Clinical Trial Radar

Name: Evaluation of the Diagnostic Performance of the Testicular Workup for Ischemia and Suspected Torsion (TWIST) Score for Assessing the Risk of Testicular Torsion in Adult Patients Presenting to the Emergency Department With Scrotal Pain
Creator: University Hospital, Linkoeping
Published: 2026-03-27
License: https://www.clinicaltrials.gov/about-site/terms-conditions#availability

beta

Trial Radar AI Trial Candidate or Patient Patient Caregiver Healthcare Pro Biotech Pro Biotech Investor Researcher Other
	Clinical Trial NCT07499024 for Testicular Torsion, Acute Scrotum, Scrotal Pain is recruiting. See the Trial Radar Card View and AI discovery tools for all the details. Or ask anything here.

One study matched filter criteria

Card View

Evaluation of the Diagnostic Performance of the Testicular Workup for Ischemia and Suspected Torsion (TWIST) Score for Assessing the Risk of Testicular Torsion in Adult Patients Presenting to the Emergency Department With Scrotal Pain - A Prospective Observational Study 1,000 Pediatric Observational

Recruiting

Clinical Trial NCT07499024 is an observational study for Testicular Torsion, Acute Scrotum, Scrotal Pain that is recruiting. It started on February 1, 2026 with plans to enroll 1,000 participants. Led by University Hospital, Linkoeping, it is expected to complete by December 31, 2029. The latest data from ClinicalTrials.gov was last updated on March 27, 2026.

Brief Summary

This prospective multicenter observational study aims to evaluate the diagnostic accuracy of the Testicular Workup for Ischemia and Suspected Torsion (TWIST) score in adult patients presenting with acute scrotal pain in Swedish Emergency Departments.

The TWIST score is a clinical decision tool originally validated in pediatric populations to stratify patients into low, intermediate, and high risk for testicular tors...

Detailed Description

Acute scrotal pain is a common presentation in Emergency Departments, but the diagnosis of testicular torsion (TT) is relatively rare. Prompt identification is crucial because TT requires urgent surgical intervention to preserve testicular viability. Delays in diagnosis, particularly due to unnecessary imaging or non-standardized clinical assessment, may result in testicular loss.

The TWIST (Testicular Workup for Is...

Official Title

Evaluation of the Diagnostic Performance of the Testicular Workup for Ischemia and Suspected Torsion (TWIST) Score for Assessing the Risk of Testicular Torsion in Adult Patients Presenting to the Emergency Department With Scrotal Pain

Conditions

Testicular TorsionAcute ScrotumScrotal Pain

Other Study IDs

UHLinkoeping
2025-07400-01 (Other Identifier) (Swedish Ethical Review Authority approval number)

NCT ID Number

NCT07499024

Start Date (Actual)

2026-02-01

Last Update Posted

2026-03-27

Completion Date (Estimated)

2029-12-31

Enrollment (Estimated)

1,000

Study Type

Observational

Status

Recruiting

Keywords

Testicular Torsion
Acute Scrotum
Testicular Workup for Ischemia and Suspected Torsion (TWIST)

Arms / Interventions

Participant Group/Arm

Intervention/Treatment

Adult ED Patients with Acute Scrotal Pain

All participants are assessed according to routine clinical care in the Emergency Department. The TWIST score is calculated from standard clinical findings but does not influence management; decisions regarding imaging or surgery follow usual clinical practice. Data on symptoms, TWIST score components, and outcomes (including surgical confirmation of testicular torsion) are collected prospectively.

N/A

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Diagnostic Accuracy of the TWIST Score (Low-Risk Group)	Number and proportion of adult patients with a low-risk TWIST score (0-2) who are confirmed not to have testicular torsion based on surgical exploration or follow-up within 30 days. This measures the sensitivity of the TWIST score to safely rule out torsion.	Up to 30 days from ED visit

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Time to exploration	Time in hours from patient arrival in the Emergency Department to surgical intervention for suspected testicular torsion.	30 days from ED visit
Testicular torsion	Number of testicular torsions found up to 30 days from ED visit	30 days from inclusion
Pain at study inclusion	Pain at inclusion to the study measured by NRS	Up to one hour from inclusion in the study.
Use of Ultrasound	If ultrasound was used during the Emergency Department visit	Up to 48 hours from inclusion or ED discharge, whichever comes first

Participation Assistant

Eligibility Criteria

Eligible Ages

Adult

Minimum Age

18 Years

Eligible Sexes

Male

Male patients aged 18-40 years

Presenting to the Emergency Department with acute scrotal pain or scrotal symptoms

Suspicion of testicular torsion before clinical assessment

Scrotal pain or symptoms caused by trauma

Symptom duration > 1 week

History of testicular surgery

Inability to provide informed consent (e.g., language barrier or cognitive limitation)

University Hospital, Linkoeping

Linkoeping University

Study Responsible Party

Daniel Wilhelms, Principal Investigator, MD,PHD, University Hospital, Linkoeping

Study Central Contact

Contact: Jens Wretborn, MD, PhD, +461030000, [email protected]

1 Study Locations in 1 Countries

Sweden

Östergötland County

Linköping University Hospital, ED, Linköping, Östergötland County, 58185, Sweden

Jens Ragnar Wretborn, MD, PhD, Contact, +46, [email protected]

Recruiting

Inclusion Criteria

Exclusion Criteria