia

General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 756000, China
招募中

Shaanxi

Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, 710068, China
招募中
Xi'an Gaoxin Hospital Neurology Department, Xi'an, Shaanxi, 710075, China
招募中
Yan 'an University Xianyang Hospital, Xianyang, Shaanxi, 716000, China
招募中

Shandong

Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, 250013, China
招募中
Liaocheng People's Hospital, Liaocheng, Shandong, 252000, China
招募中

Sichuan

West China Hospital of Sichuan University, Chengdu, Sichuan, 610041, China
招募中

Zhejiang

Children's Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310052, China
招募中
Ningbo Women and Children's Hospital, Ningbo, Zhejiang, 315012, China
招募中
The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China
招募中
Lu 'an People's Hospital, Lu'an, China
招募中
Children's Hospital of Shanghai, Shanghai, China
招募中
Shengjing Hospital of China Medical University, Shenyang, China
招募中
The First Affiliated Hospital of Shihezi University School of Medicine, Shihezi, China
进行中（不再招募）
Wuhan Children's Hospital, Wuhan, China
招募中

Alabama

Achieve Clinical Research, LLC d/b/a Accel Research Sites-Neurology and Neurodiagnostic of Alabama, Birmingham, Alabama, 35244, United States
进行中（不再招募）

Arizona

Perseverance Research Center, LLC, Scottsdale, Arizona, 85253, United States
招募中
Physicians Research Group, Tempe, Arizona, 85284, United States
进行中（不再招募）

California

Advanced Research Center, Inc., Anaheim, California, 92805, United States
招募中
Adult & Child Neurology Medical Associates, Costa Mesa, California, 92627, United States
招募中
ProScience Research Group, Culver City, California, 90230, United States
招募中
Memorial Health Services, Fountain Valley, California, 92708, United States
招募中
Neuro-Pain Medical Center, Fresno, California, 93710, United States
招募中
Regents of the University of California (UC San Diego), La Jolla, California, 92093, United States
招募中
Adult & Child Neurology Medical Associates, Long Beach, California, 90806, United States
招募中
Miller Children's & Women's Hospital Long Beach, Long Beach, California, 90806, United States
招募中
National Research Institute, Los Angeles, California, 90057, United States
进行中（不再招募）
Velocity Clinical Research - North Hollywood, North Hollywood, California, 91606, United States
进行中（不再招募）
Children's Hospital of Orange County - Inpatient Pharmacy, Orange, California, 92868, United States
尚未招募
Children's Hospital of Orange County - Neuroscience Center, Orange, California, 92868, United States
尚未招募
Children's Hospital of Orange County, Orange, California, 92868, United States
尚未招募
The Neurology Group, Pomona, California, 91767, United States
招募中
University of California, Davis Midtown Clinic, Sacramento, California, 95816, United States
进行中（不再招募）
UC Davis Medical Center, Investigational Drug Service (IDS) Pharmacy, Sacramento, California, 95817, United States
进行中（不再招募）
University of California, Davis Clinical and Translational Science Center Clinical Research (CCRC), Sacramento, California, 95817, United States
进行中（不再招募）
Velocity Clinical Research, San Bernardino (IP Delivery and Administering Location), San Bernardino, California, 92408, United States
招募中
Pacific Clinical Research Management Group LLC, Upland, California, 91786, United States
进行中（不再招募）
Sunwise Clinical Research, Walnut Creek, California, 94596, United States
招募中

Colorado

Children's Hospital Colorado- lnvestigational Drug Services, Aurora, Colorado, 80045, United States
招募中
Children's Hospital Colorado, Aurora, Colorado, 80045, United States
招募中
Colorado Springs Neurological Associates, PC, Colorado Springs, Colorado, 80907, United States
招募中
Colorado Springs Neurological Associates, PC, Colorado Springs, Colorado, 80919, United States
招募中

Connecticut

CT Clinical Research, Cromwell, Connecticut, 06416, United States
招募中
Connecticut Children's Medical Center, Hartford, Connecticut, 06106, United States
进行中（不再招募）
Ki Health Partners, LLc, dba New England Institute for Clinical Research, Stamford, Connecticut, 06905, United States
招募中

Delaware

Nemours Children's Hospital, Delaware, Wilmington, Delaware, 19803, United States
进行中（不再招募）

District of Columbia

Children's National Medical Center, Washington D.C., District of Columbia, 20010, United States
招募中

Florida

Topaz Clinical Research, Inc., Apopka, Florida, 32703, United States
进行中（不再招募）
Beautiful Minds Clinical Research Center, Cutler Bay, Florida, 33157, United States
已终止
DeLand Clinical Research Unit, DeLand, Florida, 32720, United States
已终止
Sarkis Clinical Trials, Gainesville, Florida, 32607, United States
进行中（不再招募）
Multi-Specialty Research Associates, Inc., Lake City, Florida, 32055, United States
进行中（不再招募）
Watson Clinic Center for Research, Inc., Lakeland, Florida, 33805, United States
已终止
Watson Clinic LLP, Lakeland, Florida, 33805, United States
已终止
AppleMed Research Group, LLC, Miami, Florida, 33126, United States
招募中
Medical Research Center of Miami II, Inc, Miami, Florida, 33134, United States
进行中（不再招募）
Nicklaus Children's Hospital, Research Institute, Miami, Florida, 33155, United States
尚未招募
South Florida Research Phase I-IV, Inc, Miami, Florida, 33166, United States
招募中
Brainstorm Research, Miami, Florida, 33176, United States
进行中（不再招募）
Advanced Research for Health Improvement, LLC/ Dr. Cordero's Pediatric Office, Naples, Florida, 34102, United States
进行中（不再招募）
Aqualane Clinical Research, Naples, Florida, 34105, United States
招募中
Coastal Clinical Research Specialists, Orange Park, Florida, 32073, United States
进行中（不再招募）
Clinical Associates of Orlando, LLC, Orlando, Florida, 32819, United States
招募中
Bioresearch Institute, Pembroke Pines, Florida, 33026, United States
已终止
Forcare Clinical Research, Tampa, Florida, 33613, United States
招募中
Premiere Research Institute at Palm Beach Neurology, West Palm Beach, Florida, 33407, United States
进行中（不再招募）

Georgia

Children's Healthcare of Atlanta, Inc., Atlanta, Georgia, 30329, United States
招募中
Childrens Healthcare of Atlanta, Atlanta, Georgia, 30329, United States
招募中
Rare Disease Research, LLC, Atlanta, Georgia, 30329, United States
进行中（不再招募）
Pivotal Clinical Research & Associates, LLC, Brunswick, Georgia, 31520, United States
招募中
CenExel iResearch, LLC, Decatur, Georgia, 30030, United States
招募中

Illinois

Chicago Headache Center & Research Institute, Chicago, Illinois, 60657, United States
招募中
AMR-Baber Research Inc, Naperville, Illinois, 60563, United States
招募中

Indiana

Options Research Group, LLC, Westfield, Indiana, 46074, United States
招募中

Iowa

Velocity Clinical Research, Sioux City, Sioux City, Iowa, 51106, United States
招募中
Integrated Clinical Trial Services, West Des Moines, Iowa, 50265, United States
招募中

Kansas

Clinical Associates Midwest, LLC, Kansas City, Kansas, 66214, United States
招募中
College Park Family Care Center Physicians Group- Neurology Research Dept., Overland Park, Kansas, 66212, United States
进行中（不再招募）

Kentucky

Kentucky Neuroscience Institute Child Neurology-- "Patients Seen", Lexington, Kentucky, 40504, United States
进行中（不再招募）
UK Center for Clinical and Translational Science (CCTS) -- "Patients Seen", Lexington, Kentucky, 40536, United States
进行中（不再招募）
University of Kentucky Hospital, Lexington, Kentucky, 40536, United States
进行中（不再招募）

Louisiana

Ochsner Clinic Foundation, New Orleans, Louisiana, 70121, United States
进行中（不再招募）
Neurology and Headache Center, Inc., Shreveport, Louisiana, 71105, United States
进行中（不再招募）

Massachusetts

Boston Clinical Trials, Boston, Massachusetts, 02131, United States
进行中（不再招募）
MedVadis Research Corporation, Waltham, Massachusetts, 02451, United States
进行中（不再招募）

Michigan

Michigan Head Pain & Neurological Institute, Ann Arbor, Michigan, 48104, United States
招募中
Corewell Health, for and on behalf of Spectrum Health Hospital and Corewell Health Medical Group, Grand Rapids, Michigan, 49503, United States
招募中
Corewell Health, Helen DeVos Children's Hospital, Grand Rapids, Michigan, 49503, United States
招募中
Wellnow Urgent Care and Research, Kalamazoo, Michigan, 49048, United States
进行中（不再招募）
Beaumont Hospital Royal Oak Campus, Royal Oak, Michigan, 48073, United States
招募中

Minnesota

Brackenridge Outpatient Research Pharmacy, Rochester, Minnesota, 55905, United States
招募中
Clinical Research Trials Unit, Rochester, Minnesota, 55905, United States
招募中
Mayo Clinic, Rochester, Minnesota, 55905, United States
招募中

Mississippi

Precise Research Centers, Flowood, Mississippi, 39232, United States
招募中

Missouri

Sharlin Health Neuroscience Research Center, Ozark, Missouri, 65721, United States
招募中
Clinvest Research, LLC, Springfield, Missouri, 65810, United States
进行中（不再招募）

Montana

Boeson Research, Great Falls, Montana, 59405, United States
招募中
Boeson Research, Kalispell, Montana, 59901, United States
进行中（不再招募）
Heart & Hands Midwifery, Kalispell, Montana, 59901, United States
进行中（不再招募）
Blue Moose Pediatrics, Missoula, Montana, 59804, United States
招募中
Boeson Research Laboratory, Missoula, Montana, 59804, United States
招募中
Boeson Research, Missoula, Montana, 59804, United States
招募中

Nebraska

Alivation Research, LLC., Lincoln, Nebraska, 68526, United States
已终止
Children's Hospital & Medical Center, Omaha, Nebraska, 68114, United States
招募中

New Jersey

HMH Jersey Shore University Medical Center, Neptune City, New Jersey, 07753, United States
招募中

New York

Dent Neurosciences Research Center, Amherst, New York, 14226, United States
招募中
True North Neurology, Commack, New York, 11725, United States
招募中
Northwell Health/ Division of Pediatric Neurology, Lake Success, New York, 11042, United States
招募中
NYU Langone Hospital-Long Island, Clinical Research Center, Mineola, New York, 11501, United States
进行中（不再招募）
NYU Langone Hospital-Long Island, Pediatric Neurology, Mineola, New York, 11501, United States
进行中（不再招募）
New York Neurology Associates, New York, New York, 10003, United States
招募中
Weill Cornell Medicine, New York, New York, 10021, United States
招募中
Mount Sinai Hospital - Pharmacy Department, New York, New York, 10029, United States
进行中（不再招募）
Columbia University Medical Center Research Pharmacy, New York, New York, 10032, United States
进行中（不再招募）
Columbia University Pediatric Neuromuscular Center, New York, New York, 10032, United States
进行中（不再招募）
Irving Center for Clinical and Translational Research, Outpatient Clinical Research Unit, New York, New York, 10032, United States
进行中（不再招募）
The Neurological Institute of New York, New York, New York, 10032, United States
进行中（不再招募）
The Trustees of Columbia University and The New York and Presbyterian Hospital, New York, New York, 10032, United States
进行中（不再招募）
North Suffolk Neurology P.C, Port Jefferson Station, New York, 11776, United States
进行中（不再招募）
Finger Lakes Clinical Research, Rochester, New York, 14618, United States
已终止
Prime Global Research, LLC, The Bronx, New York, 10456, United States
已终止

North Carolina

New Hope Clinical Research, Charlotte, North Carolina, 28211, United States
进行中（不再招募）
OnSite Clinical Solutions, LLC, Charlotte, North Carolina, 28277, United States
招募中
Velocity Clinical Research, Inc., Durham, North Carolina, 27701, United States
招募中
Headache Wellness Center, PC, Greensboro, North Carolina, 27405, United States
招募中

Ohio

Akron Children's Hospital, Akron, Ohio, 44308, United States
招募中
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 45229, United States
招募中
Velocity Clinical Research, Cincinnati, Ohio, 45242, United States
招募中
University Hospitals Cleveland Medical Center, Cleveland, Ohio, 44106, United States
招募中
Nationwide Children's Hospital, Columbus, Ohio, 43205, United States
进行中（不再招募）
Wellnow Urgent Care and Research, Columbus, Ohio, 43228, United States
进行中（不再招募）
Neuro-Behavioral Clinical Research, Inc., North Canton, Ohio, 44720, United States
进行中（不再招募）

Oklahoma

IPS Research Company, Oklahoma City, Oklahoma, 73106, United States
进行中（不再招募）
Lynn Institute of Tulsa, Tulsa, Oklahoma, 74135, United States
进行中（不再招募）

Oregon

Velocity Clinical Research, Grants Pass, Grants Pass, Oregon, 97527, United States
进行中（不再招募）
Providence Health & Services Investigational Drug Services Westside, Portland, Oregon, 97225, United States
招募中
Providence Neuroscience Institute - Research Coordinator's Office, Portland, Oregon, 97225, United States
招募中
Providence Pediatric Neurology, Portland, Oregon, 97225, United States
招募中
Providence St. Vincent Medical Center, Portland, Oregon, 97225, United States
招募中

Pennsylvania

Clario, Philadelphia, Pennsylvania, 19103, United States
招募中
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, 19104, United States
进行中（不再招募）

Rhode Island

Velocity Clinical Research-Providence, East Greenwich, Rhode Island, 02818, United States
招募中

South Carolina

Premier Neurology, PC, Greenville, South Carolina, 29605, United States
进行中（不再招募）
Tribe Clinical Research, LLC, Greenville, South Carolina, 29607, United States
进行中（不再招募）
Velocity Clinical Research - Greenville, Greenville, South Carolina, 29615, United States
进行中（不再招募）

Tennessee

Holston Medical Group., Kingsport, Tennessee, 37660, United States
进行中（不再招募）
Holston Medical Group, Kingsport, Tennessee, 37660, United States
进行中（不再招募）
Le Bonheur Children's Hospital - Outpatient Building, Memphis, Tennessee, 38103, United States
招募中
Le Bonheur Children's Hospital, Memphis, Tennessee, 38103, United States
招募中
Le Bonheur Childrens Hospital - Childrens Foundation Research Institute, Memphis, Tennessee, 38103, United States
招募中
Access Clinical Trials, Inc., Nashville, Tennessee, 37203, United States
进行中（不再招募）

Texas

Dell Children's Medical Center, Austin, Texas, 78723, United States
招募中
Child Neurology Consultants of Austin - South Austin, Austin, Texas, 78749, United States
招募中
Child Neurology Consultants of Austin - Central Austin, Austin, Texas, 78757, United States
招募中
BioBehavioral Research of Austin, Austin, Texas, 78759, United States
进行中（不再招募）
Houston Clinical Trials, LLC, Bellaire, Texas, 77401, United States
招募中
Infinite Research Group, LLC, Dallas, Texas, 75201, United States
招募中
Children's Medical Center, Dallas, Dallas, Texas, 75235, United States
招募中
Children's Medical Center, Pediatric Anesthesiology Research (Study supplies only), Dallas, Texas, 75235, United States
招募中
Cedar Health Research, Dallas, Texas, 75251, United States
招募中
FutureSearch Trials of Dallas, LLC, Dallas, Texas, 75251, United States
招募中
The University of Texas Southwestern Medical Center, Dallas, Texas, 75390, United States
招募中
ANESC Research, El Paso, Texas, 79912, United States
招募中
North Texas Institute of Neurology and Headache, Frisco, Texas, 75034, United States
进行中（不再招募）
UTHealth Houston, Houston, Texas, 77030, United States
招募中
Pain and Headache Centers of Texas, Houston, Texas, 77054, United States
招募中
SCLA Management, Houston, Texas, 77077, United States
招募中
Houston Clinical Research,LLC., Houston, Texas, 77081, United States
进行中（不再招募）
NeuroCare Plus, Houston, Texas, 77094, United States
招募中
AIM Trials, LLC, Plano, Texas, 75093, United States
招募中

Utah

JBR Clinical Research, Salt Lake City, Utah, 84107, United States
招募中
Wasatch Clinical Research , LLC(Administrative Location), Salt Lake City, Utah, 84107, United States
招募中

Vermont

The University of Vermont Medical Center, Burlington, Vermont, 05401, United States
进行中（不再招募）

Virginia

Pediatric Research of Charlottesville, LLC (Regulatory Only), Charlottesville, Virginia, 22902, United States
招募中
Pediatric Research of Charlottesville, LLC, Charlottesville, Virginia, 22902, United States
招募中
Children's Hospital of the King's Daughters, Norfolk, Virginia, 23507, United States
招募中
Children's Specialty Group, PLLC, Norfolk, Virginia, 23507, United States
招募中
Children's Specialty Group, PLLC, Division of Childhood & Adolescent Neurology, Norfolk, Virginia, 23510, United States
招募中
National Clinical Research, Inc., Richmond, Virginia, 23294, United States
进行中（不再招募）

Washington

Northwest Clinical Research Center, Bellevue, Washington, 98007, United States
招募中
Eastside Therapeutic Resource, Inc. dba Core Clinical Research, Everett, Washington, 98201, United States
进行中（不再招募）
Seattle Children's Hospital Investigational Drug Services, Seattle, Washington, 98105, United States
招募中
Seattle Children's Hospital, Seattle, Washington, 98105, United States
招募中

Wisconsin

Clinical Investigation Specialists, Inc, Kenosha, Wisconsin, 53144, United States
招募中
University Hospital, Madison, Wisconsin, 53792, United States
招募中

British Columbia

OCT Research ULC, Kelowna, British Columbia, V1Y 1Z9, Canada
招募中

Quebec

Diex Recherche Sherbrooke Inc, Sherbrooke, Quebec, J1L 0H8, Canada
进行中（不再招募）

Fukuoka

Jinnouchi Neurosurgical Clinic, Kasuga-shi, Fukuoka, 816-0802, Japan
招募中
Ikeda Neurosurgical Clinic, Kasuga-shi, Fukuoka, 816-0824, Japan
招募中

Gunma

Hikita Pediatric Clinic, Kiryu-shi, Gunma, 3760035, Japan
招募中

Hyōgo

Konan Medical Center, Higashinada-ku Kobe-shi, Hyōgo, 658-0064, Japan
招募中
Yamaguchi Clinic, Nishinomiya-shi, Hyōgo, 663-8204, Japan
招募中

Ibaraki

Mito Kyodo General Hospital, Mito, Ibaraki, 310-0015, Japan
招募中

Kagoshima-ken

Tanaka Neurosurgery & Headache Clinic, Kagoshima, Kagoshima-ken, 890-0052, Japan
招募中

Miyagi

Sendai Headache and Neurology Clinic, Taihaku-ku Sendai-shi, Miyagi, 982-0014, Japan
招募中

Osaka

Tennoji Dai Brain Clinic, Abeno-ku Osaka-shi, Osaka, 545-0053, Japan
招募中
Tominaga Clinic, Naniwa-ku, Osaka, 556-0015, Japan
招募中

Tokyo

Tokyo Headache Clinic, Shibuya-ku, Tokyo, 151-0051, Japan
招募中
Tokyo Medical University Hospital, Shinjuku-ku, Tokyo, 160-0023, Japan
尚未招募
Local lndependent Administrative Corporation Hiroshima City Hospital Organization Hiroshima City, Hiroshima, 730-8518, Japan
招募中

Mexico City

Clinstile S.A. de C.V., Col. Roma Norte, Mexico City, C.P. 06700., Mexico
招募中

Sinaloa

Neurociencias Estudios Clinicos S.C., Culiacán, Sinaloa, 800200, Mexico
招募中

State of Mexico

Clinical Reseach Institute, S.C., Tlalnepantla, State of Mexico, C.P. 54055, Mexico
招募中
Unidad de Investigacion en Salud de Chihuahua S.C., Chihuahua City, 31203, Mexico
招募中

Lower Silesian Voivodeship

MIGRE Polskie Centrum Leczenia Migreny Anna Gryglas-Dworak, Wroclaw, Lower Silesian Voivodeship, 52-210, Poland
招募中
NZOZ Wielospecjalistyczna Poradnia Lekarska SYNAPSIS, Lech Szczechowski, Katowice, 40-123, Poland
进行中（不再招募）
Centrum Medyczne Plejady, Krakow, 30-363, Poland
招募中
Wojewódzki Specjalistyczny Szpital Dzieciecy im. Sw. Ludwika w Krakowie, Apteka Szpitalna, Krakow, 31-503, Poland
招募中
Clinical Research Center Sp. z.o.o. Medic-R Spolka komandytowa, Poznan, 61-731, Poland
招募中
Euromedis Sp. z o. o., Szczecin, 70-111, Poland
进行中（不再招募）

Cantabria

Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, 39008, Spain
进行中（不再招募）
Hospital Universitario Vall d'Hebron, Barcelona, 08035, Spain
招募中
Centre d'Atencio Primaria Balenya, Barcelona, 08550, Spain
进行中（不再招募）
Instituto de Investigaciones del Sueno, Madrid, 28036, Spain
进行中（不再招募）
Hospital Universitario Virgen del Rocío, Seville, 41013, Spain
招募中
Hospital Clinico Universitario de Valladolid, Valladolid, 47005, Spain
招募中

Skåne LÄN [se-12]

ProbarE i Lund AB, Lund, Skåne LÄN [se-12], 22222, Sweden
招募中
Avdelningen för kliniska Prövningar, Universitetssjukhuset Örebro, Örebro, 703 62, Sweden
进行中（不再招募）
ProbarE i Stockholm AB, Stockholm, 113 29, Sweden
招募中
Leicester Royal Infirmary, Leicester, LE1 5WW, United Kingdom
进行中（不再招募）
Re:Cognition Health Limited, London, W1G 9JF, United Kingdom
招募中
Great Ormond Street Hospital for Children NHS Foundation Trust, London, WC1N 3JH, United Kingdom
招募中