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Clinical Trial NCT06916221 for Long-Term Memory, Inhibitory Control is recruiting. See the Trial Radar Card View and AI discovery tools for all the details. Or ask anything here. | ||
University of California, San FranciscoBID LTM Digital Intervention in Aging
Healthy aging is typically accompanied by diminished capability for learning and retrieval of high-fidelity long-term memory (LTM). The decline in these faculties is accelerated and becomes significant deficits in LTM and cognitive control functions at the level or a diagnosis of Mild Cognitive Impairment (MCI). Training with the navigation game, relative to training with control games, is expected to improve LTM performance for older adult participants.
Researchers will compare two different digital interventions to assess whether they may be helpful in improving cognitive function.
Participants will conduct study activities remotely (e.g., at-home):
- Baseline Assessment. Complete a series of cognitive assessments and surveys.
- Intervention. Engage in a digital intervention for up to 8 weeks.
- Post Intervention Assessment. Complete the same cognitive assessments and surveys as the Baseline Assessment.
- Follow-Up Assessment. Six months after the intervention ends, participants will complete the same cognitive assessments and surveys as the Baseline Assessment.
Participants are provided by the study team with an Apple iPad 10th Generation (2024) at their home address, which will enable them to complete all study tasks at home via Nexus. All required applications will be pre-loaded on the device.
Participants will receive notifications and reminders to complete study tasks by email, through in-app reminders, or SMS. They can view their task list and progress in their personal dashboard in Nexus.
Study procedures include a series of surveys and brief tests of memory and attention as Baseline Tests, which make take up to 120 minutes and can be completed across more than one session.
Participants will engage with their assigned training application to complete 45 minutes of training, several days a week for up to 8 weeks for a total of 1000 minutes of training. Participants will be randomly assigned to one of two intervention apps, which encourage long-term memory.
Once their assigned training regimen is complete, participants will again fulfill a series of surveys and brief tests of memory and attention as Post-Training Tests, which make take up to 120 minutes and can be completed across more than one session.
Six months after completion of all Post-Training Tests, participants will be fulfill a third series of surveys and brief tests of memory and attention as Follow-Up Tests, which make take up to 120 minutes and can be completed across more than one session.
Behavioral Intervention Development Core - Long Term Memory Digital Intervention in Aging
cognitive aging
memory
| Participant Group/Arm | Intervention/Treatment |
|---|---|
Active ComparatorLong Term Memory Multi-session cognitive intervention as a computer game that presents an adaptive spatial wayfinding challenge. | Long Term Memory Tablet computer game designed to stimulate environmental enrichment via an adaptive and immersive experience learning virtual neighborhoods and errands in order to complete assigned errands. |
Active ComparatorWorder Multi-session cognitive intervention as a computer game that presents a word puzzle. | Worder Tablet computer game designed to stimulate interest in solving word puzzles, much like the Boggle game. |
| Outcome Measure | Measure Description | Time Frame |
|---|---|---|
MDT change in recognition memory | Psychometric test for proportion correct in memory for studied images of common objects versus paired similar lures | baseline promptly before, post-training promptly after regimen is completed, and follow up six months after post-training tests |
TOUR change in cued recall memory | Psychometric test for proportion of details correctly recalled from recent autobiographical memory | baseline promptly before, post-training promptly after regimen is completed, and follow up six months after post-training tests |
| Outcome Measure | Measure Description | Time Frame |
|---|---|---|
Cognitive Assessment change in working memory | Psychometric test for proportion of number of correctly identified images from working memory span | baseline promptly before, post-training promptly after regimen is completed, and follow up six months after post-training tests |
- Minimum of 12 years of education
- English fluency: All task instructions are presented in English language text. In order to control for sufficient and equivalent participant comprehension of the procedures and instructions, we require their self-report of fluency in English.
- Normal or corrected-to-normal vision
- Normal or corrected-to-normal hearing
- Medically healthy older adults, including those with below-average cognitive performance /MCI patients without dementia referred by neuropsychologists (i.e., no participant medical records will be reviewed).
- Under the age of 60
- Clinical diagnosis of neurological or psychiatric disorder Clinical diagnosis of dementia or AD8 score of >4
- Visually or hearing impaired without correction to normal
- Regularly (one or more times per week) practicing an instrument within the last year
- 10 years or more of formal musical instrument training
University of California, San Francisco704 active trials to exploreNational Institute on Aging (NIA)California