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Clinical Trial NCT07410481 for PTSD - Post Traumatic Stress Disorder, Cardiac Arrest (CA) is not yet recruiting. See the Trial Radar Card View and AI discovery tools for all the details. Or ask anything here.
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Trial of Acceptance and Mindfulness-based Exposure Therapy (AMBET) and Present Centered Therapy (PCT) 90

Not yet recruiting
Clinical Trial NCT07410481 is an interventional study for PTSD - Post Traumatic Stress Disorder, Cardiac Arrest (CA) and is currently not yet recruiting. Enrollment is planned to begin on 1 March 2026 and continue until the study accrues 90 participants. Led by Columbia University, this study is expected to complete by 31 December 2028. The latest data from ClinicalTrials.gov was last updated on 13 February 2026.
Brief Summary
The goal of this clinical trial is to learn if a new therapy called Acceptance- and Mindfulness-Based Exposure Therapy (AMBET) helps treat post-traumatic stress disorder (PTSD) in people who survived a cardiac arrest. This study will compare AMBET to another psychotherapy treatment called Present Centered Therapy (PCT) to see which therapy is more effective in treating PTSD.

The main questions it aims to answer are:...

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Official Title

A Randomized Clinical Trial of Acceptance and Mindfulness-based Exposure Therapy (AMBET) and Present Centered Therapy (PCT)

Conditions
PTSD - Post Traumatic Stress DisorderCardiac Arrest (CA)
Other Study IDs
NCT ID Number
NCT07410481
Start Date (Actual)
2026-03-01
Last Update Posted
2026-02-13
Completion Date (Estimated)
2028-12-31
Enrollment (Estimated)
90
Study Type
Interventional
PHASE
N/A
Status
Not yet recruiting
Primary Purpose
Treatment
Design Allocation
Randomized
Interventional Model
Parallel
Masking
Single
Arms / Interventions
Participant Group/ArmIntervention/Treatment
ExperimentalAcceptance- and mindfulness-based exposure therapy (AMBET)
Remotely delivered psychotherapy combining exposure therapy with mindfulness.
Acceptance and Mindfulness Based Exposure Therapy
Eight sessions of exposure therapy combined with mindfulness delivered via videoconferencing platform. AMBET will consist of 90-minute weekly sessions for 4 weeks, then every other week for 4 more sessions.
Active ComparatorPresent-Centered Therapy (PCT)
Remotely delivered psychotherapy that focuses on increasing adaptive responses to current life stressors and difficulties.
Present-Centered Therapy
Twelve 60-minute weekly sessions of psychotherapy delivered via videoconferencing platform.
Primary Outcome Measures
Outcome MeasureMeasure DescriptionTime Frame
Change in PTSD symptoms over time
Change in symptoms as measured by the Clinician Administered PTSD Scale (CAPS-5) from pre- to post-treatment. The full score range is 0 - 80, where lower scores indicate lower symptom levels of PTSD.
Baseline, At 6 weeks, Post-treatment: Approximately 3 months and 6 months from intake
Secondary Outcome Measures
Outcome MeasureMeasure DescriptionTime Frame
Change in depressive symptoms over time
Change in symptoms as measured by the Hamilton Depression Rating Scale (HDRS-24) from pre- to post-treatment. The full score range is 0 - 76, where lower scores indicate lower symptom levels of depression.
Baseline, At 6 weeks, Post-treatment: approximately 3 months and 6 months from intake
Participation Assistant
Eligibility Criteria

Eligible Ages
Adult, Older Adult
Minimum Age
18 Years
Eligible Sexes
All
  1. Between 18 and 81 years old at the time of consent
  2. Fluency in English
  3. Medical history of cardiac arrest >3 months ago
  4. Clinically elevated PTSD symptoms (Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) score ≥25)
  5. U.S. Resident

  1. Lifetime history of primary psychotic or bipolar disorders
  2. Current substance use disorder (moderate or severe in the past 6 months)
  3. Active suicidal ideation with some intent to act in past 12 months, and/or suicide attempt in past 24 months
  4. Substantial cognitive impairment (Mini Mental Status Exam (MMSE) score <25)
  5. Initiation of new psychotropic medication <3 months ago
  6. Non-cardiac etiology of CA (drowning, bleeding, trauma, drug overdose, etc)
  7. Terminal illness with life expectancy <1 year
  8. Concurrent psychotherapy for PTSD
Columbia University logoColumbia University
National Institute on Aging (NIA) logoNational Institute on Aging (NIA)
Study Responsible Party
Yuval Neria, Principal Investigator, Professor of Clinical Medical Psychology, Columbia University
Study Central Contact
Contact: Yuval Neria, Ph.D., 212-543-6061, [email protected]
Contact: Maja Bergman, Ph.D., 212-543-6061, [email protected]
1 Study Locations in 1 Countries

New York

Columbia University Irving Medical Center, New York, New York, 10032, United States
Maja Bergman, Ph.D., Contact, [email protected]
Yuval Neria, Principal Investigator