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Clinical Trial NCT05869747 (FCRP) for Exposure, Cardiopulmonary is active, not recruiting. See the Trial Radar Card View and AI discovery tools for all the details. Or ask anything here.
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Firefighter Collaborative Research Project (FCRP)

Active, not recruiting
Clinical Trial NCT05869747 (FCRP) is an interventional study for Exposure, Cardiopulmonary that is active, not recruiting. It started on 22 June 2023 with plans to enroll 1,500 participants. Led by University of Arizona, it is expected to complete by 31 December 2025. The latest data from ClinicalTrials.gov was last updated on 4 June 2025.
Brief Summary
The goal of this research is to test interventions to reduce firefighter cardiovascular, cognitive, and overall disease risks, including but not limited to risks associated with Per- and Polyfluorinated Substances (PFAS) exposure. Approximately 1,500 - 2,000 firefighters will be enrolled in the Fire Fighter Cancer Cohort Study (FFCCS). Among these individuals, those that express interest will then be screened for eligibility for the Firefighter Collaborative Research Project (FCRP) using information they provided for the Fire Fighter Cancer Cohort Study. Firefighters enrolled in the study will provide an initial blood sample and urine sample. The blood sample will be analyzed to determine the participant's PFAS levels. Based upon serum PFAS levels and responses from the screening survey, eligible participants will be randomly assigned into one of the following interventions: 1. Blood Donation, or Plasma Donation or Blood/Plasma Control Group; 2. Zone 2 Training or Zone 2 Control; 3. Intermittent Fasting or Intermittent Fasting Control. Individuals participating in the blood donation, plasma donation or blood/plasma control group would donate blood every 12 weeks, plasma every 6 weeks, or not donate blood or plasma. Participants in this intervention arm would continue this for a 12-month period. Individuals in the zone 2 training, zone 2 training control, intermittent fasting or intermittent fasting control group would participate in their intervention or control for a 4-month period. After 4 to 12 months participating in an intervention or control group, participants will be asked to provide a final urine sample and blood draw to determine if and to what degree their PFAS levels or other cardiovascular disease and other health risks have changed.
Official Title

Firefighter Collaborative Research Project

Conditions
ExposureCardiopulmonary
Publications
Scientific articles and research papers published about this clinical trial:
Other Study IDs
  • FCRP
NCT ID Number
NCT05869747
Start Date (Actual)
2023-06-22
Last Update Posted
2025-06-04
Completion Date (Estimated)
2025-12-31
Enrollment (Estimated)
1,500
Study Type
Interventional
PHASE
N/A
Status
Active, not recruiting
Keywords
Firefighters
Primary Purpose
Other
Design Allocation
Randomized
Interventional Model
Parallel
Masking
Single
Arms / Interventions
Participant Group/ArmIntervention/Treatment
Active ComparatorBlood Donation
Blood Donation
Participants asked to donate whole blood at a donation facility from a list provided by the study.
Surveys
Participants were asked to complete surveys throughout the study to monitor intervention progress and to collect baseline and end-of-study data.
Active ComparatorPlasma Donation
Plasma Donation
Participants asked to donate plasma at a donation facility from a list provided by the study.
Surveys
Participants were asked to complete surveys throughout the study to monitor intervention progress and to collect baseline and end-of-study data.
Placebo ComparatorBlood/Plasma Control
Surveys
Participants were asked to complete surveys throughout the study to monitor intervention progress and to collect baseline and end-of-study data.
Active ComparatorZone 2 Training
Zone 2 Training
Participants asked to work out in their custom Zone 2 heart range 4 times a week for 45 to 60 minutes.
Surveys
Participants were asked to complete surveys throughout the study to monitor intervention progress and to collect baseline and end-of-study data.
Active ComparatorIntermittent Fasting
Intermittent Fasting
Participants asked to engage in an intermittent fasting routine of a 16 hour fast followed by an 8 hour eating period at least 4 times a week.
Surveys
Participants were asked to complete surveys throughout the study to monitor intervention progress and to collect baseline and end-of-study data.
Placebo ComparatorZone 2 Control
Surveys
Participants were asked to complete surveys throughout the study to monitor intervention progress and to collect baseline and end-of-study data.
Placebo ComparatorIntermittent Fasting Control
Surveys
Participants were asked to complete surveys throughout the study to monitor intervention progress and to collect baseline and end-of-study data.
Primary Outcome Measures
Outcome MeasureMeasure DescriptionTime Frame
Change in concentration of PFAS levels in serum
PFAS levels are per- and polyfluoroalkyl substance levels measured from a biological sample
12 months
Change in epigenetic age
Epigenetic age is a mathematically derived age estimators that are based on combinations of methylation values that change with age at specific CpGs in the genome.
4 months
Eligibility Criteria

Eligible Ages
Adult, Older Adult
Minimum Age
18 Years
Eligible Sexes
All
Accepts Healthy Volunteers
Yes
  • Active firefighter (including emergency medical responder and all firefighter subgroups) with either a volunteer or career status
  • Individual plans to remain in active service with their current agency for the next 2 years (not planning to retire or resign)
  • 18 years of age and older
  • Fluently speak and write in English
  • All sexes, races, and ethnicities
  • Enrolled in the Fire Fighter Cancer Cohort Study (FFCCS) prior to enrolling in the Firefighter Collaborative Research Project (FCRP)
  • Complete a signed and dated informed consent document that indicates the participant has been informed of all aspects of the study prior to enrollment
  • Agree to avoid participating in FCRP intervention activities outside of their assigned intervention group for the duration of the study
  • Able to comply with scheduled visits, laboratory tests and other study procedures
  • BMI of 17.5 kg/m2 or greater and be greater than 115 pounds
  • Must also be eligible to donate blood and blood-based products if randomized into the blood or plasmapheresis intervention groups

  • Not able to fluently speak or write in English
  • Less than 18 years of age
  • Currently a tobacco smoker or vaping (e.g. >2 cigarettes or cigars, or incidents of vaping in the past month)
  • Those with planned travel or extended leave (e.g. >6 weeks) that would prevent their ability to participate in other interventions
  • Those who are pregnant, breastfeeding, or have given birth within the past year
  • Those with a history or diagnosis of any significant metabolic, hematologic, pulmonary, cardiovascular, gastrointestinal, neurological, immune, hepatic, renal, urological disorders, severe injury or cancer that, in the opinion of the investigator, would potentially put the candidate at risk.

Exclusion criteria from study for those outside of Arizona:

• Those with PFOS levels <5 ng/ml

Exclusion criteria from blood or plasma donation intervention:

  • Those with any medical contraindication (medical condition or medication) to blood donation
  • Those that donated blood or plasma in the past three months
  • Those knowing they have a condition indicative of levels of hemoglobin, hematocrit, red blood cells, or iron below the lower limit of normal levels

Exclusion criteria from the intermittent fasting intervention:

  • Those with a history or diagnosis of diabetes, hypoglycemia thyroid disease, and/or an eating disorder
  • Those who recently participated in intermittent fasting or Time Restricted Eating
  • Those that recently used antidiabetic medication such as Semaglutide (sold as Ozempic, Wegovy, and Rybelsus) or Tirzepatide (sold as Mounjaro) for the treatment of type 2 diabetes or for weight loss will also be excluded from this group.
  • Use of drugs that might affect intermittent fasting or eating behaviors
  • Those outside of the state of Arizona

Exclusion from the zone-2 physical activity intervention:

  • Currently participating in zone 2 physical activity training
  • Currently participating in more than 120 minutes per week of aerobic, cardiovascular training (e.g. jogging, cycling, walking, swimming, HIIT) at >60% of their max heart rate.
  • Those outside of the state of Arizona or in cities in Arizona where access to CPET testing is not possible
University of Arizona logoUniversity of Arizona
Arizona State University logoArizona State University
No contact data.
7 Study Locations in 1 Countries

Arizona

Gilbert Fire & Rescue Department, Gilbert, Arizona, 85295, United States
Green Valley Fire, Green Valley, Arizona, 85622, United States
Tucson Fire Department Headquarters, Tucson, Arizona, 85701, United States
Tucson Fire Department Station 9, Tucson, Arizona, 85711, United States
University of Arizona, Tucson, Arizona, 85719, United States
Northwest Fire District, Tucson, Arizona, 85743, United States
Drexel Heights Fire, Tucson, Arizona, 85746, United States