Beta
Trial Radar KI
enums.trial_summary.trial_summary_welcome
Eine Studie entspricht den Filterkriterien
Kartenansicht
Zurück zur Suche

Exercise Effects on Adipose Tissue Structure and Function (LG)

Offene Rekrutierung
Die Details der klinischen Studie sind hauptsächlich auf Englisch verfügbar. Trial Radar KI kann jedoch helfen! Klicken Sie einfach auf 'Studie erklären', um die Informationen zur Studie in der ausgewählten Sprache anzuzeigen und zu besprechen.
Die klinische Studie NCT04812314 (LG) ist eine interventionsstudie zur Untersuchung von Fettleibigkeit, Metabolisches Syndrom, Stoffwechselkrankheit, Insulinresistenz, Gewichtsverlust, Gewichtszunahme und hat den Status offene rekrutierung. Die Studie startete am 1. März 2021 und soll 46 Teilnehmer aufnehmen. Durchgeführt von Universität Michigan ist der Abschluss für 1. März 2030 geplant. Die Daten von ClinicalTrials.gov wurden zuletzt am 29. Juni 2025 aktualisiert.
Kurzbeschreibung
Participants will be randomized into one of two different experimental groups: 1) Exercise group and 2) No exercise (control group). Subject participation in the study will involve a series of metabolic tests before and after participants undergo a 10% weight loss program (with or without exercise training depending on group randomization). After completing this weight loss portion of the study, participants will then be required to adhere to a high calorie diet program to regain half of the weight the participant lost - followed by the same series of metabolic tests.
Ausführliche Beschreibung
Exercise is among the first line treatments for obesity and obesity-related diseases, yet it is shocking how little is known about how exercise works to improve health. Expanding the knowledge about novel exercise-induced adaptations in fat tissue of obese individuals and furthering the understanding about mechanisms underlying these adaptations could lead to innovative approaches for preventing and treating insulin resistance and obesity-related diseases.

Overall, the researchers believe that exercise training modifies key processes in subcutaneous fat tissue that may contribute to an increase body fat storage capacity (without increasing fat mass). The research team anticipates that exercise will evoke an even more potent adaptive response when fat tissue is dynamically changing in response to alterations in nutritional status (i.e., weight loss and weight regain).

Participants will be randomized into one of two different experimental groups: 1) Exercise group and 2) No exercise (control group). Subject participation in the study will involve a series of metabolic tests before and after participants undergo a 10% weight loss program (with or without exercise training depending on group randomization). After completing this weight loss portion of the study, participants will then be required to adhere to a high calorie diet program to regain half of the weight the participant lost - followed by the same series of metabolic tests. After the participant completes the study, the study team will help the participant to lose more weight. Total involvement in the study for each participant will likely be about 8-10 months.

Offizieller Titel

Exercise Effects on Adipose Tissue Structure and Function

Erkrankungen
FettleibigkeitMetabolisches SyndromStoffwechselkrankheitInsulinresistenzGewichtsverlustGewichtszunahme
Weitere Studien-IDs
  • LG
  • HUM00175528
NCT-Nummer
NCT04812314
Studienbeginn (tatsächlich)
2021-03-01
Zuletzt aktualisiert
2025-06-29
Studienende (vorauss.)
2030-03-01
Geplante Rekrutierung
46
Studientyp
Interventionsstudie
PHASE
Nicht zutreffend
Status
Offene Rekrutierung
Primäres Ziel
Grundlagenforschung
Zuteilungsmethode
Randomisiert
Interventionsmodell
Parallel
Verblindung
Keine (offene Studie)
Studienarme/Interventionen
Teilnehmergruppe/StudienarmIntervention/Behandlung
ExperimentellExercise
This exercise prescription represents a common or "conventional" form of physical activity (e.g., moderate/brisk walking). If assigned to this group, participants will perform 45 minutes of moderate intensity continuous steady-state exercise at 70% maximal heart rate (HRmax) to expend 250 calories 4 days per week.
Übung
Participants will complete a moderate intensity continuous exercise 4 days/week.
ExperimentellNo exercise
Subjects assigned to this group are to remain sedentary (no planned physical exercise) throughout the duration of the study.
Keine Bewegung
Participants will remain sedentary throughout the duration of the study.
Hauptergebnismessungen
ErgebnismessungBeschreibung der MessungZeitrahmen
Oral Glucose Tolerance Test (OGTT)
A test in which glucose is given and blood samples taken afterward to determine how quickly it is cleared from the blood will be completed at each clinical visit appointment..
2 hours
Adipose Tissue Fibrosis
measured histologically using Sirus Red Staining, quantified using ImageJ software at each clinical visit appointment.
30 minutes
Muscle Capillarization
measured immunohistochemically using an antibody for CD31, quantified using ImageJ software at each clinical visit appointment.
30 minutes
Adipose Capillarization
measured immunohistochemically using an antibody for CD31, quantified using ImageJ software at each clinical visit appointment.
30 minutes
Fat Cell Size
measured histologically using Hematoxylin and eosin (H \& E) staining, quantified using ImageJ software at each clinical visit appointment.
3 minutes
Nebenergebnismessungen
ErgebnismessungBeschreibung der MessungZeitrahmen
Blood Lipid Profile
A panel of blood tests that screens for abnormalities in blood lipids will be measured at each clinical visit appointment.
15 minutes
Blood Pressure
The pressure of circulating blood against the walls of blood vessels will be measured at screening and each clinical visit appointment.
10 minutes
Eignungskriterien

Zugelassene Altersgruppen
Erwachsene
Mindestalter
18 Years
Zugelassene Geschlechter
Alle
  • Age: 18-40
  • Body Mass Index: 27-45 kg/m2
  • No regularly planned exercise/physical activity for at least 6 months
  • Women must have regularly occurring menses and must be premenopausal

  • Evidence/history of cardiovascular or metabolic disease
  • Medications known to affect lipid or glucose metabolism, or inflammation
  • Weight instability ≥ ± 6 pounds in the last 3 months
  • Tobacco or e-cigarette users
  • Women must not be pregnant or actively lactating
University of Michigan logoUniversität Michigan488 aktive klinische Studien zum Erkunden
Verantwortliche Partei
Jeffrey F Horowitz, Hauptprüfer, professor of Movement Science and director of the Substrate Metabolism Laboratory (SML) at the University of Michigan School of Kinesiology
Zentrale Studienkontakte
Kontakt: Suzette Howton, 734-647-9850, [email protected]
1 Studienstandorte in 1 Ländern

Michigan

University of Michigan, Ann Arbor, Michigan, 48109, United States
Jeffrey F Horowitz, Kontakt, 7346471076, [email protected]
Offene Rekrutierung