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Clinical Trial NCT07502248 for Postoperative Pain, Total Hip Arthroplasty (THA) is not yet recruiting. See the Trial Radar Card View and AI discovery tools for all the details. Or ask anything here. | ||
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PENG Block With or Without PPD Block for Postoperative Analgesia After Total Hip Arthroplasty 40 Randomized
Clinical Trial NCT07502248 is an interventional study for Postoperative Pain, Total Hip Arthroplasty (THA) and is currently not yet recruiting. Enrollment is planned to begin on April 5, 2026 and continue until the study accrues 40 participants. Led by Kirsehir Ahi Evran Universitesi, this study is expected to complete by June 5, 2027. The latest data from ClinicalTrials.gov was last updated on March 30, 2026.
Brief Summary
This single-center, prospective, randomized controlled clinical trial aims to compare the postoperative analgesic efficacy of PENG block with or without posterior pericapsular deep gluteal block in adult patients undergoing elective primary total hip arthroplasty under spinal anesthesia. Total hip arthroplasty is commonly associated with moderate to severe postoperative pain. Although PENG block provides analgesia fo...Show More
Detailed Description
This study is planned as a single-center, prospective, randomized, controlled, double-blind trial in adult patients undergoing elective primary total hip arthroplasty under spinal anesthesia. Eligible participants will be patients aged 18 years or older, classified as ASA physical status I-III, and able to provide informed consent. Patients with ASA IV-V, serious cardiac, respiratory, hepatic, or renal disease, neuro...Show More
Official Title
Comparison of the Efficacy of Pericapsular Nerve Group (PENG) Block Versus PENG Block Added to Posterior Pericapsular Deep Gluteal (PPD) Block for Postoperative Analgesia in Total Hip Arthroplasty
Conditions
Postoperative PainTotal Hip Arthroplasty (THA)Other Study IDs
- KAEAH-THA-PENG-PPD-01
NCT ID Number
Start Date (Actual)
2026-04-05
Last Update Posted
2026-03-30
Completion Date (Estimated)
2027-06-05
Enrollment (Estimated)
40
Study Type
Interventional
PHASE
N/A
Status
Not yet recruiting
Keywords
PENG block
PPD block
Postoperative analgesia
Numeric Rating Scale
PPD block
Postoperative analgesia
Numeric Rating Scale
Primary Purpose
Treatment
Design Allocation
Randomized
Interventional Model
Parallel
Masking
Double
Arms / Interventions
| Participant Group/Arm | Intervention/Treatment |
|---|---|
Active ComparatorPENG Block Participants in this arm will receive ultrasound-guided PENG block after spinal anesthesia for postoperative analgesia during primary total hip arthroplasty. In addition, lateral femoral cutaneous nerve block will be performed. | PENG block Ultrasound-guided pericapsular nerve group block performed after spinal anesthesia for postoperative analgesia in patients undergoing primary total hip arthroplasty. In Group 1, PENG block will be performed in the supine position using an in-plane technique, and 20 mL of 0.25% bupivacaine will be injected between the psoas tendon and iliopubic ramus. In both groups, lateral femoral cutaneous nerve block will also be ...Show More |
Active ComparatorPENG Plus PPD Block Participants in this arm will receive ultrasound-guided PENG block followed by ultrasound-guided posterior pericapsular deep gluteal block after spinal anesthesia for postoperative analgesia during primary total hip arthroplasty. In addition, lateral femoral cutaneous nerve block will be performed. | PENG block Ultrasound-guided pericapsular nerve group block performed after spinal anesthesia for postoperative analgesia in patients undergoing primary total hip arthroplasty. In Group 1, PENG block will be performed in the supine position using an in-plane technique, and 20 mL of 0.25% bupivacaine will be injected between the psoas tendon and iliopubic ramus. In both groups, lateral femoral cutaneous nerve block will also be ...Show More Deep posterior gluteal compartment block Ultrasound-guided posterior pericapsular deep gluteal block performed after PENG block and spinal anesthesia for postoperative analgesia in patients undergoing primary total hip arthroplasty. In Group 2, the block will be performed in the lateral decubitus position with the hip and knee flexed to 90 degrees, and 30 mL of 0.25% bupivacaine will be injected after needle placement to the posterior acetabular rim near th...Show More |
Primary Outcome Measures
Secondary Outcome Measures
| Outcome Measure | Measure Description | Time Frame |
|---|---|---|
Postoperative pain intensity at 6 hours measured by Numeric Rating Scale (NRS) | Postoperative pain intensity will be assessed using the Numeric Rating Scale (NRS), where 0 indicates no pain and 10 indicates the worst imaginable pain. The primary comparison between groups will be the NRS score at postoperative 6 hours | 6 hours after surgery |
| Outcome Measure | Measure Description | Time Frame |
|---|---|---|
Postoperative pain intensity over the first 24 hours measured by Numeric Rating Scale (NRS) | Postoperative pain intensity will also be assessed in the recovery room and at postoperative 2, 12, and 24 hours using the Numeric Rating Scale (NRS) | Recovery room, 2 hours, 12 hours, and 24 hours after surgery |
Total analgesic consumption during the first 24 hours | Total amount of analgesic medication consumed within the first 24 hours after surgery will be recorded and compared between groups | 24 hours after surgery |
Time to first rescue analgesic requirement | Time from block performance to first additional analgesic requirement will be recorded | Up to 24 hours after surgery |
Time to first mobilization | Time to first standing or mobilization after surgery will be recorded and compared between groups | Up to 24 hours after surgery |
Ankle dorsiflexion motor strength | Ankle dorsiflexion motor strength will be assessed postoperatively to evaluate possible motor weakness related to block spread. | Recovery room, 2 hours, 6 hours, 12 hours, and 24 hours after surgery |
Participation Assistant
Eligibility Criteria
Eligible Ages
Adult, Older Adult
Minimum Age
18 Years
Eligible Sexes
All
- Adults aged 18 years and older
- American Society of Anesthesiologists (ASA) physical status I-III
- Scheduled for elective primary total hip arthroplasty under spinal anesthesia
- Able to provide written informed consent
- ASA physical status IV or V
- Serious concomitant cardiac, respiratory, hepatic, or renal disease
- Known neuropsychiatric disorder
- Cognitive impairment preventing understanding or response to the Numeric Rating Scale (NRS)
- Coagulopathy
- Local anesthetic allergy
- Infection or scar at the block site
- Failed block
- Refusal to participate
- Signs of local anesthetic systemic toxicity after block
- Patients in the PENG plus PPD group who would be exposed to a total local anesthetic dose above 3 mg/kg in patients weighing less than 50 kg
- Revision total hip arthroplasty
- Total hip arthroplasty planned for fracture
Kirsehir Ahi Evran UniversitesiStudy Responsible Party
Guzin Ceran, Principal Investigator, Assistant Professor, Department of Anesthesiology and Reanimation, Kirsehir Ahi Evran Universitesi
Study Central Contact
Contact: Guzin Ceran Assistant Professor, MD, +90-506-163-0936, [email protected]
Contact: Abdulkadir Apaydin, MD, +90-531-951-2333, [email protected]
No location data.