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临床试验 NCT07173140 (RIM) 针对肾癌，磁共振成像，Small Renal Mass，Kidney Cancers目前进行中（不再招募）。请查看临床试验雷达卡片视图和 AI 发现工具了解所有详情，或在此提出任何问题。 | ||
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伦敦大学学院Renal Tumour Imaging Using MRI (RIM) 30
临床试验详情主要以英语提供。然而，试验雷达 AI可以提供帮助！只需点击“试验详解”即可查看和讨论您选择的语言的试验信息。
临床试验NCT07173140 (RIM)是一项针对肾癌，磁共振成像，Small Renal Mass，Kidney Cancers的干预性研究试验，目前试验状态为进行中（不再招募）。试验始于2024年11月20日，计划招募30名患者。该研究由伦敦大学学院主导，预计于2025年9月30日完成。试验数据来源于ClinicalTrials.gov，最后更新时间为2025年9月15日。
简要概括
This study investigates whether new types of MRI scans can tell the difference between different kidney tumours before surgery. Currently, imaging scans can detect kidney tumours and their size, but they aren't effective at determining the tumour type or its aggressiveness. Biopsies are an option, but they are invasive and may miss important cancerous cells. The aim is to use imaging to determine which tumours are ag...显示更多
官方标题
A Two Site Pilot Study of Functional and Microstructural Imaging Using Magnetic Resonance Imaging in Patients With Renal Tumours
疾病
肾癌磁共振成像Small Renal MassKidney Cancers出版物
关于此临床试验发表的科学文章和研究论文：其他研究标识符
- RIM
- 162190
NCT编号
实际开始日期
2024-11-20
最近更新发布
2025-09-15
预计完成日期
2025-09-30
计划入组人数
30
研究类型
干预性研究
试验分期 (阶段)
不适用
试验状态
进行中（不再招募）
关键词
Renal cancer
MRI
Small Renal Mass
Kidney Cancer
MRI
Small Renal Mass
Kidney Cancer
主要目的
诊断
分配方式
非随机
干预模型
平行
盲法
无（开放性试验）
试验组/干预措施
| 参与者组/试验组 | 干预措施/治疗方法 |
|---|---|
无干预Histological characterisation of renal tumours Histological samples of ten patients with tumour histology will be retreived from the Royal Free Hospital Biobank. Slides will be stained using H\&E and CD34 and cell size, stromal space and vascularity will be estimated and used to inform diffusion weighted imaging models. | 不适用 |
实验性Comparison of microstructural MRI to histology 10 patients with small renal tumours will undergo microstructural MRI. Following MRI the tumours will be surgically resected. The MRI will be co-registered with histology. The degree of correlation between the MRI and underlying histology will be determined. | 磁共振成像 Participants undergo an additional MRI scan using novel MRI sequences |
实验性Repeatability of MRI of small renal masses The repeatability of the MRI scan of the small renal mass will be determined by participants undergoing a repeat MRI examination shortly after the first (within 14 d) on the same scanner. | 磁共振成像 Participants undergo an additional MRI scan using novel MRI sequences |
主要终点
| 结果指标 | 度量标准描述 | 时间框架 |
|---|---|---|
Diagnostic accuracy of proton density fat fraction (PDFF) to differentiate different histological subtypes of renal tumours. | PDFF mean values will be calculated for each tumour in arms 2 and 3. Following surgery the means for each histological subtype will be calculated and tested for statistical significance. | 1 year |
Repeatability of proton density fat fraction (PDFF) measurements. | Participants in arm 3 will undergo repeat scanning with a short time interval between scans. The repeatability of PDFF measurements will be assessed using within subject standard deviation, repeatability coefficients and Bland-Altman analysis. | 1 year |
参与助手
资格标准
适龄参与研究
成人, 老年人
最低年龄要求
18 Years
适龄性别
全部
- Aged 18 and over
- Confirmed renal tumour ≤ 7 cm planned for surgical resection
- Willing and able to provide written informed consent
- Able to lie supine for the duration of an MRI
- Contraindication to MRI e.g., cardiac pacemaker
- Contraindication to MR contrast agents
- Pregnancy
- Breastfeeding
- Deranged renal function (eGFR <30) in the last three months.
- Previous treatment of the renal tumour e.g., ablation, radiotherapy
伦敦大学学院268 个活跃的临床试验可供探索- Royal Free Hospital NHS Foundation Trust
- 伦敦大学学院268 个活跃的临床试验可供探索
没有联系数据。
1 位于 1 个国家/地区的研究中心
University College London, London, United Kingdom