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O estudo clínico NCT07351032 para PARKINSON DISEASE (Disorder) está em recrutamento. Consulte a visualização em cartões do Radar de Estudos Clínicos e as ferramentas de descoberta de IA para ver todos os detalhes. Ou pergunte qualquer coisa aqui.
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Understanding How Movements Are Transferred From Task to Task in Parkinson's Disease 24

Em recrutamento
Os detalhes do estudo clínico estão disponíveis principalmente em inglês. No entanto, a IA Trial Radar pode ajudar! Basta clicar em 'Explicar o estudo' para visualizar e discutir as informações do estudo no idioma selecionado.
O estudo clínico NCT07351032 é um estudo intervencionista para PARKINSON DISEASE (Disorder). Seu status atual é: em recrutamento. O estudo começou em 18 de novembro de 2025 e pretende incluir 24 participantes. Coordenado por a Universidade McGill e deve ser concluído em 1 de maio de 2026. Essas informações foram atualizadas no ClinicalTrials.gov em 20 de janeiro de 2026.
Resumo
The purpose of this study is to understand how a specific brain area, the Posterior Parietal Cortex (PPC), plays a role in movement transfer from walking on a split-belt treadmill (SBT) to walking on the ground in people with Parkinson's disease (PwPD).

Here, investigators will apply repeated transcranial magnetic stimulation (rTMS) to upregulate the PPC. Then, the differences in the gait parameters between pre- and...

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Descrição detalhada
The split-belt training has been shown to modulate gait in PwPD, but the skill transfer from the SBT training to the overground walking is poorly understood.

In this project, the subjects will visit the lab on three occasions: day 1 is for the clinical assessment based on the questionnaires, the 10-Meter Walk Task, as well as finding TMS targets and thresholds for the tibialis anterior (TA) and first dorsal inteross...

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Título oficial

Neural Mechanism of Skill Transfer in Parkinson's Disease

Condições médicas
PARKINSON DISEASE (Disorder)
Outros IDs do estudo
  • 24-12-053
Número NCT
NCT07351032
Data de início (real)
2025-11-18
Última atualização postada
2026-01-20
Data de conclusão (estimada)
2026-05
Inscrição (estimada)
24
Tipo de estudo
Intervencionista
FASE
N/A
Status
Em recrutamento
Palavras-chave
Transcranial Magnetic Stimulation
Split-belt Treadmill
Gait
Motor Adaptation
Propósito principal
Ciência básica
Alocação do design
Randomizado
Modelo de intervenção
Paralelo
Cegamento (Mascaramento)
Duplo-cego
Braços / Intervenções
Grupo de participantes/BraçoIntervenção/Tratamento
OutroActive rTMS First followed by Sham rTMS Second
Session 1: active rTMS (iTBS) over the right PPC Session 2: sham rTMS (iTBS) over the right PPC
Transcranial Magnetic Stimulation Active
ACTIVE: intermittent Theta Burst Stimulation (a patterned form of rTMS). The participants will receive iTBS (50hz bursts at 5Hz for 600 pulses for a total duration of 3-minutes) over the right PPC at 80% RMT of the FDI.
Transcranial Magnetic Stimulation Sham
SHAM: 2 coils on top of each other will be used instead of 1. The coil furthest to the head will be reversed. The coil on the head will not be stimulating but the reversed coil will (current directed away from the brain) with stimulate with the same parameters at the active stimulation (intermittent Theta Burst Stimulation (a patterned form of rTMS). The participants will receive iTBS (50hz bursts at 5Hz for 600 puls...Mostrar mais
OutroSham rTMS First followed by Active rTMS Second
Session 1: sham rTMS (iTBS) over the right PPC Session 2: active rTMS (iTBS) over the right PPC
Transcranial Magnetic Stimulation Active
ACTIVE: intermittent Theta Burst Stimulation (a patterned form of rTMS). The participants will receive iTBS (50hz bursts at 5Hz for 600 pulses for a total duration of 3-minutes) over the right PPC at 80% RMT of the FDI.
Transcranial Magnetic Stimulation Sham
SHAM: 2 coils on top of each other will be used instead of 1. The coil furthest to the head will be reversed. The coil on the head will not be stimulating but the reversed coil will (current directed away from the brain) with stimulate with the same parameters at the active stimulation (intermittent Theta Burst Stimulation (a patterned form of rTMS). The participants will receive iTBS (50hz bursts at 5Hz for 600 puls...Mostrar mais
Desfecho primário
Medida de desfechoDescrição da medidaPrazo
Stride length
The forward distance travelled by a foot during a gait cycle (cm) measured during overground walking and on the SBT with the Ambulatory Parkinson's Disease Monitoring (APDM) mobility lab system. A higher score indicates better gait control.
Day 2 and Day 3
Dual Support
The percentage of the gait cycle when both feet are in contact with the ground (%) will be measured during overground walking and on the SBT with the Ambulatory Parkinson's Disease Monitoring (APDM) mobility lab system. A higher score indicates a longer time for both feet to be in contact with the ground.
Day 2 and Day 3
Desfecho secundário
Medida de desfechoDescrição da medidaPrazo
Cadence
The number of steps per minute will be measured during overground walking and on the SBT with the Ambulatory Parkinson's Disease Monitoring (APDM) mobility lab system. A higher score indicates better gait control.
Day 2 and Day 3
Gait Speed
The speed of the subject, measured as the distance traveled in the gait cycle divided by the gait cycle duration (m/s) during overground walking and on the SBT will be measured with the Ambulatory Parkinson's Disease Monitoring (APDM) mobility lab system. A higher score indicates better gait control.
Day 2 and Day 3
Turning Velocity
The peak angular velocity of the turn (deg/s) during overground walking will be measured with the Ambulatory Parkinson's Disease Monitoring (APDM) mobility lab system. The higher score indicates better turning performance.
Day 2 and Day 3
Steps in turn
The number of steps taken in one turn during overground walking will be measured with the Ambulatory Parkinson's Disease Monitoring (APDM) mobility lab system. The higher score indicates better turning performance.
Day 2 and Day 3
Step length
The distance between the heels of two consecutive steps (m) during overground walking will be measured with a custom MATLAB script. The higher score indicates better gait control.
Day 2 and Day 3
Cortical Excitability
The cortical excitability will be assessed using a dual coil setup where two coils are placed on 2 different locations of the scalp at the same time. One coil will be positioned over the PPC, and the other over the TA hotspot. A total of 50 stimuli will be randomly delivered: 25 pulses will be applied solely over the TA hotspot (TA), and the other 25 paired pulses in which a PPC stimulus precedes the TA stimulus by 4 milliseconds (PPC + TA). Cortical excitability will be quantified by using the following ratio: (PPC + TA) / (TA). The higher score indicates the greater excitability of the neurons along the PPC-M1 pathway.
Day 2 and Day 3
Assistente de participação
Critérios de elegibilidade

Idades elegíveis
Adulto, Idoso
Idade mínima
50 Years
Sexos elegíveis
Todos
  • a confirmed diagnosis of idiopathic Parkinson's disease
  • absence of freezing of gait confirmed by a "No" answer to the second item of the New Freezing of Gait Questionnaire (NFOGQ) and no observation of FOG during a freezing provoking test
  • no other neurological diagnosis
  • no severe musculoskeletal/orthopedic or vestibular condition that interferes with walking and or significantly affects balance
  • no mild cognitive impairment (Montreal Cognitive Assessment ≥ 25)
  • able to walk independently and without assistive device for 30 minutes
  • no previous experience with split-belt treadmill.

  • severe dyskinesia that interacts with walking and balance hearing or visual impairment
  • observed inability to walk safely on a tied-belt treadmill
  • neurological disorders other than PD or other pathology (e.g., orthopedic) interfering with mobility. - contradiction for TMS
  • implanted deep brain stimulator.
McGill University logoUniversidade McGill
Responsável pelo estudo
Caroline Paquette, Investigador principal, Associate Professor, McGill University
Contato central do estudo
Contato: Tomoha Ogawa, BA, 514-398-2488, [email protected]
1 Locais do estudo em 1 países

Quebec

McGill University - Currie Gymnasium, Montreal, Quebec, H2W 1S4, Canada
Tomoha Ogawa, BA, Contato, 514-398-2488, [email protected]
Caroline Paquette, PhD, Investigador principal
Em recrutamento