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Clinical Trial NCT07488598 for Chronic Cough is recruiting. See the Trial Radar Card View and AI discovery tools for all the details. Or ask anything here.
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Efficacy of Behavioral Therapy for Chronic Refractory Cough 30

Recruiting
Clinical Trial NCT07488598 is an interventional study for Chronic Cough that is recruiting. It started on March 10, 2026 with plans to enroll 30 participants. Led by Assiut University, it is expected to complete by May 10, 2027. The latest data from ClinicalTrials.gov was last updated on March 23, 2026.
Brief Summary
Chronic cough is defined as cough persisting for more than eight weeks. It is a common clinical problem that significantly impairs patients' physical, psychological, and social quality of life. Chronic cough remains a diagnostic and therapeutic challenge despite systematic evaluation and treatment of common etiologies such as asthma, gastroesophageal reflux disease
Detailed Description
Chronic cough is defined as cough persisting for more than eight weeks. It is a common clinical problem that significantly impairs patients' physical, psychological, and social quality of life. Chronic cough remains a diagnostic and therapeutic challenge despite systematic evaluation and treatment of common etiologies such as asthma, gastroesophageal reflux disease .

A substantial proportion of patients continue to ...

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Official Title

Efficacy of Behavioral Therapy for Chronic Refractory Cough in Patients With Laryngeal Hyperresponsiveness

Conditions
Chronic Cough
Other Study IDs
  • Chronic Refractory Cough
NCT ID Number
NCT07488598
Start Date (Actual)
2026-03-10
Last Update Posted
2026-03-23
Completion Date (Estimated)
2027-05-10
Enrollment (Estimated)
30
Study Type
Interventional
PHASE
N/A
Status
Recruiting
Primary Purpose
Treatment
Design Allocation
N/A
Interventional Model
Single Group
Masking
None (Open Label)
Arms / Interventions
Participant Group/ArmIntervention/Treatment
ExperimentalBehavioral Therapy for chronic cough
About 30 patients suffering from chronic cough persisting for more than eight weeks that is refractory to standard medical treatment for common causes of chronic cough, including asthma, gastroesophageal reflux disease
Behavioral Therapy
to evaluate the efficacy of behavioral therapy for chronic cough in patients with laryngeal hyperresponsiveness in order to assess its role as a non-pharmacological management strategy. This will provide an efficient plan of therapy for such challenging condition.
Primary Outcome Measures
Outcome MeasureMeasure DescriptionTime Frame
Treatment of Chronic Cough
The patient's subjective response to treatment, categorized as: resolved, improved, no change, or worse. it will be assisted by Cough-Specific Quality of Life: Leicester Cough Questionnaire (LCQ): The primary measure of cough-specific health-related quality of life (QoL). and also assesses physical, psychological, and social domains
6 months
Participation Assistant
Eligibility Criteria

Eligible Ages
Adult
Minimum Age
18 Years
Eligible Sexes
All
  • Eligible participants are adults aged ≥18 years i.e. normal chest radiograph.
  • participants with chronic cough persisting for more than eight weeks that is refractory to standard medical treatment for common causes of chronic cough, including asthma, gastroesophageal reflux disease .
  • Participants are required to exhibit clinical features suggestive of laryngeal hyperresponsiveness, such as cough triggered by phonation, laughter, cold air, or irritant exposure, with associated laryngeal symptoms including throat irritation, dysphonia, or frequent throat clearing.

  • Patients are excluded if they are current smokers or had ceased smoking within six months
  • patients have evidence of active pulmonary or cardiac disease, recent respiratory tract infection, recent angiotensin-converting enzyme inhibitor use.
  • significant structural laryngeal pathology, neurological disorders affecting cough reflex control, or inability to comply with study procedures.
  • Head &neck pathology e.g sinusitis, glottal insufficiency or primary muscle tension dysphonia
Assiut University logoAssiut University
Study Responsible Party
Mohamed Shaaban Mohamed, Principal Investigator, Resident at of Phoniatric, ENT Department,Faculty of Medicine, Assiut University
Study Central Contact
Contact: Mohamed Shaaban Mohamed Mahfouz, Resident, +201094817965, [email protected]
1 Study Locations in 1 Countries
Assuit University hospitals, Asyut, Egypt
Eman Sayed Hassan, Professor, Contact, +201004082014, [email protected]
Mohamed Fawzy Hassan, Professor, Contact, +201003032335, [email protected]
Recruiting