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Clinical Trial NCT07366060 (TON-PRF-CH) for Cervicogenic Headache, Third Occipital Nerve is recruiting. See the Trial Radar Card View and AI discovery tools for all the details. Or ask anything here.
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Effectiveness of Third Occipital Nerve Pulsed Radiofrequency in Cervicogenic Headache (TON-PRF-CH) 25

Recruiting
Clinical Trial NCT07366060 (TON-PRF-CH) is an interventional study for Cervicogenic Headache, Third Occipital Nerve that is recruiting. It started on February 1, 2026 with plans to enroll 25 participants. Led by Ankara City Hospital Bilkent, it is expected to complete by September 1, 2026. The latest data from ClinicalTrials.gov was last updated on January 26, 2026.
Brief Summary
Cervicogenic headache is a secondary headache disorder originating from cervical spine structures and is frequently associated with chronic pain, functional limitation, and impaired quality of life. The third occipital nerve, which innervates the C2-3 zygapophyseal joint, plays an important role in the pathophysiology of cervicogenic headache.

Pulsed radiofrequency is a minimally invasive interventional pain managem...

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Detailed Description
Cervicogenic headache is a chronic secondary headache disorder arising from cervical spine structures, particularly the C2-3 zygapophyseal joint and its innervating third occipital nerve. This condition is often resistant to conservative therapies and may significantly impair daily functioning and sleep quality.

Pulsed radiofrequency is a neuromodulatory technique that delivers intermittent high-frequency electrical...

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Official Title

Evaluation of the Effectiveness of Third Occipital Nerve Pulsed Radiofrequency Treatment in Patients With Cervicogenic Headache

Conditions
Cervicogenic HeadacheThird Occipital Nerve
Publications
Scientific articles and research papers published about this clinical trial:
Other Study IDs
  • TON-PRF-CH
  • TABED 1-25-1390
NCT ID Number
NCT07366060
Start Date (Actual)
2026-02-01
Last Update Posted
2026-01-26
Completion Date (Estimated)
2026-09-01
Enrollment (Estimated)
25
Study Type
Interventional
PHASE
N/A
Status
Recruiting
Keywords
cervicogenic headache
Pulsed Radiofrequency
Third Occipital Nerve
TON PRF
Primary Purpose
Treatment
Design Allocation
N/A
Interventional Model
Single Group
Masking
None (Open Label)
Arms / Interventions
Participant Group/ArmIntervention/Treatment
ExperimentalTON PRF Treatment
Participants diagnosed with cervicogenic headache who demonstrate a positive response to diagnostic third occipital nerve block will receive ultrasound-guided pulsed radiofrequency treatment of the third occipital nerve.
Third Occipital Nerve Pulsed Radiofrequency
Ultrasound-guided pulsed radiofrequency treatment applied to the third occipital nerve at the C2-3 zygapophyseal joint level for the management of cervicogenic headache.
Primary Outcome Measures
Outcome MeasureMeasure DescriptionTime Frame
Change in pain intensity measured by Visual Analog Scale (VAS)
Pain intensity will be assessed using the Visual Analog Scale (VAS) to evaluate changes in headache-related pain following third occipital nerve pulsed radiofrequency treatment.
Baseline, and 1, 2, and 3 months after the procedure
Secondary Outcome Measures
Outcome MeasureMeasure DescriptionTime Frame
Number of headache days per month
The number of days with headache per month will be recorded using patient headache diaries during follow-up.
Baseline, and 1, 2, and 3 months after the procedure
Participation Assistant
Eligibility Criteria

Eligible Ages
Adult, Older Adult
Minimum Age
18 Years
Eligible Sexes
All
  • Age 18 years or older
  • Diagnosis of cervicogenic headache according to the International Classification of Headache Disorders, 3rd edition (ICHD-3)
  • Availability of cranial and cervical spine imaging
  • At least 5 headache days per month
  • Inadequate response to pharmacological and/or physical therapy treatments
  • Ability to understand and provide written informed consent
  • Positive response to ultrasound-guided diagnostic third occipital nerve block, defined as at least 50% reduction in pain intensity or patient-reported meaningful improvement

  • Secondary headache disorders other than cervicogenic headache according to ICHD-3
  • Signs or symptoms of cervical nerve root irritation and/or spinal stenosis
  • Sensory deficit in the greater occipital nerve dermatome
  • Cranio-cervical structural defects or anatomical abnormalities at or near the target site
  • Local or systemic infection
  • Non-pharmacological headache treatment within the last 3 months (e.g., physical therapy, botulinum toxin A, acupuncture, ozone therapy, cognitive behavioral therapy)
  • Pregnancy or suspected pregnancy
  • Known allergy to local anesthetic agents
  • History of malignancy
  • Known organic disease of the brain or spinal cord
  • History of cranial or cervical surgery within the last 12 months
  • Bleeding or coagulation disorders or use of oral anticoagulant therapy
  • Comorbid conditions that may cause headache (e.g., uncontrolled hypertension, intracranial lesions)
  • Conditions that may interfere with treatment adherence or outcome assessment (e.g., psychiatric disorders, dementia)
  • Request for re-treatment due to development of contralateral pain or other pain conditions during follow-up
  • Refusal to undergo the intervention or withdrawal of consent at any stage of the study
Ankara City Hospital Bilkent logoAnkara City Hospital Bilkent
Study Responsible Party
Hatice Babaoğlan, Principal Investigator, medical doctor, Ankara City Hospital Bilkent
Study Central Contact
Contact: Hatice Babaoğlan, 0533 7783642, [email protected]
1 Study Locations in 1 Countries

Ankara

Ankara City Hospital Bilkent, Ankara, Ankara, Turkey (Türkiye)
Ankara Bilkent city hospital, Contact
Recruiting