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Sun Yat-sen UniversityIschemic Preconditioning Reduces the Severity of Acute Kidney Injury After Partial Nephrectomy 174 Remote
Clinical Trial NCT07497958 is an interventional study for Renal Cell Carcinoma (RCC), Renal Function Abnormal and is currently not yet recruiting. Enrollment is planned to begin on April 1, 2026 and continue until the study accrues 174 participants. Led by Sun Yat-sen University, this study is expected to complete by December 31, 2028. The latest data from ClinicalTrials.gov was last updated on March 27, 2026.
Brief Summary
It is demonstrated that remote ischemic preconditioning can alleviate the degree of acute renal injury on the operated side in patients undergoing partial nephrectomy.
Detailed Description
The study cohort was randomly divided into two groups. One group received remote ischemic preconditioning one day before partial nephrectomy, while the other group underwent partial nephrectomy directly. The degree of acute renal injury on the operated side was compared between the two groups
Official Title
Ischemic Preconditioning Reduces the Severity of Acute Kidney Injury After Partial Nephrectomy: a Randomized Controlled Clinical Study
Conditions
Renal Cell Carcinoma (RCC)Renal Function AbnormalOther Study IDs
- B2026-114
NCT ID Number
Start Date (Actual)
2026-04-01
Last Update Posted
2026-03-27
Completion Date (Estimated)
2028-12-31
Enrollment (Estimated)
174
Study Type
Interventional
PHASE
N/A
Status
Not yet recruiting
Keywords
Renal Function Abnormal
Acute kidney injury
Partial nephrectomy
Ischemic preconditioning
Acute kidney injury
Partial nephrectomy
Ischemic preconditioning
Primary Purpose
Treatment
Design Allocation
Randomized
Interventional Model
Parallel
Masking
None (Open Label)
Arms / Interventions
| Participant Group/Arm | Intervention/Treatment |
|---|---|
ExperimentalExperimental : Ischemic preconditioning One day before the surgery, use a sphygmomanometer to apply pressure to the patient's upper limb to 200mmHg for 5 minutes, then reduce the pressure to 0mmHg for 5 minutes, repeating this process for a total of 3 cycles. On the second day, perform a routine partial nephrectomy | Ischemic preconditioning One day before the surgery, use a sphygmomanometer to apply pressure to the patient's upper limb to 200mmHg for 5 minutes, then reduce the pressure to 0mmHg for 5 minutes, repeating this process for a total of 3 cycles. On the second day, perform a routine partial nephrectomy |
Active ComparatorComparator : No ischemic preconditioning Routine partial nephrectomy | NO ischemic preconditioning Routine partial nephrectomy |
Primary Outcome Measures
Secondary Outcome Measures
| Outcome Measure | Measure Description | Time Frame |
|---|---|---|
AIRD spectrum score based on the patient's preoperative creatinine level and postoperative peak creatinine level | The AIRD spectrum score was defined as: (observed peak SCr - SCr ideal-peak)/(SCr worstcase-peak - SCr ideal-peak） The range of this indicator should be between 0 and 1, with 0 and 1 representing two extreme situations. 0 indicates that the kidney on the operated side is completely undamaged, while 1 indicates that the kidney on the operated side has completely lost its function. | 2 weeks after partial nephrectomy |
| Outcome Measure | Measure Description | Time Frame |
|---|---|---|
Recovery from ischemia based on the changes in creatinine levels before and after the partial nephrectomy and volume retention rate after the partial nephrectomy | Recovery from ischemia = (%GFR saved)/(%parenchymal mass preserved) | 3 month after surgery |
Participation Assistant
Eligibility Criteria
Eligible Ages
Adult, Older Adult
Minimum Age
18 Years
Eligible Sexes
All
Patients who are scheduled to undergo partial nephrectomy, with no specific surgical procedure limitation, including laparoscopic surgery, robot-assisted surgery, and open surgery
Aged 18 to 80
Possess good organ function status: sufficient organ function (based on the normal values of the clinical trial center)
- Blood routine test: WBC≥3.5×10^9/L, absolute neutrophil count ≥1.5×10^9/L, PLT≥75.0×10^9/L, HGB≥80g/L;
- Liver function: Total bilirubin ≤1.5×upper limit of normal (ULN), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤2.5×ULN;
- The anesthesiologist assesses that the patient cannot tolerate general anesthesia surgery
- Individuals with severe cardiovascular and cerebrovascular diseases, uncontrolled hypertension, and diabetes
- Estimated glomerular filtration rate (eGFR) < 30 ml/min/1.73m²
- Horseshoe kidney
- Solitary kidney
- Pregnant women
Sun Yat-sen University1239 active studies to exploreStudy Responsible Party
ZHOU FANGJIAN, Principal Investigator, professor, Sun Yat-sen University
Study Central Contact
Contact: Fangjian Zhou, professor, 020-87343865, [email protected]
1 Study Locations in 1 Countries
Guangdong
651 Dongfeng Road East, Yuexiu District, Guangzhou, P.R. China Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, 510000, China