Name: An Open-label, Multi-center, Long-term Extension Study to Evaluate the Long-term Safety and Tolerability of Admilparant in Participants With Pulmonary Fibrosis
Creator: Bristol-Myers Squibb
Published: 2026-03-02
License: https://www.clinicaltrials.gov/about-site/terms-conditions#availability

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	Clinical Trial NCT07441408 for Pulmonary Fibrosis is not yet recruiting. See the Trial Radar Card View and AI discovery tools for all the details. Or ask anything here.

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Long-term Extension Study to Evaluate Safety and Tolerability of Admilparant in Participants With Pulmonary Fibrosis Phase 3 2,277

Not yet recruiting

Clinical Trial NCT07441408 is designed to study Treatment for Pulmonary Fibrosis. This Phase 3 interventional study is not yet recruiting. Enrollment is planned to begin on December 16, 2026 until the study accrues 2,277 participants. Led by Bristol-Myers Squibb, this study is expected to complete by March 30, 2030. The latest data from ClinicalTrials.gov was last updated on March 2, 2026.

Brief Summary

The purpose of this study is to evaluate the long-term safety and tolerability of Admilparant in participants who completed participation in parent studies IM027-068 (for idiopathic pulmonary fibrosis (IPF)) and IM027-1015 (for progressive pulmonary fibrosis (PPF)).

Official Title

An Open-label, Multi-center, Long-term Extension Study to Evaluate the Long-term Safety and Tolerability of Admilparant in Participants With Pulmonary Fibrosis

Conditions

Pulmonary Fibrosis

Other Study IDs

IM027-1016
2025-522373-10 (Other Identifier) (EU CTR)
U1111-1322-7787 (Other Identifier) (WHO)

NCT ID Number

NCT07441408

Start Date (Actual)

2026-12-16

Last Update Posted

2026-03-02

Completion Date (Estimated)

2030-03-30

Enrollment (Estimated)

2,277

Study Type

Interventional

PHASE

Phase 3

Status

Not yet recruiting

Keywords

LPA1 receptor antagonist
Idiopathic pulmonary fibrosis
Progressive pulmonary fibrosis
Long-term extension
IPF
PPF
IM027068
IM0271015
Follow up

Primary Purpose

Treatment

Design Allocation

N/A

Interventional Model

Single Group

Masking

None (Open Label)

Arms / Interventions

Participant Group/Arm	Intervention/Treatment
ExperimentalBMS-986278 Arm	BMS-986278 Specified dose on specified days

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Number of Participants With Treatment Emergent Adverse Events (TEAEs)		Up to Week 100
Number of Participants With Serious Adverse Events (SAEs)		Up to Week 100
Number of Participants With AEs leading to Discontinuation		Up to Week 100
Number of Participants With AEs leading to Deaths		Up to Week 100
Number of Participants With Clinically Significant Laboraty Abnormalities		Up to Week 100
Number of Participants With Clinically Significant Electocardiogram (ECG) Abnormalities		Up to Week 100
Number of Participants With Clinically Significant Vital Sign Abnormalities		Up to Week 100

Participation Assistant

Eligibility Criteria

Eligible Ages

Child, Adult, Older Adult

Eligible Sexes

All

- Participants must have completed participation in either IM027068 or IM0271015 (defined as receiving study intervention (IMP) until completion of EOT visit).

Clinically significant AE that resulted in discontinuation or interruption of IMP (Investigational Medicinal Product) in IM027068 or IM0271015 without reinitiation of IMP.
Exhibit symptoms of heart failure at rest.
History of lung reduction surgery or lung transplant. Note: Being on the transplantation list is allowed.
Participants with known PAH (Pulmonary Arterial Hypertension) who has been on single drug therapy that now requires multi-drug therapy.
Other protocol-defined Inclusion/Exclusion criteria apply.

Bristol-Myers Squibb

Study Central Contact

Contact: BMS Clinical Trials Contact Center www.BMSClinicalTrials.com, 855-907-3286, [email protected]

Contact: First line of the email MUST contain NCT # and Site #.

111 Study Locations in 16 Countries

Argentina

Buenos Aires

Local Institution - 0013, Florida, Vicente López, Buenos Aires, 1602, Argentina

Site 0013, Contact

Local Institution - 0014, Mar del Plata, Buenos Aires, 7600, Argentina

Site 0014, Contact

Local Institution - 0007, Quilmes, Buenos Aires, 1878, Argentina

Site 0007, Contact

Local Institution - 0009, San Juan Bautista, Buenos Aires, 1888, Argentina

Site 0009, Contact

Local Institution - 0003, Mar del Plata, B, 7600, Argentina

Site 0003, Contact

Córdoba Province

Local Institution - 0001, Córdoba, Córdoba Province, X5003DCE, Argentina

Site 0001, Contact

Mendoza Province

Local Institution - 0002, Godoy Cruz, Mendoza Province, 5501, Argentina

Site 0002, Contact

Local Institution - 0011, Mendoza, M, 5500, Argentina

Site 0011, Contact

Local Institution - 0015, Rosario, S, 2000, Argentina

Site 0015, Contact

Local Institution - 0010, Buenos Aires, C1056ABI, Argentina

Site 0010, Contact

Local Institution - 0008, Santa Fe, 3000, Argentina

Site 0008, Contact

Australia

New South Wales

Local Institution - 0287, Camperdown, New South Wales, 2050, Australia

Site 0287, Contact

Queensland

Local Institution - 0290, Chermside, Queensland, 4032, Australia

Site 0290, Contact

Local Institution - 0291, Greenslopes, Queensland, 4120, Australia

Site 0291, Contact

Local Institution - 0293, South Brisbane, Queensland, 4101, Australia

Site 0293, Contact

South Australia

Local Institution - 0289, Adelaide, South Australia, 5000, Australia

Site 0289, Contact

Victoria

Local Institution - 0288, Frankston, Victoria, 3199, Australia

Site 0288, Contact

Western Australia

Local Institution - 0285, Murdoch, Western Australia, 6150, Australia

Site 0285, Contact

Local Institution - 0292, Nedlands, Western Australia, 6009, Australia

Site 0292, Contact

Local Institution - 0286, Melbourne, 3128, Australia

Site 0286, Contact

Local Institution - 0284, Wentworthville, NSW2145, Australia

Site 0284, Contact

Belgium

Namur

Local Institution - 0249, Yvoir, Namur, 5530, Belgium

Site 0249, Contact

Vlaams-Brabant

Local Institution - 0252, Leuven, Vlaams-Brabant, 3000, Belgium

Site 0252, Contact

Local Institution - 0248, Brussels, 1200, Belgium

Site 0248, Contact

Local Institution - 0251, Kortrijk, 8500, Belgium

Site 0251, Contact

Local Institution - 0250, Liège, 4000, Belgium

Site 0250, Contact

Chile

Maule Region

Local Institution - 0051, Talca, Maule Region, 3466706, Chile

Site 0051, Contact

Región de Valparaíso

Local Institution - 0050, Quillota, Región de Valparaíso, 2260000, Chile

Site 0050, Contact

Colombia

ANT

Local Institution - 0044, Medellín, ANT, 050021, Colombia

Site 0044, Contact

Local Institution - 0047, Medellín, ANT, 050034, Colombia

Site 0047, Contact

Local Institution - 0043, Bogotá, DC, 110111, Colombia

Site 0043, Contact

Local Institution - 0046, Bogotá, DC, 110131, Colombia

Site 0046, Contact

Santander Department

Local Institution - 0041, Floridablanca, Santander Department, 681004, Colombia

Site 0041, Contact

VAC

Local Institution - 0040, Santiago de Cali, VAC, 760046, Colombia

Site 0040, Contact

Local Institution - 0039, Bogotá, 0, Colombia

Site 0039, Contact

Local Institution - 0048, Bogotá, Colombia

Site 0048, Contact

Local Institution - 0042, Manizales, 0, Colombia

Site 0042, Contact

Local Institution - 0045, Zipaquirá, 250252, Colombia

Site 0045, Contact

Denmark

Capital Region

Local Institution - 0487, Hellerup, Capital Region, 2900, Denmark

Site 0487, Contact

Region Midt

Local Institution - 0488, Aarhus, Region Midt, 8200, Denmark

Site 0488, Contact

Region Syddanmark

Local Institution - 0486, Odense C, Region Syddanmark, 5000, Denmark

Site 0486, Contact

Local Institution - 0489, Copenhagen, 2100, Denmark

Site 0489, Contact

Finland

Laensi-Suomen Laeaeni

Local Institution - 0491, Turku, Laensi-Suomen Laeaeni, 20521, Finland

Site 0491, Contact

Local Institution - 0490, Helsinki, 00290, Finland

Site 0490, Contact

France

Auvergne-Rhône-Alpes

Local Institution - 0245, Grenoble, Auvergne-Rhône-Alpes, 38043, France

Site 0245, Contact

Maine-et-Loire

Local Institution - 0236, Angers, Maine-et-Loire, 49933, France

Site 0236, Contact

Pays de la Loire Region

Local Institution - 0246, Nantes, Pays de la Loire Region, 44093, France

Site 0246, Contact

Provence-Alpes-Côte d'Azur Region

Local Institution - 0243, Marseille, Provence-Alpes-Côte d'Azur Region, 13015, France

Site 0243, Contact

Local Institution - 0242, Bobigny, 93009, France

Site 0242, Contact

Local Institution - 0238, Brest, 29609, France

Site 0238, Contact

Local Institution - 0244, Dijon, 21000, France

Site 0244, Contact

Local Institution - 0240, Nice, 06000, France

Site 0240, Contact

Local Institution - 0239, Paris, 75018, France

Site 0239, Contact

Local Institution - 0241, Pessac, 33604, France

Site 0241, Contact

Local Institution - 0247, Saint-Genis-Laval, 69563, France

Site 0247, Contact

Local Institution - 0237, Toulouse, 31059, France

Site 0237, Contact

Ireland

Dublin

Local Institution - 0495, Tallaght, Dublin, 0, Ireland

Site 0495, Contact

Louth

Local Institution - 0493, Drogheda, Louth, A92 VW28, Ireland

Local Institution - 0494, Dublin, 0, Ireland

Site 0494, Contact

Local Institution - 0492, Dublin, D15 X40D, Ireland

Site 0492, Contact

Mexico

Aguascalientes

Local Institution - 0019, Aguascalientes, Aguascalientes, 20116, Mexico

Site 0019, Contact

Chihuahua

Local Institution - 0037, Chihuahua City, Chihuahua, 31203, Mexico

Site 0037, Contact

DIF

Local Institution - 0036, México, DIF, 14050, Mexico

Site 0036, Contact

Edo de Mexico

Local Institution - 0023, Metepec, Edo de Mexico, 52170, Mexico

Site 0023, Contact

Jalisco

Local Institution - 0022, Guadalajara, Jalisco, 44160, Mexico

Site 0022, Contact

Local Institution - 0021, Guadalajara, Jalisco, 44340, Mexico

Site 0021, Contact

Michoacán

Local Institution - 0024, Morelia, Michoacán, 58260, Mexico

Site 0024, Contact

Nuevo León

Local Institution - 0038, Monterrey, Nuevo León, 64460, Mexico

Site 0038, Contact

Oaxaca

Local Institution - 0017, Oaxaca City, Oaxaca, 68000, Mexico

Site 0017, Contact

Local Institution - 0020, Oaxaca City, Oaxaca, 68020, Mexico

Site 0020, Contact

Yucatán

Local Institution - 0035, Col Garcia Binersa, Yucatán, 97070, Mexico

Site 0035, Contact

Local Institution - 0034, Mérida, Yucatán, 97125, Mexico

Site 0034, Contact

Local Institution - 0018, Guadalajara, 44130, Mexico

Site 0018, Contact

Netherlands

South Holland

Local Institution - 0256, Rotterdam, South Holland, 3061BC, Netherlands

Site 0256, Contact

Local Institution - 0253, Amsterdam, 1081 BT, Netherlands

Site 0253, Contact

Local Institution - 0257, Heerlen, 6419 PC, Netherlands

Site 0257, Contact

Local Institution - 0254, Leiden, 2300 RC, Netherlands

Site 0254, Contact

Local Institution - 0255, Nieuwegein, 3425 CM, Netherlands

Site 0255, Contact

Peru

LIM

Local Institution - 0063, Lima, LIM, 15033, Peru

Site 0063, Contact

Local Institution - 0059, San Miguel, LIM, 15088, Peru

Site 0059, Contact

Local Institution - 0058, Lima, 15023, Peru

Site 0058, Contact

Local Institution - 0061, Lima, 15073, Peru

Site 0061, Contact

Local Institution - 0064, Lima, Lima 27, Peru

Site 0064, Contact

Local Institution - 0060, Lima, LIMA 31, Peru

Site 0060, Contact

Local Institution - 0065, Lima, Lima 41, Peru

Site 0065, Contact

Local Institution - 0062, Piura, 20001, Peru

Site 0062, Contact

Portugal

Porto District

Local Institution - 0081, Vila Nova de Gaia, Porto District, 4434-502, Portugal

Site 0081, Contact

Local Institution - 0077, Lisbon, 1769-001, Portugal

Site 0077, Contact

Local Institution - 0078, Loures, 2674-514, Portugal

Site 0078, Contact

Local Institution - 0079, Porto, 4099-001, Portugal

Site 0079, Contact

Local Institution - 0082, Porto, 4200-319, Portugal

Site 0082, Contact

South Korea

Local Institution - 0195, Seoul, 140-887, South Korea

Site 0195, Contact

Spain

Cantabria

Local Institution - 0083, Santander, Cantabria, 39008, Spain

Site 0083, Contact

Local Institution - 0085, Santiago de Compostela, C, 15706, Spain

Site 0085, Contact

Local Institution - 0069, Barcelona, 08036, Spain

Site 0069, Contact

Local Institution - 0074, Barcelona, 08907, Spain

Site 0074, Contact

Local Institution - 0075, Barcelona, 8035, Spain

Site 0075, Contact

Local Institution - 0071, Coslada, 28822, Spain

Site 0071, Contact

Local Institution - 0073, Girona, 17001, Spain

Site 0073, Contact

Local Institution - 0068, Madrid, 28006, Spain

Site 0068, Contact

Local Institution - 0067, Madrid, 28040, Spain

Site 0067, Contact

Local Institution - 0084, Madrid, 28040, Spain

Site 0084, Contact

Local Institution - 0072, Madrid, 28046, Spain

Site 0072, Contact

Local Institution - 0076, Málaga, 29010, Spain

Site 0076, Contact

Local Institution - 0070, Oviedo, 33006, Spain

Site 0070, Contact

Taiwan

Local Institution - 0323, Kaohsiung City, 807, Taiwan

Site 0323, Contact

Local Institution - 0321, Kaohsiung City, 83301, Taiwan

Site 0321, Contact

Local Institution - 0322, Taichung, 404332, Taiwan

Site 0322, Contact

Local Institution - 0325, Taichung, 407, Taiwan

Site 0325, Contact

Local Institution - 0324, Taipei, 100, Taiwan

Site 0324, Contact

Local Institution - 0326, Taipei, 112, Taiwan

Site 0326, Contact

Long-term Extension Study to Evaluate Safety and Tolerability of Admilparant in Participants With Pulmonary Fibrosis Phase 3 2,277

Inclusion Criteria

Exclusion Criteria