Clinical Trial Radar

Name: PENG vs Femoral Block for Hip Fracture, A Pragmatic Cluster-Randomized Study
Creator: Weill Medical College of Cornell University
Published: 2025-07-18
License: https://www.clinicaltrials.gov/about-site/terms-conditions#availability

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	Clinical Trial NCT07073209 for Hip Fractures is recruiting. See the Trial Radar Card View and AI discovery tools for all the details. Or ask anything here.

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PENG vs Femoral Block for Hip Fracture Analgesia 352 Randomized

Recruiting

Clinical Trial NCT07073209 is an interventional study for Hip Fractures that is recruiting. It started on July 10, 2025 with plans to enroll 352 participants. Led by Weill Medical College of Cornell University, it is expected to complete by April 1, 2027. The latest data from ClinicalTrials.gov was last updated on August 28, 2025.

Brief Summary

This study aims to compare the Pericapsular Nerve Group (PENG) block with femoral block for hip fracture pain. Participants presenting to the hospital with a diagnosis of hip fracture and consenting to analgesic block will receive either a PENG or femoral block. The choice of block will be dictated by a randomized monthly schedule, and all participants presenting during each four-week period will receive the designat...Show More

Detailed Description

Each year, 250,000 adults in the US and 1.6 million worldwide suffer hip fractures. Peripheral nerve blocks, including femoral blocks, administered soon after admission to patients presenting with hip fractures have been shown to produce clinically and statistically significant reductions in pain scores, opioid consumption, the incidence of confusional state, and the time to mobilization.

Historically, lower extremi...

Official Title

PENG vs Femoral Block for Hip Fracture, A Pragmatic Cluster-Randomized Study

Conditions

Hip Fractures

Publications

Neuman MD, Feng R, Carson JL, Gaskins LJ, Dillane D, Sessler DI, Sieber F, Magaziner J, Marcantonio ER, Mehta S, Menio D, Ayad S, Stone T, Papp S, Schwenk ES, Elkassabany N, Marshall M, Jaffe JD, Luke C, Sharma B, Azim S, Hymes RA, Chin KJ, Sheppard R, Perlman B, Sappenfield J, Hauck E, Hoeft ...

Other Study IDs

24-07027709

NCT ID Number

NCT07073209

Start Date (Actual)

2025-07-10

Last Update Posted

2025-08-28

Completion Date (Estimated)

2027-04

Enrollment (Estimated)

352

Study Type

Interventional

PHASE

N/A

Status

Recruiting

Keywords

Pain
Anesthesia
Analgesia
Hip Fracture
Peripheral nerve block
Regional Anesthesia

Primary Purpose

Treatment

Design Allocation

Randomized

Interventional Model

Crossover Assignment

Masking

None (Open Label)

Arms / Interventions

Participant Group/Arm	Intervention/Treatment
ExperimentalPENG Block Administration Policy for the administration of the PENG block as per clinical guidelines to all subjects presenting to the hospital with a diagnosis of hip fracture and consenting to analgesic block	PENG Block Administration Policy for the PENG block administration: 30 mL of Bupivacaine 0.25% 1:200,000 epinephrine Dexamethasone 4 mg% While these drugs are administered to participants, the intervention under evaluation is the PENG Block anesthesia technique. Bupivacaine , epinephrine Dexamethasone 30 mL of Bupivacaine 0.25% 1:200,000 epinephrine Dexamethasone 4 mg%
ExperimentalFemoral Block Administration Policy for the administration of the Femoral block as per clinical guidelines to all subjects presenting to the hospital with a diagnosis of hip fracture and consenting to analgesic block	Femoral Block Administration Policy for the Femoral block administration: 30 mL of Bupivacaine 0.25% 1:200,000 epinephrine Dexamethasone 4 mg While these drugs are administered to participants, the intervention under evaluation is the Femoral Block anesthesia technique. Bupivacaine , epinephrine Dexamethasone 30 mL of Bupivacaine 0.25% 1:200,000 epinephrine Dexamethasone 4 mg%

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Mean Change in Numerical Rating Scale (NRS) Pain Score One Hour Post Block for all Subjects	The Numerical Rating Scale (NRS) measures the intensity of pain a subject experiences. where subjects rate their pain on a scale from zero to ten and each number corresponds to a different level of intensity. The lowest score 0 represents no pain and the highest score 10 represents the most intense feeling of pain.	Baseline, 1-hour post block
Mean Change in Numerical Rating Scale (NRS) Pain Score One-Hour Post Block in Intracapsular Hip Fractures	The Numerical Rating Scale (NRS) measures the intensity of pain a subject experiences. where subjects rate their pain on a scale from zero to ten and each number corresponds to a different level of intensity. The lowest score 0 represents no pain and the highest score 10 represents the most intense feeling of pain.	Baseline, 1-hour post block
Mean Change in Numerical Rating Scale (NRS) Pain Score One-Hour Post Block in Extracapsular Hip Fractures	The Numerical Rating Scale (NRS) measures the intensity of pain a subject experiences. where subjects rate their pain on a scale from zero to ten and each number corresponds to a different level of intensity. The lowest score 0 represents no pain and the highest score 10 represents the most intense feeling of pain.	Baseline, 1-hour post block

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Mean NRS Pain Scores up to 24 Hours Post-block for all Subjects	The Numerical Rating Scale (NRS) measures the intensity of pain a subject experiences. where subjects rate their pain on a scale from zero to ten and each number corresponds to a different level of intensity. The lowest score 0 represents no pain and the highest score 10 represents the most intense feeling of pain.	0-24 hours post block
Mean NRS Pain Scores up to 24 Hours Post-block in Intracapsular Hip Fractures	The Numerical Rating Scale (NRS) measures the intensity of pain a subject experiences. where subjects rate their pain on a scale from zero to ten and each number corresponds to a different level of intensity. The lowest score 0 represents no pain and the highest score 10 represents the most intense feeling of pain.	0-24 hours post block
Mean NRS Pain Scores up to 24 Hours Post-block in Extracapsular Hip Fractures	The Numerical Rating Scale (NRS) measures the intensity of pain a subject experiences. where subjects rate their pain on a scale from zero to ten and each number corresponds to a different level of intensity. The lowest score 0 represents no pain and the highest score 10 represents the most intense feeling of pain.	0-24 hours post block
Number of Oral Morphine Equivalents Administered for all Subjects	Milligrams of oral morphine equivalent opioid consumption up to 24 hours post-block. Non-morphine opioids will be converted to an equivalent morphine dosage in milligrams for comparison across both block types. Oral morphine equivalent dosages are calculated using: Wen RY et al. A Comparison of Institutional Opioid Equianalgesia Tools: A National Study. J Palliat Med. 2022;25:1686	0-24 hours post block
Number of Oral Morphine Equivalents Administered in Intracapsular Hip Fractures	Milligrams of oral morphine equivalent opioid consumption up to 24 hours post-block. Non-morphine opioids will be converted to an equivalent morphine dosage in milligrams for comparison across both block types. Oral morphine equivalent dosages are calculated using: Wen RY et al. A Comparison of Institutional Opioid Equianalgesia Tools: A National Study. J Palliat Med. 2022;25:1686	0-24 hours post block
Number of Oral Morphine Equivalents Administered in Extracapsular Hip Fractures	Milligrams of oral morphine equivalent opioid consumption up to 24 hours post-block. Non-morphine opioids will be converted to an equivalent morphine dosage in milligrams for comparison across both block types. Oral morphine equivalent dosages are calculated using: Wen RY et al. A Comparison of Institutional Opioid Equianalgesia Tools: A National Study. J Palliat Med. 2022;25:1686	0-24 hours post block

Participation Assistant

Eligibility Criteria

Eligible Ages

Adult, Older Adult

Minimum Age

18 Years

Eligible Sexes

All

Male or female ≥ 18 years of age.
ASA Classification 1-4
Documentation of a hip fracture diagnosis along with radiologic read indicating fracture location
Written, informed consent for analgesic peripheral block placement

Altered mental status to the extent that it limits ability to report pain score
Patient or health care proxy refusal of analgesic nerve block
Allergy to study medications or contraindication to peripheral nerve block
Chronic pain diagnosis on preoperative opioids

Weill Medical College of Cornell University

New York Presbyterian Hospital

Study Central Contact

Contact: Michele Steinkamp, BSN, RN, 212-746-2953, [email protected]

Contact: Mark Abdelmassih, B.S., 212-746-2774, [email protected]

1 Study Locations in 1 Countries

United States

New York

Weill Cornell Medicine, Manhattan, New York, 10065, United States

Tiffany Tedore, M.D., Contact, (212) 746-2725, [email protected]

Michele Steinkamp, R.N., Contact, +1 212 746 2953, [email protected]

Recruiting

PENG vs Femoral Block for Hip Fracture Analgesia 352 Randomized

Inclusion Criteria

Exclusion Criteria