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Clinical Trial NCT06278285 (Maigrir_OT) for Obesity is recruiting. See the Trial Radar Card View and AI discovery tools for all the details. Or ask anything here. | ||
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Effect of Agonist GLP1 on Adipose Tissue in Patients Undergoing Bariatric Surgery (Maigrir_OT) 40
Clinical Trial NCT06278285 (Maigrir_OT) is an interventional study for Obesity that is recruiting. It started on March 6, 2024 with plans to enroll 40 participants. Led by Centre Hospitalier Universitaire de Nice, it is expected to complete by March 6, 2027. The latest data from ClinicalTrials.gov was last updated on March 27, 2026.
Brief Summary
Normalizing weight gain and preventing the redistribution of body fat is a major health issue, and could help prevent the onset of various symptoms of metabolic syndrome. Above all, it is important to understand the mechanisms by which these different treatments affect adipose tissue. To this end, the investigators will first study the impact of GLP-1 analogues on adipose tissue. The main objective is to show that su...Show More
Official Title
Effect of Agonist GLP1 on Adipose Tissue in Patients Undergoing Bariatric Surgery
Conditions
ObesityOther Study IDs
- Maigrir_OT
- 21-AOIP-01
NCT ID Number
Start Date (Actual)
2024-03-06
Last Update Posted
2026-03-27
Completion Date (Estimated)
2027-03-06
Enrollment (Estimated)
40
Study Type
Interventional
PHASE
N/A
Status
Recruiting
Primary Purpose
Diagnostic
Design Allocation
Non-Randomized
Interventional Model
Parallel
Masking
None (Open Label)
Arms / Interventions
| Participant Group/Arm | Intervention/Treatment |
|---|---|
Otherwhole blood in a GLP1 Oxytocyne assay in a GLP1 analogue or non-analogue patient population | Blood GLP1 On the day of surgery, the surgeon will remove visceral adipose tissue (1 cm3) from the operative waste. The adipose tissue is separated into 2 samples, one frozen in nitrogen, the other embedded in formalin. The samples are then sent to the Institut de Biologie de Valrose (iBV) to assess any differences between the two groups of patients (patients treated with anti-GLP-1 analogues |
Otherwhole blood in non analague patient population Oxytocyne assay in a GLP1 analogue or non-analogue patient population | Blood No treated GLP1 On the day of surgery, the surgeon will remove visceral adipose tissue (1 cm3) from the operative waste. The adipose tissue is separated into 2 samples, one frozen in nitrogen, the other embedded in formalin. The samples are then sent to the Institut de Biologie de Valrose (iBV) to assess any differences between the two groups of patients (patients treated with patients not treated with anti-GLP-1 analogues) and the ...Show More |
Primary Outcome Measures
Secondary Outcome Measures
| Outcome Measure | Measure Description | Time Frame |
|---|---|---|
Rate of oxytocin | show that subjects treated with a GLP-1 agonist have a significant change in oxytocin levels compared with subjects not treated with a GLP-1 agonist. | one time (before surgery) |
| Outcome Measure | Measure Description | Time Frame |
|---|---|---|
Fibrosis rate | compare adipose tissue caracteristics between patients treated by analog GLP1 and not treated by analog GLP1 | At surgery |
Participation Assistant
Eligibility Criteria
Eligible Ages
Adult, Older Adult
Minimum Age
18 Years
Eligible Sexes
All
- Patient over 18 years of age.
- Patient able to read and understand the information/consent leaflet.
- Patient with BMI > 35 with at least one comorbidity. Or BMI > 40
- Indication for digestive surgery validated in a multidisciplinary consultation meeting and prior agreement accepted by the CPAM.
- Membership of a social security scheme
- Patient's signed informed consent
- For subjects in the GLP-1 analogue group: GLP-1 analogue taken for at least 3 months.
- For non-GLP-1 analogue group: never taken GLP-1 analogues.
- Pregnant or breast-feeding women.
- Vulnerable patients (under guardianship)
- Patients deprived of liberty
Centre Hospitalier Universitaire de NiceStudy Central Contact
Contact: ROUX Christian, PhD, +3349209220, [email protected]
Contact: Iannelli Antonio, PhD, [email protected]
1 Study Locations in 1 Countries
Alpes-maritimes
CHU de Nice - Hôpital de l'Archet, Nice, Alpes-maritimes, 06200, France
Roux Christian, PhD, Contact, +33492039220, [email protected]
Iannelli Antonio, PhD, Contact, [email protected]
Iannelli Antonio, PhD, Principal Investigator
Recruiting