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Clinical Trial NCT07496086 for Postoperative Pain is recruiting. See the Trial Radar Card View and AI discovery tools for all the details. Or ask anything here. | ||
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External Oblique Intercostal Block Versus Transversus Abdominis Plane Combined With Rectus Sheath Block on Postoperative Pain in Laparoscopic Radical Gastrectomy 100 Randomized Novel Treatment
Clinical Trial NCT07496086 is an interventional study for Postoperative Pain that is recruiting. It started on March 20, 2026 with plans to enroll 100 participants. Led by General Hospital of Ningxia Medical University, it is expected to complete by November 3, 2026. The latest data from ClinicalTrials.gov was last updated on March 27, 2026.
Brief Summary
Postoperative pain is highly prevalent following laparoscopic radical gastrectomy. Although Transversus abdominis plane block combined with rectus sheath block(TAP+RSB） can effectively alleviate this pain, it still has many limitations. The external oblique intercostal plane block (EOIB) is a novel nerve block technique that may provide well postoperative analgesia for upper abdominal surgery. Therefore, this study e...Show More
Detailed Description
Laparoscopic radical gastrectomy (including subtotal and total gastrectomy) is the most commonly used surgical approach for gastric cancer. Although this technique is less invasive than traditional open surgery, more than 50% of patients still experience moderate to severe acute pain in the early postoperative period, making effective postoperative pain management essential. Regional nerve blockade techniques have be...Show More
Official Title
Effects of Ultrasound-guided External Oblique Intercostal Block Versus Transversus Abdominis Plane Combined With Rectus Sheath Block on Postoperative Pain in Laparoscopic Radical Gastrectomy
Conditions
Postoperative PainOther Study IDs
- Lingzi-2026-2
NCT ID Number
Start Date (Actual)
2026-03-20
Last Update Posted
2026-03-27
Completion Date (Estimated)
2026-11-03
Enrollment (Estimated)
100
Study Type
Interventional
PHASE
N/A
Status
Recruiting
Primary Purpose
Treatment
Design Allocation
Randomized
Interventional Model
Parallel
Masking
Double
Arms / Interventions
| Participant Group/Arm | Intervention/Treatment |
|---|---|
ExperimentalEOIB After patients entering the operating room, an intravenous line was established, and External Oblique Intercostal Plane Block was performed under ultrasound guidance. | EOIB With the patient in the supine position, a high-frequency linear array probe (6-15 MHz) is used to perform a sagittal parasagittal oblique scan at the level of the 6th rib, between the right anterior axillary line and midclavicular line. The external oblique muscle, intercostal muscles, and ribs are identified. Using an in-plane technique, a 21G, 100mm block needle is inserted from a superomedial to inferolateral dir...Show More |
ExperimentalTAP+RSB After patients entering the operating room, an intravenous line was established, and Transversus abdominis plane block combined with rectus sheath block was performed under ultrasound guidance. | TAP+RSB With the patient in the supine position, above the umbilicus, a linear ultrasound transducer was positioned transversely on the rectus abdominis muscle, and 15 mL of ropivacaine 0.375% was injected into both sides of the aspect between the rectus abdominis muscle and the posterior rectus sheath with a 22G 70-mm block needle using the in-plane technique. At the midaxillary line, a linear ultrasound transducer was posi...Show More |
Primary Outcome Measures
Secondary Outcome Measures
| Outcome Measure | Measure Description | Time Frame |
|---|---|---|
Cumulative opioid consumption within 24 hours postoperatively | Cumulative opioid consumption within 24 hours postoperatively. Conversion to morphine equivalent dose (mg) | 24 hours after surgery |
| Outcome Measure | Measure Description | Time Frame |
|---|---|---|
Pain Intensity | Pain at rest and during coughing will be assessed using the Numerical Rating Scale (NRS, 0-10) at 2, 6, 12, 24, 48, and 72 hours postoperatively.0 represents no pain, and 10 represents the most pain. | 2, 6, 12, 24, 48, and 72 hours postoperatively |
Quality of Recovery | The 15-item Quality of Recovery scale (QoR-15) was used for assessment at 24, 48, and 72 hours postoperatively. The higher the score, the better the recovery quality | 24,48,72 hours after surgery |
sleep quality | Sleep quality was assessed using the Richards-Campbell Sleep Questionnaire (RCSQ) on postoperative nights.0 points represent very poor sleep, while 100 points represent very good sleep | 24,48,72 hours after surgery |
Participation Assistant
Eligibility Criteria
Eligible Ages
Adult, Older Adult
Minimum Age
18 Years
Eligible Sexes
All
- Patients aged over 18 years
- Classified as ASA I-III
- Scheduled for elective laparoscopic radical gastrectomy under general anesthesia
- Voluntarily participated and provided written informed consent.
- Chronic opioid dependence or prior use of analgesic medications for >3 months;
- Inability to communicate due to severe dementia, language barriers, or terminal illness;
- History of central and/or peripheral nervous system disorders;
- Severe renal insufficiency (serum creatinine >442 μmol/L or requiring renal replacement therapy) or severe hepatic insufficiency (Child-Pugh class C);
- Allergy to local anesthetics.
- Expected to be transferred to ICU after surgery.
- Refuse patient control agenesia after surgery.
General Hospital of Ningxia Medical UniversityStudy Central Contact
Contact: lingzi Yin, Doctoral, 86-951-674-3252, [email protected]
1 Study Locations in 1 Countries
General hospital of Ningxia medical university, Yinchuan, China
lingzi Yin, Doctoral, Contact, 86-951-674-3252, [email protected]
Recruiting