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Clinical Trial NCT01176578 (EPC-DM) for Type 2 Diabetes Mellitus is active, not recruiting. See the Trial Radar Card View and AI discovery tools for all the details. Or ask anything here.
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Exercise Endothelial Progenitor Cells (EPCs) and Type 2 Diabetes (EPC-DM)

Active, not recruiting
Clinical Trial NCT01176578 (EPC-DM) is an interventional study for Type 2 Diabetes Mellitus that is active, not recruiting. It started on 1 July 2011 with plans to enroll 70 participants. Led by Baltimore VA Medical Center, it is expected to complete by 31 December 2026. The latest data from ClinicalTrials.gov was last updated on 19 September 2025.
Brief Summary
The discovery of the role of endothelial progenitor cells (EPCs) and their involvement in the cardiovascular complications of type 2 diabetes (T2DM) would quickly have a significant impact on the millions of Americans who have T2DM. This project is designed to 1) determine the mechanisms underlying EPC dysfunction in older, sedentary adults with T2DM compared those with normal glucose metabolism and impaired glucose metabolism, and 2) determine if aerobic exercise training is an efficacious therapy for EPC dysfunction in T2DM, and whether improvement in EPC number and function translates to improved endothelial function, increased capillarization, and improved glucose metabolism in T2DM.
Official Title

Exercise Training, CACs, and Vascular Function in Older Veterans With IGT (Impaired Glucose Tolerance)

Conditions
TYPE 2 Diabetes Mellitus
Other Study IDs
  • EPC-DM
  • HP-00047188
NCT ID Number
NCT01176578
Start Date (Actual)
2011-07
Last Update Posted
2025-09-19
Completion Date (Estimated)
2026-12-31
Enrollment (Estimated)
70
Study Type
Interventional
PHASE
N/A
Status
Active, not recruiting
Primary Purpose
Prevention
Design Allocation
Non-Randomized
Interventional Model
Parallel
Masking
None (Open Label)
Arms / Interventions
Participant Group/ArmIntervention/Treatment
ExperimentalT2DM
Type 2 Diabetes Mellitus
Aerobic Exercise Training
6 months of aerobic exercise training, 3 days per week
ExperimentalIGT
Impaired Glucose Tolerance
Aerobic Exercise Training
6 months of aerobic exercise training, 3 days per week
Active ComparatorNGT
Normal Glucose Tolerance
Aerobic Exercise Training
6 months of aerobic exercise training, 3 days per week
Primary Outcome Measures
Outcome MeasureMeasure DescriptionTime Frame
Endothelial progenitor cell number
Baseline
Endothelial progenitor cell number
6-month
Skeletal muscle capillarization
Baseline
Skeletal muscle capillarization
6-month
Secondary Outcome Measures
Outcome MeasureMeasure DescriptionTime Frame
Cardiorespiratory Fitness
Baseline
Cardiorespiratory Fitness
6-month
Eligibility Criteria

Eligible Ages
Adult, Older Adult
Minimum Age
50 Years
Eligible Sexes
All
Accepts Healthy Volunteers
Yes
  • Age 50-80
  • Non-smoker
  • If woman, postmenopausal >1 year

  • History of heart disease or stroke
  • Cancer
  • Poorly controlled hypertension or dyslipidemia
  • Kidney or Liver diseases
Baltimore VA Medical Center logoBaltimore VA Medical Center
University of Maryland, Baltimore logoUniversity of Maryland, Baltimore200 active trials to explore
Study Responsible Party
Steven J. Prior, Ph.D., Principal Investigator, Assistant Professor, Baltimore VA Medical Center
No contact data.
1 Study Locations in 1 Countries

Maryland

Baltimore VA Medical Center, Baltimore, Maryland, 21201, United States