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Clinical Trial NCT07360327 for CABG, Dexmedetomidine, Ketamine, Opioid Free Anesthesia, Opioid Based Anesthesia is not yet recruiting. See the Trial Radar Card View and AI discovery tools for all the details. Or ask anything here.
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Role of Opioid Free Anaesthesia in Elderly Patients Undergoing Elective Coronary Artery Bypass Graft Surgeries With Cardiopulmonary Bypass in Enhanced Recovery After Surgeries 60 Senior-Focused

Not yet recruiting
Clinical Trial NCT07360327 is an interventional study for CABG, Dexmedetomidine, Ketamine, Opioid Free Anesthesia, Opioid Based Anesthesia and is currently not yet recruiting. Enrollment is planned to begin on January 1, 2026 and continue until the study accrues 60 participants. Led by Ain Shams University, this study is expected to complete by December 1, 2026. The latest data from ClinicalTrials.gov was last updated on January 22, 2026.
Brief Summary
The introduction of synthetic opioids in 1960 to general anesthesia together with sedative hypnotics and muscle relaxants allowed the appearance of the concept of multimodal balanced anesthesia. Although they help in achieving hemodynamic stability during anesthesia of open heart surgeries, their administration consequences are neither scarce nor benign to the patient. Perioperative opioids are associated with increa...Show More
Detailed Description
Study Procedures: o Randomization will allocate patients into two groups: Opioid-free (F) and Opioid-based (O) anesthesia, with numbers drawn from sealed envelopes. o Group F will receive analgesia through ketamine and dexmedetomidine based on Ideal Body Weight (IBW). o Group O will receive fentanyl for analgesia, also based on IBW. o IBW is calculated using ARDSnet formulas (Brower et al., 2000). o For men, IBW is 5...Show More
Official Title

Role of Opioid Free Anaesthesia in Elderly Patients Undergoing Elective Coronary Artery Bypass Graft Surgeries With Cardiopulmonary Bypass in Enhanced Recovery After Surgeries

Conditions
CABGDexmedetomidineKetamineOpioid Free AnesthesiaOpioid Based Anesthesia
Other Study IDs
  • FMASU MD239/2025
NCT ID Number
NCT07360327
Start Date (Actual)
2026-01-01
Last Update Posted
2026-01-22
Completion Date (Estimated)
2026-12-01
Enrollment (Estimated)
60
Study Type
Interventional
PHASE
N/A
Status
Not yet recruiting
Primary Purpose
Supportive Care
Design Allocation
Randomized
Interventional Model
Parallel
Masking
Quadruple
Arms / Interventions
Participant Group/ArmIntervention/Treatment
Active ComparatorOpioid free anesthesia group
Patients will receive dexmedetomidine and ketamine
Opioid Free Anesthesia
group (F) receive dexmedetomidine and ketamine
Active ComparatorOpioid based group
Patients will receive fentanyl
Opioid Based Anesthesia
Opioid based group receive fentanyl
Primary Outcome Measures
Outcome MeasureMeasure DescriptionTime Frame
Enhanced recovery time
From transfer the patient to icu till extubation
24 hours
Enhanced recovery defined as time of extubation
Time from extubation after transfer to icu
24 hours
Secondary Outcome Measures
Outcome MeasureMeasure DescriptionTime Frame
POCD
Post operative delerium by cam score which has 4 features ....to diagnose delerium patient must have 3 features
1 week
Post operative opioid consumption
Total morphine consumption
IN the first 24 hour after surgery ...total morphine consumption
Cortisol level
cortisol level
24 hours
Participation Assistant
Eligibility Criteria

Eligible Ages
Older Adult
Minimum Age
65 Years
Eligible Sexes
All
  • Age group: above 65 years old of both sex. Undergoing an elective coronary artery bypass graft surgeries with cardiopulmonary bypass.

  • Past or ongoing history of drug abuse.
  • Psychiatric disease and cognitive disorders.
  • Inability to perform the confusion assessment method for the intensive care unit (CAM-ICU) test.
  • EF<40 %.
  • 1st or 2nd degree Heart block.
  • HR <50 bpm.
  • Allergy from drugs used in this study.
  • Use of a left ventricular assist device, IAB or ECMO pri
Ain Shams University logoAin Shams University344 active studies to explore
Study Central Contact
Contact: Mahmoud Mohamed Abdelrhman mohamed, Assistant lecturer, 01024242615, [email protected]
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