IA Trial Radar | ||
|---|---|---|
El ensayo clínico NCT07104500 (VANQUISH 1) para Pérdida de peso está activo, no reclutando. Consulte la vista de tarjeta del Radar de Ensayos Clínicos y las herramientas de descubrimiento de IA para conocer todos los detalles. O haga cualquier pregunta aquí. | ||
Un estudio coincide con los criterios de filtro
Vista de tarjeta
Volver a la búsqueda
Viking TherapeuticsVK2735 for Weight Management Phase 3 (VANQUISH 1) Fase III 4500 Aleatorizado Doble ciego Controlado con placebo
Los detalles del ensayo clínico están disponibles principalmente en inglés. ¡Sin embargo, IA Trial Radar puede ayudar! Simplemente haga clic en 'Explicar el estudio' para ver y discutir la información del estudio en el idioma que haya seleccionado.
El ensayo clínico NCT07104500 (VANQUISH 1) está diseñado para estudiar el tratamiento de Pérdida de peso. Es un estudio intervencionista de Fase III. Su estado actual es: activo, no reclutando. El estudio se inició el 23 de junio de 2025, con el objetivo de reclutar a 4500 participantes. Dirigido por Viking Therapeutics, se espera que finalice el 1 de agosto de 2027. Los datos se actualizaron por última vez en ClinicalTrials.gov el 24 de noviembre de 2025.
Resumen
This is a phase 3, multicenter, 78-week randomized, double-blind, placebo-controlled, parallel arm study that will evaluate the weight loss efficacy as well as safety, tolerability, pharmacodynamic effects, and pharmacokinetics of VK2735 in adults who are obese (BMI ≥30 kg/m2) or overweight (BMI ≥27 kg/m2) with one or more weight related comorbid condition without Type 2 Diabetes.
Título oficial
A Phase 3 Randomized, Double-Blind, Placebo-Controlled, 78-Week Efficacy and Safety Study of VK2735 Administered Subcutaneously for Weight Management in Participants Without Type 2 Diabetes Who Are Obese, or Overweight With at Least One Weight-related Comorbid Condition
Condiciones médicas
Pérdida de pesoOtros ID del estudio
- VANQUISH 1
- VK2735-301
Número del NCT
Inicio del estudio (real)
2025-06-23
Última actualización
2025-11-24
Fecha de finalización (estimada)
2027-08-01
Inscripción (prevista)
4500
Tipo de estudio
Intervencionista
FASE
Fase III
Estado general
Activo, no reclutando
Objetivo principal
Tratamiento
Método de asignación
Aleatorizado
Modelo de intervención
Paralelo
Enmascaramiento
Triple ciego
Brazos / Intervenciones
| Grupo de participantes | Intervención/Tratamiento |
|---|---|
Comparador placeboPlacebo Assignment VK2735 Placebo Comparator Once Weekly | VK2735 VK2735 is a peptide GLP-1 and GIP dual agonist administered Once Weekly |
ExperimentalActive Assignment (Dose 1) VK2735 7.5mg Once Weekly | VK2735 VK2735 is a peptide GLP-1 and GIP dual agonist administered Once Weekly |
ExperimentalActive Assignment (Dose 2) VK2735 12.5mg Once Weekly | VK2735 VK2735 is a peptide GLP-1 and GIP dual agonist administered Once Weekly |
ExperimentalActive Assignment (Dose 3) VK2735 17.5mg Once Weekly | VK2735 VK2735 is a peptide GLP-1 and GIP dual agonist administered Once Weekly |
Resultado primario
Resultado secundario
| Medida de resultado | Descripción de la medida | Periodo de tiempo |
|---|---|---|
Percentage change in body weight from baseline for participants receiving VK2735 after 78 weeks of treatment | 78 Weeks |
| Medida de resultado | Descripción de la medida | Periodo de tiempo |
|---|---|---|
Percentage of participants who achieve ≥5%, ≥10%, ≥15% and ≥20% body weight reduction after 78 weeks of treatment | 78 Weeks |
Asistente de participación
Criterios de elegibilidad
Criterios de edad
Adulto, Adulto mayor
Edad mínima
18 Years
Criterios de sexo
Todos
Age ≥18 years of age at the time of signing the informed consent
Body mass index (BMI) ≥30 kg/m2 OR ≥27 kg/m2 with at least one weight-related co- morbid condition (treated or untreated)
- Weight-related co-morbid conditions include hypertension, dyslipidemia, obstructive sleep apnea or cardiovascular disease
- Cardiovascular disease includes, for example, ischemic cardiovascular disease, New York Heart Association (NYHA) Functional Class I-III heart failure
- BMI calculated at the Screening visit will be used to determine eligibility
- History of or current clinically significant medical disorder that, in the opinion of the Investigator, does not support study participation
- Self-reported body weight change of 5% or more within 3 months of screening
- Have a prior or planned surgical treatment for obesity (excluding liposuction or abdominoplasty if performed >1 year prior to screening)
- Have or plan to have endoscopic and/or device-based therapy for obesity or have had device removal within the last 6 months prior to screening (such as, mucosa ablation, gastric artery embolization, intragastric balloon, duodenal-jejunal endoluminal line)
- Current or past diagnosis of diabetes mellitus (including type 1, type 2, except gestational diabetes)
- Treatment with glucose-lowering agent(s) within 90 days before screening
- Personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia type 2 (MEN2)
- History of acute or chronic pancreatitis
Viking TherapeuticsNo hay datos de contacto.
137 Centros del estudio en 2 países
Viking Clinical Site #1130, Mayagüez, 00680, Puerto Rico
Viking Clinical Site #1086, San Juan, 00927, Puerto Rico
Alabama
Viking Clinical Site #1037, Birmingham, Alabama, 35235, United States
Viking Clinical Site #1064, Birmingham, Alabama, 35249, United States
Viking Clinical Site #1128, Huntsville, Alabama, 35801, United States
Viking Clinical Site #1081, Mobile, Alabama, 36608, United States
Arizona
Viking Clinical Site #1005, Chandler, Arizona, 85210, United States
Viking Clinical Site #1017, Flagstaff, Arizona, 86001, United States
Viking Clinical Site #1018, Peoria, Arizona, 85381, United States
Viking Clinical Site #1135, Scottsdale, Arizona, 85260, United States
Viking Clinical Site #1019, Tucson, Arizona, 85711, United States
Arkansas
Viking Clinical Site #1036, Little Rock, Arkansas, 72211, United States
California
Viking Clinical Site #1071, Chula Vista, California, 91911, United States
Viking Clinical Site #1070, Escondido, California, 92025, United States
Viking Clinical Site #1054, Huntington Park, California, 90255, United States
Viking Clinical Site #1014, Lake Forest, California, 92630, United States
Viking Clinical Site #1129, Lemon Grove, California, 91945, United States
Viking Clinical Site #1051, Lincoln, California, 95648, United States
Viking Clinical Site #1050, Long Beach, California, 90815, United States
Viking Clinical Site #1055, Los Angeles, California, 90057, United States
Viking Clinical Site #1078, Manteca, California, 95336, United States
Viking Clinical Site #1053, Montclair, California, 91763, United States
Viking Clinical Site #1068, Panorama City, California, 91402, United States
Viking Clinical Site #1132, Rolling Hills Estates, California, 90274, United States
Viking Clinical Site #1131, San Diego, California, 92103, United States
Viking Clinical Site #1104, Santa Maria, California, 93458, United States
Viking Clinical Site #1052, Spring Valley, California, 91978, United States
Viking Clinical Site #1109, Tustin, California, 92780, United States
Viking Clinical Site #1067, Van Nuys, California, 91405, United States
Viking Clinical Site #1079, Walnut Creek, California, 94598, United States
Colorado
Viking Clinical Site #1119, Denver, Colorado, 80210, United States
District of Columbia
Viking Clinical Site #1123, Washington D.C., District of Columbia, 20036, United States
Florida
Viking Clinical Site #1013, Clearwater, Florida, 33756, United States
Viking Clinical Site #1121, Clearwater, Florida, 33761, United States
Viking Clinical Site #1003, Cooper City, Florida, 33024, United States
Viking Clinical Site #1112, DeLand, Florida, 32720, United States
Viking Clinical Site #1107, Delray Beach, Florida, 33445, United States
Viking Clinical Site #1083, Fort Myers, Florida, 33912, United States
Viking Clinical Site #1058, Jacksonville, Florida, 32216, United States
Viking Clinical Site #1076, Lakeland, Florida, 33803, United States
Viking Clinical Site #1060, Lakewood Rch, Florida, 34211, United States
Viking Clinical Site #1117, Miami, Florida, 33122, United States
Viking Clinical Site #1059, New Port Richey, Florida, 34652, United States
Viking Clinical Site #1012, Ocoee, Florida, 34761, United States
Viking Clinical Site #1056, Palmetto Bay, Florida, 33157, United States
Viking Clinical Site #1011, Port Orange, Florida, 32127, United States
Viking Clinical Site #1057, West Palm Beach, Florida, 33407, United States
Georgia
Viking Clinical Site #1116, Atlanta, Georgia, 30329, United States
Viking Clinical Site #1030, Columbus, Georgia, 31904, United States
Viking Clinical Site #1120, Rincon, Georgia, 31326, United States
Viking Clinical Site #1093, Savannah, Georgia, 31406, United States
Viking Clinical Site #1025, Woodstock, Georgia, 30189, United States
Hawaii
Viking Clinical Site #1062, Honolulu, Hawaii, 96814, United States
Idaho
Viking Clinical Site #1080, Meridian, Idaho, 83642, United States
Illinois
Viking Clinical Site #1006, Chicago, Illinois, 60607, United States
Viking Clinical Site #1090, Chicago, Illinois, 60640, United States
Viking Clinical Site #1138, Westmont, Illinois, 60559, United States
Indiana
Viking Clinical Site #1127, Valparaiso, Indiana, 46383, United States
Iowa
Viking Clinical Site #1022, West Des Moines, Iowa, 50266, United States
Kansas
Viking Clinical Site #1099, Wichita, Kansas, 67207, United States
Kentucky
Viking Clinical Site #1069, Lexington, Kentucky, 40509, United States
Viking Clinical Site #1040, Lexington, Kentucky, 40513, United States
Viking Clinical Site #1009, Louisville, Kentucky, 40213, United States
Louisiana
Viking Clinical Site #1118, Baton Rouge, Louisiana, 70808, United States
Viking Clinical Site #1139, Baton Rouge, Louisiana, 70809, United States
Viking Clinical Site #1106, Lafayette, Louisiana, 70508, United States
Viking Clinical Site #1020, Metairie, Louisiana, 70006, United States
Viking Clinical Site #1087, Monroe, Louisiana, 71201, United States
Maryland
Viking Clinical Site #1094, Chevy Chase, Maryland, 20815, United States
Viking Clinical Site #1066, Rockville, Maryland, 20854, United States
Massachusetts
Viking Clinical Site #1103, Boston, Massachusetts, 02114, United States
Viking Clinical Site #1001, Methuen, Massachusetts, 01844, United States
Viking Clinical Site #1136, Needham, Massachusetts, 02492, United States
Michigan
Viking Clinical Site #1038, Ypsilanti, Michigan, 48197, United States
Mississippi
Viking Clinical Site #1140, Gulfport, Mississippi, 39503, United States
Missouri
Viking Clinical Site #1031, City of Saint Peters, Missouri, 63303, United States
Viking Clinical Site #1016, Kansas City, Missouri, 64131, United States
Viking Clinical Site #1125, Springfield, Missouri, 65807, United States
Viking Clinical Site #1108, St Louis, Missouri, 63108, United States
Montana
Viking Clinical Site #1010, Butte, Montana, 59701, United States
Nebraska
Viking Clinical Site #1075, Omaha, Nebraska, 68134, United States
Nevada
Viking Clinical Site #1035, Las Vegas, Nevada, 89148, United States
Viking Clinical Site #1034, Reno, Nevada, 89511, United States
New Hampshire
Viking Clinical Site #1065, Lebanon, New Hampshire, 03756, United States
New Jersey
Viking Clinical Site #1095, Marlton, New Jersey, 08009, United States
New Mexico
Viking Clinical Site #1029, Albuquerque, New Mexico, 87109, United States
New York
Viking Clinical Site #1088, Albany, New York, 12205, United States
Viking Clinical Site #1042, East Syracuse, New York, 13057, United States
Viking Clinical Site #1096, Hartsdale, New York, 10530, United States
Viking Clinical Site #1133, New York, New York, 10036, United States
Viking Clinical Site #1142, New York, New York, 10065, United States
Viking Clinical Site #1021, The Bronx, New York, 10455, United States
Viking Clinical Site #1032, Westfield, New York, 14787, United States
North Carolina
Viking Clinical Site #1141, Charlotte, North Carolina, 28250, United States
Viking Clinical Site #1122, Durham, North Carolina, 27701, United States
Viking Clinical Site #1144, Fayetteville, North Carolina, 28304, United States
Viking Clinical Site #1026, Greensboro, North Carolina, 27410, United States
Viking Clinical Site #1110, Morehead City, North Carolina, 28557, United States
Viking Clinical Site #1061, Morehead City, North Carolina, 28857, United States
North Dakota
Viking Clinical Site #1027, Fargo, North Dakota, 58104, United States
Ohio
Viking Clinical Site #1043, Cincinnati, Ohio, 45219, United States
Viking Clinical Site #1074, Cincinnati, Ohio, 45242, United States
Viking Clinical Site #1044, Cleveland, Ohio, 44122, United States
Viking Clinical Site #1089, Columbus, Ohio, 43215, United States
Oklahoma
Viking Clinical Site #1113, Norman, Oklahoma, 73069, United States
Viking Clinical Site #1137, Tulsa, Oklahoma, 74133, United States
Oregon
Viking Clinical Site #1102, Medford, Oregon, 97504, United States
Viking Clinical Site #1097, Portland, Oregon, 97202, United States
Viking Clinical Site #1126, Portland, Oregon, 97210, United States
Rhode Island
Viking Clinical Site #1045, East Greenwich, Rhode Island, 02818, United States
South Carolina
Viking Clinical Site #1028, Greenville, South Carolina, 29607, United States
Viking Clinical Site #1134, Myrtle Beach, South Carolina, 29572, United States
Viking Clinical Site #1023, North Charleston, South Carolina, 29405, United States
Tennessee
Viking Clinical Site #1004, Knoxville, Tennessee, 37909, United States
Viking Clinical Site #1008, Nashville, Tennessee, 37203, United States
Texas
Viking Clinical Site #1047, Abilene, Texas, 79606, United States
Viking Clinical Site #1063, Austin, Texas, 78131, United States
Viking Clinical Site #1007, Austin, Texas, 78705, United States
Viking Clinical Site #1091, Bellaire, Texas, 77401, United States
Viking Clinical Site #1124, Brownsville, Texas, 78526, United States
Viking Clinical Site #1049, Dallas, Texas, 75230, United States
Viking Clinical Site #1048, Dallas, Texas, 75235, United States
Viking Clinical Site #1111, Frisco, Texas, 75033, United States
Viking Clinical Site #1046, Houston, Texas, 77040, United States
Viking Clinical Site #1077, Lampasas, Texas, 76550, United States
Viking Clinical Site #1143, San Antonio, Texas, 78215, United States
Viking Clinical Site #1085, San Antonio, Texas, 78222, United States
Viking Clinical Site #1073, San Antonio, Texas, 78229, United States
Viking Clinical Site #1101, Waco, Texas, 76710, United States
Utah
Viking Clinical Site #1002, Ogden, Utah, 84405, United States
Viking Clinical Site #1092, Salt Lake City, Utah, 84107, United States
Viking Clinical Site #1039, Sandy City, Utah, 84094, United States
Viking Clinical Site #1024, St. George, Utah, 84790, United States
Virginia
Viking Clinical Site #1098, Arlington, Virginia, 22205, United States
Viking Clinical Site #1082, Suffolk, Virginia, 23435, United States
Washington
Viking Clinical Site #1072, Renton, Washington, 98057, United States
Viking Clinical Site #1041, Spokane, Washington, 99218, United States