治験レーダーAI | ||
|---|---|---|
治験 NCT06557707（対象：ストレス）は募集中です。詳細は治験レーダーのタイル表示と AI 発見ツールで確認するか、ここで質問してください。 | ||
フィルター基準に一致する試験が1件見つかりました
タイル表示
検索に戻る
バージニア・コモンウェルス大学Cardiovascular Health & Early Stress 120
治験（臨床試験）の詳細は主に英語で提供されていますが、治験レーダーAIがサポートします！「治験解説」をクリックして、選択した言語で試験情報を表示し、議論してください。
治験番号 NCT06557707 は 観察研究 臨床試験 で、ストレス に関するものです。現在は 募集中 で、2022年1月20日 から開始しています。120 名の参加者 の募集が計画されています。この試験は バージニア・コモンウェルス大学 によって主導され、2028年12月1日 に完了予定です。ClinicalTrials.gov からの最新更新日は 2025年9月4日 です。
概要
Childhood adversity is highly prevalent, with 59% of the U.S. population reporting at least one adverse childhood experience (ACE). Substantial evidence links childhood adversity to cardiometabolic disease later in the life course, including heart disease, diabetes, and stroke, which are 3 of the top 10 causes of mortality in the United States.
ACEs encompass many possible traumatic and distressing experiences, incl...
もっと見る詳細説明
Current knowledge supports that ACEs trigger emotional stress, anxiety, fear, and discomfort in the individual. Acute and intense mental stress leads to structural changes in the amygdala, prolonged activation of the hypothalamic-pituitary-adrenal axis, and hyperactivation of the sympathetic nervous system. Then, the body secretes hormones to activate the cardiovascular system to cope with stress with a rapid increas...もっと見る
公式タイトル
Cardiovascular Health & Early Stress
疾患名
ストレスその他の研究識別子
- HM20021768
群（アーム）／介入
| 参加グループ/群 | 介入/治療法 |
|---|---|
Young individuals ACE (ages 18-30 years old) Young individuals who experienced accumulative adverse childhood experiences | Childhood stress Based on stress-related information, participants will be divided into those who were exposed to adversity during childhood and those who were not exposed. |
Children ACE (ages 9-17 years old) Children who experienced accumulative adverse childhood experiences . | Childhood stress Based on stress-related information, participants will be divided into those who were exposed to adversity during childhood and those who were not exposed. |
Young individuals No ACE (ages 18-30 years old) Young individuals who have not experienced accumulative adverse childhood experiences | 該当なし |
Children No ACE (ages 9-17 years old) Children who have not experienced accumulative adverse childhood experiences. | 該当なし |
主要評価項目
副次評価項目
| 評価指標 | 指標の説明 | 時間枠 |
|---|---|---|
Vascular function | This test examines how the blood vessels respond to different challenges and expand. It is used to characterize the cardiovascular health of the subject's blood vessels. Different events and substances will be used (under an IND) to test how the blood vessels react. The test is completed using Laser Doppler Speckle Contrast. We will measure how much the blood vessels dilate. Greater dilation, better vascular function. | Baseline |
Cardiac Function | An evaluation of cardiac response will be monitored non-invasively. We will use ultrasound to visualize the heart and the blood vessels. | Baseline |
Cardiac MRI (CMR) | Cardiac MRI will be completed to monitor early signs of poor functionality. | Baseline |
| 評価指標 | 指標の説明 | 時間枠 |
|---|---|---|
Spirometry | Subjects will undergo a lung function test to measure how well their lungs work. The volume of air moving in and out of the lungs will be assessed. FEV1 will be evaluated. FEV1 is the amount of air a person can exhale in the first second after inhaling as deeply as possible. | Baseline |
Lung Diffusing Capacity | Subjects will undergo a lung function test to measure how well their air is diffused from their lungs. DLCO will be evaluated. DLCO stands for diffusing capacity of the lungs for carbon monoxide, and it's a pulmonary function test that measures how well oxygen moves from the lungs into the bloodstream. | Baseline |
Complete blood count | Blood analysis | Baseline |
HbA1c | Blood analysis | Baseline |
C-Reactive protein | Blood analysis | Baseline |
Questionnaires | Lifestyle and stress related questionnaires will be completed by the participants including lifestyle, adversity during childhood, stress risk. | Baseline |
Arterial Stiffness | A non-invasive assessment will be used to measure how fast the participant's blood travels, which is a measure of how stiff their arteries are. | Baseline |
参加アシスタント
適格基準
対象年齢
小児, 成人
試験の最低年齢
9 Years
対象性別
全て
健康なボランティアを受け入れる
はい
Cohort 1
- Men and pre-menopausal women
- 18-30 years old
Cohort 2
- males and females
- 9-17 years old
Cohort 1
- Evidence of cardiovascular, pulmonary, renal, hepatic or cerebral diseases
- Evidence of pregnancy or currently nursing.
- Having a history of chronic pain
- Having a history of rheumatoid arthritis
Cohort 2
- Evidence of cardiovascular, pulmonary, renal, hepatic or cerebral diseases
- Evidence of pregnancy or currently nursing.
- Having a history of chronic pain
- Having a history of rheumatoid arthritis
バージニア・コモンウェルス大学試験中央連絡先
連絡先: Paula Rodriguez Miguelez, (804) 396-4498, [email protected]
1 1カ国の場所
Virginia
Virginia Commonwealth University, Richmond, Virginia, 23298, United States
Paula Rodriguez Miguelez, 連絡先, 804-396-4498, [email protected]
募集中