רדאר קליני AI | ||
|---|---|---|
הניסוי הקליני NCT07104500 (VANQUISH 1) עבור ירידה במשקל הוא פעיל, לא מגייס. לכל הפרטים, עיינו בתצוגת הכרטיסים של רדאר ניסויים קליניים ובכלי הגילוי של AI. אפשר גם לשאול כל דבר כאן. | ||
מחקר אחד תואם לקריטריוני המסנן
תצוגת כרטיסים
חזרה לחיפוש
ויקינג תרפיוטיקסVK2735 for Weight Management Phase 3 (VANQUISH 1) שלב III 4,500 אקראי סמיות כפולה מבוקר פלסבו
פרטי הניסויים הקליניים זמינים בעיקר באנגלית. רדאר קליני AI יכול לעזור! לחץ על 'הסבר את המחקר' כדי לצפות ולשוחח על מידע מהמחקר בשפה המועדפת עליך.
ניסוי קליני NCT07104500 (VANQUISH 1) מתקיים כדי לבדוק את טיפול עבור ירידה במשקל. זהו מחקר שלב III מסוג התערבותי שנמצא כעת במצב פעיל, לא מגייס. המחקר התחיל ב-23 ביוני 2025 ומתוכנן לכלול 4,500 משתתפים. המחקר מנוהל על ידי ויקינג תרפיוטיקס וצפוי להסתיים ב-1 באוגוסט 2027. מידע זה עודכן לאחרונה באתר ClinicalTrials.gov ב-24 בנובמבר 2025.
סיכום קצר
This is a phase 3, multicenter, 78-week randomized, double-blind, placebo-controlled, parallel arm study that will evaluate the weight loss efficacy as well as safety, tolerability, pharmacodynamic effects, and pharmacokinetics of VK2735 in adults who are obese (BMI ≥30 kg/m2) or overweight (BMI ≥27 kg/m2) with one or more weight related comorbid condition without Type 2 Diabetes.
כותרת רשמית
A Phase 3 Randomized, Double-Blind, Placebo-Controlled, 78-Week Efficacy and Safety Study of VK2735 Administered Subcutaneously for Weight Management in Participants Without Type 2 Diabetes Who Are Obese, or Overweight With at Least One Weight-related Comorbid Condition
מצבים רפואיים
ירידה במשקלמזהי מחקר נוספים
- VANQUISH 1
- VK2735-301
מספר NCT
תחילת המחקר (בפועל)
2025-06-23
עדכון אחרון שפורסם
2025-11-24
סיום המחקר (מוערך)
2027-08-01
משתתפים (מתוכנן)
4,500
סוג המחקר
התערבותי
שלב
שלב III
סטטוס
פעיל, לא מגייס
מטרה ראשית
טיפול
הקצאת טיפול
אקראי
דגם מתערב
קבוצות מקבילות
עיוורון
משולש
זרועות / התערבויות
| קבוצת משתתפים/זרוע | התערבות/טיפול |
|---|---|
פלצבו להשוואהPlacebo Assignment VK2735 Placebo Comparator Once Weekly | VK2735 VK2735 is a peptide GLP-1 and GIP dual agonist administered Once Weekly |
ניסיActive Assignment (Dose 1) VK2735 7.5mg Once Weekly | VK2735 VK2735 is a peptide GLP-1 and GIP dual agonist administered Once Weekly |
ניסיActive Assignment (Dose 2) VK2735 12.5mg Once Weekly | VK2735 VK2735 is a peptide GLP-1 and GIP dual agonist administered Once Weekly |
ניסיActive Assignment (Dose 3) VK2735 17.5mg Once Weekly | VK2735 VK2735 is a peptide GLP-1 and GIP dual agonist administered Once Weekly |
מדדי תוצאה ראשיים
מדדי תוצאה משניים
| מדד תוצאה | תיאור המדידה | טווח זמן |
|---|---|---|
Percentage change in body weight from baseline for participants receiving VK2735 after 78 weeks of treatment | 78 Weeks |
| מדד תוצאה | תיאור המדידה | טווח זמן |
|---|---|---|
Percentage of participants who achieve ≥5%, ≥10%, ≥15% and ≥20% body weight reduction after 78 weeks of treatment | 78 Weeks |
עוזר השתתפות
קריטריוני זכאות
גילאים מוערכים למחקר
מבוגר, גיל שלישי
גיל מינימלי למחקר
18 Years
מגדרים מוערכים למחקר
הכל
Age ≥18 years of age at the time of signing the informed consent
Body mass index (BMI) ≥30 kg/m2 OR ≥27 kg/m2 with at least one weight-related co- morbid condition (treated or untreated)
- Weight-related co-morbid conditions include hypertension, dyslipidemia, obstructive sleep apnea or cardiovascular disease
- Cardiovascular disease includes, for example, ischemic cardiovascular disease, New York Heart Association (NYHA) Functional Class I-III heart failure
- BMI calculated at the Screening visit will be used to determine eligibility
- History of or current clinically significant medical disorder that, in the opinion of the Investigator, does not support study participation
- Self-reported body weight change of 5% or more within 3 months of screening
- Have a prior or planned surgical treatment for obesity (excluding liposuction or abdominoplasty if performed >1 year prior to screening)
- Have or plan to have endoscopic and/or device-based therapy for obesity or have had device removal within the last 6 months prior to screening (such as, mucosa ablation, gastric artery embolization, intragastric balloon, duodenal-jejunal endoluminal line)
- Current or past diagnosis of diabetes mellitus (including type 1, type 2, except gestational diabetes)
- Treatment with glucose-lowering agent(s) within 90 days before screening
- Personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia type 2 (MEN2)
- History of acute or chronic pancreatitis
ויקינג תרפיוטיקסאין נתוני קשר.
137 מיקומי המחקר ב-2 מדינות
Alabama
Viking Clinical Site #1037, Birmingham, Alabama, 35235, United States
Viking Clinical Site #1064, Birmingham, Alabama, 35249, United States
Viking Clinical Site #1128, Huntsville, Alabama, 35801, United States
Viking Clinical Site #1081, Mobile, Alabama, 36608, United States
Arizona
Viking Clinical Site #1005, Chandler, Arizona, 85210, United States
Viking Clinical Site #1017, Flagstaff, Arizona, 86001, United States
Viking Clinical Site #1018, Peoria, Arizona, 85381, United States
Viking Clinical Site #1135, Scottsdale, Arizona, 85260, United States
Viking Clinical Site #1019, Tucson, Arizona, 85711, United States
Arkansas
Viking Clinical Site #1036, Little Rock, Arkansas, 72211, United States
California
Viking Clinical Site #1071, Chula Vista, California, 91911, United States
Viking Clinical Site #1070, Escondido, California, 92025, United States
Viking Clinical Site #1054, Huntington Park, California, 90255, United States
Viking Clinical Site #1014, Lake Forest, California, 92630, United States
Viking Clinical Site #1129, Lemon Grove, California, 91945, United States
Viking Clinical Site #1051, Lincoln, California, 95648, United States
Viking Clinical Site #1050, Long Beach, California, 90815, United States
Viking Clinical Site #1055, Los Angeles, California, 90057, United States
Viking Clinical Site #1078, Manteca, California, 95336, United States
Viking Clinical Site #1053, Montclair, California, 91763, United States
Viking Clinical Site #1068, Panorama City, California, 91402, United States
Viking Clinical Site #1132, Rolling Hills Estates, California, 90274, United States
Viking Clinical Site #1131, San Diego, California, 92103, United States
Viking Clinical Site #1104, Santa Maria, California, 93458, United States
Viking Clinical Site #1052, Spring Valley, California, 91978, United States
Viking Clinical Site #1109, Tustin, California, 92780, United States
Viking Clinical Site #1067, Van Nuys, California, 91405, United States
Viking Clinical Site #1079, Walnut Creek, California, 94598, United States
Colorado
Viking Clinical Site #1119, Denver, Colorado, 80210, United States
District of Columbia
Viking Clinical Site #1123, Washington D.C., District of Columbia, 20036, United States
Florida
Viking Clinical Site #1013, Clearwater, Florida, 33756, United States
Viking Clinical Site #1121, Clearwater, Florida, 33761, United States
Viking Clinical Site #1003, Cooper City, Florida, 33024, United States
Viking Clinical Site #1112, DeLand, Florida, 32720, United States
Viking Clinical Site #1107, Delray Beach, Florida, 33445, United States
Viking Clinical Site #1083, Fort Myers, Florida, 33912, United States
Viking Clinical Site #1058, Jacksonville, Florida, 32216, United States
Viking Clinical Site #1076, Lakeland, Florida, 33803, United States
Viking Clinical Site #1060, Lakewood Rch, Florida, 34211, United States
Viking Clinical Site #1117, Miami, Florida, 33122, United States
Viking Clinical Site #1059, New Port Richey, Florida, 34652, United States
Viking Clinical Site #1012, Ocoee, Florida, 34761, United States
Viking Clinical Site #1056, Palmetto Bay, Florida, 33157, United States
Viking Clinical Site #1011, Port Orange, Florida, 32127, United States
Viking Clinical Site #1057, West Palm Beach, Florida, 33407, United States
Georgia
Viking Clinical Site #1116, Atlanta, Georgia, 30329, United States
Viking Clinical Site #1030, Columbus, Georgia, 31904, United States
Viking Clinical Site #1120, Rincon, Georgia, 31326, United States
Viking Clinical Site #1093, Savannah, Georgia, 31406, United States
Viking Clinical Site #1025, Woodstock, Georgia, 30189, United States
Hawaii
Viking Clinical Site #1062, Honolulu, Hawaii, 96814, United States
Idaho
Viking Clinical Site #1080, Meridian, Idaho, 83642, United States
Illinois
Viking Clinical Site #1006, Chicago, Illinois, 60607, United States
Viking Clinical Site #1090, Chicago, Illinois, 60640, United States
Viking Clinical Site #1138, Westmont, Illinois, 60559, United States
Indiana
Viking Clinical Site #1127, Valparaiso, Indiana, 46383, United States
Iowa
Viking Clinical Site #1022, West Des Moines, Iowa, 50266, United States
Kansas
Viking Clinical Site #1099, Wichita, Kansas, 67207, United States
Kentucky
Viking Clinical Site #1069, Lexington, Kentucky, 40509, United States
Viking Clinical Site #1040, Lexington, Kentucky, 40513, United States
Viking Clinical Site #1009, Louisville, Kentucky, 40213, United States
Louisiana
Viking Clinical Site #1118, Baton Rouge, Louisiana, 70808, United States
Viking Clinical Site #1139, Baton Rouge, Louisiana, 70809, United States
Viking Clinical Site #1106, Lafayette, Louisiana, 70508, United States
Viking Clinical Site #1020, Metairie, Louisiana, 70006, United States
Viking Clinical Site #1087, Monroe, Louisiana, 71201, United States
Maryland
Viking Clinical Site #1094, Chevy Chase, Maryland, 20815, United States
Viking Clinical Site #1066, Rockville, Maryland, 20854, United States
Massachusetts
Viking Clinical Site #1103, Boston, Massachusetts, 02114, United States
Viking Clinical Site #1001, Methuen, Massachusetts, 01844, United States
Viking Clinical Site #1136, Needham, Massachusetts, 02492, United States
Michigan
Viking Clinical Site #1038, Ypsilanti, Michigan, 48197, United States
Mississippi
Viking Clinical Site #1140, Gulfport, Mississippi, 39503, United States
Missouri
Viking Clinical Site #1031, City of Saint Peters, Missouri, 63303, United States
Viking Clinical Site #1016, Kansas City, Missouri, 64131, United States
Viking Clinical Site #1125, Springfield, Missouri, 65807, United States
Viking Clinical Site #1108, St Louis, Missouri, 63108, United States
Montana
Viking Clinical Site #1010, Butte, Montana, 59701, United States
Nebraska
Viking Clinical Site #1075, Omaha, Nebraska, 68134, United States
Nevada
Viking Clinical Site #1035, Las Vegas, Nevada, 89148, United States
Viking Clinical Site #1034, Reno, Nevada, 89511, United States
New Hampshire
Viking Clinical Site #1065, Lebanon, New Hampshire, 03756, United States
New Jersey
Viking Clinical Site #1095, Marlton, New Jersey, 08009, United States
New Mexico
Viking Clinical Site #1029, Albuquerque, New Mexico, 87109, United States
New York
Viking Clinical Site #1088, Albany, New York, 12205, United States
Viking Clinical Site #1042, East Syracuse, New York, 13057, United States
Viking Clinical Site #1096, Hartsdale, New York, 10530, United States
Viking Clinical Site #1133, New York, New York, 10036, United States
Viking Clinical Site #1142, New York, New York, 10065, United States
Viking Clinical Site #1021, The Bronx, New York, 10455, United States
Viking Clinical Site #1032, Westfield, New York, 14787, United States
North Carolina
Viking Clinical Site #1141, Charlotte, North Carolina, 28250, United States
Viking Clinical Site #1122, Durham, North Carolina, 27701, United States
Viking Clinical Site #1144, Fayetteville, North Carolina, 28304, United States
Viking Clinical Site #1026, Greensboro, North Carolina, 27410, United States
Viking Clinical Site #1110, Morehead City, North Carolina, 28557, United States
Viking Clinical Site #1061, Morehead City, North Carolina, 28857, United States
North Dakota
Viking Clinical Site #1027, Fargo, North Dakota, 58104, United States
Ohio
Viking Clinical Site #1043, Cincinnati, Ohio, 45219, United States
Viking Clinical Site #1074, Cincinnati, Ohio, 45242, United States
Viking Clinical Site #1044, Cleveland, Ohio, 44122, United States
Viking Clinical Site #1089, Columbus, Ohio, 43215, United States
Oklahoma
Viking Clinical Site #1113, Norman, Oklahoma, 73069, United States
Viking Clinical Site #1137, Tulsa, Oklahoma, 74133, United States
Oregon
Viking Clinical Site #1102, Medford, Oregon, 97504, United States
Viking Clinical Site #1097, Portland, Oregon, 97202, United States
Viking Clinical Site #1126, Portland, Oregon, 97210, United States
Rhode Island
Viking Clinical Site #1045, East Greenwich, Rhode Island, 02818, United States
South Carolina
Viking Clinical Site #1028, Greenville, South Carolina, 29607, United States
Viking Clinical Site #1134, Myrtle Beach, South Carolina, 29572, United States
Viking Clinical Site #1023, North Charleston, South Carolina, 29405, United States
Tennessee
Viking Clinical Site #1004, Knoxville, Tennessee, 37909, United States
Viking Clinical Site #1008, Nashville, Tennessee, 37203, United States
Texas
Viking Clinical Site #1047, Abilene, Texas, 79606, United States
Viking Clinical Site #1063, Austin, Texas, 78131, United States
Viking Clinical Site #1007, Austin, Texas, 78705, United States
Viking Clinical Site #1091, Bellaire, Texas, 77401, United States
Viking Clinical Site #1124, Brownsville, Texas, 78526, United States
Viking Clinical Site #1049, Dallas, Texas, 75230, United States
Viking Clinical Site #1048, Dallas, Texas, 75235, United States
Viking Clinical Site #1111, Frisco, Texas, 75033, United States
Viking Clinical Site #1046, Houston, Texas, 77040, United States
Viking Clinical Site #1077, Lampasas, Texas, 76550, United States
Viking Clinical Site #1143, San Antonio, Texas, 78215, United States
Viking Clinical Site #1085, San Antonio, Texas, 78222, United States
Viking Clinical Site #1073, San Antonio, Texas, 78229, United States
Viking Clinical Site #1101, Waco, Texas, 76710, United States
Utah
Viking Clinical Site #1002, Ogden, Utah, 84405, United States
Viking Clinical Site #1092, Salt Lake City, Utah, 84107, United States
Viking Clinical Site #1039, Sandy City, Utah, 84094, United States
Viking Clinical Site #1024, St. George, Utah, 84790, United States
Virginia
Viking Clinical Site #1098, Arlington, Virginia, 22205, United States
Viking Clinical Site #1082, Suffolk, Virginia, 23435, United States
Washington
Viking Clinical Site #1072, Renton, Washington, 98057, United States
Viking Clinical Site #1041, Spokane, Washington, 99218, United States
Viking Clinical Site #1130, Mayagüez, 00680, Puerto Rico
Viking Clinical Site #1086, San Juan, 00927, Puerto Rico