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Clinical Trial NCT07161648 for Fat Metabolism is recruiting. See the Trial Radar Card View and AI discovery tools for all the details. Or ask anything here.
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Use of Neuromuscular Electrical Stimulation to Prevent Exercise Resistance 30 Exercise-Based

Recruiting
Clinical Trial NCT07161648 is an interventional study for Fat Metabolism that is recruiting. It started on 17 October 2024 with plans to enroll 30 participants. Led by Colorado State University, it is expected to complete by 30 September 2026. The latest data from ClinicalTrials.gov was last updated on 14 November 2025.
Brief Summary
The study will find out if 100 minutes of electrical stimulation of muscle prevents the unfavorable consequence of insufficient exercise.
Detailed Description
Exercise resistance is characterized by the absence of exercise induced improvements in fat metabolism following a meal, and results from prolonged sedentary behavior between successive workouts (i.e. 2+ sedentary days between exercise bouts). The suggested energy expenditure threshold for avoiding exercise resistance is the equivalent of walking ~8,500 steps/day. However, population data indicate that the typical a...Show More
Official Title

Use of Neuromuscular Electrical Stimulation to Prevent Exercise Resistance

Conditions
Fat Metabolism
Other Study IDs
  • 5208
NCT ID Number
NCT07161648
Start Date (Actual)
2024-10-17
Last Update Posted
2025-11-14
Completion Date (Estimated)
2026-09-30
Enrollment (Estimated)
30
Study Type
Interventional
PHASE
N/A
Status
Recruiting
Keywords
exercise
exercise resistance
electrical stimulation
Primary Purpose
Prevention
Design Allocation
Randomized
Interventional Model
Crossover Assignment
Masking
None (Open Label)
Arms / Interventions
Participant Group/ArmIntervention/Treatment
No InterventionEstablishing the normal benefit of exercise
Study participants will complete treadmill exercise. During the same day, they will walk a minimum of 8,500 steps. The next day, fat oxidation will be measured after eating a high-fat meal.
N/A
No InterventionDemonstrating exercise resistance
Study participants will complete treadmill exercise. They will walk no more than 5,000 steps on the same day. The next day, fat oxidation will be measured after eating a high-fat meal.
N/A
ExperimentalTrying to prevent exercise resistance
Study participants will complete treadmill exercise. They will walk no more than 5,000 steps on the same day. They will receive 100 minutes of neuromuscular electrical stimulation. The next day, fat oxidation will be measured after eating a high-fat meal.
neuromuscular electrical stimulation
The study participants will engage in 100-minutes of neuromuscular electrical stimulation (NMES). NMES pads are sticky pieces of plastic, similar in size to a 25-cent coin. The pads will be placed on the bellies of thigh muscles (the vastus lateralis, vastus medialis), and calf muscles (the long and short head of the gastrocnemius). These skeletal muscles are selected due to their size (thereby promoting a bigger inc...Show More
Primary Outcome Measures
Outcome MeasureMeasure DescriptionTime Frame
Fat oxidation
Circulating triglyceride concentration after eating a high fat meal.
Blood will be sampled and triglyceride concentration measured. Study participants will eat a meal. Blood will be sampled and triglyceride concentration measured every 30-minutes for 4 hours.
Participation Assistant
Eligibility Criteria

Eligible Ages
Adult
Minimum Age
18 Years
Eligible Sexes
All
Accepts Healthy Volunteers
Yes
  • Regularly active (more than 30 minutes of exercise per day, 3 days per week, over the previous 12 months)
  • Ability to complete at least one hour of treadmill exercise (i.e. jogging/running),
  • Willing to abstain from caffeine and alcohol for 24-hours prior to three different study visits
  • Competency in English

  • Current or previous injuries that may hinder a participant's ability to exercise on a treadmill
  • A history of cardiopulmonary disorder that may be contra-indicative to treadmill exercise
  • Current use of cardio-pulmonary medication to treat a cardio-pulmonary condition
  • Currently breastfeeding
  • Pregnancy
Colorado State University logoColorado State University
Study Responsible Party
Christopher Bell, Principal Investigator, Associate Prof, Colorado State University
Study Central Contact
Contact: Christopher Bell, PhD, 970-491-7522, [email protected]
Contact: Ally Tripure, B.S., 9704913495, [email protected]
1 Study Locations in 1 Countries

Colorado

Colorado State University, Fort Collins, Colorado, 80523, United States
Christopher Bell, Contact, 9704917522, [email protected]
Ally Tripure, Contact, 9704913495, [email protected]
Recruiting