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临床试验 NCT07302737 针对心力衰竭，谵妄混乱状态目前尚未招募。请查看临床试验雷达卡片视图和 AI 发现工具了解所有详情，或在此提出任何问题。 | ||
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艾因夏姆斯大学Delirium and Heart Failure 100 生物标志物驱动
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临床试验NCT07302737是一项针对心力衰竭，谵妄混乱状态的观察研究试验，当前状态为尚未招募。试验尚未开始，计划于2026年1月20日开始，预计招募100名患者。该研究由艾因夏姆斯大学主导，计划于2026年8月1日完成。试验数据来源于ClinicalTrials.gov，最后更新时间为2025年12月24日。
简要概括
Biomarkers such as Systemic Immune-Inflammation Index (SII) and TG/Glucose Ratio (TyG) have shown promise in predicting delirium, reflecting the roles of inflammation and metabolic disturbances in its pathophysiology. This study aims to compare the predictive value of SII and the TyG ratio among other chemical and physiological biomarkers for diagnosing delirium and detecting its severity in older adults with heart f...显示更多
官方标题
Accuracy of Different Biomarkers for Predicting Delirium in Older Adults With Heart Failure
疾病
心力衰竭谵妄混乱状态其他研究标识符
- FMASU MD195/2025
NCT编号
实际开始日期
2026-01-20
最近更新发布
2025-12-24
预计完成日期
2026-08-01
计划入组人数
100
研究类型
观察研究
试验状态
尚未招募
关键词
Heart failure
delirium
older adults
delirium
older adults
试验组/干预措施
| 参与者组/试验组 | 干预措施/治疗方法 |
|---|---|
cases hospitalized older patients with heart failure and delirium | 全面老年评估 multidimensional assessment of cognition, physical, function, mood, social status of the participants the Confusion Assessment Method (CAM test) or CAM-ICU standardized tool designed to quickly and accurately diagnose delirium by assessing four key features: acute mental change, inattention, and either disorganized thinking or altered consciousness. The original CAM is used for communicative patients on general wards, relying on conversation, while the CAM-ICU is adapted for critically ill, often non-verbal patients in the ICU, using non-verbal tasks and sedation scales...显示更多 Delirium Rating Scale - Revised-98 The Delirium Rating Scale-Revised-98 (DRS-R-98) is a standardized, expert-rated clinical tool designed specifically to measure the severity of delirium and help distinguish it from other psychiatric disorders, such as dementia, depression, and schizophrenia. Unlike the CAM/CAM-ICU, which provides a simple "yes/no" diagnosis, the DRS-R-98 quantifies how severe a patient's delirium is at a given point in time and track...显示更多 blood biomarkers complete blood count(to obtain systemic inflammatory index) ,triglyceride (TG) and glucose, Liver and kidney function tests and serum electrolytes level |
controls age and gender matched heart failure older patients without delirium | 全面老年评估 multidimensional assessment of cognition, physical, function, mood, social status of the participants the Confusion Assessment Method (CAM test) or CAM-ICU standardized tool designed to quickly and accurately diagnose delirium by assessing four key features: acute mental change, inattention, and either disorganized thinking or altered consciousness. The original CAM is used for communicative patients on general wards, relying on conversation, while the CAM-ICU is adapted for critically ill, often non-verbal patients in the ICU, using non-verbal tasks and sedation scales...显示更多 blood biomarkers complete blood count(to obtain systemic inflammatory index) ,triglyceride (TG) and glucose, Liver and kidney function tests and serum electrolytes level |
主要终点
次要终点
| 结果指标 | 度量标准描述 | 时间框架 |
|---|---|---|
the sensitivity and specificity of different biomarkers of delirium in heart failure older patient | assess sensitivity and specificity of the systemic inflammatory index (SII), Rate Pressure Product (RPP), and TG/glucose ratio in predicting delirium | Within 24 hours of hospital admission |
| 结果指标 | 度量标准描述 | 时间框架 |
|---|---|---|
in hospital morbidity | follow up cohort for possible complications like acute kidney injury, infections, or adverse drug events | From enrollment to the hospital discharge about 6 weeks |
In hospital mortality | cohort follow up throughout hospital course and mortality recorded | From enrollment to hospital discharge about 6 weeks |
参与助手
资格标准
适龄参与研究
成人, 老年人
最低年龄要求
60 Years
适龄性别
全部
接受健康志愿者
是
Heart failure stage C
- cognitive impairment
- Major Neurological Conditions: (e.g., stroke, traumatic brain injury).
- Hematological diseases that affect platelet, neutrophil, and lymphocyte counts.
- Cardiogenic Shock
- Sepsis
- Ongoing Treatment with Immunosuppressants, or corticosteroids
艾因夏姆斯大学没有联系数据。
1 位于 1 个国家/地区的研究中心
Ain Shams University hospitals, Cairo, 11566, Egypt
Doha Rasheedy, Professor, 联系人, 0201001193544, [email protected]