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Clinical Trial NCT03084445 for Exposure to Environmental Pollution is active, not recruiting. See the Trial Radar Card View and AI discovery tools for all the details. Or ask anything here.
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Impact of Exposure to Environmental Pollutants on Birth Outcomes in an Israeli Cohort 2,394 Pregnancy Preventive Novel Treatment Prevention

Active, not recruiting
Clinical Trial NCT03084445 is an observational study for Exposure to Environmental Pollution that is active, not recruiting. It started on 1 September 2013 with plans to enroll 2,394 participants. Led by Assaf-Harofeh Medical Center, it is expected to complete by 31 December 2025. The latest data from ClinicalTrials.gov was last updated on 31 July 2024.
Brief Summary
Objectives and hypothesis The scale and diversity of chemicals in worldwide use today is vast. Many of these chemicals are released into the environment where they are found in air, water, soil, house dust, and in the food supply, resulting in exposure to humans. Characterizing the extent of exposure and the effects of exposure in vulnerable populations, such as pregnant women and children, is of the utmost importanc...Show More
Detailed Description
Objectives and hypothesis The scale and diversity of chemicals in worldwide use today is vast, ranging from pharmaceuticals and food products, to plastics, gasoline, and semiconductor chips. Many of these chemicals are released into the environment where they are found in air, water, soil, in house dust, and in the food supply, resulting in exposure to humans. Characterizing the extent of exposure and the effects of ...Show More
Official Title

Impact of Exposure to Environmental Pollutants on Birth Outcomes in an Israeli Cohort

Conditions
Exposure to Environmental Pollution
Other Study IDs
  • 12/12
NCT ID Number
NCT03084445
Start Date (Actual)
2013-09
Last Update Posted
2024-07-31
Completion Date (Estimated)
2025-12-31
Enrollment (Estimated)
2,394
Study Type
Observational
Status
Active, not recruiting
Keywords
Brominated Flame Retardants (BFRs)
Phthalates
pregnant women
newborn
Heavy Metals
Volatile Organic Compounds
Primary Outcome Measures
Outcome MeasureMeasure DescriptionTime Frame
Measuring envinromental polutants, including heavy metals, VOCs, PBDEs and phthalates levels in collected samples
assessment of BFRs and phthalates body burdens through measurement of these chemicals in maternal and paternal serum and urine, cord blood, breastmilk and neonatal meconium among several representative sub-populations
48 months after end of specimens collection
Secondary Outcome Measures
Outcome MeasureMeasure DescriptionTime Frame
associations between exposure to nvinromental polutants, including heavy metals, VOCs, PBDEs and phthalates and few maternal and infant pregnancy and birth parameters and endocrine functions
To examine associations between exposure to PBDEs and phthalates and (a) pregnancy complications, (b) anthropometrics at birth (i.e. birth weight adjusted for gestational age, ponderal index, head circumference adjusted for gestational age), and (c) cryptorchidism incidence, (d) maternal and infant thyroid function
48 months after end of specimens collection
Participation Assistant
Eligibility Criteria

Eligible Ages
Adult, Older Adult
Minimum Age
18 Years
Eligible Sexes
All
Accepts Healthy Volunteers
Yes
  • Israeli Arabs, Jews from Russia, Jews from Ethiopia, Jews with an Ashkenazic background and Jews with a Sephardic background

  • refuse to take part in the study
Assaf-Harofeh Medical Center logoAssaf-Harofeh Medical Center
No contact data.
3 Study Locations in 1 Countries
Rambam Medical Center, Haifa, Israel
Lis Medical Center, Tel Aviv, Israel
Assaf Harofeh Medical Center, Ẕerifin, 70300, Israel