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Clinical Trial NCT06207032 for Cancer is recruiting. See the Trial Radar Card View and AI discovery tools for all the details. Or ask anything here.
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TEMPUS ARIES: A Biobank Registry Platform Study in Oncology 500 Biomarker-Driven

Recruiting
Clinical Trial NCT06207032 is an observational study for Cancer that is recruiting. It started on June 26, 2024 with plans to enroll 500 participants. Led by Tempus AI, it is expected to complete by June 1, 2029. The latest data from ClinicalTrials.gov was last updated on February 24, 2026.
Brief Summary
This study is a non-interventional, multicenter, multicohort evaluation of participants with cancer who will undergo longitudinal plasma ctDNA biomarker profiling at specific time points in addition to standard of care therapy.
Official Title

TEMPUS ARIES: A Biobank Registry Platform Study in Oncology

Conditions
Cancer
Publications
Scientific articles and research papers published about this clinical trial:
  • Thomas M. Pharma and the benefits of Real World Data. Drug Discovery World (DDW). Published November 4, 2021. Accessed May 5, 2023. https://www.ddw-online.com/trends-analysis-pharma-and-the-benefits-of-real-world-data-13702-202111/
  • Office of the Commissioner. Oncology Real World Evidence Program. U.S. Food and Drug Administration. Accessed Ma...
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Other Study IDs
  • TP-CA-007
  • Pro00076336 (Other Identifier) (Advarra)
NCT ID Number
NCT06207032
Start Date (Actual)
2024-06-26
Last Update Posted
2026-02-24
Completion Date (Estimated)
2029-06-01
Enrollment (Estimated)
500
Study Type
Observational
Status
Recruiting
Keywords
ctDNA
Next-Generation Sequencing
Oncology
Arms / Interventions
Participant Group/ArmIntervention/Treatment
Cohort 001: KRAS mutated CRC
No intervention.
N/A
Cohort 002: KRAS mutated PDAC
No intervention.
N/A
Cohort 003: KRAS mutated NSCLC
No intervention.
N/A
Cohort 004: Gastric 1L Plus
No intervention.
N/A
Cohort 005: mCRPC 1L Plus
No intervention.
N/A
Cohort 006: Pan Tumor ADCs
No intervention.
N/A
Cohort 007: Stage III-IV EGFR Activating Mutation NSCLC
No intervention.
N/A
Primary Outcome Measures
Outcome MeasureMeasure DescriptionTime Frame
Changes in ctDNA from baseline, on-treatment and post-treatment blood samples.
Assess ctDNA kinetics using ctDNA clearance factors such as time to clearance, best overall clearance rate, best confirmed clearance, and time to ctDNA recurrence and correlate with standard of care therapy real-world outcomes such as overall survival, progression-free survival, time to next treatment, and time to treatment discontinuation.
5 years
Secondary Outcome Measures
Outcome MeasureMeasure DescriptionTime Frame
Generation of DNA, RNA, immune and other multiomic datasets.
Use blood and tissue based next generation sequencing to uncover biomarkers that may predict outcomes, identify markers related to disease, identify markers related to mechanism of drug action, and inform future research.
5 years
Participation Assistant
Eligibility Criteria

Eligible Ages
Adult, Older Adult
Minimum Age
18 Years
Eligible Sexes
All
  1. ≥18 years of age
  2. Willing to participate in the research
  3. Able to provide informed consent
  4. Must be diagnosed with cancer

1. Not willing or able to have additional blood samples collected
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Study Central Contact
Contact: Lauren Lopez, 8007394137, [email protected]
32 Study Locations in 2 Countries

Alabama

Alabama Oncology, Birmingham, Alabama, 35233, United States
Amanda Joseph, Contact, [email protected]
Matthew Tucker, MD, Principal Investigator
Recruiting

California

PIH Health Whittier Hospital & PIH Health Physicians, Whittier, California, 90605, United States
Kristine Bradbury, Contact, 562-698-0811, [email protected]
Lisa Wang, MD, Principal Investigator
Recruiting

Connecticut

Eastern CT and Hematology and Oncology Associates, Norwich, Connecticut, 06360, United States
James Champlin, Contact, 860-886-8362, [email protected]
Dennis Slater, Principal Investigator
Recruiting

Florida

Cancer Specialists of North Florida, Jacksonville, Florida, 32256, United States
Erin Shephard, Contact, 904-538-4488, [email protected]
Mehdi Moezi, Contact
Recruiting

Georgia

Morehouse, Atlanta, Georgia, 30310, United States
Justyn Dawson, Contact, [email protected]
Roland Matthews, Principal Investigator
Recruiting
Piedmont Healthcare, Atlanta, Georgia, 30318, United States
Jeff Whorton, Contact, [email protected]
Sope Olugbile, Principal Investigator
Recruiting

Illinois

Southern Illinois Healthcare, Carterville, Illinois, 62918, United States
Sarmad Nomani, Contact, [email protected]
Muhammad Popalzai, Principal Investigator
Recruiting
Hope and Healing Cancer Services, Hinsdale, Illinois, 60521, United States
Ellen Gustafson, Contact, [email protected]
Srilata Gundala, Principal Investigator
Recruiting
Cancer Care Specialists of Illinois, O'Fallon, Illinois, 62269, United States
Kaitlynn Zeisset, Contact, [email protected]
James Wade, Principal Investigator
Recruiting
Illinois Cancer Care, Peoria, Illinois, 61615, United States
Carrey Geoffroy, Contact, [email protected]
Pankaj Kumar, Principal Investigator
Recruiting
Northwest Oncology and Hematology, Rolling Meadows, Illinois, 60008, United States
Terminated

Indiana

Fort Wayne, Fort Wayne, Indiana, 46804, United States
Terminated
Goshen Center for Cancer Care, Goshen, Indiana, 46526, United States
Rachel Behrman, Contact, 5743642649, [email protected]
James Wheeler, MD, Principal Investigator
Recruiting

Kentucky

St. Claire Healthcare, Morehead, Kentucky, 40351, United States
Terminated

Maryland

Frederick Health Regional System, Frederick, Maryland, 21702, United States
Charity Drummond, Contact, [email protected]
Patrick Mansky, Principal Investigator
Recruiting

Massachusetts

Southcoast Centers for Cancer Care, Fairhaven, Massachusetts, 02719, United States
Shana Medeiros, Contact, [email protected]
Sonia Seng, Principal Investigator
Recruiting

Missouri

Hannibal Regional Healthcare System, Inc., Hannibal, Missouri, 63401, United States
Lindsey Gander, Contact, 573-629-3926, [email protected]
Kevin Palka, MD, Principal Investigator
Recruiting
Lake Regional Health, Osage Beach, Missouri, 65065, United States
Aleks Shin, Contact, [email protected]
Carla Ostronic, Principal Investigator
Recruiting
Mosaic Life Care, Saint Joseph, Missouri, 64506, United States
Active, not recruiting
Oncology Hematology Associates, Springfield, Missouri, 65807, United States
Roger Holden, Contact, 417-882-4880, [email protected]
Robert Ellis, MD, Principal Investigator
Recruiting

Nevada

Hope Cancer Care of Nevada, Las Vegas, Nevada, 89103, United States
Terminated
Cancer Care Specialists - Reno, Reno, Nevada, 89511, United States
Layla Tapia, Contact, 775-329-0222, [email protected]
Aaron Bowman, MD, Principal Investigator
Recruiting

New Jersey

New Jersey Cancer Center, Belleville, New Jersey, 07109, United States
Terminated
Regional Cancer Care Associates, Belleville, New Jersey, 07109, United States
Terminated

New York

Hematology Oncology Associates of Central NY, East Syracuse, New York, 13057, United States
Nicole Coleman, Contact, [email protected]
Ajeet Gajra, MD, Principal Investigator
Recruiting
Cayuga Medical Center, Ithaca, New York, 14850, United States
Danielle Rao, Contact, 607-252-3939, [email protected]
Nisha Ajit, Principal Investigator
Recruiting

North Dakota

Sanford Roger Maris Cancer Center (Fargo), Fargo, North Dakota, 58102, United States
Angie Bruns, Contact, [email protected]
Daniel Almquist, Principal Investigator
Recruiting

Ohio

Aultman Medical Group, Canton, Ohio, 44710, United States
Carla Larch, Contact, [email protected]
Razz Khan, Principal Investigator
Recruiting
Taylor Cancer Research Center, Maumee, Ohio, 43537, United States
Jennifer Martinez, Contact, [email protected]
John Nemunaitis, MD, Principal Investigator
Recruiting

Pennsylvania

Cancer Care Associates of York, York, Pennsylvania, 17403, United States
Clarissa Vega, Contact, [email protected]
Chanh Hyunh, Principal Investigator
Recruiting

Washington

Cancer Care Northwest, Spokane, Washington, 99216, United States
Joy Tinsen, Contact, [email protected]
Nik Rademaker, Principal Investigator
Recruiting

Puerto Rico

Pan American Center for Oncology Trials, Rio Piedras, Puerto Rico, 00935, Puerto Rico
Josselyn Molina-Avila, MD, Contact, [email protected]
Recruiting