رادار التجارب AI | ||
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حالة التجربة السريرية NCT05671068 لـ Myoclonus-dystonia، DYT11 هي نشط (التجنيد مغلق). اطلعوا على جميع التفاصيل في عرض البطاقة الخاص برادار التجارب السريرية وأدوات اكتشاف الذكاء الاصطناعي. أو يمكنكم طرح أي سؤال هنا. | ||
EMOTION & COGNITION in MYOCLONUS DYSTONIA (AGENT10-ECODYST)
Myoclonus dystonia (DYT-SGCE) is characterized by myoclonus and dystonia. Such condition is associated with a high prevalence of psychiatric symptoms which are part of the phenotype. The mechanisms underlying these non-motor symptoms are still poorly understood.
Objective:
To investigate the neural correlates of cognition and emotion in DYT-SGCE.
Design:
Participants will have 1 - 2 visits at the clinical center. The total participation time is less than 24 hours.
Participants will have a medical interview and a neurological exam. They may give a urine sample before MRI.
Participants will have a short neuropsychologic and psychiatric interviews. Participants will have MRI scans. They will do small tasks or be asked to imagine things during the scanning.
DYT-SGCE patients and healthy volunteers (HV) between 15 and 60 years old.
CEREBELLAR INVOLVEMENT in MOTOR, COGNITIVE and EMOTIONAL PROCESSES in MYOCLONUS DYSTONIA
- Roze E, Lang AE, Vidailhet M. Myoclonus-dystonia: classification, phenomenology, pathogenesis, and treatment. Curr Opin Neurol. 2018 Aug;31(4):484-490. doi: 10.1097/WCO.0000000000000577.
- Peall KJ, Dijk JM, Saunders-Pullman R, Dreissen YE, van Loon I, Cath D, Kurian MA, Owen MJ, Foncke EM, Morris HR, Gasser T, Bressman S, Asmus F, Tijssen MA. Psychiatric disorders, myoclonus dystonia and SGCE: an international study. Ann Clin Transl Neurol. 2015 Nov 20;3(1):4-11. doi: 10.1002/acn3.263. eCollection 2016 Jan.
- C22-18
- 2022-A00786-37 (معرف آخر) (ID RCB)
| مجموعة المشاركين/مجموعة | تَدَخُّل/علاج |
|---|---|
DYT-SGCE Patients with myoclonus dystonia (DYT-SGCE) | غ/م |
Healthy volunteers Control group | غ/م |
| مقياس النتيجة | وصف القياس | الإطار الزمني |
|---|---|---|
BOLD signal derived from the functional magnetic resonance imaging | Explore the differences in DYT-SGCE compared to HV | 46 month |
For all participants:
- Age between 15-60 years
- Able to give informed consent.
For patients:
- An established diagnostic of DYT-SGCE
- No change in medication (related to DYT-SGCE) for a month
For controls:
- No neurological symptoms
- No medication except oral contraception
- No deprivation of liberty
- Inability to give a consent
- Established cognitive alteration
- Contraindication to MRI (per MRI safety checklist)
- Severe chronic psychiatric illness
Institut National de la Santé Et de la Recherche Médicale, Franceمستشفيات باريس العامةParis