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Clinical Trial NCT07341308 for Metabolism Changes, Vitamin D is recruiting. See the Trial Radar Card View and AI discovery tools for all the details. Or ask anything here.
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Does Vitamin C Increase the Body Heat Generated By The Nervous System? 20

Recruiting
Clinical Trial NCT07341308 is an interventional study for Metabolism Changes, Vitamin D that is recruiting. It started on 17 March 2025 with plans to enroll 20 participants. Led by Colorado State University, it is expected to complete by 8 December 2026. The latest data from ClinicalTrials.gov was last updated on 14 January 2026.
Brief Summary

The goals of this clinical trial are to determine whether or not vitamin C is able to: (1) increase the body heat generated by the sympathetic nervous system; and, (2) increase circulating vitamin D concentration during sympathetic nervous system stimulation in adult humans aged 18-40 years who meet the criteria for overweight based on body mass index. The main question it aims to answer are:

  1. By how much does bod...
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Detailed Description
Participants will be required to visit the lab twice. During each visit, beta-adrenergic receptors will be stimulated with isoproterenol. The two visits are identical in every way with one exception: during one visit the isoproterenol will be delivered with saline only, and during the other visit the isoproterenol will be delivered with saline and vitamin C. The order of the visits will be randomized. Body temperatur...Show More
Official Title

Does Vitamin C Increase the Body Heat Generated By The Nervous System?

Conditions
Metabolism ChangesVitamin D
Other Study IDs
  • 6115
NCT ID Number
NCT07341308
Start Date (Actual)
2025-03-17
Last Update Posted
2026-01-14
Completion Date (Estimated)
2026-12-08
Enrollment (Estimated)
20
Study Type
Interventional
PHASE
N/A
Status
Recruiting
Keywords
isoproterenol
vitamin c
vitamin d
body temperature
Primary Purpose
Basic Science
Design Allocation
Randomized
Interventional Model
Crossover Assignment
Masking
Single
Arms / Interventions
Participant Group/ArmIntervention/Treatment
No InterventionResponse to beta-adrenergic stimulation without vitamin C
Isoproterenol will be infused with saline only
N/A
ExperimentalAdding vitamin C to beta-adrenergic receptor stilmulation
Isoproterenol will be infused with vitamin C
Vitamin C
Vitamin C will be co-infused with isoproterenol
Primary Outcome Measures
Outcome MeasureMeasure DescriptionTime Frame
Body Temperature
Body temperature will be measured using an oral thermometer
Prior to and immediately after a dose of isoproterenol. This corresponds to 0 minutes (baseline) and immediately after each dose of isoproterenol at minutes 30, 60 and 90.
Vitamin D
Circulating vitamin D concentration
Prior to and immediately after a dose of isoproterenol. This corresponds to 0 minutes (baseline) and immediately after each dose of isoproterenol at minutes 30, 60 and 90.
Participation Assistant
Eligibility Criteria

Eligible Ages
Adult
Minimum Age
18 Years
Eligible Sexes
All
Accepts Healthy Volunteers
Yes
  • Age 18-40 years (inclusive)
  • Body mass index greater than or equal to 25 kg/m2 and less than 30 kg/m2
  • Weight stable (no change in body mass greater than 5 Lbs. within the previous 6 months.
  • Willing to abstain from caffeine and alcohol for 24-hours prior to two different study visits
  • Competency in English as assessed by comprehension of the Informed Consent. This is study involves invasive procedures and infusion of a systemic vasoactive agent (isoproterenol); for safety reasons, the ability for clear and rapid communication will be necessary between the research participants and the investigators.

  • History of autonomic, cardio-pulmonary, and/or metabolic disease (including heart failure, hypertension, arrhythmia, vascular disease, and/or diabetes)
  • Pregnancy or breast feeding
  • Habitual use of tobacco/nicotine products or recreational drugs (2 or more uses within the previous month)
  • History of a "sulfite allergy" as it is a relative contraindication to isoproteronol use.
  • Has ingested vitamin supplements and/or antioxidant supplements during the previous 4-weeks (e.g. Vitamin C, Vitamin E, Multi-vitamins, etc.)
Colorado State University logoColorado State University
Study Central Contact
Contact: Christopher Bell, PhD, 9704917522, [email protected]
Contact: Taylor Ewell, M.S., 9704913495, [email protected]
1 Study Locations in 1 Countries

Colorado

Colorado State University, Fort Collins, Colorado, 80523, United States
Christopher Bell, PhD, Contact, 9704917522, [email protected]
Taylor Ewell, MS, Contact, 9704913495, [email protected]
Recruiting