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Investigation of the Evolution of Gastric Emptying by Gastric Ultra Sonography in Patients Treated With GLP-1 Receptor Agonists on a 7 Days Pausing Period. 40 Observacional

Ainda não recrutando
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O estudo clínico NCT06388213 é um estudo observacional para Diabetes mellitus, tipo 2, Anestesia, Aspiração pulmonar de conteúdo gástrico. Seu status atual é: ainda não recrutando. O recrutamento está programado para iniciar em 1 de junho de 2024, com o objetivo de incluir 40 participantes. Coordenado por University Hospital, Geneva e deve ser concluído em 1 de maio de 2026. Essas informações foram atualizadas no ClinicalTrials.gov em 1 de maio de 2024.
Resumo
Glucagon-like-peptide-1 is a hormone released by the gut enteroendocrine cells. Its secretion occurs after each meal to enable production of insulin and inhibits the production of glucagon to lower after meal glycemia. It also inhibits gastric emptying and food intake. GLP-1 RA plays a role on GLP-1 receptors present on islet beta cells and delta cells of the pancreas to control insulin. GLP-1 receptors are also pres...Mostrar mais
Descrição detalhada
The study design consists in a prospective monocentric observational study comparing 2 groups of patients either treated by GLP-1 RA (more than 3 months) or without GLP-1 RA treatment. The investigators will perform a gastric echography, in both groups to define gastric residue after a fasting period of at least 6 hours for solids and 2 hours for liquids. Patients will have free access to any eating regimen before fa...Mostrar mais
Título oficial

Investigation of Gastric Emptying in Patients Treated With GLP-1 Receptor Agonists

Condições médicas
Diabetes mellitus, tipo 2AnestesiaAspiração pulmonar de conteúdo gástrico
Outros IDs do estudo
  • GLP-1 RA patients GE by GUS
Número NCT
NCT06388213
Data de início (real)
2024-06
Última atualização postada
2024-05-01
Data de conclusão (estimada)
2026-05
Inscrição (estimada)
40
Tipo de estudo
Observacional
Status
Ainda não recrutando
Palavras-chave
Glucagon Like Peptide 1 Receptors Agonists
Gastric Emptying
Gastric Ultrasound
Braços / Intervenções
Grupo de participantes/BraçoIntervenção/Tratamento
Non GLP-1 RA group
Patient aged 18 years or older in healthy condition with no gastroparetic treatment and without history of gastro-intestinal pathology, respecting fasting period of 6 hours for solid or thick liquid (juice, milk, sparkling water and soda) and 2 hours for clear liquid (still water, black coffee or tea).
Gastric Ultrasonography
Evaluation of cross sectional area of the antrum by gastric ultrasonography in healthy patients and in patient treated by GLP-1 receptor agonists after a fasting period (6 hours for solid and 2 hours for clear liquids). For the GLP-1 receptor agonists group the gastric ultrasonochography will be repeated each 2 days during 7 days. In the non GLP-1 receptors agonists group the evaluation will be executed one time.
GLP-1 RA group
Patients aged 18 years or older, treated with GLP-1 receptor agonists, respecting fasting period of 6 hours for solid or thick liquid (juice, milk, sparkling water and soda) and 2 hours for clear liquid (still water, black coffee or tea).
Gastric Ultrasonography
Evaluation of cross sectional area of the antrum by gastric ultrasonography in healthy patients and in patient treated by GLP-1 receptor agonists after a fasting period (6 hours for solid and 2 hours for clear liquids). For the GLP-1 receptor agonists group the gastric ultrasonochography will be repeated each 2 days during 7 days. In the non GLP-1 receptors agonists group the evaluation will be executed one time.
Desfecho primário
Medida de desfechoDescrição da medidaPrazo
Change of antral cross sectional area in patients pausing 7 days GLP-1 RA treatment.
7 days
Desfecho secundário
Medida de desfechoDescrição da medidaPrazo
Time course of change in gastric volume
7 days
Assistente de participação
Critérios de elegibilidade

Idades elegíveis
Adulto, Idoso
Idade mínima
18 Years
Sexos elegíveis
Todos
Aceita voluntários saudáveis
Sim

Patients over 18yrs old treated with GLP-1 receptor agonists for at least three months

Patients known for gastrointestinal motility disorders, history of gastric surgery, large hiatal hernia, or inability to lie in the right lateral decubitus position.
University Hospital, Geneva logoUniversity Hospital, Geneva
Responsável pelo estudo
Eduardo Schiffer, Investigador principal, Professor, University Hospital, Geneva
Contato central do estudo
Contato: Marc Pugliese, +41783061685, [email protected]
Sem dados de locais.